临床药师在药品不良反应监测中的专业作用

目的探讨在大型综合医院药品不良反应(Adr)监测工作中,临床药师的专业作用。方法临床药师实施对Adr的全程监测,并对其进行有效干预。结果充分发挥药师专业特长,促进临床合理用药,降低Adr的发生。结论临床药师在Adr监测工作中有重要的专业作用

Hospitalization Expenses of Breast Cancer with Different Payments Based on Gamma Model

目的分析不同支付方式的女性乳腺癌患者住院费用,为合理控制乳腺癌住院费用提供依据。方法收集厦门市某三甲医院2004-2012年入院接受治疗且信息完整的女性乳腺癌患者的人口学、疾病、治疗和住院费用资料,采用Gamma模型分析医保与非医保患者的各项住院费用的差异,并估计边际均值及其95%可信区间。结果共纳入451例乳腺癌住院患者,其中医保患者占71.2%;医保与非医保患者中位住院费用分别为12696.4元和11216.5元,其中药品费分别占40.0%和38.8%,检查费分别占23.2%和22.5%,床位费分别占4.5%和4.3%。在控制协变量的影响后,医保和非医保患者的总住院费用(8889.5元vs 6807.6元)、药品费(1721.2元vs 1290.9元)、检查费(3366.5元vs 2400.6元)和床位费(488.9元vs 299.6元)差异均有统计学意义,医保患者的总住院费用、药品费、检查费和床位费分别是非医保患者的1.31、1.33、1.40和1.63倍。结论基于Gamma模型分析支付方式对乳腺癌住院费用的影响具有一定的科学合理性。医疗支付方式在一定程度上影响女性乳腺癌患者的住院费用,医保患者住院费用高于非医保患者,药品费、检查费和床位费是主要的差异来源。Objective To study the difference of hospitalization expenses between insured and uninsured female breast cancer patients with Gamma model. Methods The female patients with breast cancer in a tertiary hospital in Xiamen from Jan1,2004 to Dec 31,2012 were recruited into our study,whose demographics,disease situation,treatment and hospitalization expenses were collected. Gamma model was applied to analyze hospitalization expenses for insured and uninsured patients under control of other covariates,and to estimate marginal means. Results The study included 451 patients with 71. 2% of which were insured. For insured and uninsured patients,the median cost of hospitalization was 12696. 4 RMB and 11216. 5 RMB,respectively. The proportions of the compositions of hospitalization cost were 40. 0% and 38. 8% for drug cost,23. 2% and 22. 5% for examination cost,4. 5% and 4. 3% for bed cost,respectively. After controlling other covariates,total hospitalization cost(8889. 5 RMB vs. 8889. 5 RM B),drug cost( 1721. 2 RMB vs. 1721. 2 RMB),examination cost( 3366. 5 RMB vs. 3366. 5RMB),and bed cost(488. 9 RMB vs. 488. 9 RMB) between insured and uninsured patients were significantly different. Total cost,drug cost,examination cost and bed cost of insured patients were higher than uninsured patients with 0. 31,0. 33,0. 40,and0. 63 times respectively. Conclusion For its advantage in deal with skewed data,the Gamma model has its own rationality and validity on analysis of hospitalization expense. The hospitalization expense of female breast cancer patients with medical insurance was higher than uninsured patients. Drug cost,examination cost and bed cost made a main contribution of difference.国家自然基金青年项目(71403229);; 厦门市科技计划项目(3502Z20143006

辣椒素治疗银屑病52例

我们从1991年5月至1992年6月应用0.025%辣椒素（CAPSAICIn）霜外涂治疗银屑病，并进行单盲对照观察，现报告如下。一、临床资料52例患者中，男29例，女23例；年龄17~65岁，平均28.6岁；病程2个月至20年。其中全身性脓疱型1例..

