202 research outputs found
Invasive Alien Species in Belgian marine waters: an information platform and checklist for science and policy support
Since 2006, the ‘VLIZ Alien Species Consortium’ has collected data and information on species that were introduced by humans in marine and brackish habitats and have established reproducing populations in the study area. The consortium consists of a network of experts in marine and brackish environments in Belgium, representing more than 22 different institutions and supported by a secretariat hosted at Flanders Marine Institute VLIZ. Evidence on invasiveness is reported for 12 of the 73 alien species that are currently included in the checklist for the study area (October 2014). The network brings together scientific information from distributed sources in a central platform. It is a first step to developing an evidence-based approach to inform environmental policy objectives for Belgian marine waters and support effective measures to address invasive alien species in the study area. The information platform and species checklist are presented, approaches for collection and integration of information are described, and opportunities for collaboration between information systems at different governance levels are briefly discussed
Metrology for MRI Safety
. Magnetic Resonance Imaging (MRI) has become an indispensable medical imaging modality with about 30 million patient exams in the EU every year and an excellent history of safe use. Nevertheless, it is continuously evolving and recent technological developments such as ultrahigh magnetic fields, parallel transmission, or MRI guided radiotherapy promise to significantly enhance the quality and the range of applicability of MRI. A major reason why these technological developments are not yet used in the clinical practice are unresolved safety issues. If the patient risk cannot be quantified reliably, a ‘safety first’ attitude naturally prevails preventing the routine use of new technologies or the scanning of subjects at high risk, e.g. carriers of metallic medical implants. The EMRP joint research project HLT 06 "Metrology for MRI Safety" aimed at providing such risk assessments for certain new developments or applications in MRI. The project was concluded in 2015 and some key results will be presented here
The effectiveness of a fundamental motor skill intervention in pre-schoolers with motor problems depends on gender but not environmental context
This study evaluated the effect of a 10-week fundamental motor skill programme in pre-schoolers with motor problems. Alongside the general effect of the intervention, we also explored possible gender differences and the role of the environmental context (living community, socio-economic status, and recreational space inside/outside the house). The intervention group (n=47; 20 ♂ and 27 ♀) received twenty 60-min motor skill sessions (2 per week) in addition to the regular physical education curriculum for pre-schoolers; the control group (n=46; 21 ♂ and 25 ♀) did not receive additional practice. General motor competence, and locomotor and object control subscales, were assessed before and after the intervention using the Test of Gross Motor Development 2nd edition (TGMD-2). Data regarding environmental factors were gathered through a questionnaire. A Group×Gender×Time ANOVA revealed that the intervention group benefited significantly from the intervention and scored better than the control group at the post-test for general motor competence and both sub-categories (locomotor and object control skill). Moreover, the intervention programme was found to be effective in helping 49% of the intervention group to achieve an average motor skill level, according to the TGMD-2 norms, while a further decline in motor competence was observed in the control group. Interestingly, the effect appeared to be gender-specific, since object control skill improved only in girls of the intervention group. Considering the environmental context, none of the above-mentioned factors was found to have an influence on the effectiveness of the intervention. The present study highlights the need for an early motor skill programme with a gender-specific approach in order to help low skilled boys and girls master a diverse set of motor skills
Outcomes of the International Oceanographic Data and Information Exchange Ocean Biogeographic Information System OBIS-Event-Data Workshop on Animal Tagging and Tracking
The Ocean Biogeographic Information System (OBIS) began in 2000 as the repository for data from the Census of Marine Life. Since that time, OBIS has expanded its goals beyond simply hosting data to supporting more aspects of marine conservation (Pooter et al. 2017). In order to accomplish those goals, the OBIS secretariat in partnership with its European node (EurOBIS) hosted at the Flanders Marine Institute (VLIZ, Belgium), and the Intergovernmental Oceanographic Commission (IOC) Committee on International Oceanographic Data and Information Exchange (IODE, 23rd session, March 2015, Brugge) established a 2-year pilot project to address a particularly problematic issue that environmental data collected as part of marine biological research were being disassociated from the biological data. OBIS-Event-Data is the solution that was developed from that pilot project, which devised a method for keeping environmental data together with the biological data (Pooter et al. 2017). OBIS is seeking early adopters of the new data standard OBIS-Event-Data from among the marine biodiversity monitoring communities, to further validate the data standard, and develop data products and scientific applications to support the enhancement of Biological and Ecosystem Essential Ocean Variables (EOVs) in the framework of the Global Ocean Observing System (GOOS) and the Marine Biodiversity Observation Network of the Group on Earth Observations (GEO BON MBON). After the successful 2-year IODE pilot project OBIS-ENV-DATA, the IOC established a new 2-year IODE pilot project OBIS-Event-Data for Scientific Applications (2017-2019). The OBIS-Event-Data data standard, building on Darwin Core, provides a technical solution for combined biological and environmental data, and incorporates details about sampling methods and effort, including event hierarchy. It also implements standardization of parameters involved in biological, environmental, and sampling details using an international standard controlled vocabulary (British Oceanographic Data Centre Natural Environment Research Council). A workshop organized by IODE/OBIS in April brought together major animal tagging and tracking networks such as the Ocean Tracking Network (OTN), the Animal Telemetry Network (ATN), the Integrated Marine Observing System (IMOS), the European Tracking Network (ETN) and the Acoustic Tracking Array Platform (ATAP) to test the OBIS-Event- Data standard through the development of some data products and science applications. Additionally, this workshop contributes to the further maturation of the GOOS EOV on fish as well as the EOV on birds, mammals and turtles. We will present the outcomes as well as any lessons learned from this workshop on problems, solutions, and applications of using Darwin Core/OBIS-Event-Data for biologging data
Long-Read Sequencing to Unravel Complex Structural Variants of CEP78 Leading to Cone-Rod Dystrophy and Hearing Loss
Inactivating variants as well as a missense variant in the centrosomal CEP78 gene
have been identified in autosomal recessive cone-rod dystrophy with hearing loss
(CRDHL), a rare syndromic inherited retinal disease distinct from Usher syndrome.
