180 research outputs found
Isidoro Bosarte y la nueva egiptomanía del final del siglo XVIII: las observaciones sobre los bellas artes entre los antiguos (1791)
Se analiza en el texto la contribución del académico Isidoro Bosarte, en sus Observaciones sobre las Bellas Artes entre los Antiguos (1791), a la nueva valoración del arte y la cultura egipcios que se produce en la segunda mitad del siglo XVIII, en el marco de la nueva visión ilustrada de la Historia.We provide an analysis of the contribution made by Isidoro Bosarte in his Observations on the Fine Arts among the Ancients (1791) to the revaluation of Egyptian art and culture which took place in the second halfof the 18th century, in the context of the conception of history characteristic of the Enlightenment
On-Line influenza virus quantification for viral production processes thanks to affinity-based surface plasmon resonance biosensor
Influenza virus seasonal epidemics, associated with the constant threat of new pandemic outbreak, challenge vaccine manufacturers to develop responsive processes that can outreach the limitations of traditional egg-based technology. Recent progress made regarding cell culture bioprocesses allowed for numerous alternative strategies to developed future vaccine candidates, as for example the recombinant HA or Virus—like Particles (VLP) vaccines. However, while cell culture allows for more versatility than ovoculture, regarding process development and monitoring, these alternatives still require optimization to seriously concurrence the traditional process. To drive these developments, WHO and regulatory agencies underlined the need for developing better influenza vaccine potency assays1,2. Actual influenza vaccine formulation and lot release rely on single-radial immunodiffusion (SRID) assay, which requires strain-specific reference sera and antigen reagents. However, the annual preparation of these reagents takes between 2 to 6 months and constitutes a critical bottleneck for the release of vaccine lots3. Additionally, SRID is not implementable for process development as such technique cannot handle in-process low concentrated and non-purified material. We developed an assay for rapid and label-free quantification of influenza hemagglutinin (HA) antigen and influenza virus based on surface plasmon resonance (SPR). The method is based on affinity capture of hemagglutinin antigen by sialic-acid terminated glycans present at the surface of the fetuin-functionalized sensor. Conditions were optimized for the regeneration of the surface, in order to run multiple sequential analyses on a unique sensor. Two types of purified standard were used during the development of the assay. Commercial trivalent inactivated vaccine (“TIV”) has been used for the determination of optimal analytical conditions, while a stock of split inactivated H1N1 virus has been produced and calibrated in our laboratory to study the specific response obtained toward this HA subtype. This assay offers a quantification of influenza hemagglutinin within minutes with a wide dynamic range (30 ng/mL-20 µg/mL). Also, the technique provides a limit of detection (LOD) 100 times lower than SRID, and a better reproducibility than SRID and its potential alternatives recently proposed (1,4,5. Additionally, the applicability of this assay for an on-line vaccine production monitoring has been validated by off-line measurement of influenza H1N1 virus particles derived from cell culture supernatant. Such a test allowed to achieve a LOD of 106 Infectious Viral Particles/mL Thus, our assay provides an innovative tool to evaluate influenza new vaccine bioprocesses, from viral production kinetics in mammalian cell culture to vaccine potency evaluation
Las ideas estéticas del marqués de Chastellux y las relaciones entre la estética enciclopedista y el idealismo alemán
