386 research outputs found
Sequence structure emission in The Red Rectangle Bands
We report high resolution (R~37,000) integral field spectroscopy of the
central region (r<14arcsec) of the Red Rectangle nebula surrounding HD44179.
The observations focus on the 5800A emission feature, the bluest of the
yellow/red emission bands in the Red Rectangle. We propose that the emission
feature, widely believed to be a molecular emission band, is not a molecular
rotation contour, but a vibrational contour caused by overlapping sequence
bands from a molecule with an extended chromophore. We model the feature as
arising in a Polycyclic Aromatic Hydrocarbon (PAH) with 45-100 carbon atoms.Comment: 13 pages, 9 figures, accepted for publication in ApJ. A version of
the paper with full resolution figures is available at:
http://www.aao.gov.au/local/www/rgs/Sequence-Structure
Unusually Weak Diffuse Interstellar Bands toward HD 62542
As part of an extensive survey of diffuse interstellar bands (DIBs), we have
obtained optical spectra of the moderately reddened B5V star HD 62542, which is
known to have an unusual UV extinction curve of the type usually identified
with dark clouds. The typically strongest of the commonly catalogued DIBs
covered by the spectra -- those at 5780, 5797, 6270, 6284, and 6614 A -- are
essentially absent in this line of sight, in marked contrast with other lines
of sight of similar reddening. We compare the HD 62542 line of sight with
others exhibiting a range of extinction properties and molecular abundances and
interpret the weakness of the DIBs as an extreme case of deficient DIB
formation in a dense cloud whose more diffuse outer layers have been stripped
away. We comment on the challenges these observations pose for identifying the
carriers of the diffuse bands.Comment: 20 pages, 4 figures; aastex; accepted by Ap
Infrared Emission from Interstellar Dust. II. The Diffuse Interstellar Medium
We present a quantitative model for the infrared emission from dust in the
diffuse interstellar medium. The model consists of a mixture of amorphous
silicate grains and carbonaceous grains, each with a wide size distribution
ranging from molecules containing tens of atoms to large grains > 1 um in
diameter. We assume that the carbonaceous grains have polycyclic aromatic
hydrocarbon (PAH)-like properties at very small sizes, and graphitic properties
for radii a > 50 A. On the basis of recent laboratory studies and guided by
astronomical observations, we propose "astronomical" absorption cross sections
for use in modeling neutral and ionized PAHs from the far ultraviolet to the
far infrared. We also propose modifications to the far-infrared emissivity of
"astronomical silicate". We calculate energy distribution functions for small
grains undergoing "temperature spikes" due to stochastic absorption of
starlight photons, using realistic heat capacities and optical properties.
Using a grain size distribution consistent with the observed interstellar
extinction, we are able to reproduce the near-IR to submillimeter emission
spectrum of the diffuse interstellar medium, including the PAH emission
features at 3.3, 6.2, 7.7, 8.6, and 11.3um. The model is compared with the
observed emission at high Galactic latitudes as well as in the Galactic plane,
as measured by COBE and IRTS. We calculate infrared emission spectra for our
dust model heated by a range of starlight intensities, and we provide tabulated
dust opacities (extended tables available at
http://www.astro.princeton.edu/~draine/dust/dustmix.html)Comment: Final version published in ApJ, 554, 778 but with factor 1.086 error
in Table 6 and Fig. 16 corrected. Main change from astro-ph version 1 is
correction of typographical errors in Table 1, and correction of typo in eq.
