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Detraining Slows and Maintenance Training Over 6 Years Halts Parkinsonian Symptoms-Progression

Introduction: There are scant data to demonstrate that the long-term non-pharmaceutical interventions can slow the progression of motor and non-motor symptoms and lower drug dose in Parkinson's disease (PD). Methods: After randomization, the Exercise-only (E, n = 19) group completed an initial 3-week-long, 15-session supervised, high-intensity sensorimotor agility exercise program designed to improve the postural stability. The Exercise + Maintenance (E + M, n = 22) group completed the 3-week program and continued the same program three times per week for 6 years. The no exercise and no maintenance control (C, n = 26) group continued habitual living. In each patient, 11 outcomes were measured before and after the 3-week initial exercise program and then, at 3, 6, 12, 18, 24, 36, 48, 60, and 72 months. Results: The longitudinal linear mixed effects modeling of each variable was fitted with maximum likelihood estimation and adjusted for baseline and covariates. The exercise program strongly improved the primary outcome, Motor Experiences of Daily Living, by ~7 points and all secondary outcomes [body mass index (BMI), disease and no disease-specific quality of life, depression, mobility, and standing balance]. In E group, the detraining effects lasted up to 12 months. E+M group further improved the initial exercise-induced gains up to 3 months and the gains were sustained until year 6. In C group, the symptoms worsened steadily. By year 6, levodopa (L-dopa) equivalents increased in all the groups but least in E + M group. Conclusion: A short-term, high-intensity sensorimotor agility exercise program improved the PD symptoms up to a year during detraining but the subsequent 6-year maintenance program was needed to further increase or sustain the initial improvements in the symptoms, quality of life, and drug dose

Studia Litteraria

Dobos István: Performativitás a XX. századi magyar regényben (A narratív előadás. Jelentő testek) p. 7-18. Törő Norbert: „Talán elvesztem valahol ezen a tájon…?” (A rögzíthetetlenségben/bizonytalanságban megalkotott én modellje Krúdy Gyula N. N.-jében) p. 19-36. Bartha Ákos: „Az autoritás mankói” (Kísérlet Nagy Lajos Kiskunhalom című művének antropológiai olvasatára) p. 36-65. Baranyai Norbert: Móricz Zsigmond zsoltárai a Nyugatban p. 65-76. Szirák Péter: Elmozgó határok (Szabó Lőrinc és Németh László romániai utazása) p. 76-85. Bertha Zoltán: „A szép mindig korszerű” (Dsida Jenő kritikai nézeteiről) p. 85-102. Lapis József: Fény, való, varázs (A szó hatalma a két világháború közötti lírában) p. 102-112. Takács Miklós: Trauma és irodalom viszonya Cseres Tibor Hideg napok című regényében p. 112-119. Márkus Béla: Talányos regény, regénytalány (Szilágyi István: Agancsbozót) p. 119-128. Pócsik Anett: A női szólam lehetőségei Polcz Alaine Egész lényeddel című önéletírásában és Mészöly Miklós Az atléta halála című regényébenv p.128-139. Keczán Mariann : Lapok egy főszerkesztő életéből p. 139-160. Áfra János: A szakralitás módozatai a kocsma terében (Bukta Imre kocsmaképeinek, Krasznahorkai László és Tarr Béla Sátántangójának intermediális vizsgálata) p.160-187

Language processing in Internet use disorder: Task-based fMRI study

Internet use disorder (IUD) is generally conceptualized as a fast-growing behavioral addiction. Several structural and functional brain alterations have been revealed in this condition, but previous behavioral studies indicated that language systems may also be impaired. We used a silent word generation task to induce brain activation in Broca’s area and other parts of the language system. Blood-oxygen-level-dependent activation analysis and psychophysiological interaction analysis were applied to assess functional brain changes. IUD was measured by the Problematic Internet Use Questionnaire and two additional questions concerning usage time and subjective rating of addiction. According to our key findings, areas strongly related to the default mode network were altered in IUD during the task. Moreover, Broca’s area showed altered functional connectivity with other language network and occipital areas in IUD. These findings may address the neural background of decreased verbal fluency performance previously reported in the literature, and we emphasize that beside the brain’s reward and inhibitory control systems, the language system is the next candidate to be involved in the pathogenesis of IUD

Elnyelheti-e Diogenész hordója Daidaloszt - Gondolatok alkotásról, utazásról, elengedésről

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Elektronikus környezetbe vetett testünk

Humankind, differentiated from nature, has always strived to extend the body and to overcome spatial boundaries. These civilizational attempts have been achieved by means of technological inventions and developments recently. The continuous technological development could, however, qualify only partially as an energyeffective means for establishing experimental spaces. The instinctive “colonization process” has been able to unfold in electronic environments.The bodily fixation and the narrow scope of attention are qualities of Internet use which cannot create the experience of full-body immersion. In contrast, Virtual Reality (VR) attempts to create a sense of full audiovisual-haptic experience in the recipient by aspiring for interactivity. However, this field does not correlate with global networks which would minimize spatial constraints and which, speaking about the Internet, are the essential sources of popularity and dynamism. Certainly, it is just a matter of time before developers attempt to integrate these currently disconnected virtual environments in a giant Internet-like fashion. What is even more likely is that sensational qualities and features of virtual reality will be assigned to the organism of the Internet. In the case of virtual reality the fixation of view was replaced by the fixation of environment, a concept that will be abandoned and followed by a constantly changing, dynamic system after the setting up of a network virtual reality.Humankind, differentiated from nature, has always strived to extend the body and to overcome spatial boundaries. These civilizational attempts have been achieved by means of technological inventions and developments recently. The continuous technological development could, however, qualify only partially as an energyeffective means for establishing experimental spaces. The instinctive “colonization process” has been able to unfold in electronic environments.The bodily fixation and the narrow scope of attention are qualities of Internet use which cannot create the experience of full-body immersion. In contrast, Virtual Reality (VR) attempts to create a sense of full audiovisual-haptic experience in the recipient by aspiring for interactivity. However, this field does not correlate with global networks which would minimize spatial constraints and which, speaking about the Internet, are the essential sources of popularity and dynamism. Certainly, it is just a matter of time before developers attempt to integrate these currently disconnected virtual environments in a giant Internet-like fashion. What is even more likely is that sensational qualities and features of virtual reality will be assigned to the organism of the Internet. In the case of virtual reality the fixation of view was replaced by the fixation of environment, a concept that will be abandoned and followed by a constantly changing, dynamic system after the setting up of a network virtual reality