Current and Prospective of Breast Cancer Biomarkers

Biomarkers have shown great promise over the past decade the process of drug development more effective and have become an integral part of diagnosis of diseases. Biosensors were integrated with biomarker detection and point-of-care detection for signal amplification, high specificity and sensitivity, rapid response time, low cost, simplicity and multi-analytical testing. In order to detect more sensitively, these particular biomarkers have been explored with the possibility of real-time measurements in order to develop simple and compact systems which can analyze complex specimens. Various biosensors including electrochemical biosensors have recently been developed based on disease-specific biomarkers in the diagnosis of cancer disease. The main objective of the book chapter is to review research with new materials/methods in electrochemical biosensing techniques to detection of breast cancer biomarkers and evaluating latest techniques for detection of important analytes in real samples. In this book chapter, the recent development of electrochemical biosensors of breast cancer biomarkers will be reviewed. Furthermore, recent and future trend application of breast cancer biomarkers will be discussed

El Sistema Pergamum en el proceso de toma de decisiones

Objetivo. Esta pesquisa, que versa sobre o sistema Pergamum como ferramenta de apoio ao processo decisório na Biblioteca Central da UFPE, objetivou avaliar como dito sistema atua no âmbito da tomada de decisão nas divisões de aquisição, processo técnico, administração e apoio ao usuário. Trata-se de um estudo de caso, de cunho exploratório, com um universo de 20 bibliotecários. Método. O método utilizado foi baseado em uma abordagem exploratória, que utilizou o questionário como instrumento de coleta de dados, tratados mediante análises qualitativa e quantitativa. Resultados. Os resultados demonstraram que a maioria dos pesquisados aplica as informações do Pergamum no apoio à tomada de decisão e considera que o sistema apóia todas as fases do processo decisório, desde a identificação de problemas até a possível solução. Dentre os módulos do Pergamum utilizados para apoio às decisões, destacaram-se: a consulta, os relatórios e Internet. Os profissionais consideram a interface do software amigável, sentem-se satisfeitos, mas indicam pontos onde o sistema deve melhorar para subsidiar as atividades. Conclusões. Foi concluído que o trabalho contribui com a literatura da área, pois os sistemas de informação, enquanto suporte aos processos decisórios de uma unidade de informação, melhoram a execução das atividades, apóiam as soluções administrativas e aumentam a qualidade dos serviços prestados.Objective. This research, about the Pergamum system as a tool for helping decision process at the Central Library of UFPE, aimed to evaluate how the system operates within the decision making in acquisition, organization of information, administration and user support. It is an exploratory case study, with an universe of 20 librarians. Method. The method used was based on an exploratory approach using the questionnaire as a tool to collect data, processed by qualitative and quantitative analysis. Results. The results showed that the majority of respondents apply the information from Pergamum in supporting decision making and believe that the system supports all stages in the decision process, from the identification of problems to their possible solution. Some modules of Pergamum used to support decisions are: the search, reports and internet. The professionals consider the software interface friendly, feel satisfied, but they indicate points where the system must improve to support the activities. Conclusions. It was concluded that this research contributes to the literature of the area, as long as the information systems support the decision making processes of an information unit, improve the execution of activities, support the administrative solutions and increase the quality of services provided.Objetivo. Esta investigación trata sobre el sistema Pergamum como herramienta de apoyo al proceso de toma de decisiones en la Biblioteca Central de la UFPE; su propósito es evaluar como dicho sistema actúa en el ámbito de la toma de decisiones, en las divisiones de adquisición, proceso técnico, administración y apoyo al usuario. Se trata de un estudio de caso, de cuño exploratório, con un universo de 20 bibliotecarios.Método. El método utilizado se baso en un abordaje exploratório, que utilizó un cuestionario como instrumento de recolección de datos, tratados mediante análisis cualitativa y cuantitativa.Resultados. Los resultados demostraron que la mayoría de los investigados aplica las informaciones del Pergamum en el apoyo a la toma de decisión y considera que el sistema apoya todas las fases del proceso decisivo, desde la identificación de problemas hasta la posible solución. De entre los módulos del Pergamum utilizados para apoyo a las decisiones, se destacaron: la consulta, los informes e Internet. Los profesionales consideran la interfaz del software amigable, se sienten satisfechos, pero indican puntos donde el sistema debe mejorar para subsidiar las actividades.Conclusiones. Se concluye que el trabajo contribuye con la literatura del área, pues los sistemas de información, mientras soporte a los procesos decisivos de una unidad de información, mejoran la ejecución de las actividades, apoyan las soluciones administrativas y aumentan la calidad de los servicios prestados

Discharge Tube Design For Reciprocating Compressor – How To Do It Right The First Time And Quickly

In order to remain competitive in compressors business by improving quality and reducing launching deadlines, the companies face everyday new challenges related to research and development of compressors. Thus, the application of numerical simulations becomes crucial to design success due to the possibility and viability of virtual models evaluations in most engineering areas. In addition to product optimization, these numerical tools are also capable of provide manufacturing solutions, propose assembly methods and evaluate target deviations due to geometric tolerances and material properties variability. This strategy significantly increases the probability of project success by avoiding redesigns and unanticipated problems during manufacturing and applications (design it right the first time). Furthermore, the union of Finite Element Method and Design for Six Sigma becomes an effective tool which, combined with powerful hardware and numerical resources, allows the development of designs each day more robust. Specifically in this article it will be presented some methods currently used in design of compressors discharge tubes based on finite element models, component robustness analysis, geometric deviations evaluation and even the knowledge about manufacturing, simulating machines and tools used to produce the tubes. The validation of numerical results with experimental data is critical to the credibility of the methodology used

Polyamine, peroxidase activity and total protein content during storage of bird-of-paradise

The present study was aimed to the determination of the effect of storage on some biochemical characteristics (PAs content, POX activity and total protein content) of flower tissue of bird-of-paradise. Flowers were selected and labeled, avoiding any mechanical damage, and randomly distributed in recipients for two postharvest trials. In the first experiment, flowers were placed in recipients containing tap water and stored in a cold room, at 7.5 \ubaC and 90 % RH, for a period of 12 days. In experiment 2, flowers were stored in room temperature for a period of 6 days. For biochemical characteristics, samples (sepals, petals, stems and bracts) from experiment 1 were collected at 0, 4, 8 and 12 days, and at 0, 2, 4 and 6 days for experiment 2. Results showed that flower bracts, stored at 7.5 \ub0C, presented a lower content of PAs (Put and Spd), when compared to samples stored at room temperature. In both experiments, a high content of PAs (Spm) was observed in flower tissues in relation to Put and Spd. An increase of POX activity was observed in sepals stored in the cold, and was related to PAs degradation during senescence. No differences in total protein content were observed between the two treatments. The present study provides numeric results on changes in level of PAs, POX activity and total protein during postharvest of bird-of-paradise