Information Sharing for improved Supply Chain Collaboration – Simulation Analysis

Collaboration among consumer good’s manufacturer and retailers is vital in order to elevate their performance. Such mutual cooperation’s, focusing beyond day to day business and transforming from a contract-based relationship to a value-based relationship is well received in the industries. Further coupling of information sharing with the collaboration is valued as an effective forward step. The advent of technologies naturally supports information sharing across the supply chain. Satisfying consumers demand is the main goal of any supply chain, so studying supply chain behaviour with demand as a shared information, makes it more beneficial. This thesis analyses demand information sharing in a two-stage supply chain. Three different collaboration scenarios (None, Partial and Full) are simulated using Discrete Event Simulation and their impact on supply chain costs analyzed. Arena software is used to simulate the inventory control scenarios. The test simulation results show that the total system costs decrease with the increase in the level of information sharing. There is 7% cost improvement when the information is partially shared and 43% improvement when the information is fully shared in comparison with the no information sharing scenario. The proposed work can assist decision makers in design and planning of information sharing scenarios between various supply chain partners to gain competitive advantage

A Transnational Political Engagement: Solidarity, Nationhood and Pan-Tamilness among the Tamils of Tamilnadu

In this study I will explore and investigate the development of the contemporary student agitation which has unfolded in the Southern Indian state of Tamilnadu since 2008 and been axed around the plight of Sri Lankan Tamils. The research concerns Indian Tamil activists in the city of Chennai, and their subjective and collective understanding of the political engagement towards the Tamils of North-East Sri Lanka. Likewise it is also a study of the political literacy, identities and actions of the Tamilnadu students and through them that of the general solidarity movement for Eelam within the Indian state of Tamilnadu. Extensive research on the political history of the Tamil regions of India and Sri Lanka will be elucidated in this thesis to provide the context which facilitated the contemporary developments in Tamilnadu. Furthermore my interests lie in tensions between the identity category of Indian promoted by the Indian nation-state and the permeating ethnic identity category of Tamil in Tamilnadu. The tension is prevalent as the pro-Sri Lankan Tamil agitation highlights Tamilness and scrutinizes Indian-ness, as a result of linkages between the Indian Central government and the Sri Lankan government. I will also explore the uniting factors which transcend traditional elements of differentiation among Indian Tamils and contribute to the activation of an overarching Tamilness and political identity. The overall theoretical focus will be on forms of transnationalism and nationalism. The activism which I study is transnational as well as of nationalist orientation, yet does not adequately fit into either dominant forms of nationalism or the concept of long distance nationalism. Hence transnationalism is discussed as the theoretical vehicle I prefer in conceptualising the political engagement of Indian Tamil youth towards the plight of Sri Lankan Tamils. Such an engagement over time has had an effect on the conceptions of Tamilnadu students and activists regarding nationhood, identity and political processes on international, regional and national levels. Globalization processes, the internet and other information sharing factors also prove to be components in facilitating furthered transnational interaction between Tamilnadu Tamil and Sri Lankan Tamil activists in a common political engagement for Eelam. The thesis is thus a study of political engagement driven by cultural connectedness, ethnic sentiments and primordial' loyalties in the contemporary world. Yet the engagement towards Sri Lankan Tamils, a population considered externally and internally as distinct from the Indian Tamils, constitutes transnational interaction and linkages, and therefore cannot be reduced to nationalist orientations. My thesis thus concerns, transnationalism, nationalist orientations and political engagement in the contemporary global era.Master i SosialantropologiSANT350MASV-SAN

Development of computer aided design system based on artificial neural network for macular hole detection

Medical imaging is a technique used to identify or study disease in the body. In order to obtain the retinal images, clinical ophthalmology broadly used a non-invasive medical imaging named optical coherence tomography (OCT). OCT images lead to visualize retina’s inner layers, which was important to identify the retinal diseases at the early stage. Macular Hole is one of the retinal disease that should be treated early. A Graphical User Interface (GUI) was created to detect the Macular Hole disease. In this paper, Computer Aided Design (CAD) system to detect Macular Hole eye disease has been developed. This disease diagnosed and need to be treated at beginning state as it will lead to vision lost if it get severe. An algorithm is proposed in this study which performs Macular Hole detection. There are browse image, pre-processing, segmentation, feature extraction and lastly classification steps. This study successfully classified the Macular Hole and normal retinal images correctly using Artificial Neural Network (ANN) classification. The accuracy of the net produced after several trials of retrain is 90%. The other statistical parameters such as precision, specificity and sensitivity was obtained from this project. In a conclusion, there was a way obtained from this study to diagnosis the patients who were suffer from this Macular Hole disease

Spectrum Sensing and Mitigation of Primary User Emulation Attack in Cognitive Radio

The overwhelming growth of wireless communication has led to spectrum shortage issues. In recent days, cognitive radio (CR) has risen as a complete solution for the issue. It is an artificial intelligence-based radio which is capable of finding the free spectrum and utilises it by adapting itself to the environment. Hence, searching of the free spectrum becomes the key task of the cognitive radio termed as spectrum sensing. Some malicious users disrupt the decision-making ability of the cognitive radio. Proper selection of the spectrum scheme and decision-making capability of the cognitive reduces the chance of colliding with the primary user. This chapter discusses the suitable spectrum sensing scheme for low noise environment and a trilayered solution to mitigate the primary user emulation attack (PUEA) in the physical layer of the cognitive radio. The tag is generated in three ways. Sequences were generated using DNA and chaotic algorithm. These sequences are then used as the initial seed value for the generation of gold codes. The output of the generator is considered as the authentication tag. This tag is used to identify the malicious user, thereby PUEA is mitigated. Threat-free environment enables the cognitive radio to come up with a precise decision about the spectrum holes