En las páginas que siguen me propongo analizar un episodio bastante poco conocido dela historia de las ideas estéticas en el siglo XVIII: la conexión entre las teorías estéticas de los enciclopedistas, de hombres como Diderot, D'Alembert, Jaucourt, Watelet, Blondel, Marmontel o Falconet, y las nuevas direcciones que en la segunda mitad del siglo XVIII iba a adquirir el desarrollo del pensamiento estético centroeuropeo gracias a la sistematización de ese nuevo idealismo cuyos máximos representantes serán, por supuesto, Winckelmann y Mengs
Multi-elastic Datacenters: Auto-scaled Virtual Clusters on Energy-Aware Physical Infrastructures
[EN] Computer clusters are widely used platforms to execute different computational workloads. Indeed, the advent of virtualization and Cloud computing has paved the way to deploy virtual elastic clusters on top of Cloud infrastructures, which are typically backed by physical computing clusters. In turn, the advances in Green computing have fostered the ability to dynamically power on the nodes of physical clusters as required. Therefore, this paper introduces an open-source framework to deploy elastic virtual clusters running on elastic physical clusters where the computing capabilities of the virtual clusters are dynamically changed to satisfy both the user application's computing requirements and to minimise the amount of energy consumed by the underlying physical cluster that supports an on-premises Cloud. For that, we integrate: i) an elasticity manager both at the infrastructure level (power management) and at the virtual infrastructure level (horizontal elasticity); ii) an automatic Virtual Machine (VM) consolidation agent that reduces the amount of powered on physical nodes using live migration and iii) a vertical elasticity manager to dynamically and transparently change the memory allocated to VMs, thus fostering enhanced consolidation. A case study based on real datasets executed on a production infrastructure is used to validate the proposed solution. The results show that a multi-elastic virtualized datacenter provides users with the ability to deploy customized scalable computing clusters while reducing its energy footprint.The results of this work have been partially supported by ATMOSPHERE (Adaptive, Trustworthy, Manageable, Orchestrated, Secure, Privacy-assuring Hybrid, Ecosystem for Resilient Cloud Computing), funded by the European Commission under the Cooperation Programme, Horizon 2020 grant agreement No 777154.Alfonso Laguna, CD.; Caballer Fernández, M.; Calatrava Arroyo, A.; Moltó, G.; Blanquer Espert, I. (2018). Multi-elastic Datacenters: Auto-scaled Virtual Clusters on Energy-Aware Physical Infrastructures. Journal of Grid Computing. 17(1):191-204. https://doi.org/10.1007/s10723-018-9449-zS191204171Buyya, R.: High Performance Cluster Computing: Architectures and Systems. Prentice Hall PTR, Upper Saddle River (1999)de Alfonso, C., Caballer, M., Alvarruiz, F., Moltó, G.: An economic and energy-aware analysis of the viability of outsourcing cluster computing to the cloud. Futur. Gener. Comput. Syst. (Int. J. Grid Comput eScience) 29, 704–712 (2013). https://doi.org/10.1016/j.future.2012.08.014Williams, D., Jamjoom, H., Liu, Y.H., Weatherspoon, H.: Overdriver: handling memory overload in an oversubscribed cloud. ACM SIGPLAN Not. 46(7), 205 (2011). https://doi.org/10.1145/2007477.1952709 . http://dl.acm.org/citation.cfm?id=2007477.1952709Valentini, G., Lassonde, W., Khan, S., Min-Allah, N., Madani, S., Li, J., Zhang, L., Wang, L., Ghani, N., Kolodziej, J., Li, H., Zomaya, A., Xu, C.Z., Balaji, P., Vishnu, A., Pinel, F., Pecero, J., Kliazovich, D., Bouvry, P.: An overview of energy efficiency techniques in cluster computing systems. Clust. Comput. 