LOCALIZED 1H-OMEGA PARTICLE-HOLE STRENGTH IN NUCLEI

A cross section enhancement, persisting to high momentum transfer, has been observed around 1HBAR omega in excitation energy in spectra from inelastic proton-, alpha- and electron scattering on Zr-90, Sn-116, Pt-196 and Pb-208. Data are presented for (p,p') at 201 MeV, (alpha,alpha') at 120 MeV and analyzed together with existing data obtained with 133.8 MeV polarized ((p) over right arrow,p') on Sn-116 and electron-scattering data on Sn-116 and Pt-196. Two different interpretations of the observed enhancement are discussed: that of the incoherent sum of all 1HBAR omega cross section and alternatively the sum over the isoscalar normal modes of all multipolarities

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity

BackgroundAn international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.MethodsFourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.ResultsThe agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).ConclusionsThe HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms