X-ray spectral and timing properties of the 2001 superburst of 4U 1636-536

Preliminary results are reported on the spectral and timing properties of the spectacular 2001 superburst of 4U 1636-536 as seen by the RXTE/PCA. The (broad-band) power-spectral and hardness properties during the superburst are compared to those just before and after the superburst. Not all of the superburst emission can be fitted by pure black-body radiation. We also gathered BeppoSAX/WFC and RXTE/ASM data, as well as other RXTE/PCA data, obtained days to months before and after the superburst to investigate the normal X-ray burst behavior around the time of the superburst. The first normal X-ray burst after the 2001 superburst was detected 23 days later. During inspection of all the RXTE/ASM data we found a third superburst. This superburst took place on June 26, 1999, which is ~2.9 yrs after the 1996 superburst and ~1.75 yrs before the 2001 superburst. The above findings are the strongest constraints observed so far on the duration of the cessation of normal X-ray bursts after a superburst and the superburst recurrence times.Comment: 4 pages, 4 figures,to appear in the proceedings of "X-Ray Timing 2003: Rossi and Beyond", eds. P. Kaaret, F.K. Lamb, & J.H. Swank (Melville, NY: AIP

Timing properties and spectral states in Aquila X-1

We have analyzed five X-ray outbursts of the neutron-star soft X-ray transient Aql X-1 and investigated the timing properties of the source in correlation with its spectral states as defined by different positions in the color-color and hardness-intensity diagrams. The hard color and the source count rate serve as the distinguishing parameters giving rise to three spectral states: a low-intensity hard state, an intermediate state and a high-intensity soft state. These states are respectively identified with the extreme island, island and banana states that characterize the atoll sources. The large amount of data analyzed allowed us to perform for the first time a detailed timing analysis of the extreme island state. Differences in the aperiodic variability between the rise and the decay of the X-ray outbursts are found in this state: at the same place in the color-color diagram, during the rise the source exhibits more power at low frequencies (< 1 Hz), whereas during the decay the source is more variable at high frequencies (> 100 Hz). The very-low frequency noise that characterizes the banana-state power spectra below 1 Hz cannot be described in terms of a single power law but a two-component model is required. In two outbursts a new 6-10 Hz QPO has been discovered and tentatively identified with the normal/flaring branch-like oscillation observed only at the highest inferred mass accretion rates. We have compared the spectral and timing properties of Aql X-1 with those of other atoll and Z sources. Our results argue against a unification scheme for these two types of neutron-star X-ray binaries.Comment: 24 pages, 4 tables, 9 figures, accepted for publication in Ap

The atoll source states of 4U 1608-52

We have studied the atoll source 4U 1608-52 using a large data set obtained with the Rossi X-ray Timing Explorer. We find that the timing properties of 4U 1608-52 are almost exactly identical to those of the atoll sources 4U 0614+09 and 4U 1728-34 despite the fact that contrary to these sources 4U 1608-52 is a transient covering two orders of magnitude in luminosity. The frequencies of the variability components of these three sources follow a universal scheme when plotted versus the frequency of the upper kilohertz QPO, suggesting a very similar accretion flow configuration. If we plot the Z sources on this scheme only the lower kilohertz QPO and HBO follow identical relations. Using the mutual relations between the frequencies of the variability components we tested several models; the transition layer model, the sonic point beat frequency model, and the relativistic precession model. None of these models described the data satisfactory. Recently, it has been suggested that the atoll sources (among them 4U 1608-52) trace out similar three-branch patterns as the Z sources in the color-color diagram. We have studied the relation between the power spectral properties and the position of 4U 1608-52 in the color-color diagram and conclude that the timing behavior is not consistent with the idea that 4U 1608-52 traces out a three-branched Z shape in the color-color diagram along which the timing properties vary gradually, as Z sources do.Comment: 43 pages, 16 figures, ApJ accepte

