39 research outputs found

    La prescription de Buprénorphine Haut Dosage (revue de pertinence des pratiques et effets des opinions des médecins)

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    Le principe du traitement de l'héroïnomanie par des substances opioïdes agonistes est connu depuis la fin des années 1960. Pourtant en France, le dispositif de traitement des pharmacodépendances aux opiacés, reposant en grande partie sur une dispensation large de la BHD n'a été mis en place qu'en 1996, face à l'urgence sanitaire de l'épidémie de SIDA chez les toxicomanes. La BHD s'intégrait alors tout autant à un projet de réduction des risques pour les toxicomanes aux prises avec le manque , qu'à une démarche addictologique d'éloignement progressif des substances. Ce positionnement ambigu de la BHD a conduit à un certain trouble des prescripteurs quant aux objectifs thérapeutiques. Après 15 ans de substitution par BHD, il nous a semblé intéressant de confirmer ou d'infirmer cette impression de non-conformité des pratiques par rapport aux recommandations HAS (23 et 24 juin 2004) et de s'interroger sur l'effet des opinions des médecins sur leurs prescriptions de BHD. 193 médecins appartenant à 3 échantillons distincts (médecins généralistes libéraux, médecins salariés et médecins participant à un réseau toxicomanie) ont été interrogés afin d'évaluer leurs pratiques de prescription de BHD (revue de pertinence) et leurs opinions principales sur le produit (étude exploratoire des opinions).NANTES-BU Médecine pharmacie (441092101) / SudocSudocFranceF

    An Archaeological and Paleontological Chronology for Daisy Cave (CA-SMI-261), San Miguel Island, California

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    We provide detailed contextual information on 25 14C dates for unusually well-preserved archaeological and paleontological remains from Daisy Cave. Paleontological materials, including faunal and floral remains, have been recovered from deposits spanning roughly the past 16,000 yr, while archaeological materials date back to ca. 10,500 BP. Multidisciplinary investigations at the site provide a detailed record of environmental and cultural changes on San Miguel Island during this time period. This record includes evidence for the local or regional extinction of a number of animal species, as well as some of the earliest evidence for the human use of boats and other maritime activities in the Americas. Data from Daisy Cave contribute to a growing body of evidence that Paleoindians had adapted to a wide variety of New World environments prior to 10,000 BP. Analysis of shell-charcoal pairs, along with isotopic analysis of associated marine shells, supports the general validity of marine shell dating, but also provides evidence for temporal fluctuations in the reservoir effect within the Santa Barbara Channel region.This material was digitized as part of a cooperative project between Radiocarbon and the University of Arizona Libraries.The Radiocarbon archives are made available by Radiocarbon and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform February 202

    Development of an Innovative Surgical Navigation System for Sacrospinous Fixation in Pelvic Surgery

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    STUDY OBJECTIVE: To validate the use of an innovative navigation method for sacrospinous fixation in surgery-like conditions as a new teaching tool and surgical method. DESIGN: Two-month experimental prospective pilot study between July and August 2021. SETTING: Biomechanics laboratory academic research. PATIENTS: A total of 29 participants took part in the study: 9 gynecological surgeons and 20 participants with no medical background. INTERVENTIONS: All participants used the 2 mocks-up. MEASUREMENTS AND MAIN RESULTS: The experiment was composed of 2 training phases dedicated to improving the hand-eye coordination and suture skills on a training mock-up and of a suturing phase on a pelvic mock-up designed to recreate the surgery-like conditions of a sacrospinous fixation. The surgeons provided qualitative feedback on the bio-accuracy of the mock-ups and evaluated the ease of use of the navigation software. Nonsurgeons were included to assess the progression of the suture performance between 2 experiments performed 1 week apart (session 1 and 2). The main objective for participants was to reach a virtual target and to stitch sacrospinous ligaments. For session 1, an overall comfort score of 7.2 of 10 was attributed to the tool; 14 (42%) surgeon suture attempts and 63 (65%) nonsurgeon suture attempts were accurate (i.e., below the 5-mm threshold). Twenty-two (67%) surgeon suture attempts and 28 (34%) nonsurgeon suture attempts were fast (i.e., in the first 2 quantiles of the duration dataset). An improvement in the nonsurgeon performance was observed between the 2 sessions in terms of duration (session 1: 46 ± 20 s; session 2: 37 ± 18 s; p=.047) and distance (session 1: 3.8 ± 1.3 mm; session 2: 3.2 ± 1.4 mm; p=10-5) for the last suturing exercise. CONCLUSION: This new motion capture-based navigation method for sacrospinous fixation tested under surgery-like conditions seemed to be accurate and effective. The next step will be to design a pelvis model more adapted to the constraints of a sacrospinous fixation and to validate the benefits of this method compared with current techniques

    4,000 Years of Human Occupation on Santa Barbara Island, California

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    Over the years, the authors have been doing background research, survey, data recovery, and collections analysis related to the prehistory of Santa Barbara Island. In this paper, we present radiocarbon dates for six of the prehistoric sites on Santa Barbara Island and discuss the potential antiquity of its initial settlement. First, however, we provide a context for our discussion by summarizing the environmental setting and history of archaeological research on the island. In the following sections, all site designations follow Greenwood's (1978:7-42) trinomial system
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