A Case of Biliary Pancreatitis Which Subsided after Endoscopic Sphincterotomy during Pregnancy

A 24-year-old pregnant patient was referred to us because of pain and tenderness in the right upper quadrant. Her liver enzymes and bilirubin levels were elevated; an abdominal ultrasound examination revealed gallstones within the gallbladder. Diagnosis of biliary pancreatitis was established based on elevated amylase levels. Oral intake was withheld; intravenous antibiotic therapy and total parenteral nutrition were administered. An endoscopic sphincterotomy without the use of fluoroscopy was performed. Abdominal pain and elevated serum amylase levels subsided after this procedure. In our case, biliary pancreatitis, which developed during pregnancy, responded well to the endoscopic sphincterotomy, and this procedure obviated the need for surgical intervention and prevented the recurrence of pancreatitis

catena-Poly[[(μ-3-hy­droxy­benzoato-κ3 O 1,O 1′:O 3)(μ-3-hy­droxy­benzoato-κ3 O 1,O 1′:O 1)(isonicotinamide-κN 1)­lead(II)] monohydrate]

In the crystal of the title polymeric compound, {[Pb(C7H5O3)2(C6H6N2O)]·H2O}n, the PbII ion is chelated by two carboxyl­ate groups of 3-hy­droxy­benzoate (HB) anions, and coordinated by one isonicotinamide mol­ecule; a carboxyl­ate O atom and a hy­droxy O atom from adjacent HB anions bridge the PbII ion to form polymeric chains along [100], in which the PbII ion is in an irregular seven-coordination geometry. The carboxyl­ate groups of the HB ions are slightly twisted away from the attached benzene rings by 2.84 (15) and 4.8 (2)°. The planes of the two benzene rings of the HB ions are oriented with respect to each other at a dihedral angle of 84.41 (8)°. In the crystal, adjacent polymeric chains inter­act via O—H⋯O, N—H⋯O and weak C—H⋯O hydrogen bonds. The solvent water mol­ecule links with the polymeric chains via O—H⋯O hydrogen bonding. π–π stacking between the benzene and pyridine rings and between the benzene rings [centroid–centroid distances = 3.731 (2) and 3.353 (2) Å] are present in the crystal

Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats

OBJECTIVE: The objective of this study was to examine the separate and combined effects of tobacco and biomass smoke exposure on pulmonary histopathology in rats. INTRODUCTION: In addition to smoking, indoor pollution in developing countries contributes to the development of respiratory diseases. METHODS: Twenty-eight adult rats were divided into four groups as follows: control group (Group I, no exposure to tobacco or biomass smoke), exposed to tobacco smoke (Group II), exposed to biomass smoke (Group III), and combined exposure to tobacco and biomass smoke (Group IV). After six months the rats in all four groups were sacrificed. Lung tissue samples were examined under light microscopy. The severity of pathological changes was scored. RESULTS: Group II differed from Group I in all histopathological alterations except intraparenchymal vascular thrombosis. There was no statistically significant difference in histopathological changes between the subjects exposed exclusively to tobacco smoke (Group II) and those with combined exposure to tobacco and biomass smoke (Group IV). The histopathological changes observed in Group IV were found to be more severe than those in subjects exposed exclusively to biomass smoke (Group III). DISCUSSION: Chronic exposure to tobacco and biomass smoke caused an increase in severity and types of lung injury. CONCLUSION: Exposure to cigarette smoke caused serious damage to the respiratory system, particularly with concomitant exposure to biomass smoke

Complications of cardiopulmonary resuscitation in non-traumatic cases and factors affecting complications

AbstractIn this study, bodily injuries related to chest compression were examined in non-traumatic death cases that underwent autopsy. This study aimed to evaluate factors that can affect these injuries.Data were collected retrospectively, and injuries related to chest compression during cardiopulmonary resuscitation were determined over a 10-year period. Age, gender and cause of death were determined, and when cardiopulmonary resuscitation was performed, cardiopulmonary resuscitation duration, intubation and the injury that occurred due to chest compression were also determined.The study included data from 203 cases. The most frequent injuries were a single fracture in the left ribs (19.7%). Only the duration of cardiopulmonary resuscitation was determined to be associated with injuries. Ventricle rupture in 1 case and liver laceration in 2 cases were the most significant injuries.It has been shown that during cardiopulmonary resuscitation, severe injuries can occur due to thoracic compression. Only a positive correlation with the duration of cardiopulmonary resuscitation was found in our study

Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease

Aim: In the present study, we aimed to assess serum concentrations of zinc (Zn), copper (Cu), iron (Fe), cadmium (Cd), lead (Pb), manganese (Mn), vitamins A (retinol), D (cholecalciferol) and E (α-tocopherol) in patients with coronary artery disease (CAD) and to compare with healthy controls

trans-Tetra­aqua­bis­(isonicotinamide-κN 1)nickel(II) bis­(3-hy­droxy­benzoate) tetra­hydrate

