Omineca Herald, January, 26, 1966

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Religie, staat en samenleving : kerken en christendom in de samenleving van vandaag

Rede ter gelegenheid van de opening van het academisch jaar 2013-2014 van de PThU op 30 augustus 2013 te Utrecht

Highways to Silence Revisited: A History of Discourse Coalitions around Traffic Noise

During the Covid-19 pandemic, the density of road traffic in the Global North decreased considerably. For those enjoying the resulting tranquillity, it prompted the hope that this experience would raise public noise awareness and alter mobility culture. Now that Global North economies are returning to pre-pandemic levels, however, not much appears to have changed. This article aims to contribute to understanding the persistence of the status quo by historically tracing discourse coalitions around traffic noise in the twentieth and early twenty-first century. Discourse coalitions are connections between groups of actors that have opposing interests but share a specific set of storylines concerning a public problem. As we will show by focusing on the issue of traffic noise in the Netherlands, the long-term results of these discourse coalitions -in terms of discourse structuration, institutionalization and destabilization- tend to shift attention away from structural interventions in traffic flows

The value of perfect information

Eutrophication from nitrogen and phosphorus has damaged the Baltic Sea, leaving large sea bottom areas without biological life, thus changing the marine ecosystem, and triggering the growth of toxic algae. Despite efforts to curb this pollution, the sea remains eutrophic. We argue that eutrophication management is subject to both uncertainty and irreversibility, and hence could explain why impacted countries may not be willing to enforce load reduction targets. This thesis focuses on the time lag of benefits following nitrogen abatement. The time taken for concentration levels to decrease after abatement is uncertain, leading to uncertain benefits. Using the quasi option value model, we calculate the value of learning this information, and thus find that removing this uncertainty is worth over 8.6 billion EUR, to all bordering countries. This could be of significant importance for actors rationally waiting for more information, before implementing expensive and irreversible policy

The anatomy of collective failure in the Netherlands

A review of evaluation findings on Dutch policy successes and failures points to the influence of political culture on policy effectiveness

Instability of Acylcarnitines in Stored Dried Blood Spots:The Impact on Retrospective Analysis of Biomarkers for Inborn Errors of Metabolism

Stored dried blood spots (DBS) can provide valuable samples for the retrospective diagnosis of inborn errors of metabolism, and for validation studies for newborn blood spot screening programs. Acylcarnitine species are subject to degradation upon long-term storage at room temperature, but limited data are available on the stability in original samples and the impact on acylcarnitine ratios. We analysed complete acylcarnitine profiles by flow-injection tandem mass spectrometry in 598 anonymous DBS stored from 2013 to 2017, at +4 degrees C during the first year and thereafter at room temperature. The concentrations of C2-, C3-, C4-, C5-, C6-, C8-, C10:1-, C10-, C12:1-, C12-, C14:1-, C14-, C16:1-, C16-, C18:2-, C18:1-, C18-, C5OH+C4DC-, C18:1OH-, and C16DC-carnitine decreased significantly, whereas a positive trend was found for free carnitine. Only the C4/C8-, C8/C10-, C14:1/C10- and C14:1/C16-carnitine ratios appeared robust for the metabolite instability. The metabolite instability may provoke the wrong interpretation of test results in the case of retrospective studies and risk the inaccurate estimation of cut-off targets in validation studies when only stored control DBS are used. We recommend including control DBS in diagnostic, retrospective cohort studies, and, for validation studies, we recommend using fresh samples and repeatedly re-evaluating cut-off targets

Influence of climate on clinical diagnostic dry eye tests: pilot study

Purpose. To analyze dry eye disease (DED) tests and their consistency in similar nonsymptomatic population samples living in two geographic locations with different climates (Continental vs. Atlantic). Methods. This is a pilot study including 14 nonsymptomatic residents from Valladolid (Continental climate, Spain) and 14 sex-matched and similarly aged residents from Braga (Atlantic climate, Portugal); they were assessed during the same season (spring) of two consecutive years. Phenol red thread test, conjunctival hyperemia, fluorescein tear breakup time, corneal and conjunctival staining, and Schirmer test were evaluated on three different consecutive visits. Reliability was assessed using the intraclass correlation coefficient and weighted kappa (J) coefficient for quantitative and ordinal variables, respectively. Results. Fourteen subjects were recruited in each city with a mean (TSD) age of 63.0 (T1.7) and 59.1 (T0.9) years (p = 0.08) in Valladolid and Braga, respectively. Intraclass correlation coefficient and J values of the tests performed were below 0.69 and 0.61, respectively, for both samples, thus showing moderate to poor reliability. Subsequently, comparisons were made between the results corresponding to the middle and higher outdoor relative humidity (RH) visit in each location as there were no differences in mean temperature (p Q 0.75) despite RH values significantly differing (p e 0.005). Significant (p e 0.05) differences were observed between Valladolid and Braga samples on tear breakup time (middle RH visit, 2.76 T 0.60 vs. 5.26 T 0.64 seconds; higher RH visit, 2.61 T 0.32 vs. 5.78 T 0.88 seconds) and corneal (middle RH, 0.64 T 0.17 vs. 0.14 T 0.10; higher RH, 0.60 T 0.22 vs. 0.0 T 0.0) and conjunctival staining (middle RH, 0.61 T 0.17 vs. 0.14 T 0.08; higher RH, 0.57 T 0.15 vs. 0.18 T 0.09). Conclusions. This pilot study provides initial evidence to support that DED test outcomes assessing the ocular surface integrity and tear stability are climate dependent. Future large-sample studies should support these outcomes also in DED patients. This knowledge is fundamental for multicenter clinical trials. Lack of consistency in diagnostic clinical tests for DED was also corroborated. (Optom Vis Sci 2015;92:e284Ye289)The authors thank M. Eugenia Mateo for statistical advice. The present study was supported by grants from Junta de Castilla y Leo´n: Grupos de Excelencia (GR217), EDU-VA145A11-2, and University of Valladolid FPI-UVa-2008. This study was also funded by FEDER through the COMPETE Program and by the Portuguese Foundation for Science and Technology (FCT) in the framework of projects PTDC/SAU-BEB/098391/ 2008, PTDC/SAU-BEB/098392/2008, and the Strategic Project PESTC/FIS/UI607/2011. No funding organizations had a role in the design or conduct of this research