Cursos pré-vestibulares populares e aprendizagem da docência: alguns encontros

This study focuses on the learning of teaching of seven teachers at CPV. The CPV is characterized for being directed to social and economically unfavorable population belonging to São Carlos and its surroundings. This study relies on educational literature about teachers’ formation and it indicates that their learning occurs as a continuum and they acquire new knowledge and remake their practice as result of reflexive thoughts about their own teaching. Based on the data of interviews with participants, it is possible to observe that teachers start to rethink about teaching from both the students’ demands and their own experiences. In addition, the teachers often develop outclass activities once they may be part of coordination group or be coordinator in their work teaching areas. All the work made by teachers during selection process for new students (that occurs every year) makes them more reflexives in relation to the attended population’s social and economic condition. Thus, the learning that comes from these experiences contributes to a new perception on their own teaching practice

Neutron Star Radius-to-mass Ratio from Partial Accretion Disc Occultation as Measured through Fe Kα\alpha Line Profiles

We present a new method to measure the radius-to-mass ratio (R/M) of weakly magnetic, disc-accreting neutron stars by exploiting the occultation of parts of the inner disc by the star itself. This occultation imprints characteristic features on the X-ray line profile that are unique and are expected to be present in low mass X-ray binary systems seen under inclinations higher than ~65 degrees. We analyse a NuSTAR observation of a good candidate system, 4U 1636-53, and find that X-ray spectra from current instrumentation are unlikely to single out the occultation features owing to insufficient signal-to-noise. Based on an extensive set of simulations we show that large-area X-ray detectors of the future generation could measure R/M to ~2{\div}3% precision over a range of inclinations. Such is the precision in radius determination required to derive tight constraints on the equation of state of ultradense matter and it represents the goal that other methods too aim to achieve in the future.Comment: 17 pages, 8 figures; this is a pre-print edition of an article that has been accepted for publication in the Astrophysical Journa

Higher levels of osteoprotegerin and immune activation/immunosenescence markers are correlated with concomitant bone and endovascular damage in HIV-suppressed patients

HIV-infected patients appear to have a significantly greater risk of non-AIDS comorbidities such as osteoporosis and atherosclerosis. Subjects with osteoporosis are at a higher risk of developing cardiovascular disease than those with normal bone mass, therefore a possible relation between these two conditions can be hypothesized. In the setting of HIV infection, several factors might contribute to bone disease and endothelial dysfunction. The aim of our study was to evaluate the relationship between bone and cardiovascular disease and to investigate the role of traditional factors, T-cell phenotype and osteoprotegerin in HIV positive subjects on effective antiretroviral therapy. We included 94 HIV positive subjects on antiretroviral therapy with virological suppression and 41 healthy subjects matched for age and gender as a control group. Carotid-Intima Media Thickness (c-IMT) and bone mineral density (BMD) were performed by ultrasound and DEXA, respectively. CD4+/CD8+ T-cell activation, senescence and osteoprotegerin plasma levels were measured by flow-cytometry and ELISA, respectively. Among HIV positive patients, 56.4% had osteopenia/osteoporosis and 45.7% had pathological c-IMT (>0.9mm). Subjects with pathological c-IMT and BMD exhibited higher CD4+ and CD8+ activated, CD8+ senescent and osteoprotegerin than subjects with normal c-IMT and BMD. HIV positive subjects with osteopenia/osteoporosis had higher c-IMT than subjects with normal BMD, and linear regression analysis showed a negative correlation between BMD and c-IMT. Several factors are implicated in the pathogenesis of non-AIDS comorbidities in HIV positive patients. Osteoprotegerin together with inflammation and immunosenescence in HIV positive patients could affect bone and vascular system and could be considered as a possible common link between these two diseases

Suggestive evidence of a multi-cytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals

