PREPARAÇÕES DO TIPO EMPANADOS À BASE DE BANANA E SOJA: UM ESTUDO PROSPECTIVO

A industrialização da banana apresenta-se como forma de minimizar as perdas da fruta “in natura”, de estimular o seu cultivo e de incentivar as exportações da fruta industrializada. Desse modo, o aproveitamento da banana pode melhorar a qualidade nutricional dos produtos alimentícios e agregar valores aos produtos à base de soja, cuja divulgação dos benefícios à saúde atribuídos ao consumo desta leguminosa contribui para o crescente aumento do interesse por alimentos à base de soja no Brasil. Assim, este trabalho visa realizar um levantamento de patentes e produções científicas relacionadas ao tema, de forma a obter informações sobre as pesquisas desenvolvidas com estes alimentos. O número de depósitos de patentes e publicações de artigos, teses e dissertações envolvendo os alimentos banana e soja é bem elevado. Porém, na produção de empanados, esse número se torna escasso, havendo somente alguns resultados relacionados com a soja

Conceptual maps : representations of History teachers’ knowledge

Este texto pretende discutir o papel dos mapas de conceitos como representações gráficas do conhecimento do professor de história, aquando o desenho de um trajecto didáctico específico. Identificar-se-ão as dificuldades inerentes à sua construção assim como possíveis modos de utilização na sala de aula de História do Ensino Básico.This text intends to discuss the role of conceptual maps as graphic representations of History teachers’ knowledge, when they draw a didactic plan. We aim also to identify the problems teachers faced during the maps construction, and as well to point out possible ways to use them in 2nd and 3rd cycle history classrooms

Dynamic culture of osteogenic cells in biomimetically coated poly(caprolactone) nanofibre mesh constructs

In our previous work, biomimetic calcium phosphate-coated poly(caprolactone) nanofibre meshes (BCP-NMs) were demonstrated to be more effective for supporting cell attachment and proliferation under static conditions, when compared with poly(caprolactone) nanofibre meshes (PCL-NMs). In many applications, in vitro cultivation of constructs using bioreactors that support efficient nutrition of cells has appeared as an important step toward the development of functional grafts. This work aimed at studying the effects of dynamic culture conditions and biomimetic coating on bone cells grown on the nanofibre meshes. BCP-NM and PCL-NM were seeded with osteoblast-like cells (MG63--human osteosarcoma-derived cell line). The cell-seeded constructs were cultured within a rotating bioreactor that simulated microgravity, at a fixed rotating speed, for different time periods, and then characterized. Cell morphology, viability, and phenotype were assessed. PCL-NM constructs presented a higher number of dead cells than BCP-NM constructs. Under dynamic conditions, the production of proteins associated with the extracellular matrix of bone was higher on BCP-NM constructs than in the PCL-NM ones, which indicates that coated samples may provide cells with a better environment for tissue growth. It is suggested that improved mass transfer in the bioreactor in combination with the appropriate substrate were decisive factors for this highly positive outcome for generating bone.This work was developed under the scope of the EU Project Network of Excellence "Expertissues'' (NMP3-CT-2004-500283) and supported by Alea jacta est Marie Curie Actions (MEST-CT-2004-008104). M. Alves da Silva would like to acknowledge the Portuguese Foundation for Science and Technology for her grant (SFRH-BD-28708-2006). Jose V. Araujo is grateful to S. Rathbone, H. Sura, I. Wimpenny, I. Dublon, G. Jones, and E. D. Pinho for useful technical discussions

Perinatal malnutrition stimulates motivation through reward and enhances drd1a receptor expression in the ventral striatum of adult mice

AbstractAimThe aim of this study was to analyze the effects of protein perinatal malnutrition on the function of dopamine DRD1 and DRD2 receptors in regards to motivation and food consumption in adult mice. The study also analyzed the effect of protein perinatal malnutrition on the gene expression of these receptors in the ventral striatum.MethodsWistar lineage mice were divided into two groups according to maternal diet: control (17% casein), n=30 and low protein (8% casein), n=30. Between 30 and 120days of life, the following factors were measured: body weight; the effect of dopamine D1 and D2 agonists on the ingestion of palatable food; the motivational aspect under the action of the D1 (SKF 38393) and D2 Quinpirole dopaminergic agonists; and the gene expression of DRD1 and DRD2 receptors in the ventral striatum.ResultsThe body weights of the malnourished animals remained significantly lower than those of the control group from 30 to 120days of life. Malnourished animals ingested a greater quantity of palatable food. There was a decrease in palatable diet consumption in both the control and malnourished groups after the application of D1 and D2 agonists; however, the anorexic effect of the D1 agonist was understated in malnourished animals. Perinatal malnutrition increases the motivational behavior of the animal when food reward is used. There was an increase in gene expression of the DRD1a receptor in the ventral striatum of malnourished animals, and there were no significant changes concerning the DRD2 receptor.ConclusionsPerinatal protein malnutrition stimulates hedonic control of eating behavior by promoting increased intake of palatable foods, possibly due to increased expression of dopamine receptor DRD1a in the ventral striatum

Relationship between microcephaly and indicators of social inequality in the state of Paraíba, Brazil