16(1), 3–15 (2013). https://doi.org/10.1007/s10586-011-0171-xDe Alfonso, C., Caballer, M., Hernández, V.: Efficient power management in high performance computer clusters. In: Proceedings of the 1st International Multi-conference on Innovative Developments in ICT, Proceedings of the International Conference on Green Computing 2010 (ICGreen 2010), 39–44 (2010)OpenNebula: OpenNebula Cloud Software https://opennebula.org/ . [Online; accessed 12-June-2017]OpenStack: OpenStack Cloud Software. http://openstack.org . [Online; accessed 12 June 2017]VMWare: VMWare vCenter Server. https://www.vmware.com/products/vcenter-server.html . [Online; accessed 12 June 2017]De Alfonso, C., Blanquer, I.: Automatic consolidation of virtual machines in on-premises cloud platforms. In: IEEE/ACM International Symposium on Cluster, Cloud and Grid Computing, pp 1070–1079 (2017). https://doi.org/10.1109/CCGRID.2017.128Chase, J.S., Irwin, D.E., Grit, L.E., Moore, J.D., Sprenkle, S.E.: Dynamic virtual clusters in a grid site manager. In: Proceedings of the 12th IEEE International Symposium on High Performance Distributed Computing, HPDC ’03, p 90. IEEE Computer Society, Washington, DC (2003). http://dl.acm.org/citation.cfm?id=822087.823392Doelitzscher, F., Held, M., Reich, C., Sulistio, A.: Viteraas: Virtual cluster as a service. In: 2011 IEEE Third International Conference on Cloud Computing Technology and Science (CloudCom), pp 652–657 (2011). https://doi.org/10.1109/CloudCom.2011.101Wei, X., Wang, H., Li, H., Zou, L.: Dynamic deployment and management of elastic virtual clusters. In: 2011 Sixth Annual Chinagrid Conference (ChinaGrid), pp 35–41 (2011). https://doi.org/10.1109/ChinaGrid.2011.31de Assuncao, M.D., di Costanzo, A., Buyya, R.: Evaluating the cost-benefit of using cloud computing to extend the capacity of clusters. In: Proceedings of the 18th ACM International Symposium on High Performance Distributed Computing, HPDC ’09, pp 141–150. ACM, New York (2009). https://doi.org/10.1145/1551609.1551635 . http://doi.acm.org/10.1145/1551609.1551635Marshall, P., Keahey, K., Freeman, T.: Elastic site: Using clouds to elastically extend site resources. In: 2010 10th IEEE/ACM International Conference on Cluster, Cloud and Grid Computing (CCGrid), pp 43–52 (2010). https://doi.org/10.1109/CCGRID.2010.80Niu, S., Zhai, J., Ma, X., Tang, X., Chen, W.: Cost-effective cloud hpc resource provisioning by building semi-elastic virtual clusters. In: Proceedings of the International Conference on High Performance Computing, Networking, Storage and Analysis, SC ’13, pp 56:1–56:12. ACM, New York (2013). https://doi.org/10.1145/2503210.2503236 . http://doi.acm.org/10.1145/2503210.2503236Bialecki, A., Cafarella, M., Cutting, D., Omalley, O.: Hadoop: a framework for running applications on large clusters built of commodity hardware. Tech. rep. Apache Hadoop. http://hadoop.apache.org (2005)MIT: StarCluster Elastic Load Balancer. http://web.mit.edu/stardev/cluster/docs/0.92rc2/manual/load_balancer.htmlAppliance, C.C.S.: Creating elastic virtual clusters. http://cernvm.cern.ch/portal/elasticclusters (2015)Research project, T.G.: The games research project. http://www.green-datacenters.eu (2013)Cioara, T., Anghel, I., Salomie, I., Copil, G., Moldovan, D., Kipp, A.: Energy aware dynamic resource consolidation algorithm for virtualized service centers based on reinforcement learning. In: 2011 10th International Symposium on Parallel and Distributed Computing (ISPDC), pp 163–169 (2011). https://doi.org/10.1109/ISPDC.2011.32Farahnakian, F., Liljeberg, P., Plosila, J.: Energy-efficient virtual machines consolidation in cloud data centers using reinforcement learning. In: 2014 22nd Euromicro International Conference on Parallel, Distributed and Network-Based Processing (PDP), pp 500–507 (2014). https://doi.org/10.1109/PDP.2014.109Masoumzadeh, S., Hlavacs, H.: Integrating