3,800 research outputs found
Equilibration of isolated macroscopic quantum systems
We investigate the equilibration of an isolated macroscopic quantum system in
the sense that deviations from a steady state become unmeasurably small for the
overwhelming majority of times within any sufficiently large time interval. The
main requirements are that the initial state, possibly far from equilibrium,
exhibits a macroscopic population of at most one energy level and that
degeneracies of energy eigenvalues and of energy gaps (differences of energy
eigenvalues) are not of exceedingly large multiplicities. Our approach closely
follows and extends recent works by Short and Farrelly [2012 New J. Phys. 14
013063], in particular going beyond the realm of finite-dimensional systems and
large effective dimensions.Comment: 19 page
Neuromuscular Blockade with Rocuronium Bromide Increases the Tolerance of Acute Normovolemic Anemia in Anesthetized Pigs
Background: The patient's individual anemia tolerance is pivotal when blood transfusions become necessary, but are not feasible for some reason. To date, the effects of neuromuscular blockade (NMB) on anemia tolerance have not been investigated. Methods: 14 anesthetized and mechanically ventilated pigs were randomly assigned to the Roc group (3.78 mg/kg rocuronium bromide followed by continuous infusion of 1 mg/kg/min, n = 7) or to the Sal group (administration of the corresponding volume of normal saline, n = 7). Subsequently, acute normovolemic anemia was induced by simultaneous exchange of whole blood for a 6% hydroxyethyl starch solution (130/0.4) until a sudden decrease of total body O-2 consumption (VO2) indicated a critical limitation of O-2 transport capacity. The Hb concentration quantified at this time point (Hb(crit)) was the primary end-point of the protocol. Secondary endpoints were parameters of hemodynamics, O-2 transport and tissue oxygenation. Results: Hb(crit) was significantly lower in the Roc group (2.4 +/- 0.5 vs. 3.2 +/- 0.7 g/dl) reflecting increased anemia tolerance. NMB with rocuronium bromide reduced skeletal muscular VO2 and total body O-2 extraction rate. As the cardiac index increased simultaneously, total body VO2 only decreased marginally in the Roc group (change of VO2 relative to baseline -1.7 +/- 0.8 vs. 3.2 +/- 1.9% in the Sal group, p < 0.05). Conclusion: Deep NMB with rocuronium bromide increases the tolerance of acute normovolemic anemia. The underlying mechanism most likely involves a reduction of skeletal muscular VO2. During acellular treatment of an acute blood loss, NMB might play an adjuvant role in situations where profound stages of normovolemic anemia have to be tolerated (e.g. bridging an unexpected blood loss until blood products become available for transfusion). Copyright (C) 2011 S. Karger AG, Base
Recent Developments of NEMO: Detection of Solar Eruptions Characteristics
The recent developments in space instrumentation for solar observations and
telemetry have caused the necessity of advanced pattern recognition tools for
the different classes of solar events. The Extreme ultraviolet Imaging
Telescope (EIT) of solar corona on-board SOHO spacecraft has uncovered a new
class of eruptive events which are often identified as signatures of Coronal
Mass Ejection (CME) initiations on solar disk. It is evident that a crucial
task is the development of an automatic detection tool of CMEs precursors. The
Novel EIT wave Machine Observing (NEMO) (http://sidc.be/nemo) code is an
operational tool that detects automatically solar eruptions using EIT image
sequences. NEMO applies techniques based on the general statistical properties
of the underlying physical mechanisms of eruptive events on the solar disc. In
this work, the most recent updates of NEMO code - that have resulted to the
increase of the recognition efficiency of solar eruptions linked to CMEs - are
presented. These updates provide calculations of the surface of the dimming
region, implement novel clustering technique for the dimmings and set new
criteria to flag the eruptive dimmings based on their complex characteristics.
The efficiency of NEMO has been increased significantly resulting to the
extraction of dimmings observed near the solar limb and to the detection of
small-scale events as well. As a consequence, the detection efficiency of CMEs
precursors and the forecasts of CMEs have been drastically improved.