Apart from this, a complex structural variant (SV) implicating CEP78 has been reported
in CRDHL. Here we aimed to expand the genetic architecture of typical CRDHL
by the identification of complex SVs of the CEP78 region and characterization of
their underlying mechanisms. Approaches used for the identification of the SVs are
shallow whole-genome sequencing (sWGS) combined with quantitative polymerase
chain reaction (PCR) and long-range PCR, or ExomeDepth analysis on whole-exome
sequencing (WES) data. Targeted or whole-genome nanopore long-read sequencing
(LRS) was used to delineate breakpoint junctions at the nucleotide level. For all SVs
cases, the effect of the SVs on CEP78 expression was assessed using quantitative
PCR on patient-derived RNA. Apart from two novel canonical CEP78 splice variants
and a frameshifting single-nucleotide variant (SNV), two SVs affecting CEP78 were
identified in three unrelated individuals with CRDHL: a heterozygous total gene deletion
of 235 kb and a partial gene deletion of 15 kb in a heterozygous and homozygous
state, respectively. Assessment of the molecular consequences of the SVs on patient’s
materials displayed a loss-of-function effect. Delineation and characterization of the 15-kb deletion using targeted LRS revealed the previously described complex CEP78
SV, suggestive of a recurrent genomic rearrangement. A founder haplotype was
demonstrated for the latter SV in cases of Belgian and British origin, respectively. The
novel 235-kb deletion was delineated using whole-genome LRS. Breakpoint analysis
showed microhomology and pointed to a replication-based underlying mechanism.
Moreover, data mining of bulk and single-cell human and mouse transcriptional datasets,
together with CEP78 immunostaining on human retina, linked the CEP78 expression
domain with its phenotypic manifestations. Overall, this study supports that the CEP78
locus is prone to distinct SVs and that SV analysis should be considered in a genetic
workup of CRDHL. Finally, it demonstrated the power of sWGS and both targeted
and whole-genome LRS in identifying and characterizing complex SVs in patients with
ocular diseases
The merit of high-frequency data in portfolio allocation
This paper addresses the open debate about the usefulness of high-frequency (HF) data in large-scale portfolio allocation. Daily covariances are estimated based on HF data of the S&P 500 universe employing a blocked realized kernel estimator. We propose forecasting covariance matrices using a multi-scale spectral decomposition where volatilities, correlation eigenvalues and eigenvectors evolve on different frequencies. In an extensive out-of-sample forecasting study, we show that the proposed approach yields less risky and more diversified portfolio allocations as prevailing methods employing daily data. These performance gains hold over longer horizons than previous studies have shown
Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample
We obtained conclusive linkage of Alzheimer disease (AD) with a candidate region of 19.7 cM at 7q36 in an extended multiplex family, family 1270, ascertained in a population-based study of early-onset AD in the northern Netherlands. Single-nucleotide polymorphism and haplotype association analyses of a Dutch patient-control sample further supported the linkage at 7q36. In addition, we identified a shared haplotype at 7q36 between family 1270 and three of six multiplex AD-affected families from the same geographical region, which is indicative of a founder effect and defines a priority region of 9.3 cM. Mutation analysis of coding exons of 29 candidate genes identified one linked synonymous mutation, g.38030G-->C in exon 10, that affected codon 626 of the PAX transactivation domain interacting protein gene (PAXIP1). It remains to be determined whether PAXIP1 has a functional role in the expression of AD in family 1270 or whether another mutation at this locus explains the observed linkage and sharing. Together, our linkage data from the informative family 1270 and the association data in the population-based early-onset AD patient-control sample strongly support the identification of a novel AD locus at 7q36 and re-emphasize the genetic heterogeneity of AD
Pensamiento crítico en estudiantes del Grado de Educación Social
El presente artículo se centra en una investigación cualitativa sobre las creencias acerca del pensamiento crítico que poseen 72 estudiantes de tercer curso del Grado de Educación Social de la Universidad de Huelva (España). Los resultados, en consonancia con otras investigaciones, muestran que el alumnado tiene un conocimiento poco detallado aunque certero de lo que significa dicha competencia, ofreciendo explicaciones generales que van en acuerdo con las ideas que tienen acerca de la Universidad, la Sociedad y la finalidad de la Educación Social. La buena disposición que muestra la mayoría del alumnado investigado choca con escasos hábitos para el pensamiento crítico, achacándolo a una formación reproductiva, a la influencia perniciosa de determinados poderes sociales y a un no-saber-hacer-y-actuar de los futuros educadores sociales.This article focuses on qualitative research on the beliefs about critical thinking held by 72
third year students of the Social Education Degree of the University of Huelva (Spain). The results show that the students have a little detailed but accurate
knowledge of what this competence means, offering general explanations that are in
line with the ideas they have about the University, Society and the purpose of Social
Education. The willingness shown by the majority of the students researched clashes
with scarce habits for critical thinking, blaming it on reproductive training, the pernicious influence of certain social powers and the non-know-how-to-act of future social educators
- …