vm selection criteria in distributed dynamic vm consolidation using fuzzy q-learning. In: 2013 9th International Conference on Network and Service Management (CNSM), pp 332–338 (2013). https://doi.org/10.1109/CNSM.2013.6727854Feller, E., Rilling, L., Morin, C.: Energy-aware ant colony based workload placement in clouds. In: 2011 12th IEEE/ACM International Conference on Grid Computing (GRID), pp 26–33 (2011). https://doi.org/10.1109/Grid.2011.13Pop, C.B., Anghel, I., Cioara, T., Salomie, I., Vartic, I.: A swarm-inspired data center consolidation methodology. In: Proceedings of the 2nd International Conference on Web Intelligence, Mining and Semantics, WIMS ’12, pp 41:1–41:7. ACM, New York (2012). https://doi.org/10.1145/2254129.2254180Marzolla, M., Babaoglu, O., Panzieri, F.: Server consolidation in clouds through gossiping. In: Proceedings of the 2011 IEEE International Symposium on a World of Wireless, Mobile and Multimedia Networks, WOWMOM ’11, pp 1–6. IEEE Computer Society, Washington, DC (2011). https://doi.org/10.1109/WoWMoM.2011.5986483Ghafari, S., Fazeli, M., Patooghy, A., Rikhtechi, L.: Bee-mmt: A load balancing method for power consumption management in cloud computing. In: 2013 Sixth International Conference on Contemporary Computing (IC3), pp 76–80 (2013). https://doi.org/10.1109/IC3.2013.6612165Ajiro, Y., Tanaka, A.: Improving packing algorithms for server consolidation. In: International CMG Conference, pp. 399–406. Computer Measurement Group (2007)Verma, A., Ahuja, P., Neogi, A.: pmapper: power and migration cost aware application placement in virtualized systems. In: Proceedings of the 9th ACM/IFIP/USENIX International Conference on Middleware, Middleware ’08, pp 243–264. Springer, New York (2008)Beloglazov, A., Abawajy, J., Buyya, R.: Energy-aware resource allocation heuristics for efficient management of data centers for cloud computing. Future Gener. Comput. Syst. 28 (5), 755–768 (2012). https://doi.org/10.1016/j.future.2011.04.017Guazzone, M., Anglano, C., Canonico, M.: Exploiting vm migration for the automated power and performance management of green cloud computing systems. In: Proceedings of the First International Conference on Energy Efficient Data Centers, E2DC’12, pp 81–92. Springer, Berlin (2012). https://doi.org/10.1007/978-3-642-33645-4_8Shi, L., Furlong, J., Wang, R.: Empirical evaluation of vector bin packing algorithms for energy efficient data centers. In: 2013 IEEE Symposium on Computers and Communications (ISCC), pp 000,009–000,015 (2013). https://doi.org/10.1109/ISCC.2013.6754915Tomás, L., Tordsson, J.: Improving cloud infrastructure utilization through overbooking. In: Proceedings of the 2013 ACM Cloud and Autonomic Computing Conference on - CAC ’13, p 1. ACM Press, New York (2013). https://doi.org/10.1145/2494621.2494627Dawoud, W., Takouna, I., Meinel, C.: Elastic vm for cloud resources provisioning optimization. In: Abraham, A., Lloret Mauri, J., Buford, J., Suzuki, J., Thampi, S. (eds.) Advances in Computing and Communications, Communications in Computer and Information Science, vol. 190, pp 431–445. Springer, Berlin (2011). https://doi.org/10.1007/978-3-642-22709-7_43Tasoulas, E., Haugerund, H.R., Begnum, K.: Bayllocator: a proactive system to predict server utilization and dynamically allocate memory resources using Bayesian networks and ballooning. In: Proceedings of the 26th International Conference on Large Installation System Administration: Strategies, Tools, and Techniques, pp. 111–122. USENIX Association (2012)Hines, M.R., Gordon, A., Silva, M., Da Silva, D., Ryu, K., Ben-Yehuda, M.: Applications know best: performance-driven memory overcommit with Ginkgo. In: 2011 IEEE Third International Conference on Cloud Computing Technology and Science, pp. 130–137. IEEE. https://doi.org/10.1109/CloudCom.2011.27 (2011)Litke, A.: