Calcium homeostasis in the central nervous system: adaptation to neurodegeneration

En aquest article, després d'una revisió dels nostres coneixements bàsics sobre moviments del alci neuronal, s'ha resentat el treball fet pel nostre grup durant els últims anys sobre neurodegeneració, juntament amb les dades obtingudes en models animals i humans en l'estudi de la precipitació cerebral del calci. Per tal d'explicar la precipitació del calci s'ha presentat i discutit un model que integra els diversos mecanismes implicats en neurodegeneració des del punt de vista de la rellevància funcional.Here we review the results of our recent studies on neurodegeneration together with data on cerebral calcium precipitation in animal models and humans. A model that integrates the diversity of mechanisms involved in neurodegeneration is presented and discussed based on the functional relevance of calcium precipitation

A Longitudinal Mixed-Methods Characterization of Family Support from Adolescence to Young Adulthood in Autism and Other Developmental Disabilities.

Although caregiving responsibilities and need for support persist and evolve across the life course in families with autistic youth or youth with other developmental disabilities (DDs), little is known about support during their childs adulthood years. Therefore, the present study used a mixed-methods approach to examine change and stability in formal and informal family support across the transition to adulthood. Caregivers of 126 individuals with autism or DDs completed a modified version of the Family Support Scale, including open-ended questions, at five time points from adolescence (age 16) into young adulthood (age 22). Caregivers reported that informal support from family members was the most frequently used, helpful, and valued source of support with relative stability across time. In contrast, the reported helpfulness, use, and value of formal support (e.g., professionals, schools) for caregivers declined over time. Qualitative content analyses revealed characteristics of highly valued support included support type (e.g., instrumental or emotional) and features of the support source (e.g., their understanding). There was a shift to valuing emotional support more than instrumental support over time, especially for caregivers of less able adults. Partnership and dependability emerged as highly valued features of the support source. These findings fit within a social convoy perspective and likely reflect the service cliff experienced by autistic individuals or people with DDs and their families. As social networks shrink over time and formal services are less readily available in adulthood, remaining sources of support, particularly from family members, become increasingly important

How safe are the new green energy resources for marine wildlife? The case of lithium

Considering the increasing use of Lithium (Li) and the necessity to fulfil this demand, labile Li occurrence in the environment will be enhanced. Thus, additional research is needed regarding the presence of this element in marine environment and its potential toxic impacts towards inhabiting wildlife. The aim of the present study was to evaluate Li toxicity based on the exposure of Mytilus galloprovincialis to this metal, assessing the biochemical changes related with mussels' metabolism, oxidative stress and neurotoxicity. For this, organisms were exposed to different Li concentrations (100, 250, 750 μg/L) for 28 days. The results obtained clearly demonstrated that Li lead to mussels' metabolism depression. The present study also revealed that, especially at the highest concentrations, antioxidant and biotransformation enzymes were not activated, leading to the occurrence of lipid peroxidation and loss of redox homeostasis, with increased content in oxidized glutathione in comparison to the reduced form. Furthermore, after 28 days, higher Li exposure concentrations induced neurotoxic effects in mussels, with a decrease in acetylcholinesterase enzyme activity. The responses observed were closely related with Li concentrations in mussels' tissues, which were more pronounced at higher exposure concentrations. Such results highlight the potential toxic effects of Li to marine species, which may even be higher under predicted climate changes and/or in the presence of other pollutants.publishe

La gamificación y el desarrollo de las habilidades cognitivas en los niños y niñas de 4 a 5 años

El presente trabajo de investigación describe la Gamificación y el desarrollo de las Habilidades Cognitivas en los niños y niñas, siendo una estrategia innovadora, atractiva y motivadora para generar el interés del estudiante y desarrollar nuevos aprendizajes a través de actividades creativas. Es importante brindar diferentes oportunidades que potencialicen sus destrezas, es por ello que, el presente trabajo tiene como objetivo “Determinar si hay relación entre la gamificación aplicada en la virtualidad por los docentes y las habilidades cognitivas adquiridas en los niños y niñas de 4 –5 años”. La metodología planteada es de enfoque cualitativo, donde se tomó como muestra a 2 docentes del área de Educación Inicial. Se obtendrá de la investigación una valorización de los recursos y medios que emplean los docentes en la virtualidad para favorecer el desarrollo de las habilidades cognitivas en los niños de 4 a 5 años