kHz Quasi-Periodic Oscillations in the low-mass X-ray binary 4U 0614+09

We report on a comprehensive analysis of the kilohertz (above 300 Hz) quasi-periodic oscillations (kHz QPOs) detected from the neutron star low-mass X-ray binary 4U0614+09 with the Rossi X-ray Timing Explorer (RXTE). With a much larger data set than previously analyzed (all archival data from February 1996 up to October 2007), we first investigate the reality of the 1330 Hz QPO reported by van Straaten et al. (2000). This QPO would be of particular interest since it has the highest frequency reported for any source. A thorough analysis of the same observation fails to confirm the detection. On the other hand, over our extended data set, the highest QPO frequency we measure for the upper kHz QPO is at about 1224 Hz; a value which is fully consistent with the maximum values observed in similar systems. Second, we demonstrate that the frequency dependence of the quality factor and amplitude of the lower and upper kHz QPOs follow the systematic trends seen in similar systems (Barret et al., 2006). In particular, 4U0614+09 shows a drop of the quality factor of the lower kHz QPO above 700 Hz. If this is due to an approach to the innermost stable circular orbit, it implies a neutron star mass of about 1.9 solar masses. Finally, when analyzing the data over fixed durations, we have found a gap in the frequency distribution of the upper QPO, associated with a local minimum of its amplitude. A similar gap is not present in the distribution of the lower QPO frequencies, suggesting some cautions when interpreting frequency ratio distributions, based on the occurrence of the lower QPO only.Comment: 10 pages, 6 color figures, 2 tables, Accepted for publication in MNRA

Peculiar spectral and power spectral behaviour of the LMXB GX 13+1

We present results of an analysis of all 480 ks of Rossi X-ray Timing Explorer Proportional Counter Array data obtained from 17 May 1998 to 11 October 1998 on the luminous low mass X-ray binary GX 13+1. We analysed the spectral properties in colour-colour diagrams (CDs) and hardness-intensity diagrams (HIDs) and fitted the power spectra with a multi-Lorentzian model. GX 13+1 traces out a curved track in the CDs on a time scale of hours, which is very reminiscent of a standard atoll track containing an island, and lower and upper banana branch. However, both count rate and power spectral properties vary along this track in a very unusual way, not seen in any other atoll or Z source. The count rate, which varied by a factor of ~1.6, along a given track first decreases and then increases, causing the motion through the HIDs to be in the opposite sense to that in the CD, contrary to all other Z and atoll sources. Along a CD track, the very low frequency noise uniquely decreases in amplitude from ~5 to ~2% (rms). The high frequency noise amplitude decreases from ~4% to less than 1% and its characteristic frequency decreases from ~10 to \~5 Hz. The 57-69 Hz quasi-periodic oscillation (QPO) found earlier is also detected, and no kHz QPOs are found. In addition the entire track shows secular motion on a time scale of about a week. The average count rate as well as the amplitude of the very low frequency noise correlate with this secular motion. We discuss a possible explanation for the peculiar properties of GX 13+1 in terms of an unusual orientation or strength of a relativistic jet.Comment: 15 pages, 13 figures. Accepted for publication in A&

UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study

The aim of the study was to investigate the associations between UGT1A1*28 genotype and (1) response rates, (2) febrile neutropenia and (3) dose intensity in patients with metastatic colorectal cancer treated with irinotecan. UGT1A1*28 genotype was determined in 218 patients receiving irinotecan (either first-line therapy with capecitabine or second-line as monotherapy) for metastatic colorectal cancer. TA7 homozygotes receiving irinotecan combination therapy had a higher incidence of febrile neutropenia (18.2%) compared to the other genotypes (TA6/TA6 : 1.5%; TA6/TA7 : 6.5%, P=0.031). TA7 heterozygotes receiving irinotecan monotherapy also suffered more febrile neutropenia (19.4%) compared to TA6/TA6 genotype (2.2%; P=0.015). Response rates among genotypes were not different for both regimens: combination regimen, P=0.537; single-agent, P=0.595. TA7 homozygotes did not receive a lower median irinotecan dose, number of cycles (P-values ⩾0.25) or more frequent dose reductions compared to the other genotypes (P-values for trend; combination therapy: 0.62 and single-agent: 0.45). Reductions were mainly (>80%) owing to grade ⩾3 diarrhoea, not (febrile) neutropenia. TA7/TA7 patients have a higher incidence of febrile neutropenia upon irinotecan treatment, but were able to receive similar dose and number of cycles compared to other genotypes. Response rates were not significantly different

