Guidelines for the market competitiveness of sustainable lightweight design by magnesium solution: a new Life Cycle Assessment integrated approach

Recent changes to the Corporate Average Fuel Economy (CAFE) are driving automakers to seek more aggressive methods for fuel consumption reductions. In the long term, policy appears to focus on conversion of the dominant 20th century internal combustion engine (ICE) to a different engine that is partially or fully hydrocarbon-free. As the future of automotive propulsion is the subject of some debate, whatever the vehicle power source will be, weight reduction of the car is sure to be a key factor to meet energy saving requirements. The need to cut CO2 emissions by reducing fuel consumption on ICE vehicles may also benefit market penetration of hydrocarbon free battery powered vehicles. A major factor in this decision will be the success in reducing battery cost for travel ranges that will make electric vehicles attractive to consumers. For the next few years, the purchase price of a hybrid or fully electric car is expected to be several thousand Euros higher than the average price of the gas-fueled vehicle. It is worth noticing that price difference is largely due to the cost of battery (EU Commission targets a reduction in the cost of batteries by 6-8% annually together with improved chemistry and the economies of scale) .To speed up the reduction in unitary mileage costs for full or hybrid electric vehicles lightweighting is again a key for success, however, a successful lightweight design will only be possible through a balanced solution that takes into account conflicting factors such as manufacturing costs, safety and crashworthiness, recycling and life cycle considerations. Life cycle considerations, particularly, have led to a large number of Life Cycle Assessment (LCA) studies to determine the carbon footprint of using lightweight materials. Three key-factors for the assessment of environmental impact of lightweight design for conventional ICE vehicle are the materials substitution factor; the fuel-mass correlation factor; and the energy intensity and recycling factors of materials production. In this work a material substitution scenario has been developed for assessing the net environmental impact of adoption of magnesium alloy panels instead of heavy steel panels, and competitive weight saving aluminum and CRFP panels. Clean-up strategies for the LCA magnesium model for the fossil-fueled automotive sector will also be discussed

PEMETAAN ZONASI SEKOLAH MENENGAH ATAS NEGERI UNTUK PPDB MENGGUNAKAN SISTEM INFORMASI GEOGRAFIS DI KOTA BANDUNG

Salah satu upaya pemerintah dalam rangka pemerataan akses pendidikan adalah mengeluarkan aturan baru dalam penerimaan peserta didik melalui Sistem Zonasi. Peraturan Menteri Pendidikan dan Kebudayaan Nomor 51 Tahun 2018 tentang Penerimaan Peserta Didik Baru (PPDB), mengatur sistem zonasi yang harus diterapkan sekolah dalam menerima calon peserta didik baru. Penelitian ini berupa aplikasi Sistem Informasi Geografis (SIG) tentang pemetaan zonasi sekolah bebasis web dengan wilayah penelitian di Kota Bandung. Webgis digunakan karena dalam penyampaian dan tampilan sistem informasi geografis lebih informatif serta mempresentasikan kondisi sebenarnya. Aplikasi ini dibuat menggunkan struktur website HTML, bahasa pemrograman (javascript dan CSS), serta menggunakan peta dasar Open Street Maps Hasil penelitian ini berupa aplikasi SIG pemetaan zonasi sekolah berbasis web di Kota Bandung . di dalam WebGIS tersebut tentunya menyajikan informasi mengenai letak lokasi dan informasi sekolah di Kota Bandung.;--One of the government's efforts in the framework of equitable access to education is to issue new rules in accepting students through the Zoning System. Minister of Education and Culture Regulation No. 51 of 2018 concerning Acceptance of New Students (PPDB), regulates the zoning system that schools must implement in accepting prospective new students. This research is in the form of Geographic Information System (GIS) application on mapping web-based school zoning with the research area in the city of Bandung. Webgis is used because in the delivery and appearance of geographic information systems more informative and presents the actual conditions. This application is made using HTML website structure, programming languages ​​(javascript and CSS), and using Open Street Maps basic maps  The results of this study in the form of GIS web-based school zoning mapping applications in the city of Bandung. in the WebGIS certainly presents information about the location of the location and school information in the city of Bandung

Condition of Seagrass Beds Ecosystem on Poncan Gadang Island Based on Macrozoobenthos Diversity

The seagrass ecosystem of Poncan Gadang island is one of the ecosystems that often come under pressure due to ecotourism activities. Pressure on these ecosystems can have an impact on the diversity of the types of animals that live in them. This research is aimed at knowing the condition of seagrass ecosystems based on the diversity of macrozoobenthos that live in them. The observation point is divided into 5 stations. At each point, a square transect of 1x1 meters is made as many as 10 pieces. Collection of macrozoobenthos samples is carried out by the hand sorting method. The samples collected were then identified at the Ecology Laboratory of the Faculty of Teacher Training and Education, University of Labuhanbatu. Data analysis uses the shannon wienner index (H'), Dominance Index (C') and Similarity Index (IS) formulas. Data analysis was done by computer program Plymouth Routines In Multivariate Ecological Research (Primer) 7th version. The results showed that there were 30 species of macrozobenthos living in the seagrass ecosystem of Poncan Gadang island, with a diversity index (H') of 3.031-3.191, a dominance index (C') of 0.0038 - 0.0053, then a similarity index (IS) of 86.792 – 98.305%. This result indicates the condition of the seagrass beds ecosystem of Poncan Gadang Island is in good condition, with a moderate level of uniformity, low dominance and high similarit

The [1,2,4]Triazolo[4,3-a]pyridine as a New Player in the Field of IDO1 Catalytic Holo-Inhibitors

Inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) are considered a promising strategy in cancer immunotherapy as they are able to boost the immune response and to work in synergy with other immunotherapeutic agents. Despite the fact that no IDO1 inhibitor has been approved so far, recent studies have shed light on the additional roles that IDO1 mediates beyond its catalytic activity, conferring new life to the field. Here we present a novel class of compounds originated from a structure-based virtual screening made on IDO1 active site. The starting hit compound is a novel chemotype based on a [1,2,4]triazolo[4,3-a]pyridine scaffold, so far underexploited among the heme binding moieties. Thanks to the rational and in silico-guided design of analogues, an improvement of the potency to sub-micromolar levels has been achieved, with excellent in vitro metabolic stability and exquisite selectivity with respect to other heme-containing enzymes

Recommendations for the management and treatment of ankylosing spondylitis

Universidade de São Paulo Faculdade de MedicinaSociedade Brasileira de Reumatologia Comissão de EspondiloartritesPontifícia Universidade Católica de Porto Alegre Hospital São LucasUSP FM Instituto de Ortopedia e TraumatologiaUniversidade Federal de São Paulo (UNIFESP)Hospital Geral de GoiâniaUniversidade Federal do ParanáPontifícia Universidade Católica de CampinasUniversidade Federal do Rio de JaneiroUniversidade Estadual do Rio de JaneiroUniversidade Federal de UberlândiaAssociação Médica BrasileiraUNIFESPSciEL

Recommendations for the management and treatment of psoriatic arthritis

Universidade Federal do Rio de JaneiroUniversidade do Estado do Rio de JaneiroUniversidade Federal do ParanáPontifícia Universidade Católica de CampinasUniversidade Federal de UberlândiaUniversidade de São Paulo Faculdade de MedicinaPontifícia Universidade Católica de Porto Alegre Hospital São LucasUSP FM Instituto de Ortopedia e TraumatologiaUniversidade Federal de São Paulo (UNIFESP)Hospital Geral de GoiâniaAssociação Médica BrasileiraSociedade Brasileira de Reumatologia Comissão de EspondiloartritesUNIFESP, EPMSciEL

Rehabilitative treatment of patients with covid-19 infection: The p.a.r.m.a. evidence based clinical practice protocol

Background: The impact of the SARS-CoV-2 on the National Health System (NHS) required a reorganization of the various levels of care, which also involved the rehabilitation reality. Aim of the work: A clinical practice review of the literature was conducted to provide operational-rehabilitation guidelines adapt-ed to the local reality and to the recent corporate reorganization in the context of the COVID-19 emergency. Methods: A practice review of the available scientific evidence was regularly conducted from the start of the COVID-19 pandemic to periodically update the clinical practice guidelines. Articles that met the following inclusion criteria were included: studies conducted on human adult subjects with COVID-19 infection, un-dergoing rehabilitation in any hospitalization setting. Results: The results of this clinical practice update were periodically discussed with colleagues and collaborators in a multi-professional team, in order to guarantee a good clinical practice protocol, named P.A.R.M.A. Conclusions: The P.A.R.M.A. protocol is the result of a periodic review literature update, which has allowed us to take charge of patients affected by COVID-19 ac-cording to the most up-to-date clinical evidences, guaranteeing a shared and uniform treatment within a local reality in an era of health emergency. (www.actabiomedica.it)

In vitro and in vivo analysis of RTK inhibitor efficacy and identification of its novel targets in glioblastomas

Treatment for glioblastoma consists of radiotherapy and temozolomide-based chemotherapy. However, virtually all patients recur, leading to a fatal outcome. Receptor tyrosine kinase (RTK)-targeted therapy has been the focus of attention in novel treatment options for these patients. Here, we compared the efficacy of imatinib, sunitinib, and cediranib in glioblastoma models. In the present work, the biologic effect of the drugs was screened by viability, cell cycle, apoptosis, migration, and invasion in vitro assays or in vivo by chick chorioallantoic membrane assay. Intracellular signaling was assessed by Western blot and the RTK targets were identified using phospho-RTK arrays. The amplified status of KIT, PDGFRA, and VEGFR2 genes was assessed by quantitative polymerase chain reaction. In a panel of 10 glioblastoma cell lines, we showed that cediranib was the most potent. In addition, cediranib and sunitinib synergistically sensitize the cells to temozolomide. Cediranib efficacy was shown to associate with higher cytostatic and unique cytotoxic effects in vitro and both antitumoral and antiangiogenic activity in vivo, which could associate with its great capacity to inhibit mitogen-activated protein kinase (MAPK) and AKT pathways. The molecular status of KIT, PDGFRA, and VEGFR2 did not predict glioblastoma cell responsiveness to any of the RTK inhibitors. Importantly, phospho-RTK arrays revealed novel targets for cediranib and sunitinib therapy. In conclusion, the novel targets found may be of value as future biomarkers for therapy response in glioblastoma and lead to the rational selection of patients for effective molecular targeted treatment.This work was funded by Fundacao para a Ciencia e Tecnologia (FCT, Portugal; Project PTDC/SAU-TOX/114549/2009) and by Pfizer/Sociedade de Ciencias Medicas de Lisboa with the award "Research in Oncology Diseases, Prof. Francisco Gentil." Olga Martinho is a recipient of a PhD fellowship (SFRH/BD/36463/2007), and Vera Miranda-Goncalves is a recipient of a research fellowship (SFRH/BI/33503/2008), both from FCT. Andre Lopes Carvalho has a Brazilian National Council for Scientific and Technological Development Scholarship (CNPq, 313181/2009-8)