A dark literary tourist at the end of life: Tezer Özlü

The blending of dark tourism and literary tourism has created a sub-niche as dark literary tourism. It offers dissimilar experiences as it incorporates distinctive motivations from literary tourism and dark tourism. This study aims to provide a better understanding of dark literary tourism motivations and experiences by offering a perspective on the concept of dark literary tourism. For that purpose, the work Journey to the End of Life by Turkish author Tezer Özlü, in which she traced three authors, Franz Kafka, Italo Svevo, and Cesare Pavese, was selected. The work was subjected to qualitative textual analysis. As a result of the analysis, the data obtained on the concept of dark literary tourism were interpreted under three headings. The findings of the study show that dark literary tourists have both dark tourist and literary pilgrim motivations, travelling for motivations such as paying homage to authors and the past, understanding their feelings by establishing closeness and connection with the authors, empathizing with their suffering, acquiring the smallest details about their lives, and experiencing their daily lives. The most crucial finding of the study is that the dark literary tourism experience allows tourists an inner journey and provides awareness about their lives

Effects of GnRH, PGF2α and oxytocin treatments on conception rate at the time of artificial insemination in lactating dairy cows

In several studies, hormones such as gonadotropin-releasing hormone (GnRH), prostaglandins and oxytocin were used to increase pregnancy rate by inducing ovulation and improving the sperm transport in the female reproductive tract in lactating dairy cattle. The objective of this study was to compare the effects of GnRH, prostaglandin F-2 alpha (PGF(2 alpha)) and oxytocin treatments at the time of artificial insemination (AI) after spontaneous oestrus on the conception rate (CR) of lactating dairy cows. Oestrus was detected by visual observations by experienced personnel. All cows (n = 430, 308 Holstein-Frisian and 122 Swedish-Red dairy cows) were inseminated based on the am/pm rule by veterinarians of the farm. After AI, cows were alternately assigned to one of the four treatment groups: (1) GnRH (n = 113); (2) PGF(2 alpha) (n = 106); (3) oxytocin (n = 106) and (4) non-treated control (n = 105). Pregnancy diagnosis was performed 28-34 and 58-64 days post-insemination by transrectal ultrasonography. Conception rates on days 28-34 and 58-64 were not different among GnRH (46.0%; 52/113 and 44.3%; 50/113), PGF(2 alpha) (37.7%; 40/106 and 35.9%; 38/106) and control (49.5%; 52/105 and 47.6%; 50/105) groups. However, conception rates were lower (P = 0.02) in oxytocin (31.1%; 33/106 and 30.2%; 32/106) than in GnRH and control groups on days 28-34 and 58-64. Other covariant factors, such as milk production, days in milk (DIM), breed, parity, service number did not affect the conception rate. Thus, there were no beneficial effects of treatments with GnRH and PGF(2 alpha) at the time of AI, and oxytocin had an adverse effect on CR in lactating dairy cows in this study

Literary hotels: A new type of literary tourism or just a product?

The study aims to evaluate the status of literary hotels in literary tourism and to discuss whether literary hotels are just a literary tourism product or should be a separate type of literary tourism. The study seeks to answer the following questions: 1) What are the literary connections of literary hotels? 2) What kind of experience do literary hotels promise according to the themes chosen? Document analysis, which is one of the qualitative research methods, was used in the research to gather data. The data used in this study include 57 hotel websites which provided information in English regarding the hotel’s literary connection on their website. Five different types of literary hotels have been found as literary-themed hotels, hotels associated with an author, hotels dedicated to an author, hotels associated with a fictional work or a character, and library hotels. The findings of the study show that literary hotels are not a single type of tourism product, but a wide-ranging type that offers a variety of products and experiences to multiple target audiences under different categories

The connectedness and risk spillovers between bitcoin spot and futures markets: evidence from intraday data

This paper examines the dynamic relation between Bitcoin spot and futures markets during the Covid-19 pandemic. Using hourly data from 2020 combined with quantile impulse response analysis and predictability in the distribution test, we attempt to ascertain whether spot or futures markets lead in the price discovery process under a variety of market conditions. Granger predictability based on the left tail, the right tail, and the center of the distribution show bidirectional predictability between spot and futures markets suggesting significant feedback effects following normal and extreme gains/losses where neither market dominates in price discovery. Using a CAViaR model and the associated impulse response functions with estimates for dynamic tail dependence, we document spillovers between quantiles of spot and futures returns. Estimates of impulse response functions at various risk levels show the futures market has an edge in influencing the spot market and figures more prominently in the price discovery process

Information and communication technologies in tourism marketing: An empirical study on the web sites of the travel agencies