Nivel de conocimientos de la enfermedad COVID-19 en pacientes diagnosticados en un centro de salud de San Martin de Porres-2021

La presente investigación tiene como Objetivo: Determinar el nivel de conocimiento de la enfermedad por COVID-19 en pacientes diagnosticados en un centro de salud del distrito de San Martin de Porres– 2022. Metodología: Cuantitativa de corte transversal, correlacional y descriptivo. La muestra se conformó por 152 pacientes diagnosticados de Covid-19. La recolección de datos se realizó con el cuestionario llamado “Nivel de conocimiento de la enfermedad por Covid-19”. Se aplicó un cuestionario con 25 ítems, validado por 05 jueces expertos con Aiken mayor a 0.60 y la confiabilidad con alfa de Cronbach para nivel de conocimiento de 0,88. Los datos recolectados se expresaron en frecuencias y porcentajes. Resultado: El 64% de encuestados tuvieron un nivel medio de conocimientos de la enfermedad por Covid-19, el 84% de encuestados tuvieron a un nivel de conocimiento medio sobre la enfermedad del Covid-19 según la dimensión información y el 57% de encuestados tuvieron un nivel medio sobre la enfermedad de Covid-19 según la dimensión cuidados preventivos. Conclusiones: Los pacientes diagnosticados de Covid-19 que fueron encuestados presentan un nivel de conocimiento medio acerca de la enfermedad.The objective: of this research is to determine the level of knowledge of the COVID-19 disease in patients diagnosed in a health center in the district of San Martin de Porres - 2022. Methodology: Quantitative cross-sectional, correlational and descriptive. The sample consisted of 152 patients diagnosed with Covid-19. The data collection was carried out with the questionnaire called "Level of knowledge of the disease by Covid-19". A questionnaire with 25 items was applied, validated by 05 expert judges with Aiken greater than 0.60 and reliability with Cronbach's alpha for a level of knowledge of 0.88. The data collected was expressed in frequencies and percentages. Result: 64% of respondents had a medium level of knowledge about the Covid-19 disease, 84% of respondents had a medium level of knowledge about the Covid-19 disease according to the information dimension and 57% of respondents they had a medium level on the Covid-19 disease according to the preventive care dimension. Conclusions: The patients diagnosed with Covid-19 who were surveyed present a medium level of knowledge about the disease

Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study

The repair of bone defects raises the interest of investigators in several health specialties. Grafting techniques with bone substitutes and laser therapies have been investigated to replace autogenous bone and accelerate the bone healing process. Objective: To evaluate the effect of photobiomodulation therapy (PBMT) associated with guided bone regeneration (GBR) in critical size defects. Material and Methods: The study was conducted on 80 male rats (Rattus norvegicus albinus, Wistar) submitted to surgical creation of a critical size defect on the calvaria, divided into eight study groups: group C (control - only blood clot); group M (collagen membrane); group PBMT (photobiomodulation therapy); group AB (autogenous bone); group AB+PBMT; group AB+M; group PBMT+M; group AB+PBMT+M. The animals were killed 30 days postoperatively. After tissue processing, bone regeneration was evaluated by histomorphometric analysis and statistical analyses were performed (Tukey test, p<0.05). Results: All groups had greater area of newly formed bone compared to group C (9.96±4.49%). The group PBMT+M (achieved the greater quantity of new bone (64.09±7.62%), followed by groups PBMT (47.67±8.66%), M (47.43±15.73%), AB+PBMT (39.15±16.72%) and AB+PBMT+M (35.82±7.68%). After group C, the groups AB (25.10±16.59%) and AB+M (22.72±13.83%) had the smallest quantities of newly formed bone. The area of remaining particles did not have statistically significant difference between groups AB+M (14.93±8.92%) and AB+PBMT+M (14.76±6.58%). Conclusion: The PBMT utilization may be effective for bone repair, when associated with bone regeneration techniques