Rectangular-bore, high-gain laser plasma tube

Rectangular-bore tube improves population inversion obtained from upper and terminal laser states, resulting in a significant increase in unsaturated gain factor. Radial field produces efficient pumping of upper laser state. Narrow tube dimensions cause increased diffusion flow of neon is metastable states to tube walls

Remote sensing of air-sea interactions

A number of preliminary concepts for the measurement or inference of fluxes across the air-sea interface through remote sensing are proposed. All the methods are achievable from aircraft with state-of-the-art technology. Only one is now ready for space implementation. The focus is on cold outbreaks. Sensible (latent) heat flux is inferred from the difference between initial surface air temperature (vapor mixing ratio) and the downwind SST (and corresponding saturation mixing ratio). The downwind growth rate of the PBL as measured by lidar also provides estimates of surface heating and the cross-inversion entrainment velocity. The lidar also provides a measure of the depth of the inversion and its penetration by surface-forced convection; this permits estimates of the surface heat flux. Lidar and radiometric measurements of cloud top height and temperature provide means of deducing the temperature sounding downstream so that heating is computed with the aid of a known sounding upstream

Experiments on Jet Flows and Jet Noise Far- Field Spectra and Directivity Patterns

Jet flows and jet noise far-field spectral and direction pattern

The imprint of thermally induced devolatilization phenomena on radon signal. Implications for the geochemical survey in volcanic areas

Thermal gradients due to magma dynamics in active volcanic areas may affect the emanating power of the substrate and the background level of radon signal. This is particularly effective in subvolcanic substrates where intense hydrothermal alteration and/or weathering processes generally form hydrous minerals, such as zeolites able to store and release great amounts of H2O (up to ∼25 wt.%) at relative low temperatures. To better understand the role played by thermally induced devolatilization reactions on the radon signal, a new experimental setup has been developed for measuring in real time the radon emission from a zeolitized volcanic tuff. Progressive dehydration phenomena with increasing temperature produce radon emissions two orders of magnitude higher than those measured during rock deformation, microfracturing and failure. In this framework, mineral devolatilization reactions can contribute significantly to produce radon emissions spatially heterogeneous and non-stationary in time, resulting in a transient state dictated by temperature gradients and the carrier effects of subsurface gases. Results from these experiments can be extrapolated to the temporal and spatial scales of magmatic processes, where the ascent of small magma batches from depth causes volatile release due to dehydration phenomena that increase the radon signal from the degassing host rock material

Institutional Repositories, Evidence Exchange, and other options to share your findings and research with the world, and how to retain your rights.

Objective 1: Understand the need for open access to research and interventions Objective 2: Be aware for the available venues for disseminating research findings Did you come up with a new intervention, and would you like to share it with the world? Would you like a secure place to put your conference posters and handouts from your AOTA and other professional presentations? If so then Open Access is for you. This discussion among peers will discuss how you are preserving your research, and how we could collaborate more to share our findings across the country

Apocalypse - 2003

Contributers include: Katy Pena, Danny Byzantine, B.Z. Niditch, Diana Smith, Donna Pucciani, Patty Dickson Pieczka, John Grey, Alan Catlin, Tracy Amirante, Effie Mihopoulous, Gertrude Rubin, Michael Brownstein, Cecilia Carboni,https://neiudc.neiu.edu/apocalypse/1006/thumbnail.jp

A Great Man\u27s Madness : An Inquiry Into Sanity and Gender in Jacobean Tragedy

This thesis delves deep into an analysis of madness in two seventeenth century tragic plays: William Shakespeare\u27s Macbeth and John Webster\u27s The Duchess of Malfi. The first portion of the dissertation will provide historical background and context. The rest will be a critical literary analysis centered around the argument that both plays present an inextricable connection between loss of mental clarity and gender

Mitochondrial alterations in Down syndrome: molecular mechanisms and therapeutic opportunities