In cells and tissues resistin affects IL-1β, IL-6, IL-8, IL-12 and TNF-α expression, thus suggesting the existence of a multi-cytokine "resistin pathway". We investigated whether such pathway does exist in humans and, if so, if it is associated with cardiovascular risk factors and with major adverse cardiovascular events (MACE). Serum cytokines were measured in 280 healthy subjects from the Gargano Study 2 (GS2) whose BMI, waist circumference, HOMA IR, triglycerides, HDL-cholesterol, systolic and diastolic blood pressure data were available and in 353 patients with type 2 diabetes and coronary artery disease from the Gargano Heart Study (GHS)-prospective design (follow-up 5.4 ± 2.5 years; 71 MACE). In GS2, cytokines mRNA levels in white blood cells were also measured. In GS2, resistin mRNA was correlated with all cytokines expression (all p < 0.001), but IL-12B. Consistently, serum resistin was correlated with all serum cytokines (all p < 0.001), but IL-12. Expression (eRPS) and serum (sRPS) resistin pathway scores (excluding IL-12) were each other correlated (p < 0.001) and both associated with cardiovascular risk factors (all p < 0.01). In GHS, sRPS was independently associated with MACE (HR = 1.44, 95% CI = 1.10-1.90). Our data indicate the existence of a resistin pathway, which is associated with cardiovascular risk factors and which strongly and independently predicts MACE

Long-term effects of different starter yeasts on colour and natural antioxidant power of red wines

AbstractEighty-seven red wines produced from red grapes of the grape variety Gaglioppo from the Calabria region (vintage 2009) were analysed by standard methods after 4 and 120 months of ageing. So, a total of 29 selected starters of Saccharomyces cerevisiae—3 wild type, 12 monoclonal cultures, and 14 hybrids—inoculated in triplicate were studied for their effects on colour and natural antioxidant power keeping of red wine. Wine ageing decreased the red component, the colour intensity, and the DPPH values while the colour hue values increased. This research has shown that the evolution of wine ageing is affected in a very different way by the starter yeast used and has allowed choosing the best yeast strain useful to produce red wine able to endure very long-time ageing, until 10 years

PERFIL METODOLÓGICO DE PESQUISAS ELABORADAS NO ÂMBITO DAS INSTITUIÇÕES DE ENSINO SUPERIOR BRASILEIRAS: UMA ANÁLISE DE PUBLICAÇÕES FEITAS PELA REVISTA CIÊNCIAS DA ADMINISTRAÇÃO

O objetivo do presente estudo é verificar a metodologia aplicada em pesquisas realizadas no âmbito das instituições de ensino superior brasileiras e publicadas pela Revista de Ciências da Administração (RCA) da Universidade Federal de Santa Catarina (UFSC), no período de 2011 a 2015. A citada Revista tem como objeto o desenvolvimento de temas na área de administração e áreas correlatadas. Neste contexto, este estudo analisa as metodologias empregadas nas pesquisas relatadas por tal periódico, utilizando, para tanto, a pesquisa bibliográfica, documental e descritiva, com abordagem qualitativa, além de elementos de estudo de caso. Os resultados obtidos indicam que, apesar do esforço dos autores na abordagem dos mais variados temas, a metodologia empregada por eles não apresenta diversidade significativa, havendo prevalência dos estudos com abordagem qualitativa e com objetivos exploratórios ou descritivos, o que se constitui em características típicas de pesquisas na área das ciências sociais aplicadas, em que se enquadra a Administração. Por fim, este artigo expõe a amplitude da metodologia científica, apesar de revelar a predileção para a adesão a métodos e técnicas típicas da abordagem qualitativa, confirmando a tendência apontada pela teoria para à área de estudo a que se referem os artigos analisados – a Social aplicada

A experiência de formação em serviço em escolas de um município do interior paulista

Este trabalho tem como foco a formação continuada em serviço, oferecida pelas coordenadoras às professoras do primeiro ano do ensino fundamental, em duas escolas da cidade de São Carlos. Investiga, ainda, a compreensão das coordenadoras acerca das estratégias propostas pela Secretaria Municipal para a implantação da política de ampliação do ensino fundamental para nove anos. Participaram do estudo duas coordenadoras pedagógicas de duas unidades escolares diferentes. Para a coleta de dados foram realizadas entrevistas com as participantes do estudo, buscando compreender de que maneira ocorreu a formação em serviço das professoras de primeiro ano, no período de implantação do programa. Com base nos depoimentos das coordenadoras, pode-se concluir que existiu uma preocupação em ouvir as professoras, consideradas atoras capazes e comprometidas com as reais necessidades dos alunos, a fim de proporcionar maior flexibilidade e maior participação docente nos processos de mudança e tomada de decisões quanto aos currículos

Invasive Candida infection: epidemiology, clinical and therapeutic aspects of an evolving disease and the role of rezafungin

Introduction: Invasive Candida Infections (ICIs) have undergone a series of significant epidemiological, pathophysiological, and clinical changes during the last decades, with a shift toward non-albicans species, an increase in the rate of exogenous infections and clinical manifestations ranging from candidemia to an array of highly invasive and life-threatening clinical syndromes. The long-acting echinocandin rezafungin exhibits potent in-vitro activity against most wild-type and azole-resistant Candida spp. including C. auris. Areas covered: The following topics regarding candidemia only and ICIs were reviewed and addressed: i) pathogenesis; ii) epidemiology and temporal evolution of Candida species; iii) clinical approach; iv) potential role of the novel long-acting rezafungin in the treatment of ICIs. Expert opinion: Authors' expert opinion focused on considering the potential role of rezafungin in the evolving context of ICIs. Rezafungin, which combines a potent in-vitro activity against Candida species, including azole-resistant strains and C. auris, with a low likelihood of drug-drug interactions and a good safety profile, may revolutionize the treatment of candidemia/ICI. Indeed, it may shorten the length of hospital stays when clinical conditions allow and extend outpatient access to treatment of invasive candidiasis, especially when prolonged treatment duration is expected

TECNOLOGIA DA INFORMAÇÃO NO AMBIENTE UNIVERSITÁRIO: UMA CONTRIBUIÇÃO PARA A GESTÃO DO CONHECIMENTO

Um dos papeis relevantes que a tecnologia da informação (TI) exerce na gestão do conhecimento é ampliar o alcance e intensificar a velocidade de transferência da informação e do conhecimento. Porém, vale mencionar que a TI fornece apenas a infra-estrutura necessária à gestão do conhecimento. Em outras palavras, visa oferecer suporte as atividades de geração, codificação ou transferência do conhecimento. O intuito é disponibilizar o conhecimento para todas as pessoas na organização. Nesse sentido, o presente artigo visa discutir como a tecnologia da informação no ambiente universitário pode contribuir para a gestão do conhecimento. Diversas tecnologias têm sido utilizadas para auxiliar a gestão do conhecimento no contexto organizacional, entre elas destacam-se: internet, intranet, extranet, workflow, groupware, gerenciamento eletrônico de documentos, mapas do conhecimento, data mining, data warehousing, entre outras. A esse respeito, sabe-se que esse novo contexto está exigindo das Instituições de Ensino Superior (IES) uma maior responsabilidade no gerenciamento da informação e do conhecimento. Nesse sentido, entende-se que os dirigentes universitários precisam dispor de uma gestão do conhecimento a fim de detectar oportunidades de interação com a sociedade, bem como obter o aumento da vantagem competitiva. Para dar subsídios a essa discussão, optou-se por um artigo de revisão, isto é, será realizada uma pesquisa bibliográfica envolvendo diversos autores

Synthesis and Evaluation of Cytostatic and Antiviral Activities of 3′ and 4′-Avarone Derivatives

A series of 3′ and 4′-substituted avarone derivatives were synthesized and tested in culture systems as antitumour and antiviral agents in comparison to avarol and avarone. 3′-alkylamino derivatives showed potent cytostatic activities against murine L1210 and human B (Raji) and T (C8166, H9) lymphoblast cells (ID50 range 1.7–3.7 μm). Avarol and avarone were six times less active. While none of the derivatives showed anti-human immunodeficiency virus (HIV) activity superior to that of the parent compounds, most of them, avarol and avarone included, were potent and selective inhibitors of poliovirus multiplication