Caloric restriction counteracts age-dependent changes in prolyl-4-hydroxylase domain (PHD) 3 expression

Caloric restriction remains the most reproducible measure known to extend life span or diminish age-associated changes. Previously, we have described an elevated expression of the prolyl-4-hydroxylase domain (PHD) 3 with increasing age in mouse and human heart. PHDs modulate the cellular response towards hypoxia by regulating the stability of the α-subunit of the transcriptional activator hypoxia inducible factor (HIF). In the present study we demonstrate that elevated PHD3, but not PHD1 or PHD2, expression is not restricted to the heart but does also occur in rat skeletal muscle and liver. Elevated expression of PHD3 is counteracted by a decrease in caloric intake (40% caloric restriction applied for 6 months) in all three tissues. Age-associated changes in PHD3 expression inversely correlated with the expression of the HIF-target gene macrophage migration inhibitory factor (MIF), which has been previously described to be involved in cellular HIF-mediated anti-ageing effects. These data give insight into the molecular consequences of caloric restriction, which influences hypoxia-mediated gene expression via PHD3

Note linguistiche ed ermeneutiche sulla tavoletta PY Tn 316

In this study a revised analysis of the Mycenaean tablet PY Tn 316 is presented, a piece of utmost importance for the knowledge of the Mycenaean language, rituals and religion. New proposals are drawn for the solution of old cruces (e.g. Myc. ma-na-sa), based on the application of a hermeneutic principle of internal coherence to each sections of the text

Commento linguistico alla scheda n. 29

New Etruscan inscriptions on a mirror

Alcune osservazioni linguistiche sul nome di Tagete

The name Tages, lacking any clear Latin or Greek etymology, is most likely related to an Etruscan form; however, it cannot be found in the theonymic repertoire passed on through captions to mirrors or wall paintings. The present work is aimed at formulating a new interpretative proposal, which, unlike previous efforts, takes into account the levels of phonetic and morphological analysis

Miceneo qo-wi-ja na-ti-qe ko-ma-we-te-ja

Abstract The Mycenaean phrase qo-wi-ja na-ti-qe ko-ma-we-te-ja, written within a difficult section of the most discussed tablet PY Tn 316, is here newly reconsidered in the light of a hermeneutic principle of internal coherence

L’àncora di Tarquinia: l’iscrizione

Forthcomin

Errors in Italian as Second Language. A Taxonomy Proposal

This essay deals with a series of strategies that second or foreign language learners adopt in an effort to avoid making predictable errors. One of the most significant and least studied aspects in the academic field is the type of strategies that are put in place to make changes in the planning of the discourse, when the elements are not available to cope with the event, the communication need or when a speaker wants to change subject from a little-known conversational or textual sector. We intend to examine the concept of competence with respect to performance, the role and type of errors, ending up eliciting a taxonomy of interventions by learners, aimed at avoiding errors in oral and written production