İzole baş ağrısı bulgusu veren serebral ven trombozları

OBJECTIVE: The aim of this study is to demonstrate the demogrophical specialities and clinical features among patients with cerebral venous thrombosis (CVT), who had admitted to our department between 2006 and 2012 and who had headache as the only presenting symptom. MATERIAL and METHODS: Thirty-two patients who had diagnosed as CVT between 2006-2012 were evaluated and 12 of them who had headache as the only presenting symptom were included to the study. RESULTS: Headache was only symptom of CVT in 12 patients (10 Female, 2 Male). 8 of these 12 patients had papilledema. 4 patients had only headache without additional sign. The lateral sinus was the most frequently involved sinus. CONCLUSION: The headache is usually progressive over a few days, but a few patients have sudden onset or even a thunderclap headache. The outcome of CVT patients with isolated headache diagnosed was favourable

Biodegradable implant materials

Implants are medical devices that have critical importance for human health. The functions expected from implant materials have increased with the advancement of medicine and engineering. Implants are used for different purposes in different areas of the body. While some implants must be permanent in the body to fulfill their duties, some implants must be removed from the implanted area after a certain period. If an implant is to be removed from the relevant area after a certain period, an operation is required for this and then, there will be a healing process. The use of biodegradable implant materials eliminates the need for this additional operation. Biodegradable materials leave their place to the tissue gradually in a certain period. Biodegradable implant materials are one of the popular research areas today and many studies are carried out in this field every year. In this chapter, information about implants, biomaterials, biodegradability concept, biodegradable metals, and biodegradable polymers is shared. Also, examples of the use of biodegradable materials in biomedical applications are included

Flue gas desulfurization by using calcined dolomite

SO2 emissions has begun to cause serious problems in industrialized countries. Today, various methods are used for removal of SO2 gas. SO2 gas is an important raw material for production of sulfuric acid. However, SO2 content of flue gas must be over 6% to produce sulfuric acid commercially. Flue gases, which don't have enough amount of SO2 to produce sulfuric acid commercially are harmful to the environment and human health and they must be filtered. In this study, calcined dolomite was used to remove SO2 in flue gas which doesn't have enough SO2 to produce sulfuric acid but have high emission values. Pyrite was used as SO2 source and SO2 removal efficiency of dolomite was determined for different experimental parameters. SO2 capturing system was thermodynamically modeled and SO2 capturing efficiency was determined as 77.81% in the experiments

Ciddi hipersomni ile prezente olan tek taraflı talamodienfalik sendrom

Talamus ve beyin sapı inmeleri organik hipersomniye neden olabilirler. Paramedian talamusun uyku regülasyonunda önemli rol oynadığına inanılır ve uyku regülasyon bozukluklarının paramedian talamus inmelerinde (PTİ) ortaya çıkabileceği bilinmektedir. Tek taraflı ve sınırlı lezyonu olan PTİ'li hastalarda hafif uyku hali daha önceden bildirilmiştir. Bu yazıda manyetik rezonans görüntülemede (MRG) sınırlı, tek taraflı talamodiensefalik iskemik lezyonu olan ancak ciddi hipesomni ile kendini gösteren bir olgu sunulmaktadır. 54 yaşında, erkek hasta hastanemize gün içi aşırı uyku hali yakınması ile başvurdu. Çekilen kranial MRG'de solda talamus seviyesinden başlayarak nükleus Ruber ve Edinger Westpall nükleusuna uzanan iskemik lezyon saptandı. İlk hafta hastanın gün boyu toplam uyku saati 23-24 saat olarak seyretti. Hastaya dopamin agonisti tedavisi başlandı (bromokriptin 2.5mg/gün başlanarak 7.5mg/gün dozuna çıkıldı). Bu tedavi ile hastanın gün boyu uyku saati basamaklı olarak azaldı ve iki ay sonra hasta normal vijilansına geri döndü. Talamus ve mezensefalik veya pontin tegmental retiküler formasyonu etkileyen lezyonlar hipersomninin nedenlerinden biridir fakat klinik prezentasyon ve hipersomninin derecesi beynin etkilenen bölgesine bağlı olarak oldukça değişken olabilmektedir. Uyku ve uyanıklığın farklı beyin yapılarınca regülasyonunun hala anlaşılması zor olduğu ve yeni olgu bildirileri ve klinik çalışmaların bu durumun daha iyi anlaşılabilmesi için faydalı olacağı görüşündeyiz.Thalamic and brainstem strokes can cause organic hypersomnia. Paramedian thalamus is believed to play an important role in the regulation of sleep, and disturbances of sleep regulation are known to occur in paramedian thalamic stroke (PTS). In patients with PTS, slight sleepiness is reported with unilateral and limited lesions. In this paper we report on a patient presenting with severe hypersomnia who has a limited, unilateral thalamodiencephalic ischemic lesion on magnetic resonance imaging (MRI). A 54 year-old man referred to our hospital with the complaint of excessive day time sleepiness. His cranial MRI revealed a unilateral ischaemic lesion beginning at the level of left thalamus and extending to nucleus Ruber and Edinger Westpall. His total day time sleep was about 23-24 hours in the first week. He had been put on dopamine agonist therapy (bromocriptine 2.5mg/day up to dose 7.5mg/day). During this medication his total day time sleep decreased gradually and after two months he returned to his normal vigilance. Lesions affecting thalamus and mesencephalic or pontine tegmental reticular formation are a cause of hypersomnia but clinical presentation and degree of hypersomnia can be various due to the affected region of the brain. We think that regulation of sleep and wakefulness by different brain structures are still elusive and new case reports and clinical trials would be helpful about clarification of this condition

