Laboratory experiments on wind-generated waves

It has long been known that the study of wind-generated waves on a water surface is difficult in the laboratory because of the large fetch, or distance downwind, needed for the growth of waves large enough to behave as gravity waves rather than capillary ripples. Johnson (1948), on the evidence of experiments by Stanton et al. (1932) and those of his own at Clear Lake, California, concludes that a channel 311 feet long with a windspeed of 4.5 feet/sec. would reproduce the prototype conditions of a 10 mile fetch with a 40 m. p. h. wind...

A note on the velocity distribution and bottom stress in a wind-driven water current system

The shear stress of the wind on a water surface is sometimes found by measuring the slope of the surface in a lake or wind tunnel. The stress on the bottom of the lake due to the return water current is an error term which has been variously estimated. An experimental method of determining the error is described, and the results indicate that it is but some 1½% of the wind stress

Zoned mantle convection

We review the present state of our understanding of mantle convection with respect to geochemical and geophysical evidence and we suggest a model for mantle convection and its evolution over the Earth’s history that can reconcile this evidence. Wholemantle convection, even with material segregated within the D00 region just above the core{mantle boundary, is incompatible with the budget of argon and helium and with the inventory of heat sources required by the thermal evolution of the Earth. We show that the deep-mantle composition in lithophilic incompatible elements is inconsistent with the storage of old plates of ordinary oceanic lithosphere, i.e. with the concept of a plate graveyard. Isotopic inventories indicate that the deep-mantle composition is not correctly accounted for by continental debris, primitive material or subducted slabs containing normal oceanic crust. Seismological observations have begun to hint at compositional heterogeneity in the bottom 1000 km or so of the mantle, but there is no compelling evidence in support of an interface between deep and shallow mantle at mid-depth. We suggest that in a system of thermochemical convection, lithospheric plates subduct to a depth that depends|in a complicated fashion|on their composition and thermal structure. The thermal structure of the sinking plates is primarily determined by the direction and rate of convergence, the age of the lithosphere at the trench, the sinking rate and the variation of these parameters over time (i.e. platetectonic history) and is not the same for all subduction systems. The sinking rate in the mantle is determined by a combination of thermal (negative) and compositional buoyancy and as regards the latter we consider in particular the e¬ect of the loading of plates with basaltic plateaux produced by plume heads. Barren oceanic plates are relatively buoyant and may be recycled preferentially in the shallow mantle. Oceanic plateau-laden plates have a more pronounced negative buoyancy and can more easily founder to the very base of the mantle. Plateau segregation remains statistical and no sharp compositional interface is expected from the multiple fate of the plates. We show that the variable depth subduction of heavily laden plates can prevent full vertical mixing and preserve a vertical concentration gradient in the mantle. In addition, it can account for the preservation of scattered remnants of primitive material in the deep mantle and therefore for the Ar and 3He observations in oceanisland basalts

New mantle convection model may reconcile conflicting evidence

Recently, a new model for mantle convection was proposed that may be more realistic than previous standard models. Exciting questions remain, of course, but we believe it can be used to reconcile otherwise conflicting evidence from different research fields and thus provide a new framework for further studies of convection

Watsan delivery - private sector involvement

Watsan delivery - private sector involvemen

A comprehensive dataset of annotated oral cavity images for diagnosis of oral cancer and oral potentially malignant disorders

The authors thank Mr. Shalindu Malshan, Ms. Yovanthi Jayasinghe, and Ms. K.P.I, Prabhani, for their help in image and data collection. We acknowledge all study participants with gratitude.Peer reviewe

Consistent Anisotropic Repulsions for Simple Molecules

We extract atom-atom potentials from the effective spherical potentials that suc cessfully model Hugoniot experiments on molecular fluids, e.g., $O_2$ and $N_2$. In the case of $O_2$ the resulting potentials compare very well with the atom-atom potentials used in studies of solid-state propertie s, while for $N_2$ they are considerably softer at short distances. Ground state (T=0K) and room temperatu re calculations performed with the new $N-N$ potential resolve the previous discrepancy between experimental and theoretical results.Comment: RevTeX, 5 figure

Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT

PURPOSEThe Tamoxifen and Exemestane Trial (TEXT)/Suppression of Ovarian Function Trial (SOFT) showed superior outcomes for premenopausal women with hormone receptor (HR)-positive breast cancer treated with adjuvant exemestane plus ovarian function suppression (OFS) or tamoxifen plus OFS versus tamoxifen alone. We previously reported the magnitude of absolute improvements in freedom from any recurrence across a continuous, composite measure of recurrence risk to tailor decision making. With longer follow-up, we now focus on distant recurrence.METHODSThe TEXT/SOFT HR-positive/human epidermal growth factor receptor 2 (HER2)-negative analysis population included 4,891 women stratified by predetermined chemotherapy use. Kaplan-Meier estimates of 8-year freedom from distant recurrence were analyzed using subpopulation treatment effect pattern plot (STEPP) methodology across subpopulations defined by the continuous composite measure of recurrence risk. For each patient, the composite risk value was obtained from a Cox model that incorporated age; nodal status; tumor size; grade; and estrogen receptor, progesterone receptor, and Ki-67 labeling index expression levels.RESULTSThe overall rate of 8-year freedom from distant recurrence was 91.1% and ranged from approximately 100% to 63% across lowest to highest composite risks. TEXT patients who received chemotherapy had an average absolute improvement with exemestane plus OFS versus tamoxifen plus OFS of 5.1%, and STEPP analysis showed improvements from less than 1% to more than 15% from lowest to highest composite risks. SOFT patients who remained premenopausal after chemotherapy had an average 5.2% absolute improvement with exemestane plus OFS versus tamoxifen and reached 10% across composite risks; for tamoxifen plus OFS versus tamoxifen, the maximum improvement was approximately 3.5%. Women who did not receive chemotherapy had a more than 97% rate of 8-year freedom from distant recurrence, and improvements with exemestane plus OFS ranged from 1% to 4%.CONCLUSIONPremenopausal women with HR-positive/HER2-negative breast cancer and high recurrence risk, as defined by clinicopathologic characteristics, may experience a 10% to 15% absolute improvement in 8-year freedom from distant recurrence with exemestane plus OFS versus tamoxifen plus OFS or tamoxifen alone. The potential benefit of escalating endocrine therapy versus tamoxifen alone is minimal for those at low recurrence risk. (c) 2019 by American Society of Clinical Oncolog

Photoelasticity of crystalline and amorphous silica from first principles

Based on density-functional perturbation theory we have computed from first principles the photoelastic tensor of few crystalline phases of silica at normal conditions and high pressure (quartz, $\alpha$-cristobalite, $\beta$-cristobalite) and of models of amorphous silica (containig up to 162 atoms), obtained by quenching from the melt in combined classical and Car-Parrinello molecular dynamics simulations. The computational framework has also been checked on the photoelastic tensor of crystalline silicon and MgO as prototypes of covalent and ionic systems. The agreement with available experimental data is good. A phenomenological model suitable to describe the photoelastic properties of different silica polymorphs is devised by fitting on the ab-initio data.Comment: ten figure