Stroke mechanism of crane trolley

Tato bakalářská práce se zabývá návrhem zdvihového mechanismu jeřábové kočky pro břemena, jejichž hmotnost nepřesáhne 5 000 kg. Práce obsahuje písemnou, a praktickou část. Písemná část práce se zabývá výpočtem hlavních rozměrů zdvihu a pevnostní kontrolou lanového bubnu. V práci jsou také zdůvodněny volby některých hlavních částí zdvihového mechanismu jako je např.: elektromotor, převodovka aj. Před výpočty jednotlivých kapitol je obvykle umístěn stručný úvod do problematiky. Praktická část obsahuje výkres celkové sestavy zdvihového mechanismu, sestavu lanového bubnu a dva výrobní výkresy.Bachelor's thesis deals with design of stroke mechanism of crane trolley loads for the weights which do not exceed 5 000 kg. This thesis divided into written and practical sections. Written part deals with the calculation of the principal dimensions of lifting and stress control of cable reel. In this work there are also given reasons for choosing certain key parts of the lifting mechanism, such as: electric motor, gearbox, etc. Prior to the calculations in each chapter there is usually located a short introduction of the topic. The practical part contains a drawing of the complete lifting mechanism, cable reel assembly and two production drawings.

Describing the complexity of systems: multi-variable "set complexity" and the information basis of systems biology

Context dependence is central to the description of complexity. Keying on the pairwise definition of "set complexity" we use an information theory approach to formulate general measures of systems complexity. We examine the properties of multi-variable dependency starting with the concept of interaction information. We then present a new measure for unbiased detection of multi-variable dependency, "differential interaction information." This quantity for two variables reduces to the pairwise "set complexity" previously proposed as a context-dependent measure of information in biological systems. We generalize it here to an arbitrary number of variables. Critical limiting properties of the "differential interaction information" are key to the generalization. This measure extends previous ideas about biological information and provides a more sophisticated basis for study of complexity. The properties of "differential interaction information" also suggest new approaches to data analysis. Given a data set of system measurements differential interaction information can provide a measure of collective dependence, which can be represented in hypergraphs describing complex system interaction patterns. We investigate this kind of analysis using simulated data sets. The conjoining of a generalized set complexity measure, multi-variable dependency analysis, and hypergraphs is our central result. While our focus is on complex biological systems, our results are applicable to any complex system.Comment: 44 pages, 12 figures; made revisions after peer revie

Mammalian cells in culture actively export specific microRNAs

The discovery of microRNAs (miRNAs) as a new class of regulators of gene expression has triggered an explosion of research, but has left many unanswered questions about how this regulation works and how it is integrated with other regulatory mechanisms. A number of miRNAs have been found to be present in blood plasma and other body fluids of humans and mice in surprisingly high concentrations. This observation was unexpected in two respects: first, the fact that these molecules are present at all outside the cell at significant concentrations; and second, that these molecules appear to be stable outside of the cell. In light of this it has been suggested that the biological function of miRNAs may also extend outside of the cell and mediate cell-cell communication^[1-5]^. Such a system would be expected to export specific miRNAs from cells in response to specific biological stimuli. We report here that after serum deprivation several human cell lines tested do export a spectrum of miRNAs into the culture medium. The export response is substantial and prompt. The exported miRNAs are found both within and outside of microvesicles and exosomes. We have identified some candidate protein components of this system outside the cell, and found one exported protein that plays a role in protecting miRNA from degradation. Our results point to a hitherto unrecognized and uncharacterized miRNA trafficking system in mammalian cells that may involve cell-cell communication

Avaliação de desempenho: como avaliar os servidores de forma justa?

Na Agência Nacional de Melhorias, órgão público federal, os servidores técnico-administrativos recebem a Gratificação de Compensação do Vencimento (GCV), a qual é paga conforme o desempenho dos servidores, aferido anualmente. Entretanto, o processo de avaliação de desempenho ocorre de forma injusta e com muitas disfunções. O desempenho dos servidores não é efetivamente avaliado, como no caso da equipe do Cláudio, que possui um servidor com desempenho aquém dos demais servidores, mas que recebe a mesma pontuaçãoNúmero de páginas: 4 p.Gestão de PessoasA nota pedagógica deste estudo de caso é de acesso restrito e exclusivo a professores e coordenadores de ensino cujos cadastros tenham sido autorizados pela coordenação da Casoteca de Gestão Pública. Se você é professor ou coordenador de ensino e deseja ter acesso à íntegra das notas pedagógicas que alguns estudos de caso possuem, solicite sua autorização de uso pleno no site da Casoteca de Gestão Pública, na opção “Cadastre-se” (http://casoteca.enap.gov.br/index.php?option=com_user&view=register&Itemid=14)

An analysis of the effect of certain music reading readiness factors on sight singing

Thesis (Ed.M.)--Boston Universit