Synthesis of 1,4,7-triazacyclononane pendant-armed chelators and their metal complexes

Pendant-armed cyclic polyamines have been demonstrated to be promising ligands for the development of new metal-based radiopharmaceuticals for positron-emission tomography (PET). Macrocyclic polyamines bearing pendant arms can effectively bind specific metals with suitable complexation kinetics and stability while attached to a tumor-targeting vector or peptide. 64Cu-radiolabeled peptides containing the chelator 1,4,7-triazacyclononane 1,4,7-triacetate have been shown to possess superior properties which overcome commonly observed problems such as demetallation and accumulation of the radio-metal in non-targeted tissues. To model these radiolabeled bioconjugates and to gain insight into this observed bio-stability, the synthesis of a copper (II) complex of a new triazacyclononane derivative containing one amide and two acetate groups (NOAM2A) has been performed. Studies of its acid inertness and electrochemistry behavior have been investigated. Complementary, copper (II) complexes of other triazacyclononane intermediates have also been explored

Multiclass Data Segmentation using Diffuse Interface Methods on Graphs

We present two graph-based algorithms for multiclass segmentation of high-dimensional data. The algorithms use a diffuse interface model based on the Ginzburg-Landau functional, related to total variation compressed sensing and image processing. A multiclass extension is introduced using the Gibbs simplex, with the functional's double-well potential modified to handle the multiclass case. The first algorithm minimizes the functional using a convex splitting numerical scheme. The second algorithm is a uses a graph adaptation of the classical numerical Merriman-Bence-Osher (MBO) scheme, which alternates between diffusion and thresholding. We demonstrate the performance of both algorithms experimentally on synthetic data, grayscale and color images, and several benchmark data sets such as MNIST, COIL and WebKB. We also make use of fast numerical solvers for finding the eigenvectors and eigenvalues of the graph Laplacian, and take advantage of the sparsity of the matrix. Experiments indicate that the results are competitive with or better than the current state-of-the-art multiclass segmentation algorithms.Comment: 14 page

Propuesta de oferta tecnológica en ganadería sostenible de alta montaña en Colombia, utilizando escarabajos coprófagos bio-recicladores

From the Humboldt Institute, research is being carried out that relates the diversity and functional activity of bio recycling dung beetles (Scarabaeinae) and the benefits for livestock production, with the aim of designing a proposal for a technological offer in sustainable livestock. The research pilot is carried out in the Chuguaca ranch; Norman cattle farms for dairy production in the central Andean zone of Colombia. The diversity of beetles was characterized by sampling with baited traps, and with terrariums the life cycle of three species was monitored: Homocopris achamas, Ontherus brevicollis and Onthophagus curvicornis. Six species of Scarabaeinae have been recorded, three of these with high activity in pastures. The non-use of Ivermectin has notably increased the activity of the beetles on the manure. The interest and investigative curiosity that the project has aroused in owners, workers, technicians and visitors to the farm, is essential for success in the path of a more environmentally friendly livestock production.A partir do Instituto Humboldt, estão sendo realizadas pesquisas que relacionam a diversidade e a atividade funcional dos escaravelhos biorrecicladores (Scarabaeinae)  e  os  benefícios  para a pecuária, com o objetivo de desenhar uma proposta de oferta tecnológica    em    pecuária   sustentável. O   piloto   de pesquisa foi realizado na fazenda Chuguaca; Fazendas de gado normando para produção de leite na zona andina central da Colômbia. A   diversidade   de   besouros foi caracterizada por amostragem com armadilhas com isca, e com terrários foi monitorizado o ciclo de vida de três espécies: Homocopris achamas, Ontherus brevicollis e Onthophagus curvicornis. Seis espécies de Scarabaeinae foram registradas, três de lãs com alta atividade em pastagens. A não utilização de ivermectina aumentou notavelmente a atividade dos besouros no estrume. O interesse e curiosidade investigativa que o projeto tem despertado nos proprietários, trabalhadores, técnicos e visitantes da quinta, é essencial para o sucesso no caminho de uma produção pecuária mais amiga do ambiente.Desde el Instituto Humboldt, se adelanta investigación que relaciona la diversidad y la actividad funcional de los escarabajos coprófagos bio-recicladores (Scarabaeinae) y los beneficios para la producción ganadera, con el objetivo de diseñar una propuesta de oferta tecnológica en ganadería sostenible. El piloto de investigación se realiza en la ganadería Chuguaca; fincas de ganado normando para producción lechera en la zona andina central de Colombia. La diversidad de escarabajos se caracterizó con muestreo con trampas cebadas, y con terrarios se hace seguimiento al ciclo de vida a tres especies: Homocopris achamas, Ontherus brevicollis y Onthophagus curvicornis. Seis especies de Scarabaeinae han sido registradas, tres de estas con alta actividad en los potreros. El no uso de la Ivermectina ha aumentado notoriamente la actividad de los escarabajos sobre el estiércol. El interés y curiosidad investigativa que ha despertado el proyecto en dueños, trabajadores, técnicos y visitantes de la finca, es fundamental para el éxito en el camino de una producción ganadera más amigable con el medio ambiente

