Coupled wake boundary layer model of wind-farms

We present and test the coupled wake boundary layer (CWBL) model that describes the distribution of the power output in a wind-farm. The model couples the traditional, industry-standard wake model approach with a "top-down" model for the overall wind-farm boundary layer structure. This wake model captures the effect of turbine positioning, while the "top-down" portion of the model adds the interactions between the wind-turbine wakes and the atmospheric boundary layer. Each portion of the model requires specification of a parameter that is not known a-priori. For the wake model, the wake expansion coefficient is required, while the "top-down" model requires an effective spanwise turbine spacing within which the model's momentum balance is relevant. The wake expansion coefficient is obtained by matching the predicted mean velocity at the turbine from both approaches, while the effective spanwise turbine spacing depends on turbine positioning and thus can be determined from the wake model. Coupling of the constitutive components of the CWBL model is achieved by iterating these parameters until convergence is reached. We illustrate the performance of the model by applying it to both developing wind-farms including entrance effects and to fully developed (deep-array) conditions. Comparisons of the CWBL model predictions with results from a suite of large eddy simulations (LES) shows that the model closely represents the results obtained in these high-fidelity numerical simulations. A comparison with measured power degradation at the Horns Rev and Nysted wind-farms shows that the model can also be successfully applied to real wind-farms.Comment: 25 pages, 21 figures, submitted to Journal of Renewable and Sustainable Energy on July 18, 201

Pharmacological Modulation of Dopamine Receptor D2-Mediated Transmission Alters the Metabolic Phenotype of Diet Induced Obese and Diet Resistant C57Bl6 Mice

High fat feeding induces a variety of obese and lean phenotypes in inbred rodents. Compared to Diet Resistant (DR) rodents, Diet Induced Obese (DIO) rodents are insulin resistant and have a reduced dopamine receptor D2 (DRD2) mediated tone. We hypothesized that this differing dopaminergic tone contributes to the distinct metabolic profiles of these animals. C57Bl6 mice were classified as DIO or DR based on their weight gain during 10 weeks of high fat feeding. Subsequently DIO mice were treated with the DRD2 agonist bromocriptine and DR mice with the DRD2 antagonist haloperidol for 2 weeks. Compared to DR mice, the bodyweight of DIO mice was higher and their insulin sensitivity decreased. Haloperidol treatment reduced the voluntary activity and energy expenditure of DR mice and induced insulin resistance in these mice. Conversely, bromocriptine treatment tended to reduce bodyweight and voluntary activity, and reinforce insulin action in DIO mice. These results show that DRD2 activation partly redirects high fat diet induced metabolic anomalies in obesity-prone mice. Conversely, blocking DRD2 induces an adverse metabolic profile in mice that are inherently resistant to the deleterious effects of high fat food. This suggests that dopaminergic neurotransmission is involved in the control of metabolic phenotype

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

Neuro Imaging Researc

Integration and isolation in the global petrochemical industry: A multi-scalar corporate network analysis

The global petrochemical industry has long been characterized by stable patterns of Western corporate and geographic leadership, but since the early 2000s, the global playing field has changed significantly. China has overtaken the United States and Europe as the world’s largest petrochemical producer, and other emerging economies have emerged as global petrochemical players. Combining insights from scholarship on global corporate elites, world city networks, and relational economic geography, this article examines patterns in the corporate networks of leading petrochemical corporations. The research is based on a multi-scalar corporate network analysis, applying social network analysis to identify board interlocks, joint venture interlocks, and spatial interlocks between corporations. Through analyzing corporate networks across multiple scales, the research reveals patterns of both integration and isolation within the petrochemical industry. Isolation is evident in disconnected regional corporate elite networks, where the established North Atlantic corporate elite is interconnected through board interlocks, while corporate networks in Asia and other emerging economies remain disconnected. However, high levels of integration within the industry are also evident in an interconnected international company system formed through joint venture collaborations, and in overlapping subsidiary networks centered on petrochemical hubs around the world. The article argues that the results demonstrate a combination of resilience and change, or path dependence and contingency, in patterns of corporate power and collaboration. Western company networks still form the social and spatial backbone of the industry, but these have been challenged by emerging strategic centers and isolated elite networks in other parts of the world. This paper contributes to debates on industrial corporate elites, multiple globalizations, and the multipolar global economy