Manage resources on overcommitted KVM hosts. Tech. rep. IBM. http://www.ibm.com/developerworks/library/l-overcommit-kvm-resources/ (2011)De Alfonso, C., Caballer, M., Alvarruiz, F., Hernández, V.: An energy management system for cluster infrastructures. Comput. Electr. Eng. 39(8), 2579–2590 (2013). https://doi.org/10.1016/j.compeleceng.2013.05.004Moltó, G., Caballer, M, de Alfonso, C.: Automatic memory-based vertical elasticity and oversubscription on cloud platforms. Futur. Gener. Comput. Syst. 56, 1–10 (2016). https://doi.org/10.1016/j.future.2015.10.002Calatrava, A., Romero, E., Moltó, G., Caballer, M., Alonso, J.M.: Self-managed cost-efficient virtual elastic clusters on hybrid Cloud infrastructures. Futur. Gener. Comput. Syst. 61, 13–25 (2016). https://doi.org/10.1016/j.future.2016.01.018 . http://authors.elsevier.com/sd/article/S0167739X16300024 , http://linkinghub.elsevier.com/retrieve/pii/S0167739X16300024Caballer, M., Chatziangelou, M., Calatrava, A., Moltó, G., Pérez, A.: IM integration in the EGI VMOps Dashboard. In: EGI Conference 2017 and INDIGO Summit 2017 (2017)Calatrava, A., Caballer, M., Moltó, G., Pérez, A.: Virtual Elastic Clusters in the EGI LToS with EC3. In: EGI Conference 2017 and INDIGO Summit 2017 (2017)Iosup, A., Li, H., Jan, M., Anoep, S., Dumitrescu, C., Wolters, L., Epema, D.H.: The grid workloads archive. Futur. Gener. Comput. Syst. 24(7), 672–686 (2008). https://doi.org/10.1016/j.future.2008.02.003 . http://www.sciencedirect.com/science/article/pii/S0167739X08000125Nordugrid dataset, the grid workloads archive (Online; accessed 27-March-2017). http://gwa.ewi.tudelft.nl/datasets/gwa-t-3-nordugrid/report/Caballer, M., Blanquer, I., Moltó, G., de Alfonso, C: Dynamic Management of Virtual Infrastructures. J. Grid Comput. 13, 53–70 (2015). https://doi.org/10.1007/s10723-014-9296-5 . http://link.springer.com/article/10.1007/s10723-014-9296-
An Augmented Reality system for the treatment of phobia to small animals viewed via an optical see-through HMD. Comparison with a similar system viewed via a video see-through
This article presents an optical see-through (OST) Augmented Reality system for the treatment of phobia to small animals. The technical characteristics of the OST system are described, and a comparative study of the sense of presence and anxiety in a nonphobic population (24 participants) using the OST and an equivalent video see-though (VST) system is presented. The results indicate that if all participants are analyzed, the VST system induces greater sense of presence than the OST system. If the participants who had more fear are analyzed, the two systems induce a similar sense of presence. For the anxiety level, the two systems provoke similar and significant anxiety during the experiment. © Taylor & Francis Group, LLC.Juan, M.; Calatrava, J. (2011). An Augmented Reality system for the treatment of phobia to small animals viewed via an optical see-through HMD. Comparison with a similar system viewed via a video see-through. International Journal of Human-Computer Interaction. 27(5):436-449. doi:10.1080/10447318.2011.552059S436449275Azuma, R. and Bishop, G. Improving static and dynamic registration in an optical see-through HMD. Proceedings of 21st Annual Conference on Computer Graphics and Interactive techniques (SIGGRAPH'94). pp.197–204.Bimber, O., & Raskar, R. (2005). Spatial Augmented Reality. doi:10.1201/b10624Botella, C., Quero, S., Banos, R. M., Garcia-Palacios, A., Breton-Lopez, J., Alcaniz, M., & Fabregat, S. (2008). Telepsychology and Self-Help: The Treatment of Phobias Using the Internet. CyberPsychology & Behavior, 11(6), 659-664. doi:10.1089/cpb.2008.0012Botella, C. M., Juan, M. C., Baños, R. M., Alcañiz, M., Guillén, V., & Rey, B. (2005). Mixing Realities? An Application of Augmented Reality for the Treatment of Cockroach