Maximum Flag-Rank Distance Codes

In this paper we extend the study of linear spaces of upper triangular matrices endowed with the flag-rank metric. Such metric spaces are isometric to certain spaces of degenerate flags and have been suggested as suitable framework for network coding. In this setting we provide a Singleton-like bound which relates the parameters of a flag-rank-metric code. This allows us to introduce the family of maximum flag-rank distance codes, that are flag-rank-metric codes meeting the Singleton-like bound with equality. Finally, we provide several constructions of maximum flag-rank distance codes

Numerical Analysis for Reduced-scale Road Tunnel Model Equipped with Axial Jet Fan Ventilation System☆

Abstract In this paper a preliminary tridimensional CFD analysis is carried out for a future realization of a reduced-scale road tunnel experimental apparatus of 1/50 equipped with different impulsive fans, traditional and alternative. The alternative jet fan is provided of inlet/outlet sections inclined at a fixed pitch angle (α=6°) toward the tunnel floor. Typically, in the experimental scale tunnel model the air flow induced by ventilation system is provided by an external fan and fully developed flow field is considered. In this paper, the authors have simulated a realistic full and reduced-scale tunnel in order to evaluate the influence of ceiling and floor roughness height on the velocity field to identify an appropriate material for a future experimental apparatus. The jet fans are simulated as a simple momentum source. The fan is considered to be infinitely thin and the discontinuous pressure rise (pressure drop) across it is defined as a function of the air velocity through the fan. In order to create a reduced-scale model from a full scale, Froude method is applied to preserve geometrical, kinematical and dynamical similitude. The results, provided in terms of axial velocity profiles in different tunnel sections, show the overlapping between velocity profiles of full scale numerical model with those of the reduced-scale model, for the both ventilation systems

Chapter Analysis of the theoretical settlement scenario implemented by the municipal plans. the case study of the Romagna coast municipalities

In Italy, the transformative predictions of the municipal urban planning instruments are very often far away from the socio-economic dynamics. In fact, the political component considers the oversizing of urban transformative projections as a solution to improve the situation of the territories in crisis for several aspects. This work analyses the projections of the urban planning instruments in force in the coastal municipalities of Emilia-Romagna. The work aims to highlight how the planned urban areas can change the future settlement structure in the case study area

Higher risk of tuberculosis reactivation when anti-TNF is combined with immunosuppressive agents. A systematic review of randomized controlled trials

Objective. Treatment with tumour necrosis factor antagonists (anti-TNF) has been recognized as a risk factor for tuberculosis (TB) reactivation. Our aim was to evaluate risk of TB reactivation in rheumatologic and non-rheumatologic diseases treated with the same anti-TNF agents with and without concomitant therapies. Methods. We searched for randomized controlled trials (RCTs) evaluating infliximab, adalimumab, and certolizumab in both rheumatologic and non-rheumatologic diseases until 2012. Results were calculated as pooled rates and/or pooled odd ratios (OR). Results. Overall, 40 RCTs with a total of 14,683 patients (anti-TNF: 10,010; placebo: 4673) were included. TB reactivation was 0.26% (26/10,010) in the anti-TNF group and 0% (0/4673) in the control group, corresponding to an OR of 24.8 (95% CI 2.4-133). TB risk was higher when anti-TNF agents were combined with methotrexate or azathioprine as compared with either controls (24/4241 versus 0/4673; OR 54; 95% CI 5.3-88) or anti-TNF monotherapy (24/4241 versus 2/5769; OR 13.3; 95% CI 3.7-100). When anti-TNF was used as monotherapy, TB risk tended to be higher than placebo (2/5769 versus 0/4673; OR 4; 95% CI 0.2-15.7). Conclusions. TB risk with anti-TNF agents appeared to be increased when these agents were used in combination with methotrexate or azathioprine as compared with monotherapy regimen. TB risk seemed to be higher than placebo, even when monotherapy is prescribed