Increasing evidence suggests that the mitochondrial dysfunction represents a hallmark in Down syndrome (DS) and that it can play a role in the pathogenesis of DS. Impaired expression/activity of PGC-1α, a crucial modulator of mitochondrial biogenesis and functions, is emerging as a common underlying cause of mitochondrial dysfunction in several diseases. The analysis of molecular mechanisms responsible for the DS phenotype identified in the over-expression of the chromosome 21 repressor gene NRIP1/RIP140 a cause of the decreased in the expression and activity of PGC-1α and of several mitochondria-related genes. We demonstrated that by silencing NRIP1 in trisomic cells it was possible to counteract the mitochondrial alterations observed in these cells, including irregular mitochondrial dynamics together with defects in the fission-fusion machinery. On this basis we tested the hypothesis that the induction of PGC-1α and of its downstream pathways might be able to reverse the mitochondrial dysfunction in DS. To this end we induced PGC-1α in trisomic fetal fibroblasts using two strategies: i) we used metformin, which stimulates PGC-1α through AMPK and SIRT1 activity; ii) we activated PGC-1α through the PPAR agonist pioglitazone. We demonstrated that both drugs were able to induce the PGC-1α pathway in trisomic cells. Both strategies stimulated respiratory capacity and increased ATP levels, while ROS production decreased. Most interestingly, both drugs affected mitochondrial dynamics promoting the formation of a mitochondrial network with branched and elongated tubular morphology. Accordingly, the expression of genes involved in the fission-fusion machinery, namely OPA1, Mitofusins and DRP-1, was modulated by either treatment, though the two drugs elicited different changes. These results indicate that the induction of PGC-1α counteracts the mitochondrial dysfunction in DS cells stimulating the mitochondrial biogenesis and promoting the formation of a mitochondrial network. We also investigated the role of chromosome 21 miRNAs in promoting mitochondrial alterations in DS. We put special attention to let-7c-5p, miR-155-5p and miR-99a-5p which are up-regulated in human fetal hearts. The study of their targets down-regulated in DS fetal hearts and involved in mitochondrial function identified the ATP translocator the SLC25A4/ANT1 as a let-7c-5p target candidate for mitochondrial anomalies. Taken all together these results indicate that unraveling the molecular mechanisms that underlie mitochondrial dysfunction in DS paves the way to new therapeutic approaches to counteract DS phenotypic traits and/or to prevent DS associated pathologies

Real-time setup to measure radon emission during rock deformation. Implications for geochemical surveillance

Laboratory experiments can represent a valid approach to unravel the complex interplay between the geochemical behaviour of radon and rock deformation mechanisms. In light of this, we present a new real-time experimental setup for analysing in continuum the alpha-emitting 222Rn and 220Rn daughters over variable stress–strain regimes. The most innovative segment of this setup consists of the radon accumulation chamber obtained from a tough and durable material that can host large cylindrical rock samples. The accumulation chamber is connected, in a closed-loop configuration, to a gas-drying unit and to a RAD7 radon monitor. A recirculating pump moves the gas from the rock sample to a solid-state detector for alpha counting of radon and thoron progeny. The measured radon signal is enhanced by surrounding the accumulation chamber with a digitally controlled heating belt. As the temperature is increased, the number of effective collisions of radon atoms increases favouring the diffusion of radon through the material and reducing the analytical uncertainty. The accumulation chamber containing the sample is then placed into a uniaxial testing apparatus where the axial deformation is measured throughout a linear variable displacement transducer. A dedicated software allows obtaining a variety of stress–strain regimes from fast deformation rates to long-term creep tests. Experiments conducted with this new real-time setup have important ramifications for the interpretation of geochemical anomalies recorded prior to volcanic eruptions or earthquakes

La reforma esperada: una educación para todos y para cada uno de ellos

El presente trabajo sustenta la posibilidad de las reformas a gran escala. Reformas sostenibles y con resultados drásticos en una legislatura. Para lo cual son necesarias dos condiciones. En primer lugar que todos los ciudadanos se unan en torno a un sueño común o propósito moral, y en segundo lugar una sólida y dinámica teoría de la acción para el cambio del sistema, dicha teoría viene a ser un conjunto de elementos guía de las acciones a nivel de sistema. Presenta dos casos de reformas exitosas en aprendizajes: la Estrategia Nacional de Lectura y Escritura en el Reino Unido y la Estrategia de Ontario en Canadá. Todo lo anterior enfocado en dos vertientes teóricas: la del derecho a la educación y la teoría de la acción de Michael Fullan