(A2). 51 pages, 16 figures, Late
Workplace learning from a socio-cultural perspective: creating developmental space during the general practice clerkship
Workplace learning in undergraduate medical education has predominantly been studied from a cognitive perspective, despite its complex contextual characteristics, which influence medical studentsâ learning experiences in such a way that explanation in terms of knowledge, skills, attitudes and single determinants of instructiveness is unlikely to suffice. There is also a paucity of research which, from a perspective other than the cognitive or descriptive one, investigates student learning in general practice settings, which are often characterised as powerful learning environments. In this study we took a socio-cultural perspective to clarify how students learn during a general practice clerkship and to construct a conceptual framework that captures this type of learning. Our analysis of group interviews with 44 fifth-year undergraduate medical students about their learning experiences in general practice showed that students needed developmental space to be able to learn and develop their professional identity. This space results from the intertwinement of workplace context, personal and professional interactions and emotions such as feeling respected and self-confident. These forces framed studentsâ participation in patient consultations, conversations with supervisors about consultations and studentsâ observation of supervisors, thereby determining the opportunities afforded to students to mind their learning. These findings resonate with other conceptual frameworks and learning theories. In order to refine our interpretation, we recommend that further research from a socio-cultural perspective should also explore other aspects of workplace learning in medical education
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide exploration across 342,596 cytosine-phosphate-guanine dinucleotides (CpGs) for potential mediators of the association between prenatal famine exposure and adult body mass index (BMI), serum triglycerides (TG), or glucose concentrations, which was followed by formal mediation analysis. DNAm mediated the association of prenatal famine exposure with adult BMI and TG but not with glucose. DNAm at PIM3 (cg09349128), a gene involved in energy metabolism, mediated 13.4% [95% confidence interval (CI), 5 to 28%] of the association between famine exposure and BMI. DNAm at six CpGs, including TXNIP (cg19693031), influencing ÎČ cell function, and ABCG1 (cg07397296), affecting lipid metabolism, together mediated 80% (95% CI, 38.5 to 100%) of the association between famine exposure and TG. Analyses restricted to those exposed to famine during early gestation identified additional CpGs mediating the relationship with TG near PFKFB3 (glycolysis) and METTL8 (adipogenesis). DNAm at the CpGs involved was associated with gene expression in an external data set and correlated with DNAm levels in fat depots in additional postmortem data. Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in early life on long-term metabolic health. The specific mechanism awaits elucidation
Integrated sustainable urban development strategies in the European Union:added value and challenges
Coronary angiography enhancement for visualization
High quality visualization on X-ray angiograms is of great significance both for the diagnosis of vessel abnormalities and for coronary interventions. Algorithms for improving the visualization of detailed vascular structures without significantly increasing image noise are currently demanded in the market. A new algorithm called stick-guided lateral inhibition (SGLI) is presented for increasing the visibility of coronary vascular structures. A validation study was set up to compare the SGLI algorithm with the conventional unsharp masking (UM) algorithm on 20 still frames of coronary angiographic images. Ten experienced QCA analysts and nine cardiologists from various centers participated in the validation. Sample scoring value (SSV) and observer agreement value (OAV) were defined to evaluate the validation result, in terms of enhancing performance and observer agreement, respectively. The mean of SSV was concluded to be 77.1 ± 11.9%, indicating that the SGLI algorithm performed significantly better than the UM algorithm (P-value < 0.001). The mean of the OAV was concluded to be 70.3%, indicating that the average agreement with respect to a senior cardiologist was 70.3%. In conclusion, this validation study clearly demonstrates the superiority of the SGLI algorithm in the visualization of coronary arteries from X-ray angiograms
Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study
ObjectiveTo determine the incidence and risk factors for neurodevelopmental impairment (NDI) in children with hemolytic disease of the fetus/newborn treated with intrauterine transfusion (IUT).Study DesignNeurodevelopmental outcome in children at least 2 years of age was assessed using standardized tests, including the Bayley Scales of Infant Development, the Wechsler Preschool and Primary Scale of Intelligence, and the Wechsler Intelligence Scale for Children, according to the children's age. Primary outcome was the incidence of neurodevelopmental impairment defined as at least one of the following: cerebral palsy, severe developmental delay, bilateral deafness, and/or blindness.ResultsA total of 291 children were evaluated at a median age of 8.2 years (range, 2â17 years). Cerebral palsy was detected in 6 (2.1%) children, severe developmental delay in 9 (3.1%) children, and bilateral deafness in 3 (1.0%) children. The overall incidence of neurodevelopmental impairment was 4.8% (14/291). In a multivariate regression analysis including only preoperative risk factors, severe hydrops was independently associated with neurodevelopmental impairment (odds ratio, 11.2; 95% confidence interval, 1.7â92.7).ConclusionIncidence of neurodevelopmental impairment in children treated with intrauterine transfusion for fetal alloimmune anemia is low (4.8%). Prevention of fetal hydrops, the strongest preoperative predictor for impaired neurodevelopment, by timely detection, referral and treatment may improve long-term outcome
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