Behind the wheel: What drives the effects of error handling?

Existing research comparing error management (a strategy focusing on increasing the positive and decreasing the negative consequences of errors) to error prevention (a strategy focusing on working faultlessly), has identified error management as beneficial for multiple outcomes. Yet, due to various methodological limitations, it is unclear whether the effects previously found are due to error prevention, error management, or both. We examine this in an experimental study with a 2 (error prevention: yes vs. no)× 2 (error management: yes vs. no) factorial design. Error prevention had negative effects on cognition and adaptive transfer performance. Error management alleviated worry and boosted one’s perceived self-efficacy. Overall, the results show that error prevention and error management have unique outcomes on negative affect, self-efficacy, cognition, and performance

Extremal Curves in 2+1-Dimensional Yang-Mills Theory

We examine the structure of the potential energy of 2+1-dimensional Yang-Mills theory on a torus with gauge group SU(2). We use a standard definition of distance on the space of gauge orbits. A curve of extremal potential energy in orbit space defines connections satisfying a certain partial differential equation. We argue that the energy spectrum is gapped because the extremal curves are of finite length. Though classical gluon waves satisfy our differential equation, they are not extremal curves. We construct examples of extremal curves and find how the length of these curves depends on the dimensions of the torus. The intersections with the Gribov horizon are determined explicitly. The results are discussed in the context of Feynman's ideas about the origin of the mass gap.Comment: Typographical errors and some misleading statements correcte

Two-Loop Quark Self-Energy in a New Formalism (II): Renormalization of the Quark Propagator in the Light-Cone Gauge

The complete two-loop correction to the quark propagator, consisting of the spider, rainbow, gluon bubble and quark bubble diagrams, is evaluated in the noncovariant light-cone gauge (lcg). (The overlapping self-energy diagram had already been computed.) The chief technical tools include the powerful matrix integration technique, the n^*-prescription for the spurious poles of 1/qn, and the detailed analysis of the boundary singularities in five- and six-dimensional parameter space. It is shown that the total divergent contribution to the two-loop correction Sigma_2 contains both covariant and noncovariant components, and is a local function of the external momentum p, even off the mass-shell, as all nonlocal divergent terms cancel exactly. Consequently, both the quark mass and field renormalizations are local. The structure of Sigma_2 implies a quark mass counterterm of the form $\delta m (lcg) = m\tilde\alpha_s C_F(3+\tilde\alpha_sW) + {\rm O} (\tilde\alpha_s^3)$, \tilde\alpha_s = g^2\Gamma(\eps)(4\pi)^{\eps -2}, with W depending only on the dimensional regulator epsilon, and on the numbers of colors and flavors. It turns out that \delta m(lcg) is identical to the mass counterterm in the general linear covariant gauge. Our results are in agreement with the Bassetto-Dalbosco-Soldati renormalization scheme.Comment: 36 pages Latex, 5 eps figures, to appear in Nucl.Phys.

Broadband microwave spectroscopy of semiconductor nanowire-based Cooper-pair transistors

The Cooper-pair transistor (CPT), a small superconducting island enclosed between two Josephson weak links, is the atomic building block of various superconducting quantum circuits. Utilizing gate-tunable semiconductor channels as weak links, the energy scale associated with the Josephson tunneling can be changed with respect to the charging energy of the island, tuning the extent of its charge fluctuations. Here, we directly demonstrate this control by mapping the energy level structure of a CPT made of an indium arsenide nanowire (NW) with a superconducting aluminum shell. We extract the device parameters based on the exhaustive modeling of the quantum dynamics of the phase-biased nanowire CPT and directly measure the even-odd parity occupation ratio as a function of the device temperature, relevant for superconducting and prospective topological qubits.Comment: Published version. Supplementary Information is available as ancillary file, raw data and calculations can be downloaded from http://doi.org/10.4121/uuid:5d54f11b-6774-4ae4-96cf-25e6a91927e

Genetic monitoring detects an overlooked cryptic species and reveals the diversity and distribution of three invasive Rattus congeners in South Africa

