Factors affecting pregnancy rates in infertile women performed abdominal myomectomy

Purpose:To evaluate pregnancy outcomes in infertile women performed abdominal myomectomy at our clinic. Patients and Methods:This retrospective study included 76 infertile women underwent abdominal myomectomy. The cases were divided into two groups according to postoperative pregnancy (Group 1, n=22), and cases with no postoperative pregnancy (Group 2, n=54). Risk factors recorded were; age, parity, size of the fibroids, body mass index (BMI), tumor markers and serum blood values. Results:A total of 76 infertile women underwent abdominal myomectomy during the study period. Of all cases 22 (28.94 %) became pregnant. There was statically significant difference between the groups in terms of age, BMI, diameter of the fibroids (p<0.05) (Table 2). The receiver operator curve (ROC) analyses showed that diameter of the fibroid may be a prognostic factor in order to assess the probability of pregnancy following abdominal myomectomy in infertile women. Conclusion:We think that in infertile women with intramural fibroids >5 cm the treatment modality should be abdominal myomectomy to increase the chance of postoperative pregnancy. [Cukurova Med J 2014; 39(4.000): 801-806

A prospective case control questionnaire study for restless leg syndrome on 600 pregnant women

Aim: To evaluate the clinical characteristics of pregnant women with restless leg syndrome (RLS)

Cytogenetic and Molecular Investigation in Children with Possible Fragile X Syndrome

Objective: Fragile X syndrome (FXS) is the most common cause of inherited mental retardation and is due to a mutation in the X-linked FMR1 gene. Molecular genetic testing and chromosome analysis are indicated for this disorder. In this context, we tried to determine the frequency of the FXS, and other chro&#172;mosomal abnormalities of Turkish pediatric neurology outpatients. Materials and Methods: Cytogenetic and molecular screenings were performed to esti-mate the prevalence of the fragile X in 107 patients with mental retardation, language disorders, hyperactivity, develop&#172;mental delay or fragile X syndrome phenotype. Only 26 out of 107 patients were screened, molecularly. Results: Cytogenetically fragile X-positive cells was found in 8 cases (7.5%) of 107 patients; in 4.7% of males and in 2.8% of females. The autosomal fragile sites (FS) was found in 14 (13.1%) cases. One (0.9%) patient had pericentric inversion of chromosome 9. Molecular analysis were performed for 26 patients and all patients showed normal CGG expansion. Conclusion: In diagnosis of fragile X syndrome, chromosome analysis must be run in conjunction with the molecular studies. It is recommended that all members of the fragile X family under risk should be screened both by cytogenetic and molecular methods. Genetic counseling can be useful to patients and families considering genetic testing. [Cukurova Med J 2012; 37(2.000): 76-83