Performance of profiled single noise barriers covered with quadratic residue diffusers

The paper describes an investigation about the acoustic performance of noise barriers with quadratic residue diffuser (QRD) tops, and with T-, Arrow-, Cylindrical and Y-shape profiles. A 2D boundary element method (BEM) is used to calculate the barrier insertion loss. The results of rigid and with absorptive coverage are also calculated for comparisons. Using QRD on the top surface of almost all barrier models presented here is found to improve the efficiency of barriers compare with using absorptive coverage at the examined receiver positions. T-shape and Arrow-shape barriers are also found to provide better performance than other shapes of barriers. The best shape of barriers for utilising QRD among the tested models is the T-shape profile barrier. It is found that reducing the design frequency of QRD shifts the performance improvement towards lower frequency, and therefore the most efficient model for traffic noise is a barrier covered with a QRD tuned to around 400 Hz. © Elsevier Ltd. All rights reserved

Performance of T-shape barriers with top surface covered with absorptive quadratic residue diffusers

A previous paper [Applied Acoustics 66 (2005) 709–730] has shown that adding a quadratic residue diffuser (QRD) to the top of a T-shape barrier can provide better barrier performance than an equivalent purely absorptive barrier. In here, we extend the study to look at the performance when a QRD is made absorptive. This paper presents an investigation on the acoustic performance of a few welled-diffusers with different absorption ability on top of a T-shape noise barrier. The absorption properties of the diffusers are modified with different sequences, by filling the wells with fiberglass, by covering the well entrance with wire meshes, and by putting perforated sheet either on the top surface or inside the wells. A 2D Boundary Element Method (BEM) is used to calculate the barrier insertion loss. The numerical and experimental results on diffuser barriers with rigid and absorptive covers are compared. Among the tested models the best method of treating diffuser barriers with absorbent agents in the QRD is found to be a perorated sheet on top or inside the diffuser wells. It is found that increasing the absorption ability of QRD by fiberglass or high resistance wire meshes has negative effect on the efficiency of a QRD barrier. It is shown that, if the increase in absorption destroys the effect of resonance in wells, it will also have negative effect on the insertion loss performance of the QRD edge barrier. © Elsevier Ltd. All rights reserved

On the modeling of sound propagation over multi-impedance discontinuities using a semiempirical diffraction formulation

Several approximate extensions of the semi-empirical De Jong model [ De Jong et al., J. Sound and Vib. 86, 23–46 (1983) ] are considered for the prediction of sound propagation over multiple impedance discontinuities. A limitation in the original formulation of the De Jong model is highlighted and a modified form that overcomes this limitation is derived based on reciprocity. This leads to the development of a model for multiple impedance discontinuities that can be used for the investigation of sound-wave propagation above a mixed, striped soft ground that is created by either porous absorbent strips, embedded grooves, or wells with different depths. The accuracy of the model is validated against the boundary element method. It is then used to evaluate the importance of the imaginary part of the admittance of the ground strips on sound attenuation along welled surface. It is shown that the attenuation performance of a surface with multiple impedance discontinuities is high when the imaginary part of the average admittance is large and negative (with an −iωt convention), but the magnitudes of the attenuation peaks are also substantially affected by diffraction from the impedance discontinuities. © 2006 Acoustical Society of Americ

The Development of an Empirical Model for Estimation of the Sensitivity to Heat Stress in the Outdoor Workers at Risk

Background: Workers who work in hot environments may be at risk for heat stress. Exposure to heat can result in occupational illnesses, including heat stroke, heat cramps, and heat exhaustion. The risk of exposure to heat depends on individual, environmental, and occupational risk factors. Individual risk factors may decrease the individual’s tolerance to heat stress. Sensitivity as an intrinsic factor may predispose a person to heat stress. Aim: This study was aimed to determine the criteria for sensitivity parameter, specify their weights using the fuzzy Delphi-analytical hierarchy, and finally providing a model to estimate sensitivity. The significant of the study is presenting a model to estimate the sensitivity to heat stress. Materials and Methods: The expert’s opinions were used to extract the criteria in Delphi method. After determining the weight of each criterion, Fuzzy analytic hierarchy Process (FAHP), by mathematical principles matrix and triangular fuzzy numbers, was applied for the prioritization of criteria. Results: According to experts’ viewpoints and considering some exclusion, 10 of 36 criteria were selected. Among 10 selected criteria, age had the highest percentage of responses (90% (27/30)) and its relative weight was 0.063. After age, the highest percentages of response were assigned to the factors of preexisting disease (66.6% (20/30)), body mass index (56.6% (17/30)), work experience (53.3% (16/30)), and clothing (40% (16/30)), respectively. Other effective criteria on sensitivity were metabolic rate, daily water consumption, smoking habits, drugs that interfere with the thermoregulatory processes, and exposure to other harmful agents. Conclusions: Eventually, based on the criteria, a model for estimation of the workers’ sensitivity to heat stress was presented for the first time, by which the sensitivity is estimated in percent.Keywords: Heat stress, Sensitivity, Personal factors, Fuzzy AH

A new, fast and semi-automated size determination method (SASDM) for studying multicellular tumor spheroids

BACKGROUND: Considering the width and importance of using Multicellular Tumor Spheroids (MTS) in oncology research, size determination of MTSs by an accurate and fast method is essential. In the present study an effective, fast and semi-automated method, SASDM, was developed to determinate the size of MTSs. The method was applied and tested in MTSs of three different cell-lines. Frozen section autoradiography and Hemotoxylin Eosin (H&E) staining was used for further confirmation. RESULTS: SASDM was shown to be effective, user-friendly, and time efficient, and to be more precise than the traditional methods and it was applicable for MTSs of different cell-lines. Furthermore, the results of image analysis showed high correspondence to the results of autoradiography and staining. CONCLUSION: The combination of assessment of metabolic condition and image analysis in MTSs provides a good model to evaluate the effect of various anti-cancer treatments

Multicellular Tumour Spheroid as a model for evaluation of [(18)F]FDG as biomarker for breast cancer treatment monitoring

BACKGROUND: In order to explore a pre-clinical method to evaluate if [(18)F]FDG is valid for monitoring early response, we investigated the uptake of FDG in Multicellular tumour spheroids (MTS) without and with treatment with five routinely used chemotherapy agents in breast cancer. METHODS: The response to each anticancer treatment was evaluated by measurement of the [(18)F]FDG uptake and viable volume of the MTSs after 2 and 3 days of treatment. RESULTS: The effect of Paclitaxel and Docetaxel on [(18)F]FDG uptake per viable volume was more evident in BT474 (up to 55% decrease) than in MCF-7 (up to 25% decrease). Doxorubicin reduced the [(18)F]FDG uptake per viable volume more noticeable in MCF-7 (25%) than in BT474 MTSs. Tamoxifen reduced the [(18)F]FDG uptake per viable volume only in MCF-7 at the highest dose of 1 μM. No effect of Imatinib was observed. CONCLUSION: MTS was shown to be appropriate to investigate the potential of FDG-PET for early breast cancer treatment monitoring; the treatment effect can be observed before any tumour size changes occur. The combination of PET radiotracers and image analysis in MTS provides a good model to evaluate the relationship between tumour volume and the uptake of metabolic tracer before and after chemotherapy. This feature could be used for screening and selecting PET-tracers for early assessment of treatment response. In addition, this new method gives a possibility to assess quickly, and in vitro, a good preclinical profile of existing and newly developed anti-cancer drugs

Investigation of heat stress and heat strain in outdoor workers: a case study in Iran

Heat stress is an important and serious threat at work and is a particular concern in outdoor occupational environments. This study aims at comparing heat stress and heat strain at different outdoor groups, examining the protective and adaptive actions which were done by workers and also provi services to them by government or employer to reduce heat load. This cross–sectional study was conducted in the hottest days of the summer 2015 in Shabestar, Iran and 53 healthy men in nine occupational groups including concrete makers, porters, construction, waste site and road making workers, stonemasons, farmers, traffic officers, and street vendors participated. A set of physiological parameters, like heart rate, blood pressure, skin temperature and etc., WBGT index details and some of the adaptive and protective parameters were measured and monitored simultaneously at different times of the day. The study finds that heat exposure in outdoor workplace is prevalent and WBGT TWA/TLVave is less than 1 in some groups like stonemasons, waste site workers, traffic officers and street vendors whereas in other studied occupations, it is more than 1.This matter is compounded by the fact that the provision of health services by employers or local government was limited, and almost all of the participants had poor or insufficient access levels to public health and welfare services. This study confirms the necessity of interventions by a range of factors, such as government plans, improvement of services in the prevention of heat stress, and planning training courses for outdoor workers to build their knowledge of heat stress

Para-chloro-2-[18F]fluoroethyl-etomidate: A promising new PET radiotracer for adrenocortical imaging.

Introduction: [11C]Metomidate ([11C]MTO), the methyl ester analogue of etomidate, was developed as a positron emission tomography (PET) radiotracer for adrenocortical tumours and has also been suggested for imaging in primary aldosteronism (PA). A disadvantage of [11C]MTO is the rather high non-specific binding in the liver, which impacts both visualization and quantification of the uptake in the right adrenal gland. Furthermore, the short 20-minute half-life of carbon-11 is a logistic challenge in the clinical setting. Objectives: The aim of this study was to further evaluate the previously published fluorine-18 (T1/2=109.5 min) etomidate analogue, para-chloro-2-[18F]fluoroethyl etomidate; [18F]CETO, as an adrenal PET tracer. Methods: In vitro experiments included autoradiography on human and cynomolgus monkey (non-human primate, NHP) tissues and binding studies on adrenal tissue from NHPs. In vivo studies with [18F]CETO in mice, rats and NHP, using PET and CT/MRI, assessed biodistribution and binding specificity in comparison to [11C]MTO. Results: The binding of [18F]CETO in the normal adrenal cortex, as well as in human adrenocortical adenomas and adrenocortical carcinomas, was shown to be specific, both in vitro (in humans) and in vivo (in rats and NHP) with an in vitro Kd of 0.66 nM. Non-specific uptake of [18F]CETO in NHP liver was found to be low compared to that of [11C]MTO. Conclusions: High specificity of [18F]CETO to the adrenal cortex was demonstrated, with in vivo binding properties qualitatively surpassing those of [11C]MTO. Non-specific binding to the liver was significantly lower than that of [11C]MTO. [18F]CETO is a promising new PET tracer for imaging of adrenocortical disease and should be evaluated further in humans