Analysis of shared heritability in common disorders of the brain

Paroxysmal Cerebral Disorder

Smoking, alcohol consumption and the use of drugs by pupils of schools for special education, vocational education and truants' projects 1990

In addition to an earlier survey "Smoking, alcohol consumption and the use of drugs by schoolchildren from the age of ten" (Steinmetz Archive Nr. P1057) among pupils of regular schools, pupils of schools for special education have been interviewed about this subject. Smoking behaviour / number of cigarettes per day / attitude of parents towards smoking / use of alcohol, kind of drinks / r. drunk at last occasion / how and did r. get the drinks / opinions of parents about drinking alcohol by r. / knowledge and use of soft drugs, use of it by friends and opinion of parents / use of sleeping pills, tranquillizers, cocaine, heroine, xtc, amphetamine / absenteeism Background variables: basic characteristics/ place of birth/ residence/ household characteristics/ occupation/employment/ education/ religio

Optimal Thermal Actuation for Mitigation of Heat-Induced Wafer Deformation

An important step in the production of integrated circuits is the projection of the pattern of electronic connections on a silicon wafer. The light used to project the pattern moves over the wafer and induces a local temperature increase. The resulting thermal expansion of the wafer leads to a significant reduction in the imaging quality of next-generation wafer scanners. Thermal actuators that move together with the projection light can be used to improve the imaging quality. Because the placement of these actuators largely determines the performance of the resulting control system, a method to support the design of an effective thermal actuator layout is presented. The proposed method computes the smallest actuation heat load that consists of a single spatial shape and respects certain constraints on wafer deformations. A gradient-based optimization algorithm is presented to compute the optimal actuation heat load. The proposed method is applied to a wafer heating problem for which the resulting shapes of the actuation heat load have a clear physical interpretation

The method of images in thermoelasticity with an application to wafer heating

The well-known method of images relates the solution of the heat equation on (Formula presented.) (typically n = 2 or n = 3) to the solution of the heat equation on certain spatial subdomains Ω of (Formula presented.) By reformulating the method of images in terms of a convolution kernel, two novel extensions are obtained in this paper. First, the method of images is extended from thermal problems to thermoelastic problems, that is, it is demonstrated how the heat-induced deformations on (Formula presented.) can be related to the heat-induced deformations on certain subdomains Ω of (Formula presented.) Secondly, an explicit expression for the convolution kernel for the disk is obtained. This enables the application of the method of images to circular domains to which it could not be applied before. The two obtained extensions lead to a computationally efficient simulation method for repetitive heat loads on a disk. In a representative simulation example of wafer heating, the proposed method is more than ten times faster than a conventional Finite Element approach

Optimal actuator shape design with input and state constraints for a wafer heating application

Thermal actuation can reduce deterioration of the imaging quality due to wafer heating. Because the placement of thermal actuators is critical for the performance of the resulting control system, a method to aid the design of an actuator layout is developed. Optimal actuator shapes are computed as the solution of an optimization problem that involves input and state constraints. The resulting actuator shapes have a clear physical interpretation for the next-generation wafer scanners and numerical results seem to indicate that the designed actuator shapes might be unique

Binational confidential enquiry of maternal deaths due to postpartum hemorrhage in France and the Netherlands:Lessons learned through the perspective of a different context of care

Objective: To learn lessons for maternity care by scrutinizing postpartum hemorrhage management (PPH) in cases of PPH-related maternal deaths in France and the Netherlands. Methods: In this binational Confidential Enquiry into Maternal Deaths (CEMD), 14 PPH-related maternal deaths were reviewed by six experts from the French and Dutch national maternal death review committees regarding cause and preventability of death, clinical care and healthcare organization. Improvable care factors and lessons learned were identified. CEMD practices and PPH guidelines in France and the Netherlands were compared in the process. Results: For France, new insights were primarily related to organization of healthcare, with lessons learned focusing on medical leadership and implementation of (surgical) checklists. For the Netherlands, insights were mainly related to clinical care, emphasizing hemostatic surgery earlier in the course of PPH and reducing the third stage of labor by prompter manual removal of the placenta. Experts recommended extending PPH guidelines with specific guidance for women refusing blood products and systematic evaluation of risk factors. The quality of CEMD was presumed to benefit from enhanced case finding, also through non-obstetric sources, and electronic reporting of maternal deaths to reduce the administrative burden. Conclusion: A binational CEMD revealed opportunities for improvement of care beyond lessons learned at the national level.</p

Roken, drinken en druggebruik onder scholieren van het Speciaal Onderwijs, het KMBO en door deelnemers aan spijbelprojecten 1990

In addition to an earlier survey "Smoking, alcohol consumption and the use of drugs by schoolchildren from the age of ten" (Steinmetz Archive Nr. P1057) among pupils of regular schools, pupils of schools for special education have been interviewed about this subject. Smoking behaviour / number of cigarettes per day / attitude of parents towards smoking / use of alcohol, kind of drinks / r. drunk at last occasion / how and did r. get the drinks / opinions of parents about drinking alcohol by r. / knowledge and use of soft drugs, use of it by friends and opinion of parents / use of sleeping pills, tranquillizers, cocaine, heroine, xtc, amphetamine / absenteeism Background variables: basic characteristics/ place of birth/ residence/ household characteristics/ occupation/employment/ education/ religio