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In Server and Agent Based Active Network Management (SAAM) architecture, a server will make routing and other important decisions on behalf of the routers in its region. In order to make the right decisions and to support QoS (e.g., IntServ and DiffServ), the SAAM server needs to maintain an accurate region-wide view of network performance. This will be achieved as routers periodically send Link State Advertisement (LSA) messages to the SAAM server. Currently, the LSA messages report two key Link Performance Statistics, the average delay and the loss rate experienced by packets. Moreover, the server needs to perform sanity checks of these statistics by probing specific links. This thesis describes a server probing solution in which the SAAM server probes a router by dynamically injecting customized probing programs into the adjacent routers. In other words, the probing will be done with the active networking approach. An important feature of the server probing solution is that the probing activities cannot be detected by the router being probed.http://archive.org/details/serverprobingfor1094532948NANATurkish Navy author.Approved for public release; distribution is unlimited

Responsive pentablock copolymers for siRNA delivery

In this study, temperature and pH responsive cationic and amphiphilic pentablock copolymers, which consist of the temperature responsive triblock Pluronic F127 sandwiched between pH responsive PDEAEM (poly(2-diethylaminoethyl methacrylate)) end blocks, were used for the first time in the development of polyplex and gold nanoparticle (AuNP) based multicomponent siRNA delivery systems (MCSs). Copolymers in both systems protected siRNA from external effects, provided cell entry and endosomal escape. The thermoreversible micellization of the hydrophobic PPO block facilitated the cellular entry while the PDEAEM blocks enhanced the endosomal escape through protonated tertiary amine groups by pH buffering. The synergistic advantages of the different blocks showed an enhanced effect in the MCSs due to attachment and surface configuration reasons. The siRNA transfection efficiency of MCSs against luciferase expressing SKOV3 cells was 15% higher than both the polyplexes alone and the commercial siRNA transfection agent Lipofectamine RNAiMax at the same applied dose, without any toxicity. The results indicated that the multicomponent systems based on the responsive cationic pentablock copolymers and gold nanoparticles have promising potential as an efficient siRNA delivery vector for future applications

Coefficient Bounds for a General Subclass of Bi-Univalent Functions

In the present investigation, we introduce and investigate a new subclass of the function class ∑ of bi-univalent functions defined in the open unit disc. We find estimates on the coefficients |a2| and |a3| for functions in the function class S∑(n, h,λ ). The results presented in this paper improve or generalize the recent works of Jothibasu [13] and other authors