Phobia. CyberPsychology & Behavior, 8(2), 162-171. doi:10.1089/cpb.2005.8.162Carlin, A. S., Hoffman, H. G., & Weghorst, S. (1997). Virtual reality and tactile augmentation in the treatment of spider phobia: a case report. Behaviour Research and Therapy, 35(2), 153-158. doi:10.1016/s0005-7967(96)00085-xGarcia-Palacios, A., Hoffman, H., Carlin, A., Furness, T. ., & Botella, C. (2002). Virtual reality in the treatment of spider phobia: a controlled study. Behaviour Research and Therapy, 40(9), 983-993. doi:10.1016/s0005-7967(01)00068-7Genc, Y., Tuceryan, M., & Navab, N. (s. f.). Practical solutions for calibration of optical see-through devices. Proceedings. International Symposium on Mixed and Augmented Reality. doi:10.1109/ismar.2002.1115086Hoffman, H. G., Garcia-Palacios, A., Carlin, A., Furness III, T. A., & Botella-Arbona, C. (2003). Interfaces That Heal: Coupling Real and Virtual Objects to Treat Spider Phobia. International Journal of Human-Computer Interaction, 16(2), 283-300. doi:10.1207/s15327590ijhc1602_08Juan, M. C., Alcaniz, M., Monserrat, C., Botella, C., Banos, R. M., & Guerrero, B. (2005). Using Augmented Reality to Treat Phobias. IEEE Computer Graphics and Applications, 25(6), 31-37. doi:10.1109/mcg.2005.143Juan, M. C., Baños, R., Botella, C., Pérez, D., Alcaníiz, M., & Monserrat, C. (2006). An Augmented Reality System for the Treatment of Acrophobia: The Sense of Presence Using Immersive Photography. Presence: Teleoperators and Virtual Environments, 15(4), 393-402. doi:10.1162/pres.15.4.393Kato, H., & Billinghurst, M. (s. f.). Marker tracking and HMD calibration for a video-based augmented reality conferencing system. Proceedings 2nd IEEE and ACM International Workshop on Augmented Reality (IWAR’99). doi:10.1109/iwar.1999.803809Nash, E. B., Edwards, G. W., Thompson, J. A., & Barfield, W. (2000). A Review of Presence and Performance in Virtual Environments. International Journal of Human-Computer Interaction, 12(1), 1-41. doi:10.1207/s15327590ijhc1201_1Owen, C. B., Ji Zhou, Tang, A., & Fan Xiao. (s. f.). Display-Relative Calibration for Optical See-Through Head-Mounted Displays. Third IEEE and ACM International Symposium on Mixed and Augmented Reality. doi:10.1109/ismar.2004.28Özbek, C., Giesler, B. and Dillmann, R. Jedi training: Playful evaluation of head-mounted augmented reality display systems. SPIE Conference Medical Imaging. Vol. 5291, pp.454–463.Renaud, P., Bouchard, S., & Proulx, R. (2002). Behavioral avoidance dynamics in the presence of a virtual spider. IEEE Transactions on Information Technology in Biomedicine, 6(3), 235-243. doi:10.1109/titb.2002.802381Schwald, B. and Laval, B. An Augmented Reality system for training and assistance to maintenance in the industrial context. International Conference in Central Europe on Computer Graphics, Visualization and Computer Vision. pp.425–432.Slater, M., Usoh, M., & Steed, A. (1994). Depth of Presence in Virtual Environments. Presence: Teleoperators and Virtual Environments, 3(2), 130-144. doi:10.1162/pres.1994.3.2.130Szymanski, J., & O’Donohue, W. (1995). Fear of Spiders Questionnaire. Journal of Behavior Therapy and Experimental Psychiatry, 26(1), 31-34. doi:10.1016/0005-7916(94)00072-
Evaluation of Fluorescent Confocal Microscopy for Intraoperative Analysis of Prostate Biopsy Cores
The use of fluorescent confocal microscopy allows fast and easy preparation of biopsy cores for intraoperative analysis. We observed strong concordance with traditional analysis in our study. The role of this technique is yet to be established
Hypercholesterolemia boosts joint destruction in chronic arthritis. An experimental model aggravated by foam macrophage infiltration
Objective: The aim of this study was to determine whether hypercholesterolemia increases articular damage in a
rabbit model of chronic arthritis.