Unilateral thalamodiencephalic syndrome presenting with severe hypersomnia

Thalamic and brainstem strokes can cause organic hypersomnia. Paramedian thalamus is believed to play an important role in the regulation of sleep, and disturbances of sleep regulation are known to occur in paramedian thalamic stroke (PTS). In patients with PTS, slight sleepiness is reported with unilateral and limited lesions. In this paper we report on a patient presenting with severe hypersomnia who has a limited, unilateral thalamodiencephalic ischemic lesion on magnetic resonance imaging (MRI). A 54 year-old man referred to our hospital with the complaint of excessive day time sleepiness. His cranial MRI revealed a unilateral ischaemic lesion beginning at the level of left thalamus and extending to nucleus Ruber and Edinger Westpall. His total day time sleep was about 23-24 hours in the first week. He had been put on dopamine agonist therapy (bromocriptine 2.5mg/day up to dose 7.5mg/day). During this medication his total day time sleep decreased gradually and after two months he returned to his normal vigilance. Lesions affecting thalamus and mesencephalic or pontine tegmental reticular formation are a cause of hypersomnia but clinical presentation and degree of hypersomnia can be various due to the affected region of the brain. We think that regulation of sleep and wakefulness by different brain structures are still elusive and new case reports and clinical trials would be helpful about clarification of this condition

Human ACE2 orthologous peptide sequences show better binding affinity to SARS-CoV-2 RBD domain: Implications for drug design

Computational methods coupled with experimental validation play a critical role in the identification of novel inhibitory peptides that interact with viral antigenic determinants. The interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and the helical peptide of human angiotensin-converting enzyme-2 (ACE2) is a necessity for the initiation of viral infection. Herein, natural orthologs of human ACE2 helical peptide were evaluated for competitive inhibitory binding to the viral RBD by use of a computational approach, which was experimentally validated. A total of 624 natural ACE2 orthologous 32-amino acid long peptides were identified through a similarity search. Molecular docking was used to virtually screen and rank the peptides based on binding affinity metrics, benchmarked against human ACE2 peptide docked to the RBD. Molecular dynamics (MD) simulations were done for the human reference and the Nipponia nippon peptide as it exhibited the highest binding affinity (Gibbs free energy; −14 kcal/mol) predicted from the docking results. The MD simulation confirmed the stability of the assessed peptide in the complex (−12.3 kcal/mol). The top three docked-peptides (from Chitinophaga sancti, Nipponia nippon, and Mus musculus) and the human reference were experimentally validated by use of surface plasmon resonance technology. The human reference exhibited the weakest binding affinity (Kd of 318–441 pM) among the peptides tested, in agreement with the docking prediction, while the peptide from Nipponia nippon was the best, with 267–538-fold higher affinity than the reference. The validated peptides merit further investigation. This work showcases that the approach herein can aid in the identification of inhibitory biosimilar peptides for other viruses