Las iglesias evangélicas en el distrito noroeste de la ciudad de Rosario: un estudio exploratorio

El presente trabajo tiene como objetivo realizar una tarea exploratoria como paso previo a investigaciones de mayor peso sobre la acción de las iglesias evangelistas en la ciudad de Rosario desde el 2011 hasta la actualidad. En este sentido, nuestra labor puede realizar un aporte a una doble vacancia en el área de estudios: en primer lugar, la dimensión temporal de la misma se inscribe en la segunda década del siglo XXI, con lo que se estaría contribuyendo a subsanar la escasez de investigaciones que den cuenta de la inscripción política evangélica en el nuevo milenio, tal como advierte Marcos Carbonelli (2010: 110). A la vez, la geografía elegida también puede realizar aportes novedosos, ya que la indagación acerca de organizaciones sociales y comunitarias que exceden el ámbito de la Provincia y de la Ciudad de Buenos Aires no se encuentra tan desarrollado como la de las que no lo hacen. Como contrapartida de esta potencialidad, debemos destacar que no hemos podido acceder a ningún trabajo previo que aborde como objeto de estudio las organizaciones evangélicas en Rosario o su Área Metropolitana. Es por ello que aquí nos proponemos una primera aproximación a las mismas. Entenderemos como cultos evangélicos a aquellos grupos religiosos que se aparten de los dogmas tradicionales de la Iglesia Católica y que logran proporcionar un sistema de vida –estructura de símbolos, valores y creencias- a partir del hito de la salvación, la Verdad revelada en forma literal en la Biblia y el misterio de la Trinidad.Facultad de Humanidades y Ciencias de la Educació

Albedos and diameters of three Mars Trojan asteroids

We observed the Mars Trojan asteroids (5261) Eureka and (101429) 1998 VF31 and the candidate Mars Trojan 2001 FR127 at 11.2 and 18.1 microns using Michelle on the Gemini North telescope. We derive diameters of 1.28, 0.78, and <0.52 km, respectively, with corresponding geometric visible albedos of 0.39, 0.32, and >0.14. The albedos for Eureka and 1998 VF31 are consistent with the taxonomic classes and compositions (S(I)/angritic and S(VII)/achrondritic, respectively) and implied histories presented in a companion paper by Rivkin et al. Eureka's surface likely has a relatively high thermal inertia, implying a thin regolith that is consistent with predictions and the small size that we derive.Comment: Icarus, in press. See companion paper 0709.1925 by Rivkin et al; two minor typos fixe

Pandemic Preparedness and Response in the Age of Technology

The Fourth Annual White Paper from the Scowcroft Institute of International Affairs at The Bush School of Government & Public Service at Texas A&M UniversityEffective pandemic preparedness and response depend on the quality as well as the speed of obtaining relevant information, especially from remote and hard to reach areas of the world, where most known and unknown disease outbreaks occur and originate. Equally important is the local/national ability to collate, analyze, and interpret the information in a form valuable for taking appropriate preventive action and response. For web-based surveillance systems to be more effective, it is important that the capacity to collate, analyze, interpret, and disseminate the information in a form that results in appropriate preventive action and response in the countries where these diseases originate. The COVID-19 pandemic has demonstrated the ability to obtain information from different sources and dissemination of such information globally. Despite the availability of information on the development of the pandemic from a Public Health Emergency of International Concern (PHEIC), many countries were unprepared when the pandemic finally reached their borders. It is not enough for countries to efficiently analyze disease surveillance data, they must actively prepare to prevent the entry of a disease into their territory and, at the same time, prepare plans and identify and initiate containment measures that need to be taken to prevent the establishment of the disease in the country

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva

BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life. DNA methylation may be the underlying association between prenatal cortisol exposure and health effects. We investigated associations between maternal CRH levels and epigenome-wide DNA methylation of cord blood in offsprings and evaluated whether these associations persisted into mid-childhood.MethodsWe investigated mother-child pairs enrolled in the prospective Project Viva pre-birth cohort. We measured DNA methylation in 257 umbilical cord blood samples using the HumanMethylation450 Bead Chip. We tested associations of maternal CRH concentration with cord blood cells DNA methylation, adjusting the model for maternal age at enrollment, education, maternal race/ethnicity, maternal smoking status, pre-pregnancy body mass index, parity, gestational age at delivery, child sex, and cell-type composition in cord blood. We further examined the persistence of associations between maternal CRH levels and DNA methylation in children's blood cells collected at mid-childhood (n = 239, age: 6.7-10.3 years) additionally adjusting for the children's age at blood drawn.ResultsMaternal CRH levels are associated with DNA methylation variability in cord blood cells at 96 individual CpG sites (False Discovery Rate &lt;0.05). Among the 96 CpG sites, we identified 3 CpGs located near the LEP gene. Regional analyses confirmed the association between maternal CRH and DNA methylation near LEP. Moreover, higher maternal CRH levels were associated with higher blood-cell DNA methylation of the promoter region of LEP in mid-childhood (P &lt; 0.05, β = 0.64, SE = 0.30).ConclusionIn our cohort, maternal CRH was associated with DNA methylation levels in newborns at multiple loci, notably in the LEP gene promoter. The association between maternal CRH and LEP DNA methylation levels persisted into mid-childhood

