Electrocatalytic oxidation of hydrazine in alkaline media promoted by iron tetrapyridinoporphyrazine adsorbed on graphite surface

The electrocatalytic oxidation of hydrazine was studied using an ordinary pyrolytic graphite electrode modified with iron tetrapyridinoporphyrazine complex (FeTPyPz), employing cyclic voltammetry and rotating disk electrode techniques. Analyses of the voltammograms recorded at different potential scan rates and the polarization curves at different electrode rotation rates showed that the reaction of electrooxidation of hydrazine on FeTPyPz occurs via 4-electrons with the formation of N2 as main product. The kinetic parameters suggest that the second electron transfer step is rate controlling. The activity of FeTPyPz depends on its Fe(II)/Fe(I) formal potential and fits well in a volcano plot that includes several iron phthalocyanines, indicating that such formal potential is a good reactivity index for these complexes

Vitamin D3 Supplementation: An Option Associated with The Treatment of Multiple Sclerosis: : A Systematic Review and Meta-Analysis

Multiple sclerosis (MS) is a chronic complex neurodegenerative disease. A systematic review and meta-analysis were conducted on observational studies and analytics on impact of Vitamin D supplementation in patients with Multiple Sclerosis. In our research, a total of 457 articles were selected and identified for analysis. This systematic review article and meta-analysis, which included evidence from randomized controlled trials conducted with patients with multiple sclerosis, revealed that Vitamin D3 supplementation is effective as an option associated with the treatment of this disease, and that it also has a diffuse protective role against various remission outbreaks in the health. Doses (50,000 IU/week) are appropriate to restore neuroimmunological parameters when used within 12 weeks

A Formação Água Clara na Região de Araçaíba - SP: registro U-Pb de uma bacia mesoproterozóica

The main objective of this work is to present U-Pb isotopic data obtained from zircons of metabasic rocks and subordinate acid and associated rocks of the Água Clara Formation in the Araçaíba region - São Paulo. The Água Clara Formation is predominantly constituted by a sequence of carbonate rocks (pure to impure marbles), calc-silicate rocks, calc schists, mica schists, amphibole schists, quartzites, garnet-chlorite-biotite schists, metacherts, basic and intermediate metatuffs, metabasites, amphibolites and cornubianites. The metabasic bodies are usually a few km long with widths of hundreds of m. They are greenish gray, fine- to medium-grained, and usually present nematoblastic texture. More isotropic terms also occur, showing granoblastic texture. They are composed of pyroxenes (diopside or augite), amphiboles (actinolite and hornblende), and plagioclases (andesine/oligoclase). The most common accessories are apatite, magnetite, epidote, titanite, and rare zircon. In thin section, preserved ophitic and subophitic textures are observed, indicating a probable igneous origin. The geochemical data suggest compositions similar to enriched midoceanic ridge basalts (E-MORB) tending to oceanic island basalts (OIB). The subalkaline, tholeiitic characteristics, similar to E-MOR basalts tending to OI basalts, suggest distension or back-arc environments as the geotectonic settings for the basic magmatism. The geochronologic and geochemical characteristics and structural patterns described for the Água Clara Formation metabasic lithotypes (probably sills and/or dikes) suggest that periodic volcanism with associated sedimentation occurred during the Mesoproterozoic at about 1500 Ma. This event represents an important marker in the volcano-sedimentary evolution of the Apiaí Domain. The Neoproterozoic values obtained refer to zircon recrystallization, to neoformation processes which affected the metabasics and amphibolites, to the emplacement of granitic and acid volcanic rocks, and to regional cooling of the Água Clara Formation.O objetivo deste trabalho fundamenta-se no estudo isotópico dos corpos metabasíticos associados à Formação Água Clara e as suas relações com as encaixantes. A Formação Água Clara é constituída predominantemente por uma seqüência de rochas carbonáticas (mármores puros a impuros). Rochas cálcio-silicáticas, cálcio xistos, mica xistos, anfibólio xistos, quartzitos, granada-clorita-biotita xistos, metacherts, metatufos básicos e intermediários, metabasitos, anfibolitos e cornubianitos. As rochas metabásicas estudadas normalmente têm dimensões longitudinais expressivas chegando a quilométricas, com dimensões transversais de até centenas de metros. São de coloração cinza - esverdeada, apresentam granulometria fina a média e textura normalmente nematoblástica. Ocorrem termos mais isótropos que exibem textura granoblástica. São compostos por piroxênios (diopsídio ou augita), anfibólios (actinolita e hornblenda) e plagioclásios (andesina/oligoclásio). Os acessórios mais comuns são apatita, magnetita, epidoto, titanita e raramente zircão. Em lâmina observa-se texturas ofíticas e subofíticas preservadas o que indica uma provável origem ígnea para esses corpos. Os dados geoquímicos sugerem composições semelhantes a basaltos enriquecidos de cadeias mesoceânicas (E-MORB) com tendências a basaltos de ilhas oceânicas (OIB). As características de basaltos toleíticos, subalcalinos semelhantes a basaltos enriquecidos de cadeias mesoceânicas com tendência a basaltos de ilhas oceânicas (OIB), permitem sugerir como ambiente geotectônico gerador deste magmatismo básico, am-bientes distensivos ou em bacias de retroarco. Os dados analíticos U-Pb (convencional, EMF e SHRIMP) obtidos para os litotipos metabásicos indicam épocas de cristalização dos zircões e conseqüente formação dessas rochas durante o mesoproterozóico, com idades do intervalo 1590 - 1470 Ma. Os valores neoproterozóicos obtidos (~600 Ma) provavelmente referem-se a processos de recristalização e neoformação de zircões nas rochas metabásicas, colocação de rochas de natureza granítica e resfriamento regional da Formação Água Clara