Furthermore, the catalogues of solar eruptive events that can be constructed by
NEMO may include larger number of physical parameters associated to the dimming
regions.Comment: 12 Pages, 5 figures, submitted to Solar Physic
Site-directed mutagenesis of proposed active-site residues of penicillin-binding protein 5 from Escherichia coli
Creating a low-dimensional quantum gas using dark states in an inelastic evanescent-wave mirror
We discuss an experimental scheme to create a low-dimensional gas of
ultracold atoms, based on inelastic bouncing on an evanescent-wave mirror.
Close to the turning point of the mirror, the atoms are transferred into an
optical dipole trap. This scheme can compress the phase-space density and can
ultimately yield an optically-driven atom laser. An important issue is the
suppression of photon scattering due to ``cross-talk'' between the mirror
potential and the trapping potential. We propose that for alkali atoms the
photon scattering rate can be suppressed by several orders of magnitude if the
atoms are decoupled from the evanescent-wave light. We discuss how such dark
states can be achieved by making use of circularly-polarized evanescent waves.Comment: 8 pages, 4 figure
Observation of radiation pressure exerted by evanescent waves
We report a direct observation of radiation pressure, exerted on cold
rubidium atoms while bouncing on an evanescent-wave atom mirror. We analyze the
radiation pressure by imaging the motion of the atoms after the bounce. The
number of absorbed photons is measured for laser detunings ranging from {190
MHz} to {1.4 GHz} and for angles from {0.9 mrad} to {24 mrad} above the
critical angle of total internal reflection. Depending on these settings, we
find velocity changes parallel with the mirror surface, ranging from 1 to {18
cm/s}. This corresponds to 2 to 31 photon recoils per atom. These results are
independent of the evanescent-wave optical power.Comment: 6 pages, 4 figure
A systematic review of prognostic factors predicting survival in patients with spinal bone metastases
Purpose: For the selection of treatment in patients with spinal bone metastases (SBM), survival estimation plays a crucial role to avoid over- and under-treatment. To aid clinicians in this difficult task, several prediction models have been developed, consisting of many different risk factors. The aim of this systematic review was to identify prognostic factors that are associated with survival in patients with SBM to support development of predictive models. Methods: A systematic review was performed with focus on prognostic factors associated with survival in patients with SBM. Two reviewers independently selected studies for inclusion and assessed the risk of bias. A level of evidence synthesis was performed for each prognostic factor. Inter-observer agreement for the risk of bias assessment was determined by the kappa-statistic. Results: After screening, 142 full-text articles were obtained, of which 22 met the eligibility criteria. A total of 43 different prognostic factors were investigated in the included studies, of which 17 were relevant to pre-treatment survival estimation. The prognostic factors most frequently associated with survival were the primary tumor and the performance status. The prognostic factors most frequently not associated with survival were age, gender, number and location of the SBM and the presence of a pathologic fracture. Conclusions: Prognostication for patients with SBM should be based on an accurate primary tumor classification, combined with a performance score. The benefit of adding other prognostic factors is doubtful
Classical Yang-Mills Black hole hair in anti-de Sitter space
The properties of hairy black holes in Einstein–Yang–Mills (EYM) theory are reviewed, focusing on spherically symmetric solutions. In particular, in asymptotically anti-de Sitter space (adS) stable black hole hair is known to exist for frak su(2) EYM. We review recent work in which it is shown that stable hair also exists in frak su(N) EYM for arbitrary N, so that there is no upper limit on how much stable hair a black hole in adS can possess
Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia
MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (<1 year) is characterized by high relapse rates and a dismal prognosis. To facilitate the discovery of novel therapeutic targets, we here searched for genes directly influenced by the repression of various MLL fusions. Methods For this, we performed gene expression profiling after siRNA-mediated repression of MLLAF4, MLL-ENL, and AF4-MLL in MLL -rearranged ALL cell line models. The obtained results were compared with various already established gene signatures including those consisting of known MLL-AF4 target genes, or those associated with primary MLL-rearranged infant ALL samples. Results Genes that were down-regulated in response to the repression of MLL-AF4 and MLL-ENL appeared characteristically expressed in primary MLL-rearranged infant ALL samples, and often represented known MLL-AF4 targets genes. Genes that were up-regulated in response to the repression of MLL-AF4 and MLL-ENL often represented genes typically silenced by promoter hypermethylation in MLL-rearranged infant ALL. Genes that were aff
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