1,106 research outputs found
Varicella-zoster virus infections in immunocompromised patients - a single centre 6-years analysis
Background: Infection with varicella-zoster virus (VZV) contemporaneously with malignant disease or immunosuppression represents a particular challenge and requires individualized decisions and treatment. Although the increasing use of varicella-vaccines in the general population and rapid initiation of VZVimmunoglobulins and acyclovir in case of exposure has been beneficial for some patients, immunocompromised individuals are still at risk for unfavourable courses. Methods: In this single center, 6-year analysis we review incidence, hospitalization and complication rates of VZVinfections in our center and compare them to published data. Furthermore, we report three instructive cases. Results: Hospitalization rate of referred children with VZV-infections was 45%, among these 17% with malignancies and 9% under immunosuppressive therapy. Rate of complications was not elevated in these two high-risk cohorts, but one ALL-patient died due to VZV-related complications. We report one 4-year old boy with initial diagnosis of acute lymphoblastic leukemia who showed a rapidly fatal outcome of his simultaneous varicella-infection, one 1.8-year old boy with an identical situation but a mild course of his disease, and an 8.5-year old boy with a steroiddependent nephrotic syndrome. This boy developed severe hepatic involvement during his varicella-infection but responded to immediate withdrawl of steroids and administration of acyclovir plus single-dose cidofovir after nonresponse to acyclovir after 48 h. Conclusion: Our data show that patients with malignant diseases or immunosuppressive therapy should be hospitalized and treated immediately with antiviral agents. Despite these measures the course of VZV-infections can be highly variable in these patients. We discuss aids to individual decision-making for these difficult situations
Search for Dark Matter Annihilation in the Galactic Center with IceCube-79
The Milky Way is expected to be embedded in a halo of dark matter particles,
with the highest density in the central region, and decreasing density with the
halo-centric radius. Dark matter might be indirectly detectable at Earth
through a flux of stable particles generated in dark matter annihilations and
peaked in the direction of the Galactic Center. We present a search for an
excess flux of muon (anti-) neutrinos from dark matter annihilation in the
Galactic Center using the cubic-kilometer-sized IceCube neutrino detector at
the South Pole. There, the Galactic Center is always seen above the horizon.
Thus, new and dedicated veto techniques against atmospheric muons are required
to make the southern hemisphere accessible for IceCube. We used 319.7 live-days
of data from IceCube operating in its 79-string configuration during 2010 and
2011. No neutrino excess was found and the final result is compatible with the
background. We present upper limits on the self-annihilation cross-section,
\left, for WIMP masses ranging from 30 GeV up to
10 TeV, assuming cuspy (NFW) and flat-cored (Burkert) dark matter halo
profiles, reaching down to cm s, and
cm s for the
channel, respectively.Comment: 14 pages, 9 figures, Submitted to EPJ-C, added references, extended
limit overvie
An All-Sky Search for Three Flavors of Neutrinos from Gamma-Ray Bursts with the IceCube Neutrino Observatory
We present the results and methodology of a search for neutrinos produced in
the decay of charged pions created in interactions between protons and
gamma-rays during the prompt emission of 807 gamma-ray bursts (GRBs) over the
entire sky. This three-year search is the first in IceCube for shower-like
Cherenkov light patterns from electron, muon, and tau neutrinos correlated with
GRBs. We detect five low-significance events correlated with five GRBs. These
events are consistent with the background expectation from atmospheric muons
and neutrinos. The results of this search in combination with those of
IceCube's four years of searches for track-like Cherenkov light patterns from
muon neutrinos correlated with Northern-Hemisphere GRBs produce limits that
tightly constrain current models of neutrino and ultra high energy cosmic ray
production in GRB fireballs.Comment: 33 pages, 14 figures; minor changes made to match published version
in the Astrophysical Journal, 2016 June 2
The IceCube Neutrino Observatory - Contributions to ICRC 2015 Part II: Atmospheric and Astrophysical Diffuse Neutrino Searches of All Flavors
Papers on atmospheric and astrophysical diffuse neutrino searches of all