Angiotensin Converting Enzyme Insertion/Deletion Gene Polymorphism: An Observational Study among Diabetic Hypertensive Subjects in Malaysia

Purpose: This study investigated the influence of angiotensin-1 converting enzyme (ACE) insertiondeletion (ID) gene polymorphism on the treatment responses of type 2 diabetic subjects at varying stages of nephropathy to ACE inhibitors (ACEI) with regard to blood pressure (MAP) and renal response (GFR). Methods: The pharmacological effect of ACE inhibition on mean arterial pressure (MAP) and glomerular filtration rate (GFR) were observed among a total of 62 subjects for a short-term duration of 15 months. MAP and GFR were calculated by standard mathematical formulae while the ACE ID genotype was determined using triple primer PCR. The general linear model repeated measures were applied to study the modulation of ACE inhibition on these parameters. Results: ACE ID genotyping of the 62 subjects showed that 19 (30.6 %) subjects had the II genotype, while 35 (56.4 %) subjects showed ID genotype and 8 (12.9 %) subjects had the DD genotype. Significant mean MAP reduction (p 0.05) from baseline values were observed among the subjects following antihypertensive treatment. However, when stratified according to ACE genotypes, no significant mean MAP and GFR changes were observed between genotypes following antihypertensive treatment (p > 0.05).Conclusion: ACE ID gene polymorphism does not determine the treatment efficacy of ACE inhibitors in the Malaysian population.Keywords: ACE genotype, ACE inhibitor, Type 2 diabetes mellitus, Diabetic nephropath

Outcome of triage results between two groups of interns subjected to different model of simulation

Background: In the emergency department, triaging is a very important for mass casualties and should not lead to any errors while doing so. In spite of subjecting interns to triaging theory classes in their final year of MBBS, they are not confident in triaging when need comes. To address this, we designed this study which aims at understanding the efficacy and type of triage based simulation education for medical interns during their 1 year internship programme.Methods: A cross sectional study with 186 intern students of a Yenepoya Medical College Hospital of Karnataka was selected for the triage simulation. The interns who could attend the entire programme were randomly divided into 2 groups of n=91 each. One group underwent desktop based triage simulation (n1=91) and the other group faced enacted patient based triage simulation training followed by test. Evaluation comprised of tests to 2 groups of interns. The first group were subjected to test following desktop triage simulation and the second group were subjected to test following enacted patient simulation based triaging.Results: The test result showed that there was significant improvement in the result obtained from the group that underwent high fidelity simulation (p<0.05).Conclusions: Simulation based training which is closed to reality leads to a significant increase in learning and recalling output compared to the traditional method

Computational identification and analysis of neurodegenerative disease associated protein kinases in hominid genomes

AbstractProtein kinases play an important role in the incidence of neurodegenerative diseases. However their incidence in non-human primates is found to be very low. Small differences among the genomes might influence the disease susceptibilities. The present study deals with finding the genetic differences of protein kinases in humans and their three closest evolutionary partners chimpanzee, gorilla and orangutan for three neurodegenerative diseases namely, Alzheimer's, Parkinson's and Huntington's diseases. In total 47 human protein kinases associated with three neurodegenerative diseases and their orthologs from other three non-human primates were identified and analyzed for any possible susceptibility factors in humans. Multiple sequence alignment and pairwise sequence alignment revealed that, 18 human protein kinases including DYRK1A, RPS6KB1, and GRK6 contained significant indels and substitutions. Further phosphorylation site analysis revealed that eight kinases including MARK2 and LTK contained sites of phosphorylation exclusive to human genomes which could be particular candidates in determining disease susceptibility between human and non-human primates. Final pathway analysis of these eight kinases and their targets revealed that these kinases could have long range consequences in important signaling pathways which are associated with neurodegenerative diseases

Mast Cells in Health and Oral Disease

Introduction: Mast cells (MC) are multifunctional secretory cells characterized by numerous large metachromatic staining protease-rich intracellular granules. They are derived from hematopoietic progenitor cells in bone marrow and do not mature into terminally differentiated cells until they reach the tissue or organ in which they become resident. They play a vital role in a number of defense and repair mechanisms due to their strategic location in the connective tissue at the interface with the microvasculature. Objectives: This review attempts to help improve our understanding on the types of MC, their morphology, staining characteristics, distribution, biological function, and their pathogenesis in inflammation, oral potentially malignant disorders, and oral squamous cell carcinoma. We hope this review recognizes the integral role of MC in oral pathological disorders and facilitates the opening of novel approaches to better therapies for improving the quality of life. Conclusion: Mast cells has shown to remodel extracellular matrix during wound healing. The entire ambit of allergic and hypersensitivity reactions are the adverse effects produced by the degranulation of MC. They participate in many inflammatory oral diseases as they possess diverse roles ranging from proinflammatory to immuno-modulatory. They accumulate at the boundary between healthy tissues and malignancies and are found in close association with blood vessels within the tumor microenvironment as they play an early role in angiogenesis

Graphite Carbon Nitride

Graphitic carbon nitride (g-C3N4), is a synthetic polymer made up of carbon, nitrogen, and some impurity hydrogen that is linked together using tris-triazine-based patterns. Because of the inclusion of N and H atoms, it has electron-rich characteristics, basic surface functions, and H-bonding motifs, compared to the bulk of carbon materials. Consequently, it’s seen as a possible replacement for carbon in material applications. A brief introduction to g-C3N4 is included in this chapter, as are the methods for synthesizing this material with various textural structures and surface morphologies, as well as its physicochemical properties. Furthermore, four parts of g-C3N4 applications are discussed. We anticipate that this work will motivate readers to look for new applications for this material in catalysis and other domains