The asymmetric unit of the title compound, [Ni(C6H6N2O)2(H2O)4](C7H5O3)2·4H2O, contains one-half of the complex cation with the NiII ion located on an inversion center, a 3-hy­droxy­benzoate counter-anion and two uncoordinated water mol­ecules. Four water O atoms in the equatorial plane around the NiII ion [Ni—O = 2.052 (2) and 2.079 (2) Å] form a slightly distorted square-planar arrangement, which is completed up to a distorted octa­hedron by the two N atoms [Ni—N = 2.075 (3) Å] from two isonicotinamide ligands. In the anion, the carboxyl­ate group is twisted from the attached benzene ring by 8.8 (3)°. In the crystal, a three-dimensional hydrogen-bonding network, formed by classical O—H⋯O and N—H⋯O hydrogen bonds, consolidates the crystal packing, which also exhibits π–π inter­actions between the benzene and pyridine rings, with centroid–centroid distances of 3.455 (2) and 3.621 (2) Å, respectively

Bis(μ-3-hy­droxy­benzoato)-κ3 O 1,O 1′:O 1;κ3 O 1:O 1,O 1′-bis­[(3-hy­droxy­benzoato-κ2 O,O′)(iso­nicotinamide-κN 1)cadmium] tetra­hydrate

In the title centrosymmetric binuclear CdII compound, [Cd2(C7H5O3)4(C6H6N2O)2]·4H2O, the six-coordinated CdII atom is chelated by the carboxyl­ate groups of the two 3-hy­droxy­benzoate (HB) anions; the two monomeric units are bridged through the two O atoms of the two carboxyl­ate groups. In the crystal, O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds link the mol­ecules into a three-dimensional network. π–π Contacts between the pyridine rings and between the benzene rings [centroid-centroid distances = 3.770 (1), 3.769 (1) and 3.632 (1) Å] may further stabilize the structure

The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion

Background/aim: To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. Materials and methods: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats and then the I/R-treated kidneys were removed. The levels of serum biochemical markers were evaluated after renal I/R. The expression levels of hepcidin-linked genes [growth differentiation factor 15 (GDF-15), bone morphogenetic protein 6 (BMP6), and hemojuvelin (HJV)] were also measured by RT-PCR technique. In addition, the tissues were evaluated histopathologically. Results: No significant association was found between renal dysfunction and I/R when compared to biochemical parameters (P > 0.05). However, differences in platelet values were statistically significant (P < 0.05). Expression levels of GDF-15, BMP6, and HJV genes increased, but this increase was not statistically significant. In addition, histopathological evaluation was performed using hematoxylin and eosin stain. This showed a significant relationship between the control group and I/R group for ischemic and nonischemic kidney scoring. Conclusion: Hepcidin and BMP6, HJV, and GDF-15 should be taken into account when investigating the process of I/R.Background/aim: To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. Materials and methods: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats and then the I/R-treated kidneys were removed. The levels of serum biochemical markers were evaluated after renal I/R. The expression levels of hepcidin-linked genes [growth differentiation factor 15 (GDF-15), bone morphogenetic protein 6 (BMP6), and hemojuvelin (HJV)] were also measured by RT-PCR technique. In addition, the tissues were evaluated histopathologically. Results: No significant association was found between renal dysfunction and I/R when compared to biochemical parameters (P > 0.05). However, differences in platelet values were statistically significant (P < 0.05). Expression levels of GDF-15, BMP6, and HJV genes increased, but this increase was not statistically significant. In addition, histopathological evaluation was performed using hematoxylin and eosin stain. This showed a significant relationship between the control group and I/R group for ischemic and nonischemic kidney scoring. Conclusion: Hepcidin and BMP6, HJV, and GDF-15 should be taken into account when investigating the process of I/R

Развитие плеврального выпота туберкулезной этиологии у больного с саркоидозом на фоне кортикостероидной терапии

A 47-year-old man was diagnosed a Lofgren's syndrome and corticosteroid therapy was started. On the seventh month of the therapy a pleural effusion developed. Although no definite diagnosis was made, anti tuberculous therapy was started empirically. Three weeks later mycobacterium growth was detected on Lowenstein-Jensen culture. The patient recovered almost completely in 2 months of the anti-tuberculous therapy. In a well controlled sarcoidosis patient who presents pleural effusion, if other causes are excluded, it would be wise to start anti-tuberculous therapy since sarcoid pleural effusion is a rare form of the disease which accompanies advanced disease and since corticosteroid therapy renders patients susceptible to tuberculosis.47-летнему мужчине был поставлен диагноз синдрома Лефгрена и начата терапия кортикостероидами. На 7-м месяце лечения у него развился плевральный выпот. Была назначена эмпирическая противотубекулезная терапия, несмотря на отсутствие окончательного диагноза. Спустя 3 нед при посеве на среду Левенштейна-Йенсена был получен рост микобактерий. На фоне противотуберкулезной терапии в течение 2 мес больной почти полностью выздоровел. Таким образом, при появлении плеврального выпота у больного с хорошо контролируемым течением саркоидоза при исключении других его причин целесообразно начинать противотуберкулезную терапию, поскольку плевральный выпот является редким проявлением саркоидоза и терапия кортикостероидами повышает риск развития туберкулеза