Condicionamento Fisiológico De Sementes De Soja, Componentes De Produção E Produtividade

The Soybean crop is extremely relevant to the Brazilian economy. Priming is a technique that allows improvement of seed quality, especially those of low vigor. Vigor is defined as the ability of the seed to perform adequately when exposed to different environmental conditions. High vigor seeds generate plants with higher emergency speed and superior yield components, favoring into a higher seed yield. The objective of this work was to evaluate the agronomic behavior of soybean plants under field conditions originated from primed seeds with different level of vigor. Yield components and soybean yield were also evaluated. Seed priming in seed with medium vigor positively influences the components (seedling emergence, first pod height, number pods/plant, number of seeds/plant, number of seeds/ pod) and favored productivity of soybean cultivar ‘M7211RR’. Different levels of vigor of soybean seeds cause differences in the number of pods/plant. © 2015, Universidade Federal de Santa Maria. All Rights Reserved.46222723

Nongenotoxic Effects And A Reduction Of The Dxr-induced Genotoxic Effects Of Helianthus Annuus Linné (sunflower) Seeds Revealed By Micronucleus Assays In Mouse Bone Marrow

Background: This research evaluated the genotoxicity of oil and tincture of H. annuus L. seeds using the micronucleus assay in bone marrow of mice. The interaction between these preparations and the genotoxic effects of doxorubicin (DXR) was also analysed (antigenotoxicity test) .Methods: Experimental groups were evaluated at 24-48 h post treatment with N-Nitroso-N-ethylurea (positive control - NEU), DXR (chemotherapeutic), NaCl (negative control), a sunflower tincture (THALS) and two sources of sunflower oils (POHALS and FOHALS). Antigenotoxic assays were carried out using the sunflower tincture and oils separately and in combination with NUE or DXR. Results: For THALS, analysis of the MNPCEs showed no significant differences between treatment doses (250-2,000 mg.Kg-1) and NaCl. A significant reduction in MNPCE was observed when THALS (2,000 mg.Kg-1) was administered in combination with DXR (5 mg.Kg-1). For POHALS or FOHALS, analysis of the MNPCEs also showed no significant differences between treatment doses (250-2,000 mg.Kg-1) and NaCl. However, the combination DXR + POHALS (2,000 mg.Kg-1) or DXR + FOHALS (2,000 mg.Kg-1) not contributed to the MNPCEs reduction. Conclusions: This research suggests absence of genotoxicity of THALS, dose-, time- and sex-independent, and its combination with DXR can reduce the genotoxic effects of DXR. POHALS and FOHALS also showed absence of genotoxicity, but their association with DXR showed no antigenotoxic effects. © 2014 Boriollo et al.; licensee BioMed Central Ltd.14Sunflowers: Helianthus (Compositae-Heliantheae) (1976) Evolution of Crop Plants, pp. 36-38. , London: Longmans Green, Simmonds NW, Heiser CBEarle, F.R., Vanetten, C.H., Clark, T.F., Wolff, I.A., Compositional data on sunflower seed (1968) J Am Oil Chem Soc, 45, pp. 876-879Salunkhe, D.K., Chavan, J.K., Adsule, R.N., Kadam, S.S., World Oilseeds: Chemistry, Technology and Utilization (1992) Sunflower, , New York: Van Nostrand ReinholdGonzáles-Pérez, S., Vereijken, J.M., Sunflower proteins: Overview of their physicochemical, structural and functional properties (2007) J Sci Food Agric, 87, pp. 2173-2191Warner, K.A., Mounts, T.L., List, G.V.R., Effects of added tocopherols on the flavor stability of purified vegetable oils (1990) Inform, 1, p. 326Ito, T., Tamura, T., Matsumoto, T., Sterol Composition of 19 vegetable oils (1973) J Am Oil Chem Soc, 50, pp. 122-125. , 10.1007/BF02633564, 4707293Trost, V.W., Characterization of corn oil, soybean oil and sunflower oil nonpolar material (1989) J Am Oil Chem Soc, 66, pp. 325-333Dupont, H.L., Sullivan, P., Evans, D.G., Vollet, J.J., Ericsson, C.D., Ackerman, P.B., Tjoa, W.S., Prevention of traveler's diarrhea (emporiatric enteritis). Prophylactic administration of subsalicylate bismuth (1980) JAMA, 243, pp. 237-241. , 10.1001/jama.1980.03300290019013, 6985681Cowan, J.C., Key factors and recent advances in the flavor stability of soybean oil (1966) J Am Oil Chem Soc, 43, pp. 300A-302A. , 318A, 320, 10.1007/BF02682424, 5328054Bierenbaum, M.L., Fleischman, A.I., Dun, J., Arnold, J., Possible toxic waste factor in coronary heart disease (1975) Lancet, 1, pp. 1008-1010Purves, D., Harvey, C., Tweats, D., Lumley, C.E., Genotoxity testing: current practices and strategies used by the pharmaceutical industry (1995) Mutagenesis, 10, pp. 297-312. , 10.1093/mutage/10.4.297, 7476265Varanda, E.A., Atividade mutagênica de plantas medicinais (2006) Rev Ciênc Farm Básica Apl, 27, pp. 1-7Mateuca, R., Lombaert, N., Aka, P.V., Decordier, I., Kirsch-Volders, M., Chromosomal changes: induction, detection methods and applicability in human biomonitoring (2006) Biochimie, 88, pp. 1515-1531. , 10.1016/j.biochi.2006.07.004, 16919864Krishna, G., Hayashi, M., In vivo rodent micronucleus assay: protocol, conduct and data interpretation (2000) Mutat Res, 455, pp. 155-166. , 10.1016/S0027-5107(00)00117-2, 11113474(1997) OECD Guideline for the Testing of Chemicals: Bacterial reverse mutation test, p. 471. , Paris, Organisation for Economic Cooperation and Development(1997) OECD Guideline for the Testing of Chemicals: In vitro mammalian chromosome aberration test, p. 473. , Paris, Organisation for Economic Cooperation and Development(1997) OECD Guideline for the Testing of Chemicals: Mammalian erythrocyte micronucleus test, p. 474. , Paris, Organisation for Economic Cooperation and DevelopmentAlves, J.M., Munari, C.C., Neto, M.A.B.M., Furtado, R.A., Senedese, J.M., Bastos, J.K., Tavares, D.C., In vivo protective effect of Copaifera langsdorffii hydroalcoholic extract on micronuclei induction by doxorubicin (2013) J Appl Toxicol, 33, pp. 854-860. , 10.1002/jat.2777, 22611044Indart, A., Viana, M., Clapés, S., Izquierdo, L., Bonet, B., Clastogenic and cytotoxic effects of lipid peroxidation products generated in culinary oils submitted to thermal stress (2007) Food Chem Toxicol, 45, pp. 1963-1967. , 10.1016/j.fct.2007.04.019, 17573172Venkatesh, P., Shantala, B., Jagetia, G.C., Rao, K.K., Baliga, M.S., Modulation of Doxorubicin-Induced Genotoxicity by Aegle marmelos in Mouse Bone Marrow: A Micronucleus Study (2007) Integr Cancer Ther, 6, pp. 42-53. , 10.1177/1534735406298302, 17351026(2010) Farmacopéia Brasileira, Agência Nacional de Vigilância Sanitária - ANVISA/Fundação Oswaldo, , Brasília: Cruz - FIOCRUZ, BrasilSex differences in the micronucleus test (1986) Mutat Res, 172, pp. 151-163. , Collaborative Study Group for the Micronucleus Test (CSGMT)Zambrano, M.A., Targa, H.J., Rabello-Gay, M.N., Physiological saline solutions as a useful tool in micronucleus and metaphase slide preparations (1982) Stain Technol, 57, pp. 48-49Lewi, D.M., Hopp, H.E., Escandon, A.S., Sunflower (Helianthus annuus L.) (2006) Methods Mol Biol, 343, pp. 291-297Heo, J.C., Woo, S.U.K., Kweon, M.A., Park, J.Y., Lee, H.K., Son, M., Rho, J.R., Lee, S.H., Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo (2008) Int J Mol Med Chem, 21, pp. 57-61Cardoso, C.C., Rodrigues, K.L., Pichara, N.L., Dall'Aglio, R., Fiorini, J.E., Fraschini, F., Diana, G.M., Carvalho, J.C.T., Olio di girasole ozonizzato associate ad acido α-lipoico e a lattobacilli: studio pre-clinico dell'azione antiulcerosa, antinfiammatoria e antibatterica (2004) Farmaci, 28, pp. 97-110Ricardo, G.A., Zullyt, Z.R., Yilian, L., Hernández, F., Menéndez, S., Efecto del OLEOZON® frente a lesiones gástricas inducidas por indometacina en ratas (Effect of OLEOZON® on gastric lesions induced by indomethacin in rats) (2007) Revista electrónica de Veterinaria, 8, pp. 1-6Rodrigues, K.L., Cardoso, C.C., Caputo, L.R., Carvalho, J.C., Fiorini, J.E., Schneedorf, J.M., Cicatrizing and antimicrobial properties of an ozonised oil from sunflower seeds (2004) Inflammopharmacology, 3, pp. 261-270Akihisa, T., Yasukawa, K., Oinuma, H., Kasahara, Y., Kimura, Y., Takase, S., Yamanouchi, S., Tamura, T., Triterpene alcohols from the flowers of Compositae and their anti-inflammatory effects (1996) Phytochemistry, 43, pp. 1255-1260. , 10.1016/S0031-9422(96)00343-3, 8987908Rojas-Molina, M., Campos-Sanches, J., Analla, M., Serrano, M., Moraga, A.A., Genotoxicity of vegetable cooking oils in the Drosophila wing spot test (2005) Environ Mol Mutagen, 45, pp. 90-95. , 10.1002/em.20078, 15611939Montero, A.C.R., Carvajal, Y.G., Rodríguez, Z.Z., López, G.F., Mirabal, J.M., Evaluación genotóxica del OLEOZON mediante los ensayos de micronúcleos en medula ósea y sangre periférica de ratón (1998) Revista CENIC: Ciências Biológicas, 29, pp. 200-202Salerno, J.W., Smith, D.E., The use of sesame oil and other vegetable oils in the inhibition of human colon cancer growth in vitro (1991) Anticancer Res, 11, pp. 209-215Cognault, S., Jourdan, M.L., Germain, E., Pitavy, R., Morel, E., Durand, G., Bougnoux, P., Lhuillery, C., Effect of an m-linolenic acid-rich diet on rat mammary tumour growth depends on the dietary oxidative status (2000) Nutr Cancer, 36, pp. 33-41. , 10.1207/S15327914NC3601_6, 10798214Nakayama, M., Ju, H.R., Sugano, M., Hirose, N., Ueki, T., Doi, F., Eynard, A.R., Effect of dietary fat and cholesterol on dimethylbenz [a]-antracene-induced mammary tumorigenesis in Sprague-Dawley rats (1993) Anticancer Res, 13, pp. 691-698La Vecchia, C., Negri, E., Franceschi, S., Decarli, A., Giacosa, A., Lipworth, L., Olive oil, other dietary fats, and the risk of breast cancer (Italy) (1995) Cancer Cause Control, 6, pp. 545-550Rao, G.N., Ney, E., Herbert, R.A., Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogen (2000) Breast Cancer Res, 64, pp. 287-296Burns, C.P., Luttenegger, D.G., Specctor, A.A., Effect of dietary fat saturation on survival of mice with L1210 Leukemia (1978) J Natl Cancer Inst, 61, pp. 513-515Bartsch, H., Nai, J., Owen, R.W., Dietary polyunsaturated fatty acids and cancer of the breast and colorectum: emerging evidence for their role as risk modifiers (1999) Carcinogenesis, 20, pp. 2209-2218. , 10.1093/carcin/20.12.2209, 10590211Boovens, J., Engelbrecht, P., Le Roux, S., Louwrens, C.C., Van der Merwe, C.F., Katzeff, I.E., Some effects of the essential fatty acids linoleic acid and alpha-Linolenic acid and of their metabolites gamma-Linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahesaenoic acid, and of prostaglandins A1 and E1 in the proliferation of human osteogenic sarcoma cells in culture (1984) Prostaglandins Leukot Med, 15, pp. 15-33. , 10.1016/0262-1746(84)90053-2, 6089235Johanning, G.L., Lin, T.Z., Unsaturated fatty acid effects on human breast cancer cell adhesion (1995) Nutr Cancer, 24, pp. 57-66. , 10.1080/01635589509514393, 7491298Newcomer, L.M., King, I.B., Wicklund, K.G., Stanford, J.L., The association of fatty acids with prostate cancer risk (2001) Prostate, 47, pp. 262-268. , 10.1002/pros.1070, 11398173Iwado, H., Naito, M., Hayatsu, H., Genotoxicity and antigenotoxicity of air-borne particulates (1991) Mutat Res, 246, pp. 93-103. , 10.1016/0027-5107(91)90110-A, 1986270Siegel, I., Liu, T.L., Yaghoubzadeh, E., Keskey, T.S., Gleicher, N., Cytotoxic effects of free fatty acids on ascites tumor cells (1987) J Natl Cancer Inst Monographs, 78, pp. 271-277Bégin, L.R., Clement, P.B., Kirk, M.E., Jothy, S., McCaughey, W.T., Ferenczy, A., Aggressive angiomyxoma of pelvic soft parts: a clinicopathologic study of nine cases (1985) Hum Pathol, 16, pp. 621-628. , 10.1016/S0046-8177(85)80112-X, 3997139Ramon, J.M., Bou, R., Romea, S., Alkiza, M.E., Jacas, M., Ribes, J., Oromi, J., Dietary fat intake and prostate cancer risk: a case-control study in Spain (2000) Cancer Cause Control, 11, pp. 679-685DeFlora, S., Ramel, C., Mechanisms of inhibitors of mutagenesis and carcinogenesis: classification and review (1988) Mutat Res, 202, pp. 285-306. , 10.1016/0027-5107(88)90193-5, 3057362Visioli, F., Bellosta, S., Galli, C., Oleuropein, the bitter principle of olives, enhances nitric-oxide production by mouse macrophages (1998) Life Sci, 62, pp. 541-546. , 10.1016/S0024-3205(97)01150-8, 9464466Santos, J.H., Graf, U., Reguly, M.L., De Andrade, H.H.R., The synergistic effects of vanillin on recombination predominate over its antigenotoxic action in relation to MMC-induced lesions in somatic cells of Drosophila melanogaster (1999) Mutat Res, 444, pp. 355-365. , 10.1016/S1383-5718(99)00101-1, 10521675Weisburger, J.H., Can cancer risks be altered by changing nutritional traditions? (1998) Cancer, 83, pp. 1278-1281. , 10.1002/(SICI)1097-0142(19981001)83:73.0.CO;2-F, 9762926Katiyar, S.K., Mohan, R.R., Agarwal, R., Mukhtar, H., Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols (1997) Carcinogenesis, 18, pp. 497-502. , 10.1093/carcin/18.3.497, 9067548Indart, A., Viana, M., Grootveld, M.C., Silwood, C.J., Sanchez-Vera, I., Bonet, B., Teratogenic actions of thermally-stressed culinary oils in rats (2002) Free Radic Res Commun Commun, 36, pp. 1051-1058Al-Shabanah, O.A., Inhibition of adriamycin-induced micronuclei by desferrioxamine in Swiss albino mice (1993) Mutat Res, 301, pp. 107-111. , 10.1016/0165-7992(93)90032-Q, 7678167Bean, C.L., Armstrong, M.J., Galloway, S.M., Effect of sampling time on chromosome aberration yield for 7 chemicals in Chinese hamster ovary cells (1992) Mutat Res, 265, pp. 31-44. , 10.1016/0027-5107(92)90037-3, 1370241Delvaeye, M., Verovski, V., De Neve, W., Storme, G., DNA breakage, cytotoxicity, drug accumulation and retention in two human ovarian tumor cell lines AZ224 and AZ364 treated with adriamycin, modulated by verapamil (1993) Anticancer Res, 13, pp. 1533-1538Dhawan, A., Kayani, M.A., Parry, J.M., Parry, E., Anderson, D., Aneugenic and clastogenic effects of doxorubicin in human lymphocytes (2003) Mutagenesis, 18, pp. 487-490. , 10.1093/mutage/geg024, 14614182Jagetia, G.C., Nayak, V., Effect of doxorubicin on cell survival and micronuclei formation in HeLa cells exposed to different doses of gamma-radiation (2000) Strahlenther Onkol, 176, pp. 422-428. , 10.1007/PL00002351, 11050916Vidhya, N., Devraj, S.N., Antioxidant effect of eugenol in rat intestine (1999) Ind J Exp Biol, 37, pp. 1192-119

Wilson chains are not thermal reservoirs

Wilson chains, based on a logarithmic discretization of a continuous spectrum, are widely used to model an electronic (or bosonic) bath for Kondo spins and other quantum impurities within the numerical renormalization group method and other numerical approaches. In this short note we point out that Wilson chains can not serve as thermal reservoirs as their temperature changes by a number of order Delta E when a finite amount of energy Delta E is added. This proves that for a large class of non-equilibrium problems they cannot be used to predict the long-time behavior.Comment: 2 page

Todavía se recetan medicamentos potencialmente hepatotóxicos a pacientes con enfermedad hepática que reciben atención terciaria: es hora de decir basta

Introduction and aim: Drug-induced liver injury (DILI) manifests as a spectrum of clinical presentations that carries morbidity and mortality. Patients with chronic liver disease (CLD), particularly hospitalized, are at high risk for developing DILI. We aimed to investigate the use of potentially hepatotoxic drugs (PHD) in patients with CLD in a tertiary university hospital. Materials and methods: Adult (≥ 18 years-old) with CLD admitted to the hospital from January 2016 to December 2018 were evaluated regarding PHD, assessing the risk of DILI and liver enzymes behavior after exposure. Results: From 931 hospitalized patients with CLD, 291 (31.3%) were exposed to hepatotoxic drugs during their hospitalization. Of those, 244 (83.8%) were cirrhotic. The most frequent causes of liver disease were hepatitis C (41.2%), followed by alcohol (13.2%), hepatitis C/alcohol (11.7%) and non-alcoholic fatty liver disease (5.8%). Decompensated cirrhosis (46.7%) was the main reason for hospital admission. The most often prescribed PHD were antibiotics (67.7%), cardiovascular drugs (34.4%), neuromodulators (26.1%) and anesthetics (19.9%). After exposure, 113 patients (38.8%) presented significant elevated liver enzymes. Surprisingly, PHD were more often prescribed in GI/Liver unit (48.8%) followed by emergency/intensive care unit (28.5%). A total of 65 patients (22%) died, however in neither case was it possible to safely infer causal relationship among PHD, liver enzymes and death. Conclusion: PHD prescription is frequent in patients with CLD even in a tertiary university hospital and in the gastroenterology and hepatology department, exposing these patients to an additional risk.Introducción y objetivo: La lesión hepática inducida por fármacos (DILI) se manifiesta como un espectro de presentaciones clínicas que conlleva morbilidad y mortalidad. Los pacientes con enfermedad hepática crónica (EHC), en particular hospitalizados, tienen un alto riesgo de desarrollar DILI. Nuestro objetivo fue investigar el uso de fármacos potencialmente hepatotóxicos (FPH) en pacientes con EHC en un hospital universitario terciario. Materiales y métodos: Se evaluó la expossición a FPH en adultos (≥ 18 años) con EHC ingresados en el hospital entre enero de 2016 y diciembre de 2018, evaluando el riesgo de DILI y el comportamiento de las enzimas hepáticas tras la exposición. Resultados: De 931 pacientes hospitalizados con EHC, 291 (31,3%) estuvieron expuestos a fármacos hepatotóxicos durante su hospitalización. De ellos, 244 (83,8%) eran cirróticos. Las causas más frecuentes de enfermedad hepática fueron la hepatitis C (41,2%), seguida del alcohol (13,2%), la hepatitis C / alcohol (11,7%) y la enfermedad del hígado graso no alcohólico (5,8%). La cirrosis descompensada (46,7%) fue el principal motivo de ingreso hospitalario. Los FPH más prescritos fueron antibióticos (67,7%), fármacos cardiovasculares (34,4%), neuromoduladores (26,1%) y anestésicos (19,9%). Tras la exposición, 113 pacientes (38,8%) presentaron elevación significativa de las enzimas hepáticas. Sorprendentemente, los FPH se prescribieron con mayor frecuencia en la unidad GI / Hígado (48,8%) seguido de la unidad de emergencia / cuidados intensivos (28,5%). Un total de 65 pacientes (22%) fallecieron, sin embargo, en ninguno de los casos fue posible inferir con seguridad la relación causal entre el FHD, las enzimas hepáticas y la muerte. Conclusión: la prescripción de FPH es frecuente en pacientes con EHC incluso en un hospital universitario terciario y en el servicio de gastroenterología y hepatología, exponiendo a estos pacientes a un riesgo adicional

Convergence of the critical attractor of dissipative maps: Log-periodic oscillations, fractality and nonextensivity

For a family of logistic-like maps, we investigate the rate of convergence to the critical attractor when an ensemble of initial conditions is uniformly spread over the entire phase space. We found that the phase space volume occupied by the ensemble W(t) depicts a power-law decay with log-periodic oscillations reflecting the multifractal character of the critical attractor. We explore the parametric dependence of the power-law exponent and the amplitude of the log-periodic oscillations with the attractor's fractal dimension governed by the inflexion of the map near its extremal point. Further, we investigate the temporal evolution of W(t) for the circle map whose critical attractor is dense. In this case, we found W(t) to exhibit a rich pattern with a slow logarithmic decay of the lower bounds. These results are discussed in the context of nonextensive Tsallis entropies.Comment: 8 pages and 8 fig

Critical Collapse of Cylindrically Symmetric Scalar Field in Four-Dimensional Einstein's Theory of Gravity

Four-dimensional cylindrically symmetric spacetimes with homothetic self-similarity are studied in the context of Einstein's Theory of Gravity, and a class of exact solutions to the Einstein-massless scalar field equations is found. Their local and global properties are investigated and found that they represent gravitational collapse of a massless scalar field. In some cases the collapse forms black holes with cylindrical symmetry, while in the other cases it does not. The linear perturbations of these solutions are also studied and given in closed form. From the spectra of the unstable eigen-modes, it is found that there exists one solution that has precisely one unstable mode, which may represent a critical solution, sitting on a boundary that separates two different basins of attraction in the phase space.Comment: Some typos are corrected. The final version to appear in Phys. Rev.

Biochemical detection of E-ADA on Neospora caninum tachyzoites and the effects of a specific enzymatic inhibitor

Objective. This study aimed to investigate the presence and activity of the ecto adenosine deaminase (E-ADA) enzyme in tachyzoites of Neospora caninum (Nc-1 strain), as well as to assess the activity of a well-known E-ADA inhibitor, the deoxycoformycin. Materials and methods. The parasites were grown in cell culture, being subsequently separated in a pellet of tachyzoites, on which the E-ADA activity was tested using the concentrations 0 (control), 0.2, 0.4 and 0.8 mg mL-1. Results. The E-ADA showed high activity, progressively increasing its activity according to the enhancement of the protein concentration. The test was carried out with different concentrations of deoxycoformycin, showing that it was able to inhibit the E-ADA present on the free form of the parasite. Conclusions. Based on these results we conclude that the E-ADA is present on tachyzoites of N. caninum, and deoxycoformycin is able to inhibit this enzyme. In this sense, knowing the negative impact of N. caninum on reproductive issue in cattle (mainly abortion), might it is an alternative in order to deal with this parasitic infection. Key words: adenosine deaminase, deoxycoformycin, neosporosis (Source: CAB, MeSH)