Background: South Africa's long and extensive trade activity has ensured ample opportunities for exotic species introduction. Whereas the rich biodiversity of endemic southern African fauna has been the focus of many studies, invasive vertebrates are generally overlooked despite potential impacts on biodiversity, health and agriculture. Genetic monitoring of commensal rodents in South Africa which uncovered the presence of Rattus tanezumi, a South-East Asian endemic not previously known to occur in Africa, provided the impetus for expanded studies on all invasive Rattus species present. Results: To this end, intensified sampling at 28 South African localities and at one site in Swaziland, identified 149 Rattus specimens. Cytochrome b gene sequencing revealed the presence of two R. tanezumi, seven R. rattus and five R. norvegicus haplotypes in south Africa. Phylogenetic results were consistent with a single, recent R. tanezumi introduction and indicated that R. norvegicus and R. rattus probably became established following at least two and three independent introductions, respectively. Intra- and inter-specific diversity was highest in informal human settlements, with all three species occurring at a single metropolitan township site. Rattus norvegicus and R. rattus each occurred sympatrically with R. tanezumi at one and five sites, respectively. Karyotyping of selected R. rattus and R. tanezumi individuals identified diploid numbers consistent with those reported previously for these cryptic species. Ordination of bioclimatic variables and MaxEnt ecological niche modelling confirmed that the bioclimatic niche occupied by R. tanezumi in south Africa was distinct from that occupied in its naturalised range in south-east Asia suggesting that factors other than climate may influence the distribution of this species. Conclusions: This study has highlighted the value of genetic typing for detecting cryptic invasive species, providing historical insights into introductions and for directing future sampling. The apparent ease with which a cryptic species can become established signals the need for broader implementation of genetic monitoring programmes. In addition to providing baseline data and potentially identifying high-risk introduction routes, the predictive power of ecological niche modelling is enhanced when species records are genetically verified

New instantons in the double-well potential

A new instanton solution is found in the quantum-mechanical double-well potential with a four-fermion term. The solution has finite action and depends on four fermionic collective coordinates. We explain why in general the instanton action can depend on collective coordinates.Comment: 10 pages, clarifications and references adde

A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

Background: Ferroquine (SSR97193) is a candidate anti-malarial currently undergoing clinical trials for malaria. To better understand its pharmacokinetic (PK) and pharmacodynamic (PD) parameters the compound was tested in the experimentally induced blood stage malaria infection model in volunteers. Methods: Male and non-pregnant female aged 18-50 years were screened for this phase II, controlled, single-centre clinical trial. Subjects were inoculated with ~1800 viable Plasmodium falciparum 3D7A-infected human erythrocytes, and treated with a single-dose of 800 mg ferroquine. Blood samples were taken at defined time-points to measure PK and PD parameters. The blood concentration of ferroquine and its active metabolite, SSR97213, were measured on dry blood spot samples by ultra-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). Parasitaemia and emergence of gametocytes were monitored by quantitative PCR. Safety was determined by recording adverse events and monitoring clinical laboratory assessments during the course of the study. Results: Eight subjects were enrolled into the study, inoculated with infected erythrocytes and treated with 800 mg ferroquine. Ferroquine was rapidly absorbed with maximal exposure after 4-8 and 4-12 h exposure for SSR97213. Non-compartmental PK analysis resulted in estimates for half-lives of 10.9 and 23.8 days for ferroquine and SSR97213, respectively. Parasite clearance as reported by parasite reduction ratio was 162.9 (95 % CI 141-188) corresponding to a parasite clearance half-life of 6.5 h (95 % CI: 6.4-6.7 h). PK/PD modelling resulted in a predicted minimal parasiticidal concentration of 20 ng/mL, and the single dosing tested in this study was predicted to maintain an exposure above this threshold for 454 h (37.8 days). Although ferroquine was overall well tolerated, transient elevated transaminase levels were observed in three subjects. Paracetamol was the only concomitant treatment among the two out of these three subjects that may have played a role in the elevated transaminases levels. No clinically significant ECG abnormalities were observed. Conclusions: The parameters and PK/PD model derived from this study pave the way to the further rational development of ferroquine as an anti-malarial partner drug. The safety of ferroquine has to be further explored in controlled human trials. Trial registration anzctr.org.au (registration number: ACTRN12613001040752), registered 18/09/201