In/Visibility in the Internet’s Third Age

Current research (see, for example, Cheong, Martin and Macfadyen, 2012) on patterns of global and intercultural new media penetration and use nevertheless reveal the thinness of earlier utopian hopes for a technologically mediated “global village.” Nevertheless, new media are transforming local, political and cultural landscapes. What has (and who have) been made newly in/visible by new media and technologies? Participants in this panel will present\ud and discuss aspects of their current research that shed light, in different ways, on questions of in/visibility in this, the Internet’s ‘Third Age’ (Wellman, 2011)

Goal processes & self-efficacy related to psychological distress in head & neck cancer patients and their partners

Purpose and objective of the research: In this cross-sectional study we used a self-regulation perspective to better understand the experience of psychological distress in head & neck (H&N) cancer patients and their partners. We examined which goals they valued and the extent to which patients and partners experience goal disturbance. Furthermore, associations were explored between goal disturbance, goal reengagement, (goal)self-efficacy, and psychological distress. Methods and sample: H&N cancer patients and their partners, recruited from the Erasmus Medical Center Rotterdam (N = 40), were interviewed and completed questionnaires, assessing the above aspects of the self-regulation theory. Key results: H&N cancer patients and their partners experienced goal disturbance from the disease. Such disturbances were in patients significantly related to more psychological distress. Higher levels of goal re-engagement were related to less psychological distress, again only significantly in patients. More self-efficacy was significantly associated with less psychological distress in both patients and partners. Conclusions: Self-regulation abilities as goal re-engagement and self-efficacy may be screened and used as target in future psychological interventions, given their potential to decrease perceived psychological distress. In view of elevated levels of goal disturbances in partners, psychological support for caring relatives in such interventions is recommended. (c) 2010 Published by Elsevier Ltd

Towards risk-driven security requirements management in agile software development

The focus on user stories in agile means non-functional requirements, such as security, are not always explicit. This makes it hard for the development team to implement the required functionality in a reliable, secure way. Security checklists can help but they do not consider the application’s context and are not part of the product backlog. In this paper we explore whether these issues can be addressed by a framework which uses a risk assessment process, a mapping of threats to security features, and a repository of operationalized security features to populate the product backlog with prioritized security requirements. The approach highlights the relevance of each security feature to product owners while ensuring the knowledge and time required to implement security requirements is made available to developers. We applied and evaluated the framework at a Dutch medium-sized software development company with promising results

Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is characterized by unexplained segmental hypertrophy that is usually most pronounced in the septum. While sarcomeric gene mutations are often the genetic basis for HCM, the mechanistic origin for the heterogeneous remodeling remains largely unknown. A better understanding of the gene networks driving the cardiomyocyte (CM) hypertrophy is required to improve therapeutic strategies. Patients suffering from HCM often receive a septal myectomy surgery to relieve outflow tract obstruction due to hypertrophy. Using single-cell RNA sequencing (scRNA-seq) on septal myectomy samples from patients with HCM, we identify functional links between genes, transcription factors, and cell size relevant for HCM. The data show the utility of using scRNA-seq on the human hypertrophic heart, highlight CM heterogeneity, and provide a wealth of insights into molecular events involved in HCM that can eventually contribute to the development of enhanced therapies