Evaluation of infertility

The most important goal of fertility investigation is to identify the cause(s) of infertility and to prescribe adequate therapy. The couple should be treated as a single unit as each partner contributes a share to the infertility potential of the couple. Evaluation should begin with the taking of a detailed history and a complete physical examination of both partners, which may point the investigation in a particular direction. However, other pertinent fertility factors should not be overlooked. A standardized and comprehensive approach to the investigation of infertility is proposed and is presented as a series of flow chart

Managing variability in decision making in swine growing-finishing units

peer-reviewedAnalysis of data collected from pig farms may be useful to understand factors affecting pig health and productive performance. However, obtaining these data and drawing conclusions from them can be done at different levels and presents several challenges. In the present study, information from 688 batches of growing-finishing (GF) pigs (average initial and final body weight of 19.1 and 108.5 kg respectively) from 404 GF farms integrated in 7 companies was obtained between July 2008 and July 2010 in Spain by survey. Management and facility factors associated with feed conversion ratio (FCR) and mortality were studied by multiple linear regression analysis in each single company (A to G) and in an overall database (OD). Factors studied were geographic location of the farm, trimester the pigs entered the farm, breed of sire and sex segregation in pens (BREGENSEG), use of circovirus vaccine, number of origins the pigs were obtained from, age of the farm, percentage of slatted floor, type of feeder, drinker and ventilation, number of phases and form of feed, antibiotic administration system, water source, and number and initial weight of pigs. Results In two or more companies studied and/or in OD, the trimester when pigs were placed in the farm, BREGENSEG, number of origins of the pigs, age of the farm and initial body weight were factors associated with FCR. Regarding mortality, trimester of placement, number of origins of the pigs, water source in the farm, number of pigs placed and the initial body weight were relevant factors. Age of the farm, antibiotic administration system, and water source were only provided by some of the studied companies and were not included in the OD model, however, when analyzed in particular companies these three variables had an important effect and may be variables of interest in companies that do not record them. Conclusions Analysing data collected from farms at different levels helps better understand factors associated with productive performance of pig herds. Out of the studied factors trimester of placement and number of origins of the pigs were the most relevant factors associated with FCR and mortality.This research was supported by the Spanish Ministerio de Ciencia e Innovación (project AGL2011-29960). We also thank the Agencia Española de Cooperación Internacional para el Desarrollo (MAEC-AECID) for research fellowship

Evaluation of infertility

The most important goal of fertility investigation is to identify the cause(s) of infertility and to prescribe adequate therapy. The couple should be treated as a single unit as each partner contributes a share to the infertility potential of the couple. Evaluation should begin with the taking of a detailed history and a complete physical examination of both partners, which may point the investigation in a particular direction. However, other pertinent fertility factors should not be overlooked. A standardized and comprehensive approach to the investigation of infertility is proposed and is presented as a series of flow chart

Distributional pattern of Sardinian orchids under a climate change scenario

The Mediterranean is one of the major biodiversity hotspots of the world. It has been identified as the “core” of the speciation process for many groups of organisms. It hosts an impressive number of species, many of which are classified as endangered taxa. Climate change in such a diverse context could heavily influence community composition, reducing ecosystems resistance and resilience. This study aims at depicting the distribution of nine orchid species in the island of Sardinia (Italy), and at forecasting their future distribution in consequence of climate change. The models were produced by following an “ensemble” approach. We analysed present and future (2070) niche for the nine species, using Land Use and Soil Type, as well as 8 bioclimatic variables as predictors, selected because of their influence on the fitness of these orchids. Climate change in the next years, at Mediterranean latitudes, is predicted to results mainly in an increase of temperature and a decrease of precipitation. In 2070, the general trend for almost all modelled taxa is the widening of the suitable areas. However, not always the newly gained areas have high probability of presence. A correct interpretation of environmental changes is needed for developing effective conservation strategies

Multiphysics simulation of corona discharge induced ionic wind

Ionic wind devices or electrostatic fluid accelerators are becoming of increasing interest as tools for thermal management, in particular for semiconductor devices. In this work, we present a numerical model for predicting the performance of such devices, whose main benefit is the ability to accurately predict the amount of charge injected at the corona electrode. Our multiphysics numerical model consists of a highly nonlinear strongly coupled set of PDEs including the Navier-Stokes equations for fluid flow, Poisson's equation for electrostatic potential, charge continuity and heat transfer equations. To solve this system we employ a staggered solution algorithm that generalizes Gummel's algorithm for charge transport in semiconductors. Predictions of our simulations are validated by comparison with experimental measurements and are shown to closely match. Finally, our simulation tool is used to estimate the effectiveness of the design of an electrohydrodynamic cooling apparatus for power electronics applications.Comment: 24 pages, 17 figure