HYDROTHERMAL SYNTHESIS AND MAGNETIC PROPERTIES OF NANOSIZED NICKEL ZINC FERRITE POWDER

用水热法分别在200℃和220℃下反应5h制备了纳米级镍锌铁氧体(Ni0.5Zn0.5Fe2O4)粉体。用X射线衍射(X-ray diffraction,XRD)分析合成的纳米Ni0.5Zn0.5Fe2O4的物相,结果表明:200℃水热反应5h得到的纳米Ni0.5Zn0.5Fe2O4粉体中含有γ-Fe2O3,220℃水热反应5h可以得到纯纳米Ni0.5Zn0.5Fe2O4粉体。用透射电镜(transmission electronmicroscope,TEM)、Mssbauer谱(Mssbauer spectroscopy,MS)、Fourier红外分析(Fourier transform infrared spectroscopy,FTIR)、振动样品磁强计(vibrating sample magnetometer,VSM)等方法表征纯纳米Ni0.5Zn0.5Fe2O4粉体。TEM结果表明:纳米Ni0.5Zn0.5Fe2O4粉体粒子为球形,粒径约为20nm。室温MS结果表明:大部分纳米Ni0.5Zn0.5Fe2O4粉体粒子表现出铁磁性,少量的表现出超顺磁性。FTIR分析表明:样品在577cm-1和420cm-1处出现NiZn铁氧体的特征峰。磁滞回线结果表明:纳米Ni0.5Zn0.5Fe2O4粉体粒子的饱和磁化强度为38.14A?m2/kg,剩磁为17.32A?m2/kg,矫顽力为29275.29A/m。Nanosized nickel zinc ferrite(Ni0.5Zn0.5Fe2O4)powder was synthesized by the hydrothermal synthesis method at 200℃ and 220 ℃for 5h,respectively.An X-ray diffraction(XRD)was adopted for the characterization of Ni0.5Zn0.5Fe2O4 powder.It is concluded that the Ni0.5Zn0.5Fe2O4 powder containedγ-Fe2O3 when it is synthesized at 200 ℃for 5h,and pure Ni0.5Zn0.5Fe2O4 powder were prepared by the hydrothermal synthesis at 220 ℃for 5h.The pure powder was characterized by a transmission electron micro-scope(TEM),Mssbauer spectrum(MS),Fourier transform spectroscopy(FTIR),and magnometry using a vibrating sample magne-tometer(VSM).The TEM results show that Ni0.5Zn0.5Fe2O4 nanoparticles are round,and are about 20 nm in diameter.The MS results reveal that most of the Ni0.5Zn0.5Fe2O4 nanoparticles show ferromagnetism and a small quantity of Ni0.5Zn0.5Fe2O4 exhibit superpara-magnetic relaxation.The FTIR results show that the bands at 577 cm-1 and 420 cm-1 are the characteristic bands of NiZn ferrite.The saturated magnetization,remanence and coercivity of Ni0.5Zn0.5Fe2O4 powder are 38.14 A·m2/kg,17.32 A·m2/kg and 29 275.29 A/m,respectively.The powder exhibits good magnetic properties.深圳大学科研(4CHQ)资助项

类泛素蛋白及其中文命名

泛素家族包括泛素及类泛素蛋白,约20种成员蛋白.近年来,泛素家族领域取得了迅猛发展,并已与生物学及医学研究的各个领域相互交叉.泛素家族介导的蛋白质降解和细胞自噬机制的发现分别于2004和2016年获得诺贝尔奖.但是,类泛素蛋白并没有统一规范的中文译名. 2018年4月9日在苏州召开的《泛素家族介导的蛋白质降解和细胞自噬》专著的编委会上,部分作者讨论了类泛素蛋白的中文命名问题,并在随后的\"泛素家族、自噬与疾病\"(Ubiquitinfamily,autophagy anddiseases)苏州会议上提出了类泛素蛋白中文翻译草案,此草案在参加该会议的国内学者及海外华人学者间取得了高度共识.冷泉港亚洲\"泛素家族、自噬与疾病\"苏州会议是由美国冷泉港实验室主办、两年一度、面向全球的英文会议.该会议在海内外华人学者中具有广泛影响,因此,参会华人学者的意见具有一定的代表性.本文介绍了10个类别的类泛素蛋白的中文命名,系统总结了它们的结构特点,并比较了参与各种类泛素化修饰的酶和它们的生物学功能.文章由45名从事该领域研究的专家合作撰写,其中包括中国工程院院士1名,相关学者4名,长江学者3名,国家杰出青年科学基金获得者18名和美国知名高校华人教授4名.他们绝大多数是参加编写即将由科学出版社出版的专著《泛素家族介导的蛋白质降解和细胞自噬》的专家

