Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression

Caloric restriction remains the most reproducible measure known to extend life span or diminish age-associated changes. Previously, we have described an elevated expression of the prolyl-4-hydroxylase domain (PHD) 3 with increasing age in mouse and human heart. PHDs modulate the cellular response towards hypoxia by regulating the stability of the α-subunit of the transcriptional activator hypoxia inducible factor (HIF). In the present study we demonstrate that elevated PHD3, but not PHD1 or PHD2, expression is not restricted to the heart but does also occur in rat skeletal muscle and liver. Elevated expression of PHD3 is counteracted by a decrease in caloric intake (40% caloric restriction applied for 6 months) in all three tissues. Age-associated changes in PHD3 expression inversely correlated with the expression of the HIF-target gene macrophage migration inhibitory factor (MIF), which has been previously described to be involved in cellular HIF-mediated anti-ageing effects. These data give insight into the molecular consequences of caloric restriction, which influences hypoxia-mediated gene expression via PHD3

Note linguistiche ed ermeneutiche sulla tavoletta PY Tn 316

In this study a revised analysis of the Mycenaean tablet PY Tn 316 is presented, a piece of utmost importance for the knowledge of the Mycenaean language, rituals and religion. New proposals are drawn for the solution of old cruces (e.g. Myc. ma-na-sa), based on the application of a hermeneutic principle of internal coherence to each sections of the text

Commento linguistico alla scheda n. 29

New Etruscan inscriptions on a mirror

Alcune osservazioni linguistiche sul nome di Tagete

The name Tages, lacking any clear Latin or Greek etymology, is most likely related to an Etruscan form; however, it cannot be found in the theonymic repertoire passed on through captions to mirrors or wall paintings. The present work is aimed at formulating a new interpretative proposal, which, unlike previous efforts, takes into account the levels of phonetic and morphological analysis

Miceneo qo-wi-ja na-ti-qe ko-ma-we-te-ja

Abstract The Mycenaean phrase qo-wi-ja na-ti-qe ko-ma-we-te-ja, written within a difficult section of the most discussed tablet PY Tn 316, is here newly reconsidered in the light of a hermeneutic principle of internal coherence

Sematogrammi nelle scritture lineari, fra iconismo e fonetismo. Aspetti teorici e definit\uf2ri

Sematograms in linear scripts, between iconicity and phoneticity. Theory and definitions \ub7 The widespread occurrence of sematograms in the Cretan Linear scripts is of utmost relevance for the study of the writing systems of the ancient Mediterranean and the overall history of writing. In fact, Linear A and Linear B are non-sematographic writing systems, but they are clearly phonographic, syllabic type systems ; in this context, the sematographic resource develops flourishingly, as an auxiliary system in accounting texts, within which it is included for the purpose of \u201cshort writing\u201d, aimed at simplifying the process of recording vast amounts of information ; such information was related to well-defined economic and legal relationships among the citizens of the ancient, Minoan and Mycenaean, palatial society. This special feature of Linear A and B is oftentimes underestimated by those who are not deeply acquainted with such writing systems ; nevertheless, it is a peculiar aspect of great theoretical significance, even more so in light of the further characteristics observed in the adaptation process from the Minoan system to the Mycenaean one. Focusing on A and B sets of sematograms, considered separately, it is worth pointing out that the classification procedures necessarily stem from a preliminary analysis of the graphic expression plan, which, in turn, requires a primary bipartition between the level of iconic and phonographic operativity. In a few, rare instances, the two levels overlap, thus enabling us to shed major light on the origin of the syllabic (Minoan) writing system, clearly of an acrophonic nature. Some particularly meaningful case studies will be showcased and some important issues concerning the usefulness of the sematographic repertoire of Linear A and B will be touched upon ; particular emphasis will be placed on the hermeneutics of the texts, both prior to (e.g. in terms of document classification, i.e. topic identification), and after the decipherment of Linear B

Ortografia sillabica del geroglifico egiziano e materiale linguistico egeo

This paper aims to provide new tools for a more reliable reading of some "Minoan" linguistic formulas readable in few Egyptian texts of the New Kingdom. The enhanced reliability of a "normalized" reading of such texts is obtained through the stabilization of standard vocalized readings of the Egyptian syllabic orthography applied to indoubted cases of Aegean toponymic material, with a phonetic revision of the values based on a network of systematic correspondences and not on the basis of comparisons between mere conventional transliterations, as was the case in previous analyses. This procedure, which implies the attempt to promptly justify the discrepancies (vowels, consonants), even minimal ones, between the forms object of comparison, guarantees a better reliability of the linguistic analysis processes and allows, for instance, to fix the degree of identifiability of possible theonymic units and even of morphological elements otherwise known from Linear A Minoan documents

L’àncora di Tarquinia: l’iscrizione

Forthcomin