Bilgi iletişim teknolojileri ve internetin gelişmesiyle birlikte turizm pazarlamasında önemli değişimler ortaya çıkmıştır. Turizm sektöründeki tüm işletmelerde olduğu gibi seyahat acentaları da bu değişimden etkilenmiş ve pazarlama anlayışlarını değiştirmişlerdir. Günümüzde seyahat acentaları geleneksel pazarlama yöntemlerini geride bırakarak sahip oldukları internet siteleri aracılığıyla pazarlama yapmaktadırlar. Bu sistemde tüketiciler ihtiyaç duydukları her türlü bilgiye internet siteleri aracılığıyla ulaşabilmekte ve online olarak rezervasyon işlemlerini gerçekleştirebilmektedirler. Son yıllarda internet tabanlı seyahat acentalarının sayılarının giderek artması, seyahat acentalarını daha etkin ve tam anlamıyla müşterilerin isteklerini karşılayan internet siteleri geliştirmeye zorlamaktadır. Bu tez kapsamında turizm pazarlamasında bilgi iletişim teknolojilerinin etkileri ortaya konulmaya çalışılmıştır. Araştırmanın uygulama bölümünde ise seyahat acentaları internet siteleri üzerine bir çalışma yapılmış ve etkin bir seyahat acentası internet sitesinde olması gereken özellikleri, son bir yıl içerisinde internet aracılığıyla en az bir adet seyahat ürünü almış müşterilerin bakış açıları ile değerlendirmeye çalışan bir anket çalışmasının sonuçlarına yer verilmiştir. Along with the development of information and communication technologies and the internet, new strategies and applications have emerged in tourism marketing. As in any business, tourism establishments, which include travel agencies, have also been affected by such changes and have started to adopt new marketing insihgts. Today, travel agencies practice marketing via worldwide web sites they own, and leave traditional marketing techniques behind. In this system, consumers can access all sorts of information through web sites and they can carry out their reservation process as online. In recent years, the increasing numbers of web-based travel agencies force travel agencies to develop web sites which are more efficient and meet the needs of customers. In this thesis, it has been attempted to present the effects of information and communication technologies in tourism marketing. In the empirical part of the research, a study has been executed on the web sites of travel agencies, while the results of a questionnaire dealing with the characteristics of an efficient travel agency web site are presented from the perspectives of customers, who have bought a travel product within the past 12 months via the internet

A New Gastronomic Route Encompassing Oleo Tourism and Wine Tourism Along the Olive Corridor of South Marmara in Türkiye

This study aims to assess the potential of oleo tourism and wine tourism within the Olive Corridor of South Marmara, one of the seven thematic tourism development corridors identified in the 2007 action plan, as part of the Türkiye Tourism Strategy 2023. Within the scope of this study, a holistic approach was taken towards the Olive Corridor of South Marmara, presenting a proposed route that encompasses oleo tourism and wine tourism products. The suggested route demonstrates that the corridor holds strong potential in terms of oleo tourism and wine tourism products, and it also possesses rich resources for destination experiences, including landscapes, cultural heritage, and outdoor activities. However, one of the findings of this study is that the corridor has room for development in terms of oleo tourism and wine tourism and should be diversified with new tourism products. Collaborations, support, incentives, marketing efforts, and contributions from producers and the local community, along with a sustainable tourism approach, have the potential to transform the corridor into a strong destination for oleo tourism and wine tourism

The impact of expected and unexpected events on Bitcoin price development: Introduction of futures market and COVID-19

This study examines the impact of two critical events, the introduction of Bitcoin futures and the COVID-19 pandemic, on Bitcoin's returns and volatility. We find that the inception of Bitcoin futures (positively) impacts its returns in the spot market while no significant interaction occurs for volatilities. The pandemic does not seem to influence Bitcoin's returns or volatility, which is consistent with the notion that Bitcoin is insulated from some global economic developments. Our tests also reveal that Bitcoin spot prices dominate its futures. This information might be useful for investors in capturing trend reversals considering the order of information disseminated. © 2023 Elsevier Inc

Validation of Altered MiRNAs in Ovarian Cancer Tumors”

