The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis

PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes. In damaged mitochondria, PINK1's importing into the inner mitochondrial membrane is prevented, PARKIN presents a partial mitochondrial localization at the outer mitochondrial membrane and DJ-1 relocates to mitochondria when oxidative stress increases. Depletion of these proteins result in abnormal mitochondrial morphology. PINK1, PARKIN, and DJ-1 participate in mitochondrial remodeling and actively regulate mitochondrial quality control. In this review, we highlight that PARKIN, PINK1, and DJ-1 should be regarded as having an important role in Cancer Biology. The STRING database and Gene Ontology (GO) enrichment analysis were performed to consolidate knowledge of well-known protein interactions for PINK1, PARKIN, and DJ-1 and envisage new ones. The enrichment analysis of KEGG pathways showed that the PINK1/PARKIN/DJ-1 network resulted in Parkinson disease as the main feature, while the protein DJ-1 showed enrichment in prostate cancer and p53 signaling pathway. Some predicted transcription factors regulating PINK1, PARK2 (PARKIN) and PARK7 (DJ-1) gene expression are related to cell cycle control. We can therefore suggest that the interplay among PINK1/PARKIN/DJ-1 network during mitochondrial quality control in cancer biology may occur at the transcriptional level. Further analysis, like a systems biology approach, will be helpful in the understanding of PINK1/PARKIN/DJ-1 network.Peer reviewedFinal Published versio

Synopsis of biological data on the blue crab, Callinectes sapidus Rathbun

This synopsis reviews taxonomy, morphology, distribution, life history, commercial hard and soft shell crab fisheries, physiology, diseases, ecology, laboratory culture methodology, and influences of environmental pollutants on the blue crab, Callinecles sapidus. Over 300 selected, published reports up to and including 1982 are covered. (PDF file contains 45 pages.

A Rational Deconstruction of Landin's SECD Machine with the J Operator

Landin's SECD machine was the first abstract machine for applicative expressions, i.e., functional programs. Landin's J operator was the first control operator for functional languages, and was specified by an extension of the SECD machine. We present a family of evaluation functions corresponding to this extension of the SECD machine, using a series of elementary transformations (transformation into continu-ation-passing style (CPS) and defunctionalization, chiefly) and their left inverses (transformation into direct style and refunctionalization). To this end, we modernize the SECD machine into a bisimilar one that operates in lockstep with the original one but that (1) does not use a data stack and (2) uses the caller-save rather than the callee-save convention for environments. We also identify that the dump component of the SECD machine is managed in a callee-save way. The caller-save counterpart of the modernized SECD machine precisely corresponds to Thielecke's double-barrelled continuations and to Felleisen's encoding of J in terms of call/cc. We then variously characterize the J operator in terms of CPS and in terms of delimited-control operators in the CPS hierarchy. As a byproduct, we also present several reduction semantics for applicative expressions with the J operator, based on Curien's original calculus of explicit substitutions. These reduction semantics mechanically correspond to the modernized versions of the SECD machine and to the best of our knowledge, they provide the first syntactic theories of applicative expressions with the J operator

Never Alone: Discovering the Path to Burnout Avoidance

Pastoral burnout, in the past century, has become an issue that captures the attention of researchers and ministry professionals alike. Experts claim that burnout is avoidable when ministers submit to an obedient, faithful pursuit of life with God rather than working at a frenzied pace to impress people and gain the approval of God. Defined as the status of an individual that has become fatigued with his or her vocation or major life activity, burnout is preceded by a long-term avoidance of the signs of weakness and an intense focus on simply working harder. Some scholars believe the primary problem is the lack of self-care, however, in what form and to what standard would self-care be measured?3 To understand the impacts of self-care in preventing burnout, self-care must be defined and contrasted with different environments deficient of such care. This study will share findings across denominational and cultural lines and the impact of different approaches to healthy ministry and what appears to prevent the effects of burnout. Additionally, this author, by examining the missing components in spiritual and personal life, compared real-life stories of ministry failures and successes by juxtaposing them with healthy, long-term ministry professionals who avoided burnout and ministry failure.This project identified the problem of burnout facing Evangelical ministers today and examined several case studies that confirm the overwhelming statistical evidence of an epidemic that has grown in recent decades, despite the abundance of research, focused studies, and preventative measures put in place. The idea is not to say denominations and churches have not taken the problem of ministry burnout seriously, but that perhaps the focus has been heavy on the treatment of symptoms rather than the causes. The solution, if discoverable, will address the root of the problem while providing some healing to the symptoms during the long process of holistic personal and spiritual health of the minister. While this author does not claim to hold the secret to perfect ministry health or the solution to higher-than-average attrition rates in caring occupations, the personal experience of burnout and emotional fatigue after a decade in ministry will lend some expertise to the potential solution. Particular attention to avoiding the temptation of quick fixes and the entertainment of suppressive devices that only exacerbate the problem will be a priority

Reanimator/Reflection: Creating Mirrors through Time with AI, Sound, Video and Live-generated Art in the Dark Age of the COVID-19 Pandemic

For my MFA thesis exhibition entitled Reanimator/Reflection, I used artificial intelligence to create three new works of sound and live-generated video art, each based on mirror reflections and 100-year-old racist post-pandemic horror literature by early 20th century American author H. P. Lovecraft. The themes of these writings mirror the issues of our current time. The primary works of Lovecraft that I referenced in the exhibition are “Herbert West: Reanimator,” (1922) a serialized tale about graduate school experiments which attempted to return the dead to life during a plague, and “Nyarlathotep,” (1920) a prose poem that suggests even our dreams might become infected as with a fever. These two particular texts were written shortly after the early 20th century influenza pandemic that lasted from 1918 to 1920; they directly address that pandemic and its associated fears; and, then as now during the time of COVID-19, these pandemic fears are often expressed in racial terms

Conflicting Currencies: An Examination of the USD and the Geoeconomics of the International Monetary System

What is the future of the United States dollar within the international monetary system? The dollar has certainly enjoyed supremacy as a unit of account, store of value, and medium exchange since World War II, but what about new challengers (most notably the euro and Chinese yuan)? Using “geoeconomic” analysis to determine what strategies or actions a state might pursue in the international political economy can help to begin answering these questions. Geoeconomic considerations used in this paper do not dismiss cultural, political, or military aspects of international power relations, they supplements them. The short-run status of USD preeminence within the international monetary system is stable, but medium and long-term prospects are more uncertain. Important currency contenders, such as the euro and yuan, raise important political and economic problems for the U.S.’s borrowing, policy options, and, ultimately, its national sovereignty. Future outcomes and possibilities will be explored to highlight the need for the U.S. to fix its domestic issues in order to retain currency supremacy and national control

Alien Registration- Millikin, Agnes (Newfield, York County)

https://digitalmaine.com/alien_docs/3205/thumbnail.jp

A Simple Application of Lightweight Fusion to Proving the Equivalence of Abstract Machines

We show how Ohori and Sasano's recent lightweight fusion by fixed-point promotion provides a simple way to prove the equivalence of the two standard styles of specification of abstract machines: (1) as a transition function together with a `driver loop' implementing the iteration of this transition function; and (2) as a function directly iterating upon a configuration until reaching a final state, if ever. The equivalence hinges on the fact that the latter style of specification is a fused version of the former one. The need for such a simple proof is motivated by our recent work on syntactic correspondences between reduction semantics and abstract machines, using refocusing