A SAM Based Global CGE Model using GTAP Data January 2005

This paper provides a technical description of a global computable general equilibrium (CGE) model that is calibrated from a Social Accounting Matrix (SAM) representation of the Global Trade Analysis Project (GTAP) database. A distinctive feature of the model is the treatment of nominal and real exchange rates and hence the specification of multiple numéraire

Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes

The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing inflammation in the stomach, the majority of infections are asymptomatic. H. pylori is the leading cause of peptic ulcer disease and gastric cancer. However, disease outcomes are related to the pattern and severity of chronic inflammation in the gastric mucosa, which in turn is influenced by both bacterial and host factors. Despite over 2 decades of intensive research, there remains an incomplete understanding of the circumstances leading to disease development, due to the fascinating complexity of the host-pathogen interactions. There is accumulating data concerning the virulence factors associated with increased risk of disease, and the majority of these have pro-inflammatory activities. Despite this, only a small proportion of those infected with virulent strains develop disease. Several H. pylori virulence factors have multiple effects on different cell types, including the induction of pro- and anti-inflammatory, immune stimulatory, and immune modulatory responses. The expression of multiple virulence factors is also often linked, making it difficult to assess the meaning of their effects in isolation. Overall, H. pylori is thought to usually modulate inflammation and limit acute damage to the mucosa, enabling the bacteria to persist. If this delicate balance is disturbed, disease may then develop

LGBT Equality and Sexual Racism

Bigots such as the trial judge in Loving have long invoked religion to justify discrimination. We agree with other scholars that neither religion nor artistic freedom justifies letting businesses discriminate. However, we also want to make manifest the tension between the public posture of LGBT-rights litigants and the practices of some LGBT people who discriminate based on race in selecting partners. We argue that some white people’s aversion to dating and forming relationships with people of color is a form of racism, and this sexual racism is inconsistent with the spirit of Loving. Part I provides a review of empirical literature on the prevalence of racial preferences in intimate relationships and shows that racial preferences are particularly pronounced among gay men. Part II supplements this overview with a qualitative exploration of how race informed the intimate experiences of people who sat for interviews as part of our ongoing study, LGBT Relationships and Well-Being. We also offer a theory that may partially explain sexual racism in the LGBT community. Specifically, exposure to mainstream gay culture may teach sexual minority men that race and desire are closely intertwined. In Part III, we propose ideas for further research, including a study that would test our theory

Fuselage structure using advanced technology fiber reinforced composites

A fuselage structure is described in which the skin is comprised of layers of a matrix fiber reinforced composite, with the stringers reinforced with the same composite material. The high strength to weight ratio of the composite, particularly at elevated temperatures, and its high modulus of elasticity, makes it desirable for use in airplane structures

A Cellular, Language Directed Computer Architecture

If a VLSI computer architecture is to influence the field of computing in some major way, it must have attractive properties in all important aspects affecting the design, production, and the use of the resulting computers. A computer architecture that is believed to have such properties is briefly discussed

The how and why of lncRNA function: An innate immune perspective.

Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts. This includes a newly identified class of genes called long noncoding RNAs (lncRNAs). The lack of sequence conservation for lncRNAs across species meant that their biological importance was initially met with some skepticism. LncRNAs mediate their functions through interactions with proteins, RNA, DNA, or a combination of these. Their functions can often be dictated by their localization, sequence, and/or secondary structure. Here we provide a review of the approaches typically adopted to study the complexity of these genes with an emphasis on recent discoveries within the innate immune field. Finally, we discuss the challenges, as well as the emergence of new technologies that will continue to move this field forward and provide greater insight into the biological importance of this class of genes. This article is part of a Special Issue entitled: ncRNA in control of gene expression edited by Kotb Abdelmohsen

Ionizing mechanisms in a cesium plasma irradiated with a ruby laser

A cesium filled diode--laser plasmadynamic converter was built to investigate the feasibility of converting laser energy to electrical energy at large power levels. Experiments were performed with a pulsed ruby laser to determine the quantity of electrons and cesium ions generated per pulse of laser beam and to determine the output voltage. A current density as high as 200 amp/sq cm from a spot of approximately 1 sq mm area and an open circuit voltage as high as 1.5 volts were recorded. A qualitative theory was developed to explain these results. In the operation of the device, the laser beam evaporates some of the cesium and ionizes the cesium gas. A dense cesium plasma is formed to absorb further the laser energy. Results suggest that the simultaneous absorption of two ruby laser photons by the cesium atoms plays an important role in the initial ionization of cesium. Inverse bremsstrahlung absorption appears to be the dominant mechanism in subsequent processes. Recombinations of electrons and cesium ions appear to compete favorably with the simultaneous absorption of two photons

Anti-Fat Attitudes in Healthcare

Background: Anti-fat attitudes and weight-based discrimination are well documented as pervasive in western society. The dominant medical narrative of weight serves to maintain the assumption that weight is wholly within an individual’s control. As such, fat people are discriminated against and blamed for their ill-health. The nation’s weight has gained further attention as a result of COVID-19 placing significant strain on our healthcare system. The current pandemic serves as another example of how fat people are discriminated against and seen as lower priority for care in comparison to others. Aims: To consider the public’s awareness and views about these issues, and whether there would be public support for future policies seeking to mitigate weight discrimination in healthcare. Method: Employing a critical realist approach, this study used qualitative methods of engaging twelve participants in semi-structured interviews. Interviews were analysed using Thematic Analysis. Results: Two main themes were identified. ‘Social Representations of Weight’ which considered the way that fat people are spoken about and the dominant narratives in our society that shape public views. The second theme, ‘Intersections with Services and Systems’ captured the moral and conceptual dilemmas involved in the prioritisation of healthcare and discrimination that fat people face. Conclusions: Findings highlighted the complex, yet flexible views that people hold in relation to fat people accessing healthcare. There was an awareness of the negative effects of discrimination on access to healthcare, and the inequity of this. Participants held contradictory views simultaneously; oscillating between the consideration that an element of discrimination is unavoidable, and possibly acceptable in some instance, whilst stating that discrimination is unethical, and that healthcare is a human right. The findings offer the hope that perhaps antifat attitudes are not as fixed as previous research indicates. Additionally, that there may be public support for policy change and the possibility of weight becoming a protected characteristic

The Human Brain: A Multimedia Tutorial For The Independent Learner

The Human Brain is a multimedia, interactive, computer-based tutorial on the structure and function of the human nervous system. In creating it, we aim to solve a number of problems, both subject specific and general. As a subject, the structure and function of the nervous system is difficult to teach using traditional methods and there is a lack of integration in the teaching of structure and function. More generally, we are concerned with the difficulties of both assessing student understanding of a particular subject and remedying any deficiencies when the student is learning independently. Finally, we hope to resolve the conflict between linear and explorative modes of presentation of material in a teaching system