Prognostic factors for patients treated with abiraterone

© Cecilia Melo Alvim. This work is licensed under the Creative Commons Attribution4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/Aim: To evaluate prostate-specific antigen response (PSAr) defined as a ≥50% decrease in PSA concentration from the pretreatment value, as a prognostic factor in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone acetate (AA). Methods: Retrospective evaluation of patients with mCRPC treated with AA. Results: 124 patients were identified. Median overall survival and progression-free survival for patients achieving PSAr versus patients without PSAr were 29.3 versus 9.7 months and 17.0 versus 5.2 months, respectively. Multivariate analysis confirmed that PSAr correlated with better overall survival (hazard ratio: 0.19; 95% CI: 0.10-0.38; p < 0.001) and progression-free survival (hazard ratio: 0.24; 95% CI: 0.14-0.41; p < 0.001). Conclusion: PSAr can be utilized as prognostic and predictive factors in mCRPC patients treated with AA.info:eu-repo/semantics/publishedVersio

The Use of Vitamin D in The Infectious Process in The Hospital Period in Childhood Effective?

Goals: To verify whether the use of Vitamin D as parallel therapy to hospital and drug treatment can be effective in the process of infectious reduction in hospitalized children. Data source: This study is a systematic review and meta-analysis of randomized controlled trials, published between 2011 and the first quarter of 2019, in the Cochrane Library, Medline, US National Library of Medicine and the National Institute of Health (PubMed), Literature databases. Latin American and Caribbean Health Sciences (Lilacs), Scopus and Web of Science. The studies were scored by the Down and Black scale associated with the quality assessment method according to the Cochrane criteria (RCT). Summary of the data: Of the 1475 studies, 09 were included. There is a direct relationship between Vitamin D level and mortality rate in hospitalized children with infections. Conclusion: This study highlighted that the vitamin D deficiency in children under serum analysis during hospitalization triggers severe immunological changes

Entanglement generation and transfer between remote atomic qubits interacting with squeezed field

A pair of two level atoms A1A2, prepared either in a separable state or in an entangled state, interacts with a single mode of two mode squeezed cavity field while a third atomic qubit B interacts with the second mode of the squeezed field in a remote cavity. We analyze, numerically, the generation, sudden death and revival of three qubit entanglement as a function of initial entanglement of qubits A1A2 and degree of squeezing of electromagnetic field. Global negativity of partially transposed state operator is used to quantify the entanglement of three atom state. It is found that the initial entanglement of two mode field as well as that of the pair A1A2, both, contribute to three atom entanglement. A maximally entangled single excitation Bell pair in first cavity and two mode field with squeeze parameter s=0.64 are the initial conditions that optimize the peak value of three qubit mixed state entanglement. A smaller value of s=0.4 under similar conditions is found to generate a three qubit mixed state with comparable entanglement dynamics free from entanglement sudden death.Comment: 14 pages, 7 figures, sections III and IV merged with section II and analytic expressions moved to Appendices A and B. Figures improved and corrected typo

Inventory and quantitative assessment of geosites and geodiversity sites: a review

"Published online: 15 January 2015"The inventory and quantitative assessment of the most valuable occurrences of geodiversity are essential steps in any geoconservation strategy and in the establishment of priorities in site management. Despite the existence of many site inventories applied to different scales (countries, municipalities, parks, etc.), the criteria used for their selection are often unclear and poorly defined. This paper proposes a new approach to the concepts of geosite and geodiversity site and reviews the procedures used in the development of a systematic site inventory applied to different scales and values. Procedures to achieve a numerical evaluation of the value and degradation risk of sites are reviewed and new criteria are proposed. Finally, guidelines are presented, bearing in mind the preparation of effective geodiversity inventories, to support geoparks’ strategies. This paper aims to contribute to a better understanding and use of the above-mentioned concepts, which are essential for the implementation of geoconservation actions worldwide.The author thanks Diamantino Pereira, Flavia Lima, and Paulo Pereira for fruitful discussions and insights; Teresa Mota for the English revision; and the reviewers for significant improvements of the first submitted version. This paper results of the research done at the University of Minho and at the Geology Centre of the University of Porto, partially founded by the Foundation for Science and Technology (Portugal), strategic project with reference PEst-OE/CTE/UI0039/2014