The urban pressure on Italian river areas

Rivers have been the hub of economic and social development in the human evolution, because they are essential resources for: agricultural development, infrastructure networks and development of the first urban strategies. Territory has had a radical transformation that led to a national average urbanization of about 10%; but this development has happened with different degrees of awareness and without uniform models and criteria. One of the main causes of this is due to an extreme fragmentation of planning, because the municipalities’ plans are a binding power modality, in force in Italy, but they don’t have significant and strategic references at regional and territorial scale. In particular, the Italian river areas have undergone a real siege by urban growth, outlining a critical scenario in terms of risks for the population and for the natural system. Some disciplines such as landscape ecology have contributed substantially to the integration of some environmental issues that have led into greater consideration for the protection of the landscape. In the same way the concept of Ecosystem Services combines knowledge, techniques and legislation to achieve the goal of sustainable planning. So, it is necessary that these scientific disciplines, which deal with environmental planning in various ways, find the right devices to guarantee a multi-criteria approach to the problem of consumption of the Natural Capital

INDICATOR ENGINEERING FOR LAND TAKE CONTROL AND SETTLEMENT SUSTAINABILITY

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Increase of productivity in arugula variety folha-larga under the application of foliar fertilizers / Aumento da produtividade em rúcula variedade folha-larga com aplicação de fertilizantes foliares

Organomineral fertilizers are fertilizers of organic origin enriched with mineral nutrients that have been presenting positive responses in several vegetable groves. The aim of this work was to use the experimental factorial design methodology 32 and response surface analysis to verify the influences of the variable productivity of the arugula var. Folha Larga. Vegetation® and Spin® foliar fertilizers were applied in factorial design 32, with three repetitions at the central point. The results of this research lead us to affirm that the central point (test 6) with application of 60 mL L-1 of the Vegetation® leaf fertilizers associated with Spin® obtained higher values for the productivity of arugula var. Folha Larga relative to the control. 

Phthalates and Bisphenol A: presence in blood serum and follicular fluid of italian women undergoing assisted reproduction techniques

Background: folliculogenesis is a strictly regulated process that may be affected by endocrine disrupting chemicals (EDCs) through sometimes not so clear molecular mechanisms. Methods: we conducted a multicentric observational study involving six fertility centers across Italy, prospectively recruiting 122 women attending a fertility treatment. Recruited women had age ≤42 years, and normal ovarian reserve. Blood and follicular fluid samples were taken for EDCs measurement using liquid chromatography tandem mass spectrometry and each woman completed an epidemiological questionnaire. Results: The main EDCs found were monobutyl phthalate (MBP) (median blood: 8.96 ng/mL, follicular fluid 6.43 ng/mL), monoethylhexyl phthalate (MEHP) (median blood: 9.16 ng/mL, follicular fluid 7.68 ng/mL) and bisphenol A (BPA) (median blood: 1.89 ng/mL, follicular fluid 1.86 ng/mL). We found that serum MBP concentration was significantly associated with the considered area (p < 0.001, adj. mean: 7.61 ng/mL, 14.40 ng/mL, 13.56 ng/mL; Area 1: Milan–Turin, Area 2: Rome–Naples; Area 3: Catania–Bari, respectively) but negatively with home plastic food packaging (p = 0.004). Follicular MBP was associated with irregular cycles (p = 0.019). No association was detected between EDCs and eating habits and other clinical and epidemiological features. Conclusions: This study represents the first Italian biomonitoring of plastic EDCs in follicular fluid, laying the basis for future prospective evaluation on oocyte quality before assisted reproduction techniques (ART

The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function

The Wiskott-Aldrich syndrome (WAS) protein (WASp) is a regulator of actin cytoskeleton in hematopoietic cells. Mutations of the WASp gene cause WAS. Although WASp is involved in various immune cell functions, its role in invariant natural killer T (iNKT) cells has never been investigated. Defects of iNKT cells could indeed contribute to several WAS features, such as recurrent infections and high tumor incidence. We found a profound reduction of circulating iNKT cells in WAS patients, directly correlating with the severity of clinical phenotype. To better characterize iNKT cell defect in the absence of WASp, we analyzed was−/− mice. iNKT cell numbers were significantly reduced in the thymus and periphery of was−/− mice as compared with wild-type controls. Moreover analysis of was−/− iNKT cell maturation revealed a complete arrest at the CD44+ NK1.1− intermediate stage. Notably, generation of BM chimeras demonstrated a was−/− iNKT cell-autonomous developmental defect. was−/− iNKT cells were also functionally impaired, as suggested by the reduced secretion of interleukin 4 and interferon γ upon in vivo activation. Altogether, these results demonstrate the relevance of WASp in integrating signals critical for development and functional differentiation of iNKT cells and suggest that defects in these cells may play a role in WAS pathology