Postural control and disability in patients with early rheumatoid arthritis

PMID: 33427617 Abstract Objectives: Rheumatoid arthritis (RA) may affect the postural control through abnormal sensory inputs and impaired motor responses. Sensory Organization Test (SOT) objectively evaluates contribution of different sensorial afferences in postural control. The aim of the study is to assess mechanisms of postural instability and their relations with disability and disease characteristics in an early RA(ERA) cohort. Methods: The equilibrium scores were assessed in 30 ERA patients and 30 age- and sex-matched controls. The somatosensory (SOM), visual (VIS) and vestibular (VEST) ratios were computed to assess the use of different sensory and the composite equilibrium score (CES) as a measure of global balance performance. Results: ERA patients had lower CES (78.4±6.0% vs. 83.4±5.0%, p=0.002), SOM ratio (98.5±1.8% vs. 99.6±2.1%, p=0.035), VIS ratio (85.2±7.6% vs. 91.5±6.0%, p=0.001) and VEST ratio (70.8±10.0% vs. 80.3±7.8%, p&lt;0.001) compared to controls. The presence of ankle arthritis correlated negatively to both SOM (r=-0.369, p=0.045) and VIS ratio (r=0.470, p=0.009), pain severity to CES (r=-0.389, p=0.045) and VIS ratio (r=-0.385, p=0.048) and HAQ-DI to CES (r=-0.591, p=0.001), SOM (r=-0.510, p=0.004) and VIS ratio (r=-0.390, p=0.033.). Patients-reported postural instability was associated with lower CES (75.4±5.4% vs. 80.7±5.5%, p=0.016) and VEST ratios (66.5±10.1% vs. 74.1±8.8%, p=0.036). SOT outcomes did not differ according to acute phase reactants, disease activity or autoantibody positivity. Conclusions: RA patients showed an early impairment of postural control related to the degree of disability and subjective postural instability. Our data suggest that the lack of balance could result from both impaired motor response and abnormal sensory organisation

Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience

We demonstrated previously that antenatal glucocorticoid treatment (AGT, gestational days 16-19) altered the size and organization of the adult rat midbrain dopaminergic (DA) populations. Here we investigated the consequences of these AGT-induced cytoarchitectural disturbances on indices of DA function in adult rats. We show that in adulthood, enrichment of striatal DA fiber density paralleled AGT-induced increases in the numbers of midbrain DA neurons, which retained normal basal electrophysiological properties. This was co-incident with changes in (i) striatal D2-type receptor levels (increased, both sexes); (ii) D1-type receptor levels (males decreased; females increased); (iii) DA transporter levels (males increased; females decreased) in striatal regions; and (iv) amphetamine-induced mesolimbic DA release (males increased; females decreased). However, despite these profound, sexually dimorphic changes in markers of DA neurotransmission, in-utero glucocorticoid overexposure had a modest or no effect on a range of conditioned and unconditioned appetitive behaviors known to depend on mesolimbic DA activity. These findings provide empirical evidence for enduring AGT-induced adaptive mechanisms within the midbrain DA circuitry, which preserve some, but not all, functions, thereby casting further light on the vulnerability of these systems to environmental perturbations. Furthermore, they demonstrate these effects are achieved by different, often opponent, adaptive mechanisms in males and females, with translational implications for sex biases commonly found in midbrain DA-associated disorders

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

The human body hosts an enormous abundance and diversity of microbes, which perform a range of essential and beneficial functions. Our appreciation of the importance of these microbial communities to many aspects of human physiology has grown dramatically in recent years. We know, for example, that animals raised in a germ-free environment exhibit substantially altered immune and metabolic function, while the disruption of commensal microbiota in humans is associated with the development of a growing number of diseases. Evidence is now emerging that, through interactions with the gut-brain axis, the bidirectional communication system between the central nervous system and the gastrointestinal tract, the gut microbiome can also influence neural development, cognition and behaviour, with recent evidence that changes in behaviour alter gut microbiota composition, while modifications of the microbiome can induce depressive-like behaviours. Although an association between enteropathy and certain psychiatric conditions has long been recognized, it now appears that gut microbes represent direct mediators of psychopathology. Here, we examine roles of gut microbiome in shaping brain development and neurological function, and the mechanisms by which it can contribute to mental illness. Further, we discuss how the insight provided by this new and exciting field of research can inform care and provide a basis for the design of novel, microbiota-targeted, therapies.GB Rogers, DJ Keating, RL Young, M-L Wong, J Licinio, and S Wesseling