To instruct and delight : how themes make an expo

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Effect of combining glucocorticoids with Compound A on glucocorticoid receptor responsiveness in lymphoid malignancies

Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL). Yet, prolonged GC use is hampered by deleterious GC-related side effects and the emergence of GC resistance. To tackle and overcome these GC-related problems, the applicability of selective glucocorticoid receptor agonists and modulators was studied, in search of fewer side-effects and at least equal therapeutic efficacy as classic GCs. Compound A (CpdA) is a prototypical example of such a selective glucocorticoid receptor modulator and does not support GR-mediated transactivation. Here, we examined whether the combination of CpdA with the classic GC dexamethasone (Dex) may improve GC responsiveness of MM and ALL cell lines. We find that the combination of Dex and CpdA does not substantially enhance GC-mediated cell killing. In line, several apoptosis hallmarks, such as caspase 3/7 activity, PARP cleavage and the levels of cleaved-caspase 3 remain unchanged upon combining Dex with CpdA. Moreover, we monitor no additional inhibition of cell proliferation and the homologous downregulation of GR is not counteracted by the combination of Dex and CpdA. In addition, CpdA is unable to modulate Dex-liganded GR transactivation and transrepression, yet, Dex-mediated transrepression is also aberrant in these lymphoid cell lines. Together, transrepression-favoring compounds, alone or combined with GCs, do not seem a valid strategy in the treatment of lymphoid malignancies

Distributed spectrum sensing in a cognitive networking testbed

In this demonstration, we show how the IBBT w-iLab.t wireless testbed, combined with multiple spectrum sensing engines designed by imec, can be used for experimentally-supported design and evaluation of cognitive networking protocols. Functionalities include the advanced characterization of the behavior of a cognitive solution under test, and characterization of the wireless experimentation environment itself

Effects of rock fragments on physical degradation of cultivated soils by rainfall

To understand better the role of rock fragments in soil and water conservation processes, the effects of rock fragments in maintaining a favourable soil structure and thus also in preventing physical degradation of tilled soils was studied. Laboratory experiments were conducted to investigate the effects of rock fragment content, rock fragment size, initial soil moisture content of the fine earth and surface rock fragment cover on soil subsidence by rainfall (i.e. change in bulk density by one or more cycles of wetting and drying). A total of 15 rainfall simulations (cumulative rainfall, 192.5 mm; mean intensity, 70 mm h−1) were carried out. Before and after each rainfall application the surface elevation of a 19-cm thick plough layer was measured with a laser microrelief meter. In all experiments, the bulk density of the fine earth increased with applied rainfall volume to reach a maximum value at about 200 mm of cumulative rainfall. From the experimental results it was concluded that the subsidence rate decreased sharply for soils containing more than 0.50 kg kg−1 rock fragments, irrespective of rock fragment size. Fine earth bulk densities were negatively related to rock fragment content beyond a threshold value of 0.30 kg kg−1 for small rock fragments (1.7–2.7 cm) and 0.50 kg kg−1 for large rock fragments (7.7 cm). Initial soil moisture content influenced subsidence only in the initial stage of the experiments, when some swelling occurred in the dry soils. Surface rock fragment cover had no significant effect on subsidence of the plough layer. Therefore, subsidence of the plough layer in these experiments appears to be mainly due to changing soil strength upon drainage rather than the result of direct transfer of kinetic energy from falling drops. The relative increase in porosity of the fine earth as well as the absolute increase in macroporosity with rock fragment content will cause deeper penetration of rainfall into the soil, resulting in water conservation. Therefore, crushing of large rock fragments into smaller ones is to be preferred over removal of rock fragments from the plough layer