Transparant afwegen; Waarden en risico's beoordelen van voedselkwaliteit

Transparante beleidsafwegingen en bredere risicobeoordelingen lijken cruciaal voor het waarmaken van de maatschappelijke aspiraties die het ministerie van LNV zich op het gebied van voedselkwaliteit heeft gesteld. De implementatie van instrumenten die dergelijke afwegingen ondersteunen blijkt echter problematisch. In dit rapport wordt ingegaan op de toepassing van een TRansparant Afwegingskader (TRAK) en het instrument van een Brede Risicobeoordeling (BRB). Deze instrumenten bieden zeker kansen, maar een succesvolle implementatie zal tijd en energie vergen gezien de knelpunten die er tegenover staan. Transparent policy decisions and broader risk assessments seem to be crucial for fulfilling the social aspirations established by the Ministry of Agriculture, Nature and Food Quality with regard to food quality. However, the use of instruments which support such decision(making seems to be encountering problems. This report discusses the application of a Transparent Consideration Framework (TRansparant AfwegingsKader, TRAK) and a Broad Risk Assessment (Brede Risicobeoordeling, BRB). These instruments certainly offer potential, but successful implementation will take time and energy in view of the problems facing them

Proposed criteria for the evaluation of the scientific quality of mandatory rat and mouse feeding trials with whole food/feed derived from genetically modified plants

In recent years, animal feeding trials conducted with whole food/feed have been a focal issue in the controversy on the safety assessment of genetically modified (GM) plants and derived food/feed. Within the scientific community and among stakeholders, quite different views have been expressed on how these studies should be conducted, analysed and interpreted, what they might add in terms of information relevant to safety and whether 90-day rodent feeding trials should be mandatory. Despite the fact that the Commission Implementing Regulation (EU) No. 503/2013 (specifying the requirements for the risk assessment of GM food/feed) requests mandatory 90-day feeding trials for GM plants with single transformation events, the controversy continues. This is due to the fact that in 2016 the European Commission will have to review this particular provision in the legislation (ibid, Article 12), and because of questions raised by long-term feeding studies with GM maize

Deliverable 6.1 - Demonstration prototype of the EuroMix model toolbox

This document describes in short the new features in a demonstration prototype of the EuroMix toolbox, developed as MCRA 8.2. An important aim of the EuroMix project is to develop and implement a web-based platform (the EuroMix toolbox) including data and models accessible to all key-actors in risk assessment and risk management. In the EuroMix project the development of a mixture selection module based on exposure was prioritised, because the choice of chemicals for the experiments depended on this. A mixture selection module was therefore developed, based on a method called sparse non-negative matrix under-approximation (SNMU). The mixture selection module was then applied to French and Dutch data, leading to a list of suggested chemicals for each adverse outcome pathway in the project

Projected material requirements for the global electricity infrastructure: generation, transmission and storage

We analyse how the global material stocks and flows related to the electricity sector may develop towards 2050. We focus on three electricity sub-systems, being generation, transmission and storage and present a model covering both bulk and critical materials such as steel, aluminium and neodymium. Results are based on the second Shared Socio-Economic Pathway scenario, with additional climate policy assumptions based on the IMAGE integrated assessment framework, in combination with dynamic stock modelling and an elaborate review of material intensities.Results show a rapid growth in the demand for most materials in the electricity sector, as a consequence of increased electricity demand and a shift towards renewable electricity technologies, which have higher material intensities and drive the expansion of transmission infrastructure and electricity storage capacity. Under climate policy assumptions, the annual demand for most materials is expected to grow further towards 2050. For neodymium, the annual demand grows by a factor 4.4. Global demand for steel and aluminium in the electricity sector grows by a factor 2 in the baseline or 2.6 in the 2-degree climate policy scenario.We show that the combination of rapid growth of capital stocks and long lifetimes of technologies leads to a mismatch between annual demand and the availability of secondary materials within the electricity sector. This may limit the sector to accomplish circular material flows, especially under climate policy assumptions. We also highlight the potential for electric vehicles to curb some of the material demand related to electricity storage through adoption of vehicle-to-grid services.Industrial Ecolog

Scenarios for anthropogenic copper demand and supply in China: implications of a scrap import ban and a circular economy transition