Commodification and ‘the commons’: the politics of privatising public water in Greece and Portugal during the Eurozone Crisis

In response to the Eurozone crisis, austerity and restructuring has been imposed on the European Union’s (EU) peripheral member states in order to receive financial bailout loans. In addition to cuts in funding of essential public services, cuts in public sector employment and further liberalisation of labour markets, this has also included pressure towards the privatisation of state assets. And yet, workers have not simply accepted these restructuring pressures. They have organised and fought back against austerity and enforced privatisation. Based on a historical materialist perspective and following a strategy of incorporated comparison, in this paper we will comparatively assess the struggles against enforced water privatisation in Greece and Portugal set against the background of the structuring conditions surrounding the Eurozone crisis

Dynamic metabolomic data analysis: a tutorial review

In metabolomics, time-resolved, dynamic or temporal data is more and more collected. The number of methods to analyze such data, however, is very limited and in most cases the dynamic nature of the data is not even taken into account. This paper reviews current methods in use for analyzing dynamic metabolomic data. Moreover, some methods from other fields of science that may be of use to analyze such dynamic metabolomics data are described in some detail. The methods are put in a general framework after providing a formal definition on what constitutes a ‘dynamic’ method. Some of the methods are illustrated with real-life metabolomics examples

Characterization of anticoagulant heparinoids by immunoprofiling

Heparinoids are used in the clinic as anticoagulants. A specific pentasaccharide in heparinoids activates antithrombin III, resulting in inactivation of factor Xa and–when additional saccharides are present–inactivation of factor IIa. Structural and functional analysis of the heterogeneous heparinoids generally requires advanced equipment, is time consuming, and needs (extensive) sample preparation. In this study, a novel and fast method for the characterization of heparinoids is introduced based on reactivity with nine unique anti-heparin antibodies. Eight heparinoids were biochemically analyzed by electrophoresis and their reactivity with domain-specific anti-heparin antibodies was established by ELISA. Each heparinoid displayed a distinct immunoprofile matching its structural characteristics. The immunoprofile could also be linked to biological characteristics, such as the anti-Xa/anti-IIa ratio, which was reflected by reactivity of the heparinoids with antibodies HS4C3 (indicative for 3-O-sulfates) and HS4E4 (indicative for domains allowing anti-factor IIa activity). In addition, the immunoprofile could be indicative for heparinoid-induced side-effects, such as heparin-induced thrombocytopenia, as illustrated by reactivity with antibody NS4F5, which defines a very high sulfated domain. In conclusion, immunoprofiling provides a novel, fast, and simple methodology for the characterization of heparinoids, and allows high-throughput screening of (new) heparinoids for defined structural and biological characteristics

Introduction: The Political Economy of Managerialism

As a set of ideas and practices, managerialism has arguably become a powerful behavioural logic shaping a range of processes and outcomes of governance in the world economy. Yet IPE has yet to directly interrogate managerialism as a distinct object of analysis. In this special issue, we bring together a range of authors to explore how managerialism reveals a set of complex histories, agents, and implications that are not self-evident and carry direct relevance for how we understand the global economy. Our main contention is that managerialism is not simply a technical means for the pursuit of policies, but has come to shape the very ways in which policy, and governance more generally, are conceived and conducted. Across a range of cases and fields, we dissect the emergence of the managerial logic, along with how it produces uneven mutations, ruptures, and forms of resistance. In doing so, we reflect upon the requirements for developing a political economy of managerialism