Effects of hyaluronic acid injections on pain and functioning in patients affected by tendinopathies: a narrative review

BACKGROUND: Tendinopathies are overuse tendon injuries showing load-dependant pain, stiffness, weakness of movement in the affected area, and impairment in the movements. The scientific interest on the role of Hyaluronic Acid (HA) for the management of tendinopathies has been increased due to its anti-inflammatory and lubricative properties. OBJECTIVE: To collect evidence regarding the effectiveness and safety of HA injections in reducing pain in patients affected by tendinopathies. METHODS: A scientific literature search was conducted using the PubMed, Medline and PEDro electronic databases. The databases were searched since their inception until July 2021. The search was limited to English language articles. Different combinations of the terms and MeSH terms 'tendinopathy', 'tendinosis', 'tendinitis', 'hyaluronic acid', 'hyaluronate', 'infiltration', 'hyaluronic injections', 'viscosupplementation' connected with various boolean operators were used for other electronic databases. RESULTS: One hundred and one records were identified from the selected databases plus three additional papers identified by the authors through other sources. After removing duplicated papers and title/abstract screening, 19 studies were included in our review (eight papers on shoulder, three on elbow, four on hand, one on knee, and three on ankle). CONCLUSION: The results showed that none of the studies report severe adverse effects and most of them support the use of HA injections in tendinopathies, with a special attention to pain reduction and functional assessment. Further studies are warranted to better investigate effects and methods of administration of HA in tendinopathies

Oxygen–ozone therapy in the rehabilitation field: state of the art on mechanisms of action, safety and effectiveness in patients with musculoskeletal disorders

In recent years, the interest in oxygen–ozone (O2O3) therapy application has considerably increased in the field of rehabilitation. Despite its widespread use in common clinical practice, the biochemical effects of O2O3 are still far from being understood, although its chemical properties seem to play a pivotal role in exerting its positive effects on different pathological conditions. Indeed, the effectiveness of O2O3 therapy might be partly due to the moderate oxidative stress produced by O3 interactions with biological components. O2O3 therapy is widely used as an adjuvant therapeutic option in several pathological conditions characterized by chronic inflammatory processes and immune over‐activation, and most musculoskeletal disorders share these pathophysiological processes. The present comprehensive review depicts the state‐of‐the‐art on the mechanisms of action, safety and effectiveness of O2O3 therapy in the complex scenario of the management of musculoskeletal disorders. Taken together, our findings suggest that O2O3 therapy seems to reduce pain and improve functioning in patients affected by low back pain and knee osteoarthritis, as reported by several studies in the literature. However, to date, further studies are warranted to clearly investigate the therapeutic effects of this promising therapy on other musculoskeletal disorders in the field of rehabilitation

Effect of virtual reality rehabilitation on functional outcomes for return-to-work patients with Parkinson's disease: an umbrella review of systematic reviews

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of substantia nigra neurons with deficiency of dopamine. The main symptoms are tremor, rigidity and bradykinesia. Rehabilitation has an important role in the treatment of this condition and virtual reality (VR) is one of the most recent tools. OBJECTIVE: The purpose of this umbrella review is to evaluate the effectiveness of VR systems on gait control for return to work in patients with PD. METHODS: The electronic search, for reviews and meta-analysis studies that investigated the effectiveness of VR on gait control in PD patients, was performed through December 2021 using the following databases: PubMed, Scopus, PEDro, and Google Scholar. Mesh terms used were: Job integration/reintegration OR return-to-work AND Parkinson's disease AND virtual reality OR exergame. No limit on the year of publication of the article was used. CONCLUSIONS: A total of 14 articles were included in our analysis. The included evidence shows a stride length improvement in patients treated with VR compared to conventional active treatments. No difference was found in walking speed. Also, the included articles show an improvement on various measures of balance, motor function and severity of PD motor symptoms. In addition, the literature shows an improvement in the quality of life and neuropsychiatric symptoms in patients undergoing VR rehabilitation training. RESULTS: he results of our study suggest that VR rehabilitation improves gait performance, particularly stride length, thus being able to provide an improvement in the quality of life and a more effective return to work training in patients with PD