Discussion sur le projet de décret relatif à l'Affaire d'Avignon et du Comtat Venaissin pour leur réunion à la France, lors de la séance du 24 mai 1791

Virieu François-Henri, comte de, Cazalès Jacques Antoine de, Menou Jacques François de Boussay, baron de, Salle Jean Baptiste, Montlosier François Dominique de Reynaud de, Bureaux de Pusy Jean-Xavier, Dupont de Bigorre Pierre Charles, Prieur (de la Marne), Dufraisse-Duchey Amable-Gilbert, Madier de Montjau Noel Joseph, Aubergeon de Murinais Guy Joseph d', Crillon François Félix Berton des Balbes, comte de, Rabaud de Saint Etienne Jean- Paul, Malouet Pierre-Victor, Clermont-Tonnerre Stanislas Marie, comte de, Foucault de Lardimalie Louis, marquis de, Verchère de Reffye Hugues, François, Faucigny-Lucinge Louis Charles, comte de, Treilhard Jean-Baptiste, Frondeville Thomas Louis de. Discussion sur le projet de décret relatif à l'Affaire d'Avignon et du Comtat Venaissin pour leur réunion à la France, lors de la séance du 24 mai 1791. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XXVI - Du 12 mai au 5 juin 1791. Paris : Librairie Administrative P. Dupont, 1887. pp. 381-382

Discussion sur le projet de décret relatif à l'Affaire d'Avignon et du Comtat Venaissin pour leur réunion à la France, lors de la séance du 24 mai 1791

Virieu François-Henri, comte de, Cazalès Jacques Antoine de, Menou Jacques François de Boussay, baron de, Salle Jean Baptiste, Montlosier François Dominique de Reynaud de, Bureaux de Pusy Jean-Xavier, Dupont de Bigorre Pierre Charles, Prieur (de la Marne), Dufraisse-Duchey Amable-Gilbert, Madier de Montjau Noel Joseph, Aubergeon de Murinais Guy Joseph d', Crillon François Félix Berton des Balbes, comte de, Rabaud de Saint Etienne Jean- Paul, Malouet Pierre-Victor, Clermont-Tonnerre Stanislas Marie, comte de, Foucault de Lardimalie Louis, marquis de, Verchère de Reffye Hugues, François, Faucigny-Lucinge Louis Charles, comte de, Treilhard Jean-Baptiste, Frondeville Thomas Louis de. Discussion sur le projet de décret relatif à l'Affaire d'Avignon et du Comtat Venaissin pour leur réunion à la France, lors de la séance du 24 mai 1791. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XXVI - Du 12 mai au 5 juin 1791. Paris : Librairie Administrative P. Dupont, 1887. pp. 381-382

Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors

International audienc

Performance of Repeated Measures of (1–3)-β-D-Glucan, Mannan Antigen, and Antimannan Antibodies for the Diagnosis of Invasive Candidiasis in ICU Patients: A Preplanned Ancillary Analysis of the EMPIRICUS Randomized Clinical Trial

International audienceBackground. We aimed to assess the prognostic value of repeated measurements of serum (1-3)-β-D-glucan (BDG), mannanantigen (mannan-Ag), and antimannan antibodies (antimannan-Ab) for the occurrence of invasive candidiasis (IC) in a high-risk nonimmunocompromised population. Methods. This was a preplanned ancillary analysis of the EMPIRICUS Randomized Clinical Trial, including nonimmunocompromised critically ill patients with intensive care unit-acquired sepsis, multiple Candida colonization, and multiple organ failure who were exposed to broad-spectrum antibacterial agents. BDG (>80 and >250 pg/mL), mannan-Ag (>125 pg/ mL), and antimannan-Ab (>10 AU) were collected repeatedly. We used cause-specific hazard models. Biomarkers were assessed at baseline in the whole cohort (cohort 1). Baseline covariates and/or repeated measurements and/or increased biomarkers were then studied in the subgroup of patients who were still alive at day 3 and free of IC (cohort 2). Results. Two hundred thirty-four patients were included, and 215 were still alive and free of IC at day 3. IC developed in 27 patients (11.5%), and day 28 mortality was 29.1%. Finally, BDG >80 pg/mL at inclusion was associated with an increased risk of IC (CSHR[IC], 4.67; 95% CI, 1.61-13.5) but not death (CSHR[death], 1.20; 95% CI, 0.71-2.02). Conclusions. Among high-risk patients, a first measurement of BDG >80 pg/mL was strongly associated with the occurrence of IC. Neither a cutoff of 250 pg/mL nor repeated measurements of fungal biomarkers seemed to be useful to predict the occurrence of IC. The cumulative risk of IC in the placebo group if BDG >80 pg/mL was 25.39%, which calls into question the efficacy of empirical therapy in this subgroup