On the nature of the X-ray absorption in the Seyfert 2 galaxy NGC 4507

We present results of the ASCA observation of the Seyfert 2 galaxy NGC 4507. The 0.5-10 keV spectrum is rather complex and consists of several components: (1) a hard X-ray power law heavily absorbed by a column density of about 3 10^23 cm^-2, (2) a narrow Fe Kalpha line at 6.4 keV, (3) soft continuum emission well above the extrapolation of the absorbed hard power law, (4) a narrow emission line at about 0.9 keV. The line energy, consistent with highly ionized Neon (NeIX), may indicate that the soft X-ray emission derives from a combination of resonant scattering and fluorescence in a photoionized gas. Some contribution to the soft X-ray spectrum from thermal emission, as a blend of Fe L lines, by a starburst component in the host galaxy cannot be ruled out with the present data.Comment: 8 pages, LateX, 5 figures (included). Uses mn.sty and epsfig.sty. To appear in MNRA

Jefe de obra: gestión y producción obra básica y pavimentación de R.P. E-52 tramo: La Tordilla-La Para (R.P. N° 17)

Práctica Supervisada (IC)--FCEFN-UNC, 2019Describe las tareas realizadas como jefe de obra en la empresa constructora THEBA SRL-ARC SRL-CORBE SRL-Pablo Federico Ute durante la pavimentación de la R.P. E-52 entres las localidades de La Tordilla y el acceso a Toro PujioFi: Audano, Emmanuel. Universidad de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Escuela de Ingeniería Civil; Argentina.Fi: Baruzzi, Alejandro G.Universidad de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Escuela de Ingeniería Civil; Argentina

THE RNA BINDING PROTEIN ZC3H10 COUPLES MITOCHONDRIAL FUNCTION AND IRON METABOLISM

Mitochondria play a crucial role in energy metabolism. Mitochondria have their own genome (mtDNA), whose replication and transcription are mainly regulated by the mitochondrial transcription factor A (Tfam). Recent researches demonstrate how mitochondria participate to a large number of cellular processes like cell cycle and differentiation. Our goal is to identify new mitochondrial regulators to light up the molecular mechanisms underlying mitochondrial function biology. We used a high throughput screening in 293 cells in order to identify positive mitochondrial regulators. By these means, we identified Zinc Finger CCCH-type containing 10 (Zc3h10) as the best hit. Following experiments demonstrated that Zc3h10 knockdown decreased mitochondrial function and differentiation in myotubes. RNA immunoprecipitation assay indicates that Zc3h10 is able to bind 410 transcripts. Several target genes are involved in energy metabolism and iron balance. Notably, Zc3h10 downregulation in C2C12 leads to iron overload while its overexpression restores ferric ion content to control levels. Collectively, our findings annotate Zc3h10 as a new mitochondrial regulator in skeletal muscle

Analizador Semántico: una extensión para un corrector ortográfico en español

En la actualidad, la mayoría de los procesadores de texto incluyen alguna utilidad de corrección ortográfica entre sus herramientas. También pueden ser encontrados en navegadores, administradores de correo electrónico y prácticamente en cualquier aplicación que requiera el ingreso de texto. El enfoque, aparentemente universal de estas herramientas, se centra en el uso de un diccionario. Este método no hace uso de las propiedades lingüísticas (morfología, sintaxis, semántica) de la palabra ni del contexto en el que es utilizada. Esto impide la detección de ciertos errores, por ejemplo, cuando se utilizan palabras que existen en el diccionario, pero por estar mal escritas tienen un signifi cado incorrecto, o cuando se usan neologismos que están bien escritos pero por no aparecer en el diccionario son considerados errores. Este trabajo extiende el desarrollo de un prototipo de corrector ortográfico que utiliza reglas de la Real Academia Española, centrándose principalmente en automatizar aquellas reglas que necesitan de la información lingüística de las palabras para su aplicación.Sociedad Argentina de Informática e Investigación Operativ

Simulación hidrodinámica de flujo sobre vertedero del dique Los Molinos (Jujuy) con modelo FLOW3D

Práctica Supervisada (IC)--FCEFN-UNC, 2016Trata del aprendizaje del uso de un programa de modelación numérica llamado Flow3D y su calibración a partir de un modelo físico construido. El elemento de estudio es el vertedero móvil del dique Los Molinos de la provincia de Jujuy, del cual se realiza un modelo físico en el canal experimental del laboratorio de hidráulica de la FCEFN. Para la comparación de los resultados se establecen diferentes escenarios hidráulicos que se modelan tanto física como numéricament

Mitochondrial dysfunction increases fatty acid β-oxidation and translates into impaired neuroblast maturation

The metabolic transition from anaerobic glycolysis and fatty acid \u3b2-oxidation to glycolysis coupled to oxidative phosphorylation is a key process for the transition of quiescent neural stem cells to proliferative neural progenitor cells. However, a full characterization of the metabolic shift and the involvement of mitochondria during the last step of neurogenesis, from neuroblasts to neuron maturation, is still elusive. Here, we describe a model of neuroblasts, Neuro2a cells, with impaired differentiation capacity due to mitochondrial dysfunction. Using a detailed biochemical characterization consisting of steady-state metabolomics and metabolic flux analysis, we find increased fatty acid \u3b2-oxidation as a peculiar feature of neuroblasts with altered mitochondria. The consequent metabolic switch favors neuroblast proliferation at the expense of neuron maturation

Transposable element-mediated rearrangements are prevalent in human genomes.

Transposable elements constitute about half of human genomes, and their role in generating human variation through retrotransposition is broadly studied and appreciated. Structural variants mediated by transposons, which we call transposable element-mediated rearrangements (TEMRs), are less well studied, and the mechanisms leading to their formation as well as their broader impact on human diversity are poorly understood. Here, we identify 493 unique TEMRs across the genomes of three individuals. While homology directed repair is the dominant driver of TEMRs, our sequence-resolved TEMR resource allows us to identify complex inversion breakpoints, triplications or other high copy number polymorphisms, and additional complexities. TEMRs are enriched in genic loci and can create potentially important risk alleles such as a deletion in TRIM65, a known cancer biomarker and therapeutic target. These findings expand our understanding of this important class of structural variation, the mechanisms responsible for their formation, and establish them as an important driver of human diversity

Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction

The commitment of mesenchymal stem cells to preadipocytes is stimulated by hormonal induction. Preadipocytes induced to differentiate repress protein synthesis, remodel their cytoskeleton, and increase mitochondrial function to support anabolic pathways. These changes enable differentiation into mature adipocytes. Our understanding of the factors that coordinately regulate the early events of adipocyte differentiation remains incomplete. Here, by using multipronged approaches, we have identified zinc finger CCCH-type containing 10 (Zc3h10) as a critical regulator of the early stages of adipogenesis. Zc3h10 depletion in preadipocytes resulted in increased protein translation and impaired filamentous (F)-actin remodeling, with the latter detrimental effect leading to mitochondrial and metabolic dysfunction. These defects negatively affected differentiation to mature adipocytes. In contrast, Zc3h10 overexpression yielded mature adipocytes with remarkably increased lipid droplet size. Overall, our study establishes Zc3h10 as a fundamental proadipogenic transcription factor that represses protein synthesis and promotes F-actin/mitochondria dynamics to ensure proper energy metabolism and favor lipid accumulation