Trisomy 21-induced Dysregulation of Microglial Homeostasis in Alzheimer’s Brains is Mediated by USP25

阿尔茨海默病（Alzheimer’s disease, AD）是一种最为常见的与记忆、认知能力退化相关的渐进性神经退行性疾病。唐氏综合征（Down’s syndrome, DS）是早发型阿尔茨海默病的一个重要风险因素，作为最常见的智力障碍遗传疾病，厦门大学医学院神经科学研究所王鑫教授团队揭示了治疗阿尔茨海默病和唐氏综合征新的治疗靶点，并且在小鼠模型上利用USP25小分子抑制剂成功地改善了阿尔茨海默病小鼠的认知功能，缓解了神经退行性病变的病理进程。该研究工作由王鑫教授指导完成，厦门大学医学院助理教授郑秋阳和博士生李桂林完成主要实验工作，王世华、朱琳、高月、邓青芳、张洪峰、张丽珊、吴美玲、狄安洁参与了部分研究工作。厦门大学医学院许华曦、赵颖俊和孙灏教授在研究过程中给予大力帮助和支持，清华大学董晨教授提供了Usp25基因敲除小鼠，厦门大学附属妇女儿童医院周裕林教授和郑良楷博士帮助收集了脑组织样品。Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer’s disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in combined murine DS-AD models. Overexpression of USP25, a deubiquitinating enzyme encoded by chromosome 21, results in microglial activation and induces synaptic and cognitive deficits, whereas genetic ablation of Usp25 reduces neuroinflammation and rescues synaptic and cognitive function in 5×FAD mice. Mechanistically, USP25 deficiency attenuates microglia-mediated proinflammatory cytokine overproduction and synapse elimination. Inhibition of USP25 reestablishes homeostatic microglial signatures and restores synaptic and cognitive function in 5×FAD mice. In summary, we demonstrate an unprecedented role for trisomy 21 and pathogenic effects associated with microgliosis as a result of the increased USP25 dosage, implicating USP25 as a therapeutic target for neuroinflammation in DS and AD.This work was supported by the National Natural Science Foundation of China (31871077, 81822014, and 81571176 to X.W.; 81701130 to Q.Z.), the National Key R&D Program of China (2016YFC1305900 to X.W.), the Natural Science Foundation of Fujian Province of China (2017J06021 to X.W.), the Fundamental Research Funds for the Chinese Central Universities (20720150061 to X.W.), and the BrightFocus Foundation (A2018214F to Yingjun Zhao). 该研究工作得到国家重点研发计划项目、国家自然科学基金、福建省自然科学基金、厦门大学校长基金的资助和支持

女子大生の咀嚼の実態と心身の各種因子との関係について

咀嚼を含めた食行為が女子大生の心身に与える影響を把握するため、マシュマロとチャーハンにおける咀嚼回数の測定並びに、生活習慣および心理状況調査を実施した。また、咀嚼回数の測定と併せて口腔部のサイズや容量、1口の食物投入量、咀嚼数、咀嚼スピード、スプーンの移動回数を測定し、体重や体脂肪量などの各種身体情報の調査も行った。　咀嚼の状況と身体特性との関係性を相関分析により検討したところ、相関関係は確認できなかった。咀嚼の状況と生活習慣との関連の検討において、メタボリックシンドロームに対するリスクと有意な負の相関関係が見られた項目は、スプーン移動回数、チャーハン摂取量、1分あたりの摂取量であった。　以上のように咀嚼の状況と生活習慣および心理状況調査結果との関係については、関連性が示唆される傾向が見られた