Relación entre el desempeño académico y las dificultades de aprendizaje derivadas de la estructura y funcionamiento cerebral en los estudiantes de grado 10 de la IE Alfonso Jaramillo Gutiérrez de la ciudad de Pereira, Colombia

Test RCMT, consentimiento informado de padres de familiaEste documento presenta los resultados del trabajo de grado realizado en la modalidad de proyecto de investigación bajo la asesoría de Mg. Jhon Jairo Peña Guerra, inscrito en la línea de investigación de Argumentación, pedagogía y aprendizaje de la ECEDU, se emplea una metodología cuantitativa empírico analítica. La muestra se define con los estudiantes de grado 10 de la IE Alfonso Jaramillo Gutiérrez de la ciudad de Pereira, Risaralda cuya finalidad es establecer la relación entre el funcionamiento cerebral (Proporcionalidad o desproporcionalidad) planteada por Waldemar de Gregori en su teoría cibernética social y el desempeño académico en el área de matemáticas así como establecer también estrategias de enseñanza que permitan realizar la medición en los cambios de estos desempeños académicos para esto se realizó una selección de grupos colaborativos e implementación de TIC.This document is result of quantitative empirical and analytical research performed in I.E Alfonso Jaramillo Gutierrez in Pereira, Colombia. Based on Theory of social cybernetics proporcionalist developed by Waldemar de Gregroy. The sample is defined with 10TH grade students the general purpose is establish the relationship between brain functioning and the academic performance in math, as well as establishing teaching strategies that allow measuring the changes in those academic performance

Initial Delay Domain UWB Channel Characterization for In-body Area Networks

Wireless Body Area Networks (WBANs) have increased the attention of the research community for the next generation wireless medical devices. Among others, Wireless Capsule Endoscopy (WCE) aims to transmit better quality images. For this, the Ultra Wideband (UWB) frequency band is becoming a good alternative to currently allocated frequencies for in-body networks, allowing higher data rate and having a low power transmission. Common channel characterization in WBANs are performed in frequency domain, i.e., analyzing the received power as a function of frequency. Nevertheless, indepth studies in delay domain analyzing the impulse response of the channel are barely considered in current literature. In this paper, an initial study in delay domain, i.e., the Power Delay Profile (PDP) characteristics, is performed. Moreover, a comparison between the channel response in frequency and delay domain is performed. This work gives an insightful view of the impulse response of the channel for in-body to on-body communications. For that, an extensive campaign of phantom measurements and software simulations are conducted.This work was supported by the European Union’s H2020:MSCA:ITN program for the ”Wireless In-body Environment Communication- WiBEC” project under the grant agreement no. 675353. This work was also funded by by the European Union’s H2020: MSCA: ITN program for the ”mmWave Communications in the Built Environments - WaveComBE” project under the grant agreement no. 766231.Pérez-Simbor, S.; Garcia-Pardo, C.; Cardona Marcet, N. (2019). Initial Delay Domain UWB Channel Characterization for In-body Area Networks. IEEE. 1-5. https://doi.org/10.1109/ISMICT.2019.8743767S1