Compte-rendu et apport de la conférence-débat : "Nature, conditionnalité et verdissement de la PAC : un tournant wallon ?", 9 novembre 2011, Espace Senghor, Gembloux, Belgique

Proceedings of the conference: "Nature, conditionnalité et verdissement de la PAC : un tournant wallon ?". 9th November 2011. Espace Senghor, Gembloux, Belgium. Recently, the European Union (EU) proposed a reform project for the Common Agricultural Policy (CAP). One of the proposed reforms consists of imposing a set aside proportion of 7% of arable land for biodiversity support purposes. A conference on this proposal was held in Gembloux, Belgium, on 9th November 2011. Such a set aside system already exists in neighboring countries. The French and Swiss systems were presented at the conference in order to highlight their advantages and limitations. Scientific arguments underlying such policies were also presented. It was shown that the creation of semi-natural elements within the agricultural matrix is an efficient way to promote biodiversity. Both the quantity and the quality of these elements need to be considered. In addition, biodiversity is likely to provide services to agriculture, notably crop pollination and pest control. Currently, uncertainties remain regarding areas that are eligible to be designated as reaching the 7% threshold. However, based on the most probable scenarios, the current likely eligible areas cover only 4.3% of arable land in Wallonia. Less than 20% of Walloon farms already reach the 7% threshold proposed by the EU. If the European project is approved, it will therefore be of great importance to have some form of societal recognition afforded to farmers for their efforts. In order to optimize the positive effects of the policy on biodiversity, it is also imperative to ensure that a high level of biological quality is reached in the areas dedicated to biodiversity and to monitor this quality using clearly defined objectives. Economical, societal and environmental issues all need to be considered when applying this policy in order to improve agricultural sustainability and to stop the decline in biodiversity in agricultural landscapes

Inverse electron demand Diels-Alder click chemistry for pretargeted PET imaging and radioimmunotherapy

This approach leverages the rapid, bio-orthogonal inverse electron demand Diels-Alder reaction between a radiolabeled tetrazine and a trans-cyclooctene-bearing antibody to enable pretargeted positron emission tomography imaging and endoradiotherapy in a murine model of cancer. Radiolabeled antibodies have shown promise as tools for both the nuclear imaging and endoradiotherapy of cancer, but the protracted circulation time of radioimmunoconjugates can lead to high radiation doses to healthy tissues. To circumvent this issue, we have developed an approach to positron emission tomography (PET) imaging and radioimmunotherapy (RIT) predicated on radiolabeling the antibody after it has reached its target within the body. This in vivo pretargeting strategy is based on the rapid and bio-orthogonal inverse electron demand Diels-Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO). Pretargeted PET imaging and RIT using TCO-modified antibodies in conjunction with Tz-bearing radioligands produce high activity concentrations in target tissues as well as reduced radiation doses to healthy organs compared to directly labeled radioimmunoconjugates. Herein, we describe how to prepare a TCO-modified antibody (humanized A33-TCO) as well as how to synthesize two Tz-bearing radioligands: one labeled with the positron-emitting radiometal copper-64 ([Cu-64]Cu-SarAr-Tz) and one labeled with the beta-emitting radiolanthanide lutetium-177 ([Lu-177]Lu-DOTA-PEG(7)-Tz). We also provide a detailed description of pretargeted PET and pretargeted RIT experiments in a murine model of human colorectal carcinoma. Proper training in both radiation safety and the handling of laboratory mice is required for the successful execution of this protocol.Peer reviewe

Overview of the marine litter status in the Atlantic Area: beach, floating and seabed litter

CleanAtlantic is an INTERREG Atlantic Area Programme project that aimed at protecting biodiversity and ecosystem services in the Atlantic Area by improving capabilities to monitor, prevent and remove (macro) marine litter. Besides, the project also contributed to raise awareness and change attitudes among stakeholders and to improve marine litter managing systems. To achieve these aims, the work was organised in 8 work packages. The present deliverable aims at synthesizing the main results obtained on the frame of the action 1 of work package 4, which focused on the Regional characterisation of marine litter in the Atlantic Area. With this purpose, an overview of marine litter status in beach, floating and seabed compartments in the Atlantic Area is presented. Additionally, the major key findings, gaps on monitoring and research as well as potential improvements and recommendations are identified. Links to the complete dedicated reports for each compartment are included in the references section. Also, an interactive map for spatial visualization of data on beach, floating and seabed litter composition and abundance in the Atlantic Area was created and is presented at the end of this report

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

Fourniture d'un reseau de capteurs analogiques a fibres optiques

Available from INIST (FR), Document Supply Service, under shelf-number : AR 16566 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEMinistere de la Recherche et de la Technologie (MRT), 75 - Paris (France)FRFranc

Systeme de mesure de temperature sur fibre optique par reflectometrie optique temporelle

SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : AR 13962 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc