Requirements for efficient cell-type proportioning: regulatory timescales, stochasticity and lateral inhibition

The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell-types. This developmental differentiation process typically involves intracellular regulatory and stochastic mechanisms to generate cell-fate diversity as well as intercellular mechanisms to coordinate cell-fate decisions at tissue level. We thus surmise that key insights about the developmental regulation of cell-type proportion can be captured by the modeling study of clustering dynamics in population of inhibitory-coupled noisy bistable systems. This general class of dynamical system is shown to exhibit a very stable two-cluster state, but also frustrated relaxation, collective oscillations or steady-state hopping which prevents from timely and reliably reaching a robust and well-proportioned clustered state. To circumvent these obstacles or to avoid fine-tuning, we highlight a general strategy based on dual-time positive feedback loops, such as mediated through transcriptional versus epigenetic mechanisms, which improves proportion regulation by coordinating early and flexible lineage priming with late and firm commitment. This result sheds new light on the respective and cooperative roles of multiple regulatory feedback, stochasticity and lateral inhibition in developmental dynamics

Some aspects of electronic topological transition in 2D system on a square lattice. Excitonic ordered states

We study the ordered "excitonic" states which develop around the quantum critical point (QCP) associated with the electronic topological transition (ETT) in a 2D electron system on a square lattice. We consider the case of hopping beyond nearest neighbors when ETT has an unusual character. We show that the amplitude of the order parameter (OP) and of the gap in the electron spectrum increase with increasing the distance from the QCP, \delta_c - \delta, where \delta = 1-n and "n" is an electron concentration. Such a behavior is different from the ordinary case when OP and the gap decrease when going away from the point which is a motor for instability. The gap opens at "hot spots" and extends untill the saddle points (SP) whatever is the doping concentration. The spectrum gets a characteristic flat shape as a result of hybrydization effect in the vicinity of two different SP's. The shape of the spectrum and the angle dependence of the gap have a striking similarity with the features observed in the normal state of the underdoped high-T$_c$ cuprates. We discuss also details about the phase diagram and the behaviour of the density of states.Comment: 15 pages, 14 EPS figures included, EPJ style included, added references, changed conten

Surface and bulk critical behaviour of the XY chain in a transverse field

The surface magnetization of the quantum XY chain in a transverse field is found for arbitrary nearest neighbour interactions in closed form. This allows to derive the bulk phase diagram in a simple way. The magnetic surface behaviour and the bulk correlation length are found exactly.Comment: 5 pages, to be published in J. Phys.

Various ordered states in a 2D interacting electron system close to an electronic topological transition

We consider a 2D electron system on a square lattice with hopping beyond nearest neighbors. The existence of the quantum critical point associated with an electronic topological transition in the noninteracting system results in density wave (DW) and high temperature d-wave superconducting (dSC) instabilities in the presence of an exchange interaction J. We analyse different DW ordering such as isotropic Spin DW (SDW), d-wave SDW, isotropic Charge DW (CDW) and d-wave CDW. The coexistence of dSC and SDW orders leads necessary to the existence of a third order which is a pi triplet superconducting (PTS) order. A new phase diagram with a mixed phase of SDW, dSC and PTS order is found. The theory is applied to high-Tc cuprates.Comment: 2 pages, 1 figure, submitted to LT22 (Physica B

Universal scaling and quantum critical behavior of CeRhSb(1-x)Sn(x)

We propose a universal scaling rho*chi=const of the electrical resistivity rho with the inverse magnetic susceptibility chi^(-1) below the temperature of the quantum-coherence onset for the Ce 4f states in CeRhSb(1-x)Sn(x). In the regime, where the Kondo gap disappears (x~0.12), the system forms a non-Fermi liquid (NFL), which transforms into a Fermi liquid at higher temperature. The NFL behavior is attributed to the presence of a novel quantum critical point (QCP) at the Kondo insulator - correlated metal boundary. The divergent behavior of the resistivity, the susceptibility, and the specific heat has been determined when approaching QCP from the metallic side.Comment: Sent to Phys. Rev. Let

Entanglement versus Correlations in Spin Systems

We consider pure quantum states of $N\gg 1$ spins or qubits and study the average entanglement that can be \emph{localized} between two separated spins by performing local measurements on the other individual spins. We show that all classical correlation functions provide lower bounds to this \emph{localizable entanglement}, which follows from the observation that classical correlations can always be increased by doing appropriate local measurements on the other qubits. We analyze the localizable entanglement in familiar spin systems and illustrate the results on the hand of the Ising spin model, in which we observe characteristic features for a quantum phase transition such as a diverging entanglement length.Comment: 4 page

Series Expansions for Excited States of Quantum Lattice Models

We show that by means of connected-graph expansions one can effectively generate exact high-order series expansions which are informative of low-lying excited states for quantum many-body systems defined on a lattice. In particular, the Fourier series coefficients of elementary excitation spectra are directly obtained. The numerical calculations involved are straightforward extensions of those which have already been used to calculate series expansions for ground-state correlations and $T=0$ susceptibilities in a wide variety of models. As a test, we have reproduced the known elementary excitation spectrum of the transverse-field Ising chain in its disordered phase.Comment: 9 pages, no figures, Revtex 3.0 The revised version corrects the incorrect (and unnecessary) statement in the original that H and H^eff are related by a unitary transformation; in fact they are related by via a similarity transformation. This has no implications for the calculations of spectra, but is important for matrix element