Epithelial ovarian cancer (EOC) is the second most important cause of cancer-relateddeaths among women worldwide. Due to the mild and common symptoms of EOC, thedisease can not be diagnosed at an early stage. Survival rate in ovarian cancer (OC)patients is limited to over 80%. When the disease spreads to the upper abdomen orother parts of the body (stage III and IV), only 20% of the patients survive for 5 years.Currently, diagnostic methods for EOC are pelvic examination, transvaginalultrasonography (TVS) and serum cancer antigen 125 (CA125), however EOC can notbe diagnosed at early stages. CA125 is the only serum biomarker routinely used forepithelial ovarian cancer and gives 99% certainty, but in postmenopausal womensensitivity to early disease is only 50-60%[1]. Therefore, finding a reliable biomarkerwith increased sensitivity to early stages of epithelial ovarian cancer remains animportant clinical problem.MicroRNAs (miRNAs) are a class of small non-coding RNAs 18-25 nucleotides inlength. MiRNAs are involved in various biological processes such as cell proliferation,development, differentiation, apoptosis. MiRNAs display abnormal expression patternsin different cancer forms. Some act as tumor suppressor genes or oncogenes.Expression of miRNAs is therefore important in the development of ovarian cancer [2].Studies have shown that there are differences in miRNA expressions between normalovarian epithelial and ovarian cancer epithelial.Hsa-mir-200c-3p, hsa-mir-4665-3p and hsa-mir-6737-3p expression levels areupregulated in ovarian cancer tissue to benign cyst samples by microarray results. Inthis study, 10 EOC tissue samples and 10 benign cyst samples (BCS) as control wereused and 3 miRNAs expression differences between these 2 groups are validated byReal-Time PCR method. This project aims to detect biomarkers with transcriptomicstudies in order to extend early 5 years survival time of women with cancer and earlydiagnosis of OC

The impact of digital finance on the natural resource market: Evidence from DeFi, oil, and gold

The purpose of this study is to examine the interconnectedness between DeFi and natural resource assets in terms of return and volatility spillovers, as well as the effectiveness of hedging, utilizing the time and frequency domain causality test and the cross-quantilogram approach. To this end, we take into account the ChainLink (LINK) and Maker (MKR) prices for the DeFi market and use crude oil (WTI) and gold prices as proxies for the natural resources market. For this purpose, we observe the daily period from March 14, 2018, to August 15, 2022, in order to evaluate the portfolio diversification benefits during the Covid-19 epidemic. The findings from the time and frequency domain causality test reveal that the price and risk structure of natural resources such as crude oil and gold are influenced by digital finance instruments, particularly during times of crisis. Moreover, the results of the cross-quantilogram approach indicate that the significant cross-correlations between DeFi tokens and natural resource markets during bearish market periods are generally negative therefore DeFi tokens can provide effective hedging for gold and crude oil investors

Selection of biomarker from candidate miRNAs for early detection of ovarian cancer

Ovarian Ovarian cancer cancercancer (OC)(OC) is one of the most most common common gynaecological gynaecological malignancies malignancies malignanciesamong among womenwomen women.In ovarian malignancies malignancies malignancies,approximately approximately approximately approximately approximately90 %of cases cases are epithelial epithelial ovarian cancer cancer(EOC), (EOC), which which is the most lethal ovarianovarian cancer cancercancer type type becausebecause becausebecause of alack of screening screening screening tests and asymptomatic asymptomatic asymptomatic asymptomatic [1].Early detection detection of EOC has agreat great importance importancein the clinic [2]. Since observation observation of cancer cancer massmass and andbiopsy biopsyareare difficult difficult in early early stages stages ,diagnosis by non -invasiveinvasive methods methods areare becomingbecoming becoming more more important important .Therefore Therefore ThereforeTherefore Therefore ,the thedetectiondetection detection of tumor tumor tumormaterials materials materials passed to body body fluids in the first stage stage of cancer cancercancer can make possible possible possible possiblethe early early diagnosis diagnosisdiagnosis of cancer cancercancer .MicroRNAs MicroRNAs (miRNAs miRNAs ), oneone type type of specific specificspecific biomarkers biomarkersbiomarkers forfor the pathogenesis pathogenesis pathogenesis pathogenesis of cancer cancercancer ,areare usedused for fordetection detection detection detection,prognosis prognosis prognosis ,diagnosis diagnosis diagnosis ,and therapy therapyin several several diseases diseases diseases [3]. The purpose purposepurpose purpose of this study was wasto identify identify identifynovel circulating circulating miRNAs miRNAsmiRNAsto be usedused usedas early early diagnosis diagnosis diagnosis andand predictionprediction prediction prediction toolstools forfor EOC .Detection Detection Detection of thethe differences differences differences differencesdifferences in miRNAs miRNAs expression expression havehave been validated validated by RT -qPCR .Different Different Different expressions expressions expressions expressions of hsa -miR -19091909 -5p, hsa hsa-miR -885885 -5p,and andhsa -letlet -7d-3pwerewere statistically statistically statistically significant significant (p <0.05 ).It has been detecteddetected detected detectedwhich which genesgenes genesand related related related pathways pathwayspathwaysaffected affected by the validated validated miRNAs miRNAs using using "Pathway "Pathway Studio" Studio" database database