flavors submitted to the 34th International Cosmic Ray Conference (ICRC 2015,
The Hague) by the IceCube Collaboration.Comment: 66 pages, 36 figures, Papers submitted to the 34th International
Cosmic Ray Conference, The Hague 2015, v2 has a corrected author lis
Search for non-relativistic Magnetic Monopoles with IceCube
The IceCube Neutrino Observatory is a large Cherenkov detector instrumenting
of Antarctic ice. The detector can be used to search for
signatures of particle physics beyond the Standard Model. Here, we describe the
search for non-relativistic, magnetic monopoles as remnants of the GUT (Grand
Unified Theory) era shortly after the Big Bang. These monopoles may catalyze
the decay of nucleons via the Rubakov-Callan effect with a cross section
suggested to be in the range of to
. In IceCube, the Cherenkov light from nucleon decays
along the monopole trajectory would produce a characteristic hit pattern. This
paper presents the results of an analysis of first data taken from May 2011
until May 2012 with a dedicated slow-particle trigger for DeepCore, a
subdetector of IceCube. A second analysis provides better sensitivity for the
brightest non-relativistic monopoles using data taken from May 2009 until May
2010. In both analyses no monopole signal was observed. For catalysis cross
sections of the flux of non-relativistic
GUT monopoles is constrained up to a level of at a 90% confidence level,
which is three orders of magnitude below the Parker bound. The limits assume a
dominant decay of the proton into a positron and a neutral pion. These results
improve the current best experimental limits by one to two orders of magnitude,
for a wide range of assumed speeds and catalysis cross sections.Comment: 20 pages, 20 figure
Improved limits on dark matter annihilation in the Sun with the 79-string IceCube detector and implications for supersymmetry
We present an improved event-level likelihood formalism for including
neutrino telescope data in global fits to new physics. We derive limits on
spin-dependent dark matter-proton scattering by employing the new formalism in
a re-analysis of data from the 79-string IceCube search for dark matter
annihilation in the Sun, including explicit energy information for each event.
The new analysis excludes a number of models in the weak-scale minimal
supersymmetric standard model (MSSM) for the first time. This work is
accompanied by the public release of the 79-string IceCube data, as well as an
associated computer code for applying the new likelihood to arbitrary dark
matter models.Comment: 24 pages, 8 figs, 1 table. Contact authors: Pat Scott & Matthias
Danninger. Likelihood tool available at http://nulike.hepforge.org. v2: small
updates to address JCAP referee repor
A combined maximum-likelihood analysis of the high-energy astrophysical neutrino flux measured with IceCube
Evidence for an extraterrestrial flux of high-energy neutrinos has now been
found in multiple searches with the IceCube detector. The first solid evidence
was provided by a search for neutrino events with deposited energies
TeV and interaction vertices inside the instrumented volume. Recent
analyses suggest that the extraterrestrial flux extends to lower energies and
is also visible with throughgoing, -induced tracks from the Northern
hemisphere. Here, we combine the results from six different IceCube searches
for astrophysical neutrinos in a maximum-likelihood analysis. The combined
event sample features high-statistics samples of shower-like and track-like
events. The data are fit in up to three observables: energy, zenith angle and
event topology. Assuming the astrophysical neutrino flux to be isotropic and to
consist of equal flavors at Earth, the all-flavor spectrum with neutrino
energies between 25 TeV and 2.8 PeV is well described by an unbroken power law
with best-fit spectral index and a flux at 100 TeV of
.
Under the same assumptions, an unbroken power law with index is disfavored
with a significance of 3.8 () with respect to the best
fit. This significance is reduced to 2.1 () if instead we
compare the best fit to a spectrum with index that has an exponential
cut-off at high energies. Allowing the electron neutrino flux to deviate from
the other two flavors, we find a fraction of at Earth.
The sole production of electron neutrinos, which would be characteristic of
neutron-decay dominated sources, is rejected with a significance of 3.6
().Comment: 16 pages, 10 figures; accepted for publication in The Astrophysical
Journal; updated one referenc
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