Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety

Functional magnetic resonance imaging studies (fMRI) have transformed our understanding of central processing of evoked pain but the typically used block and event-related designs are not best suited to the study of ongoing pain. Here we used arterial spin labelling (ASL) for cerebral blood flow mapping to characterise the neural correlates of perceived intensity of osteoarthritis (OA) pain and its interrelation with negative affect. Twenty-six patients with painful knee OA and twenty-seven healthy controls underwent pain phenotyping and ASL MRI at 3T. Intensity of OA pain correlated positively with blood flow in the anterior mid-cingulate cortex (aMCC), subgenual cingulate cortex (sgACC), bilateral hippocampi, bilateral amygdala, left central operculum, mid-insula, putamen and the brainstem. Additional control for trait anxiety scores reduced the pain-CBF association to the aMCC, whilst pain catastrophizing scores only explained some of the limbic correlations. In conclusion, we found that neural correlates of reported intensity of ongoing chronic pain intensity mapped to limbic-affective circuits, and that the association pattern apart from aMCC was explained by trait anxiety thus highlighting the importance of aversiveness in the experience of clinical pain

Denomination and primary education in the Netherlands (1870-1984): a spatial diffusion perspectice

Examining board: Claudius Gellert, Munich University (supervisor) ; Herman van der Wusten, University of Amsterdam ; Hans Daalder, Leiden University ; Ian Budge, University of Essex ; Stefano Bartolini, Università degli Studi di FirenzeDefence date: 24 February 198

Education as a verzuiling phenomenon : public and independent education in the Netherlands

Digitised version produced by the EUI Library and made available online in 2020

Neurobiological mechanisms of treatment resistant depression : functional, structural and molecular imaging studies.

This thesis investigated the neurobiological mechanisms of TRD using functional, structural and molecular imaging studies. First the neurobiological mechanisms of MDD were investigated and revealed decreased functional connectivity between the ventral and dorsal network. Thereafter, structural connectivity analyses of the uncinate fasciculus showed decreased integrity of this white matter tract in MDD patients. These structural abnormalities were negatively associated with the functional connectivity between the subgenual ACC and medial temporal lobe in MDD patients which suggests that structural abnormalities may lead to functional abnormalities. Regarding TRD, this thesis showed that TRD patients are characterized by a specific decreased functional connectivity between neurocognitive networks relative to both non-TRD and healthy controls. Furthermore, a preliminary [123I]IBZM SPECT study showed no difference in striatal D2/3R availability between TRD patients and healthy controls which suggests TRD is not characterized by altered dopaminergic transmission. Furthermore, this thesis showed that resting state DMN connectivity is a predictive marker for the clinical response to nucleus accumbens DBS in severe TRD patients. These findings together suggests that MDD is characterized by a pathological interaction between the dorsal and ventral network which corroborates the limbic-cortical dysregulation model. TRD is specifically characterized by abnormal network interaction between two neurocognitive networks; the cognitive control network and default mode network. Future work should perform longitudinal analyses to determine how functional connectivity of neural networks evolves over time, and to develop a general definition of TRD preferably for different stages of the disease

Acrylonitril: Overzicht van de verschillende processen

Document(en) uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science