10,524 research outputs found
Quantitative Description of Strong-Coupling of Quantum Dots in Microcavities
We have recently developed a self-consistent theory of Strong-Coupling in the
presence of an incoherent pumping [arXiv:0807.3194] and shown how it could
reproduce quantitatively the experimental data [PRL 101, 083601 (2008)]. Here,
we summarize our main results, provide the detailed analysis of the fitting of
the experiment and discuss how the field should now evolve beyond merely
qualitative expectations, that could well be erroneous even when they seem to
be firmly established.Comment: Submitted to the AIP Conference Proceedings Series for the ICPS 2008
(Rio de Janeiro). 2 pages, reduced-quality figur
The Effects of Inlet Flow Modification on Cavitating Inducer Performance
This paper explores the effect of inlet flow modification on the cavitating and noncavitating performance of two cavitating inducers, one of simple helical design and the other a model of the low-pressure LOX pump in the Space Shuttle Main Engine. The modifications were generated by sections of honeycomb, both uniform and nonuniform. Significant improvement in the performance over a wide range of flow coefficients resulted from the use of either honeycomb section. Measurements of the axial and swirl velocity profiles of the flows entering the inducers were made in order to try to understand the nature of the inlet flow and the manner in which it is modified by the honeycomb sections
Solving the One-Dimensional Time-Independent Schr\"odinger Equation with High Accuracy: The LagrangeMesh Mathematica Package
In order to find the spectrum associated with the one-dimensional
Schr\"oodinger equation, we discuss the Lagrange Mesh method (LMM) and its
numerical implementation for bound states. After presenting a general overview
of the theory behind the LMM, we introduce the LagrangeMesh package: the
numerical implementation of the LMM in Mathematica. Using few lines of code,
the package enables a quick home-computer computation of the spectrum and
provides a practical tool to study a large class of systems in quantum
mechanics. The main properties of the package are (i) the input is basically
the potential function and the interval on which is defined; and (ii) the
accuracy in calculations and final results is controllable by the user. As
illustration, a highly accurate spectrum of some relevant quantum systems is
obtained by employing the commands that the package offers. In fact, the
present work can be regarded as a user guide based on worked examples.Comment: File LagrangeMesh.wl can be provided to the interested reader, just
contact the author via email. Alternatively, it can be found at
https://github.com/JuanCarlosdelValle/LagrangeMesh-Packag
Electrostatic control of quantum dot entanglement induced by coupling to external reservoirs
We propose a quantum transport experiment to prepare and measure
charge-entanglement between two electrostatically defined quantum dots.
Coherent population trapping, as realized in cavity quantum electrodynamics,
can be carried out by using a third quantum dot to play the role of the optical
cavity. In our proposal, a pumping which is quantum mechanically
indistinguishable for the quantum dots drives the system into a state with a
high degree of entanglement. The whole effect can be switched on and off by
means of a gate potential allowing both state preparation and entanglement
detection by simply measuring the total current.Comment: 5 pages, 4 figures, Latex2e with EPL macros, to appear in Europhysics
Letter
Interactomics and targeted protein degradation for kinase substrate discovery
Reversible phosphorylation is one of the most important post translational modifications that has allowed us as a species to quickly adapt to changing molecular environments due to external stimulation. This process is only capable through the activity of kinases to carry out the targeting of specific substrates defined by their recognition motif allowing for selective phosphorylation and activation and inactivation of distinct pathways as well as other changes that permit cell survival. By being so important for the maintenance of the cells disruption often leads to worsening of the cells, leading to various diseases like cancer, immunological and neurodegenerative disorders. This is why the comprehension of kinases, and their substrates is so important for making progress in the medical care of the patients.
For this exact purpose we chose Polo like kinase 2 (Plk2) as the target of study. Even though a great deal of knowledge exists about it, like the fact that it plays roles during the cell cycle, cell differentiation, ontogenesis, stress response, tumorigenesis, neurodegenerative diseases, and inflammation. The mechanisms at play i.e the specific interactions that permits its function in all these systems is not entirely known. As such, we employed the use CRISPR/Cas9 as the method of genetic modification for the endogenous tagging of Plk2 with the auxin inducible degron (AID) for the selective degradation of our target. After having observed through LC/MS the limitations of being a low abundant protein, we combined proximity labeling through Turbo-ID and targeted degradation as a method of accomplishing this task. We were successful in the identification of novel substrates of Plk2 in the cell cycle, and capable of study the interactome of Plk2 in asynchronous and G1/S arrested cells. Providing a sundry of new insight into Plk2 biology and the diversification of its interactions.
AID technology in combination with proximity labeling provides the next steps in the ability of study for any type of protein. Capable of gathering information about the context of the protein in regard to its environment, the interactions, and what the absence of that protein would have for specific pathways, while minimizing off-target effects
Experimental verification of the non-equilibrium model for predicting behavior in the char zone of a charring ablator Status report
Experimental simulation to establish accuracy of nonequilibrium flow model with system simulating charring during ablatio
Solution of the Frozen Flow Momentum Equation Status Report
Momentum equation solved for frozen flow in char zone of charring ablato
Exciting polaritons with quantum light
We discuss the excitation of polaritons---strongly-coupled states of light
and matter---by quantum light, instead of the usual laser or thermal
excitation. As one illustration of the new horizons thus opened, we introduce
Mollow spectroscopy, a theoretical concept for a spectroscopic technique that
consists in scanning the output of resonance fluorescence onto an optical
target, from which weak nonlinearities can be read with high precision even in
strongly dissipative environments.Comment: 5 pages, 3 figure
Production and decays of supersymmetric Higgs bosons in spontaneously broken R-parity
We study the mass spectra, production and decay properties of the lightest
supersymmetric CP-even and CP-odd Higgs bosons in models with spontaneously
broken R-parity (SBRP). We compare the resulting mass spectra with expectations
of the Minimal Supersymmetric Standard Model (MSSM), stressing that the model
obeys the upper bound on the lightest CP-even Higgs boson mass. We discuss how
the presence of the additional scalar singlet states affects the Higgs
production cross sections, both for the Bjorken process and the "associated
production". The main phenomenological novelty with respect to the MSSM comes
from the fact that the spontaneous breaking of lepton number leads to the
existence of the majoron, denoted J, which opens new decay channels for
supersymmetric Higgs bosons. We find that the invisible decays of CP-even
Higgses can be dominant, while those of the CP-odd bosons may also be sizeable.Comment: 21 pages, 8 figures; minor changes, final version for publicatio
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