ABSTRACT Objective To analyze the relationship between microcephaly and social inequality indicators in the state of Paraíba during the biennium January 2015 and December 2016. Methods Ecological study with data from newborn microcephaly records and municipal socioeconomic, environmental, and demographic indicators was conducted using two health information systems from the Brazilian Ministry of Health (SINASC and SINAN) and the Brazilian Institute of Geography and Statistics. A Poisson multiple regression model was applied with a significance level of 5%. Results Among 223 municipalities in Paraíba, 74 registered new cases of microcephaly. The number of Zika virus cases, number of inhabitants, number of households without adequate water supply, and household income were predictor variables of the number of new cases of microcephaly in Paraíba. Conclusion Microcephaly is associated with indicators of social inequality in Paraíba. Zika virus cases, water supply, and family income are the indicators that best explain the increase in microcephaly cases. Therefore, these variables must be monitored by health professionals and authorities

Mulheres submetidas à cirurgia bariátrica: um estudo reflexivo sobre os cuidados reprodutivos e psicossociais / Women undergoing bariatric surgery: a reflective study on reproductive and psychosocial care

Este estudo objetivou desenvolver uma reflexão teórico-crítica a respeito de informações na literatura sobre os cuidados reprodutivos e psicossociais com as mulheres submetidas à cirurgia bariátrica. Os descritores: Obesidade, Cirurgia bariátrica; Saúde reprodutiva; Depressão; Qualidade de vida e seus sinônimos foram utilizados nas bases de dados Medline, Lilacs, Google Scholar, Cochrane e Pubmed para buscar artigos relacionados com a temática. No estudo discute-se a cirurgia bariátrica e os seus aspectos epidemiológicos e psicossociais, considerando a sua relação com a fertilidade, sexualidade, gestação e contracepção, ressaltando-se o uso do sistema intrauterino liberador de levonorgestrel. A gestação é contraindicada nos primeiros meses após a cirurgia, portanto, mulheres no menacme devem receber orientações pré operatórias sobre contracepção segura, que ao mesmo tempo interfira minimamente sobre a perda de peso, função sexual e estado psicosocial, além de atuar no controle da anemia ferropriva e colaborar para a compensação de suas comorbidades. Portanto, a mulher submetida a cirurgia bariátrica precisa de atendimento na sua integralidade, pois após o procedimento cirúrgico a usuária possui várias carências, necessitando de uma assistência de qualidade e resoluta que contemple os fatores relacionados a saúde reprodutiva, a sexualidade e os aspectos psicossociais

COVID-19 outcomes in people living with HIV: Peering through the waves

Objective: To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods: This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results: Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions: Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group

Multicenter validation of PIM3 and PIM2 in Brazilian pediatric intensive care units

ObjectiveTo validate the PIM3 score in Brazilian PICUs and compare its performance with the PIM2.MethodsObservational, retrospective, multicenter study, including patients younger than 16 years old admitted consecutively from October 2013 to September 2019. We assessed the Standardized Mortality Ratio (SMR), the discrimination capability (using the area under the receiver operating characteristic curve – AUROC), and the calibration. To assess the calibration, we used the calibration belt, which is a curve that represents the correlation of predicted and observed values and their 95% Confidence Interval (CI) through all the risk ranges. We also analyzed the performance of both scores in three periods: 2013–2015, 2015–2017, and 2017–2019.Results41,541 patients from 22 PICUs were included. Most patients aged less than 24 months (58.4%) and were admitted for medical conditions (88.6%) (respiratory conditions = 53.8%). Invasive mechanical ventilation was used in 5.8%. The median PICU length of stay was three days (IQR, 2–5), and the observed mortality was 1.8% (763 deaths). The predicted mortality by PIM3 was 1.8% (SMR 1.00; 95% CI 0.94–1.08) and by PIM2 was 2.1% (SMR 0.90; 95% CI 0.83–0.96). Both scores had good discrimination (PIM3 AUROC = 0.88 and PIM2 AUROC = 0.89). In calibration analysis, both scores overestimated mortality in the 0%–3% risk range, PIM3 tended to underestimate mortality in medium-risk patients (9%–46% risk range), and PIM2 also overestimated mortality in high-risk patients (70%–100% mortality risk).ConclusionsBoth scores had a good discrimination ability but poor calibration in different ranges, which deteriorated over time in the population studied

Estudos Artísticos

Arte em transe. De um modo especializado, dentro do projeto criadores sobre outras obras, a revista Croma interessa-se pela implicação, a intervenção, e a valorização. Nesta sétima edição reuniram-se 17 artigos que tomam como ponto comum a abordagem de obras que exigem diferentes formas de participação. As propostas artísticas não funcionam sem a interação das pessoas. O seu suporte vital, funcional, o seu sentido, estas dimensões, materiais e imateriais, convergem para as pessoas vivas que com elas atuam. Sobre estes artigos podemos promover diferentes abordagens. Mas interessará estudar o que motivou os temas apresentados. Podem detetar-se regularidades dentro dos espaços de implicação que privilegiamos na revista Croma. Quais são estas regularidades? Encontramos alguns núcleos problematizadores comuns: o género, a inclusão, a migração, o corpo, a identidade.info:eu-repo/semantics/publishedVersio