清朝西南地區義學的經費來源與管理

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兩性平權之研究─以女性警官陞遷為例

隨著婦女就業情形的普遍，兩性議題也愈顯得重要，欲落實兩性平權，法律是最根本之道，從近年政府制定「兩性工作平等法」及「性別平等教育法」對於推進兩性平權，均具有劃時代的意義。所謂「玻璃天花板效應」（glass ceiling effect），就是一種不易被察覺的、人為的或組織的偏差所造成的無形阻礙，使得女性在事業生涯方面，無法獲得與男性公平競爭的機會。本研究藉由對玻璃天花板、陞遷、性別角色等相關理論與實務之檢視，對我國女性警官陞遷潛藏之問題進行探討，期能依據研究結果，提出一些建議，以供女性警官個人及有關機關參考。 在研究方法方面，本研究係採用問卷調查法為主，以我國女性警官為普測對象，取得回收有效問卷525份。研究問卷內容包含影響陞遷之「社會心理」構面、「歧視偏差」構面、「系統結構」構面與「陞遷發展」構面及女性警官個人基本資料等量表。問卷調查所得資料運用電腦統計套裝軟體SPSS for Windows 10.0版，以描述性統計分析、t考驗、單因子變異數分析及Pearson積差相關等統計分析方法進行資料處理： 本研究經由實證分析之後，歸納結論如下： 一、就各構面之認知程度而言：其同意程度依次為影響陞遷之「社會心理」構面，其次是「陞遷發展」構面，再次是「歧視偏差」構面，最後為「系統結構」構面。 二、就各構面之認知差異情形而言：在「社會心理」構面上，因年齡、婚姻、子女數、教育程度、警官年資、職務官階、服務單位、有無進修、現任職位及代理主管的不同而有顯著差異存在；在「歧視偏差」構面上，因婚姻、職務官階、工作內容、現任職位及代理主管的不同而有顯著差異存在；在「系統結構」構面上，因工作照顧、教育程度、職務官階、有無進修及代理主管的不同而有顯著差異存在；在「陞遷發展」構面上，因有無進修、現任職位及代理主管的不同而有顯著差異存在。 三、就各構面之相關分析而言：本研究所探討的四個構面的關連非常強，不論是整體或是其各個的因素之間均達顯著水準的正相關。With the rise of female employment rate in workplace, gender issues have been of higher importance in recent years. To realize gender equality in workplace, legislation serves to be the most fundamental solutions of all. Following the enactment of the Gender Equality in Employment Law and the Gender Equality Education Law, Taiwan female employees have seen landmark on their workplace status. But the so-called glass-ceiling effects, are less perceivable, man-made or organizational bias still persist, which deprive female employees of an equal opportunity as those bestowed on their male counterparts. In this study, the author will discuss the obstacles posed for Taiwan’s female police officers in their quest organizational positions based on the observation from the theoretical and practical sides of glass-ceiling effects, promotional and gender roles, and will further propose suggestions for improvements for female police officers. Methodologically, this study uses questionnaire survey research, with female police officers as subjects and results in 525 successful samples. Contents of the questionnaire include facets of promotional importance, such as socio-psychology, discrimination bias, systematic structures, promotional development and personal information. With the analysis of descriptive statistics, t-test, one way ANOVA and the Pearson product-moment correlation coefficient supported by SPSS for Windows 10.0, information gathered from the results of questionnaire is processed: After empirical analysis, our conclusions are: 1.On the acknowledgement level of each facet: respondents find most of their agreements on the importance of obstacles to their promotion, are socio-psychology, promotional development, discrimination bias and systematic structure. 2.On the perceptional difference of each facet: on the socio-psychological aspect, there are differences according to the age, marital status, children number, educational level, years of working as police officer, rank, current position, deputy supervisor, further education. On the discrimination bias facet, there are differences according to marital status, rank, job description, current position and deputy supervisor. On the systematic structure facet, the differences exists among respondents of different educational level, rank, further education and deputy supervisor. On the promotional development facet, there are differences according to further education, current position and deputy supervisor. 3.On the correlation analysis of each facet: the four facets discussed in the study has strong correlations, no matter individual factor or integral whole has all reached a high standard level of positive relationship