A multi-Lorentzian timing study of the atoll sources 4U 0614+09 and 4U 1728-34

We present the results of a multi-Lorentzian fit to the power spectra of two kilohertz QPO sources; 4U 0614+09 and 4U 1728-34. This work was triggered by recent results of a similar fit to the black-hole candidates (BHCs) GX 339-4 and Cyg X-1 by Nowak in 2000. We find that one to six Lorentzians are needed to fit the power spectra of our two sources. The use of exactly the same fit function reveals that the timing behaviour of 4U 0614+09 and 4U 1728-34 is almost identical at luminosities which are about a factor 5 different. As the characteristic frequency of the Lorentzians we use the frequency, nu_max, at which each component contributes most of its variance per log frequency as proposed by Belloni, Psaltis & van der Klis in 2001. When using nu_max instead of the centroid frequency of the Lorentzian, the recently discovered hectohertz Lorentzian is practically constant in frequency. We use our results to test the suggestions by, respectively, Psaltis Belloni and van der Klis in 1999 and Nowak in 2000 that the two Lorentzians describing the high-frequency end of the broad-band noise in BHCs in the low state can be identified with the kilohertz QPOs in the neutron star low mass X-ray binaries. We find, that when the two kilohertz QPOs are clearly present, the low-frequency part of the power spectrum is too complicated to draw immediate conclusions from the nature of the components detected in any one power spectrum. However, the relations we observe between the characteristic frequencies of the kilohertz QPOs and the band-limited noise, when compared to the corresponding relations in BHCs, hint towards the identification of the second-highest frequency Lorentzian in the BHCs with the lower kilohertz QPO. They do not confirm the identification of the highest-frequency Lorentzian with the upper kilohertz QPO.Comment: 30 pages, 35 figures, ApJ accepted; changed name of BLN QPO into very low-frequency Lorentzian, removed table 4 and figure 8 from previous versio

Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population

Personalised Therapeutic

Relations Between Timing Features and Colors in the X-Ray Binary 4U 0614+09

We study the correlations between timing and X-ray spectral properties in the low mass X-ray binary 4U 0614+09 using a large (265-ks) data set obtained with the Rossi X-ray Timing Explorer. We find strong quasi-periodic oscillations (QPOs) of the X-ray flux, like the kilohertz QPOs in many other X-ray binaries with accreting neutron stars, with frequencies ranging from 1329 Hz down to 418 Hz and, perhaps, as low as 153 Hz. We report the highest frequency QPO yet from any low mass X-ray binary at 1329+-4 Hz, which has implications for neutron star structure. This QPO has a 3.5-sigma single-trial significance, for an estimated 40 trials the significance is 2.4-sigma. Besides the kilohertz QPOs, the Fourier power spectra show four additional components: high frequency noise (HFN), described by a broken power-law with a break frequency between 0.7 and 45 Hz, very low frequency noise (VLFN), which is fitted as a power-law below 1 Hz, and two broad Lorentzians with centroid frequencies varying from 6 to 38 Hz and 97 to 158 Hz, respectively. We find strong correlations between the frequencies of the kilohertz QPOs, the frequency of the 6 to 38 Hz broad Lorentzian, the break frequency of the HFN, the strength of both the HFN and the VLFN and the position of the source in the hard X-ray color vs. intensity diagram. The frequency of the 97 to 158 Hz Lorentzian does not correlate with these parameters. We also find that the relation between power density and break frequency of the HFN is similar to that established for black hole candidates in the low state. We suggest that the changing mass accretion rate is responsible for the correlated changes in all these parameters.Comment: ApJ, referee