Copper is widely used in buildings, transportation and home appliances, resulting in steadily increasing demand in China. From 2013 on, China has implemented the "Green Fence" policy to restrict copper scrap imports, which have affected and will continue to affect its future copper supply. To explore how China's copper demand can be met in the future, including the effects of the "Green Fence" policy change, in this paper a stock-driven approach is combined with a scenario analysis. We compare two scenarios (Continuity Policy, Circular Economy) and assess the influence of the "Green Fence" policy on each. We conclude that effective measures to prolong product lifetime could lead to a significant reduction in copper demand. Given the limited scope for domestic mining, China will still have to depend largely on imports of primary material in the form of concentrates and refined copper or, otherwise, put major emphasis on its recycling industry and continue to import high-quality copper scrap. In combination with the establishment of a state-of-the-art, efficient and environmentally friendly recycling industry, secondary copper could satisfy the bulk of Chinese copper demand and this could be an opportunity for China to transition to a more circular economy with regard to copper.Industrial Ecolog

Uncovering the Global Life Cycles of the Rare Earth Elements

The rare earth elements (REE) are a group of fifteen elements with unique properties that make them indispensable for a wide variety of emerging, critical technologies. Knowledge of the life cycles of REE remains sparse, despite the current heightened interest in their future availability. Mining is heavily concentrated in China, whose monopoly position and potential restriction of exports render primary supplies vulnerable to short and long-term disruption. To provide an improved perspective we derived the first quantitative life cycles (for the year 2007) for ten REE: lanthanum (La), cerium (Ce), praseodymium (Pr), neodymium (Nd), samarium (Sm), europium (Eu), gadolinium (Gd), terbium (Tb), dysprosium (Dy), and yttrium (Y). Of these REE, Ce and Nd in-use stocks are highest; the in-use stocks of most REE show significant accumulation in modern society. Industrial scrap recycling occurs only from magnet manufacture. We believe there is no post-customer recycling of any of these elements

Scenariostudie materiaal-voorraad, vraag en secundair aanbod in gebouwen: Onderdeel van het werkprogramma Monitoring & Sturing Circulaire Economie

Industrial Ecolog

Effect of aerobic exercise training and cognitive behavioural therapy on reduction of chronic fatigue in patients with facioscapulohumeral dystrophy: protocol of the FACTS-2-FSHD trial

<p>Abstract</p> <p>Background</p> <p>In facioscapulohumeral dystrophy (FSHD) muscle function is impaired and declines over time. Currently there is no effective treatment available to slow down this decline. We have previously reported that loss of muscle strength contributes to chronic fatigue through a decreased level of physical activity, while fatigue and physical inactivity both determine loss of societal participation. To decrease chronic fatigue, two distinctly different therapeutic approaches can be proposed: aerobic exercise training (AET) to improve physical capacity and cognitive behavioural therapy (CBT) to stimulate an active life-style yet avoiding excessive physical strain. The primary aim of the FACTS-2-FSHD (acronym for Fitness And Cognitive behavioural TherapieS/for Fatigue and ACTivitieS in FSHD) trial is to study the effect of AET and CBT on the reduction of chronic fatigue as assessed with the Checklist Individual Strength subscale fatigue (CIS-fatigue) in patients with FSHD. Additionally, possible working mechanisms and the effects on various secondary outcome measures at all levels of the International Classification of Functioning, Disability and Health (ICF) are evaluated.</p> <p>Methods/Design</p> <p>A multi-centre, assessor-blinded, randomized controlled trial is conducted. A sample of 75 FSHD patients with severe chronic fatigue (CIS-fatigue ≥ 35) will be recruited and randomized to one of three groups: (1) AET + usual care, (2) CBT + usual care or (3) usual care alone, which consists of no therapy at all or occasional (conventional) physical therapy. After an intervention period of 16 weeks and a follow-up of 3 months, the third (control) group will as yet be randomized to either AET or CBT (approximately 7 months after inclusion). Outcomes will be assessed at baseline, immediately post intervention and at 3 and 6 months follow up.</p> <p>Discussion</p> <p>The FACTS-2-FSHD study is the first theory-based randomized clinical trial which evaluates the effect and the maintenance of effects of AET and CBT on the reduction of chronic fatigue in patients with FSHD. The interventions are based on a theoretical model of chronic fatigue in patients with FSHD. The study will provide a unique set of data with which the relationships between outcome measures at all levels of the ICF could be assessed.</p> <p>Trial registration</p> <p>Dutch Trial Register, NTR1447.</p

Levonorgestrel-releasing intrauterine system versus endometrial ablation for heavy menstrual bleeding

Acknowledgments: We thank all the women who participated in this trial; the participating general practitioners, gynecologists, and hospitals; the research nurses; and the staff of the Dutch Consortium for Studies in Women’s Health and Reproduction.Peer reviewedPublisher PD