Methods: Hypercholesterolemia was induced in 18 rabbits by administrating a high-fat diet (HFD). Fifteen rabbits
were fed normal chow as controls. Chronic antigen-induced arthritis (AIA) was induced in half of the HFD and
control rabbits, previously immunized, by intra-articular injections of ovalbumin. After sacrifice, lipid and systemic
inflammation markers were analyzed in blood serum. Synovium was analyzed by Krenn score, multinucleated cell
counting, immunohistochemistry of RAM11 and CD31, and TNF-a and macrophage chemoattractant protein-1
(MCP-1) gene expression. Active bone resorption was assessed by protein expression of receptor activator of
nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG) and quantification of cathepsin K, contact surface
and the invasive area of pannus into bone.
Results: Rabbits receiving the HFD showed higher total serum cholesterol, HDL, triglycerides and CRP levels than
rabbits fed a normal diet. Synovitis score was increased in HFD, and particularly in AIA and AIA + HFD groups. AIA
+ HFD synovium was characterized by a massive infiltration of RAM11+ cells, higher presence of multinucleated
foam cells and bigger vascularization than AIA. Cathepsin K+ osteoclasts and the contact surface of bone resorbing
pannus were also increased in rabbits with AIA + HFD compared with AIA alone. Synovial TNF-a and MCP-1 gene
expression was increased in AIA and HFD rabbits compared with healthy animals. RANKL protein expression in AIA
and AIA + HFD groups was higher compared with either HFD or normal groups.
Conclusions: This experimental model demonstrates that hypercholesterolemia increments joint tissue damage in
chronic arthritis, with foam macrophages being key players in this process.This work was supported by research grants from Instituto de Salud Carlos III
(PS09/01625, GH-B and PS09/00034, RL). IP-P is the recipient of a fellowship
from Fundacion Conchita Rábago. MJM-C and RG are both recipients of a
Sara Borrell contract from Instituto de Salud Carlos III. RL was funded by
Instituto de Salud Carlos III through a research staff stabilization progra
Las categorías de la crítica de arte romántica en España
La gran importancia del Setecientos para la historia crítica contemporáneaestriba sobre todo en la definición histórica del discurso estético, en una formalización de la epistemología del sujeto, de sus legalidades éticas y culturales, que culminará en el siglo siguiente con la generalización de la teoría del genio. Por tanto, no podemos hablar del genio romántico sin establecer antes, en un breve recorrido, sus precedentes iluministas
Evaluación de los estilos educativos parentales en una muestra de estudiantes filipinos: implicaciones educativas
Un cuerpo teórico importante de investigación sugiere que el estilo autoritativo de los padres se asocia con unas mejoras en diversos aspectos de ajuste psicosocial de los adolescentes. Este artículo desarrolla y analiza la tipología de los estilos educativos parentales en el contexto de jóvenes filipinos. A partir de una muestra de 3.601 estudiantes, se muestra que el estilo autoritativo se asocia con mayor autoestima, menor impulsividad, mayor intención de alcanzar metas positivas en el futuro, mejor rendimiento académico, menor prevalencia de experiencia sexual y mayor rechazo de diversas formas de sexismo
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