49 research outputs found
Quality Websites: An Application of the Kano Model to Website Design
In the emerging global electronic market, the creation of customer centered websites will become increasingly important. This paper uses Kano\u27s Model of Quality to develop a conceptual framework for investigating features in the web environment that satisfy basic, performance, and excitement needs of potential customers. The researchers classify features commonly used in the web environment according to Kano’ s three quality dimensions for products and services. Plans to empirically test this conceptually based classification are forthcoming. Among the possible implications and contributions of this research are the differentiation of web design features that customers take for granted from those that add value in the performance of web specific tasks and those that generate delight, motivation, and loyalty of website users
Panel: Interdisciplinary Paradigms for IS Education: The Information School
Education for the information profession is in a state of radical change and re-design. Academic units are being reorganized around new interdisciplinary paradigms, while new curriculums are being developed to address the needs of a growing and diverse information profession. Existing schools, which offer multiple information degrees and are based upon interdisciplinary models, such as Syracuse, Pittsburgh, Drexel and Rutgers universities have been or are now joined by others, such as the University of Michigan and the University of California at Berkeley. Plans are in place to create new “information schools” at Penn State, Indiana University, UNC Charlotte, and other universities. New information colleges are being considered from the University of Arizona to the University of Rhode Island - and many points between
Important Design Features in Different Web Site Domains: An Empirical Study of User Perceptions
The i-School movement
No Abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57317/1/14504301131_ftp.pd
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Influence of Addition Order and Contact Time on Thorium(IV) Retention by Hematite in the Presence of Humic Acids
Organizational Cultures of Libraries as a Strategic Resource
Theorists have suggested that organizational culture is a strategic
resource that has value in ensuring the continuing existence and
success of organizations (Michalisin, Smith, & Kline, 1997; Barney, 1986,
1991; Hult, Ketchen, & Nichols, 2002; Gordon, 1985). This assertion is supported
by various studies that have linked organizational culture to broad
strategic outcomes such as an organization???s ability to manage knowledge
(Davenport, Long, & Beers, 1998; Storck & Hill, 2000), innovation capability
(Hauser, 1998), and strategic management of information technology
(Kaarst-Brown & Robey, 1999; Reich & Benbasat, 2000; Schein, 1985). Based
on this research, we suggest that there are characteristics of organizational
cultures in information-based organizations that lead to increased collaboration,
collegiality, and organizational effectiveness.
The present article explores these characteristics and examines whether
organizational culture can be leveraged as a strategic asset to attract staff,
create favorable assessments by administrators and funders, and cast library
institutions in a positive light for independent media and accreditation bodies.
We believe that identification of those characteristics of organizational
cultures that are uniquely relevant to the growth and success of libraries
can provide current and future library leaders with guidance, models, and
intellectual resources to enhance personal and organizational success.published or submitted for publicatio