Gender Specific Disruptions in Emotion Processing in Younger Adults with Depression

Background: One of the principal theories regarding the biological basis of major depressive disorder (MDD) implicates a dysregulation of emotion-processing circuitry. Gender differences in how emotions are processed and relative experience with emotion processing might help to explain some of the disparities in the prevalence of MDD between women and men. This study sought to explore how gender and depression status relate to emotion processing. Methods: This study employed a 2 (MDD status) × 2 (gender) factorial design to explore differences in classifications of posed facial emotional expressions (N=151). Results: For errors, there was an interaction between gender and depression status. Women with MDD made more errors than did nondepressed women and men with MDD, particularly for fearful and sad stimuli (Ps Ps P=.01). Men with MDD, conversely, performed similarly to control men (P=.61). Conclusions: These results provide novel and intriguing evidence that depression in younger adults (years) differentially disrupts emotion processing in women as compared to men. This interaction could be driven by neurobiological and social learning mechanisms, or interactions between them, and may underlie differences in the prevalence of depression in women and men. Depression and Anxiety, 2009. Published 2008 Wiley-Liss, Inc

Veinte años de producción científica en psicología en la Universidad Católica de Colombia: análisis bibliométrico de la investigación publicada (1983 - 2002)

Se presenta un detallado análisis bibliométrico de los artículos producto de la actividad científica de la Facultad de Psicología de la Universidad Católica de Colombia publicados desde 1983 hasta el 2002. Se revisaron las tres principales bases de datos Psicodoc, PsycInfo, PsycLit, además de una revisión directa en revistas de Psicología y Ciencias afines. A partir de los artículos encontrados se construyó una base de datos, que incluía autor o autores, otras instituciones con quien se publicó, áreas de investigación, lugar de publicación, tipo de publicación, modalidad y fuente donde fue encontrado. En resumen se encontró lo siguiente: setenta y dos artículos en catorce revistas, nueve de ellas internacionales y cinco nacionales, de las cuales en aproximadamente once de las catorce, es decir, el 78.57% se encuentra incluida en alguna base de datos o índice internacional, sin embargo un 79.16% de los artículos encontrados se encuentran concentrados en revistas nacionales, y solo el 20.83% en las internacionales. Un 43% de los artículos fueron escritos por mas de un autor lo que muestra una importante producción en grupo y el 57 % es producto de actividad individual y por autores que no repitieron, es importante también reseñar que algunos autores jalonan la producción general, es así como cinco autores concentran el 35 % del total el 65% restante escribió entre uno y dos artículos el área de mayor trabajo es la clínica seguida por la básica y la educativa y el 71 % de la misma se concentra en los últimos cinco años y aquí es claro el papel tan relevante que ha tenido la publicación de la revista en la producción de artículos el 51 % se han publicado en Acta Colombiana De Psicología.A detailed bibliometric analysis is presented of the articles product of the scientific activity of the Psychology Department at the Catholic University between 1983 to 2002. In this order the Psicodoc, PsycInfo, PsycLit databases were revised, besides other psychological and related science journals. The collected data included for each article: author (s), other institution that supported, year, place, type of publication, modality and source where was found. The results showed: The production of 72 published articles in 14 journal (nine international and five Colombian), of which in approximately eleven of the fourteen, that is to say, the 78.6% is found included in data base or international index, nevertheless 79% of the articles found are concentrated in colombian journals, and 20.83% in the international journals. 43% of the articles were written by but of an author what shows an important production in group and 57% is individual product of activity and by authors that did not repeat. Is important also show that some authors mark the general production, is as well as five authors concentrate 35% of the total. 65% remainder wrote between one and two articles. Finally, the most production areas, in order, were clinical, basic and educative. and 71% of the same one concentrates on the last five years and here is clear the so prominent role that has had the publication of the magazine in the production of articles 51% have been published in Acta Colombiana de Psicología

Affective Circuitry and Risk for Alcoholism in Late Adolescence: Differences in Frontostriatal Responses Between Vulnerable and Resilient Children of Alcoholic Parents

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65950/1/j.1530-0277.2007.00605.x.pd

Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent

The coronavirus disease 2019 (COVID-19) outbreak in North, Central, and South America has become the epicenter of the current pandemic. We have suggested previously that the infection rate of this virus might be lower in people living at high altitude (over 2,500 m) compared to that in the lowlands. Based on data from official sources, we performed a new epidemiological analysis of the development of the pandemic in 23 countries on the American continent as of May 23, 2020. Our results confirm our previous finding, further showing that the incidence of COVID-19 on the American continent decreases significantly starting at 1,000 m above sea level (masl). Moreover, epidemiological modeling indicates that the virus transmission rate is lower in the highlands (>1,000 masl) than in the lowlands (<1,000 masl). Finally, evaluating the differences in the recovery percentage of patients, the death-to-case ratio, and the theoretical fraction of undiagnosed cases, we found that the severity of COVID-19 is also decreased above 1,000 m. We conclude that the impact of the COVID-19 decreases significantly with altitude

First report of Trichinella spiralis from the white-eared (Didelphis albiventris) and the thick-tailed opossum (Lutreolina crassicaudata) in central Argentina

Trichinellosis is a zoonotic disease caused by nematodes of the genus Trichinella. Humans, who are the final hosts, acquire the infection by eating raw or undercooked meat of different animal origin. Trichinella spiralis is an encapsulated species that infects mammals and is widely distributed in different continents. In Argentina, this parasite has been reported in the domestic cycle that includes pigs and synanthropic hosts (mainly rats and some carnivores). This is the first report of T. spiralis in the opossums Didelphis albiventris and Lutreolina crassicaudata in Argentina, and the first report in opossums in South America. In this survey, Trichinella larvae were detected by enzymatic digestion in three D. albiventris and one L. crassicaudata captured on pig and dairy farms located in the northeast of Buenos Aires province. The microscopic examination of the 32 larvae isolated presented the diagnostic characteristic of the genus Trichinella. Two larvae isolated from two D. albiventris and one from L. crassicaudata were identified as T. spiralis by nested multiplex PCR and confirmed by sequencing. Further research to determine the burdens of T. spiralis in opossums may contribute to a better understanding of the risk of T. spiralis transmission to the synanthropic populations.Fil: Castaño Zubieta, R.. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Ruiz, M.. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Morici, G.. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Lovera, Rosario. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernández, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Caracostantogolo, Jorge Luis. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Cavia, Regino. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Piii‐37

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109838/1/cptclpt2006257.pd

Therapeutic efficacy of ormeloxifene against hepatocellular carcinoma

Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and leading cause of cancer related deaths worldwide. Severe toxicity and drug resistance to available chemotherapeutic agents display ineffective clinical response. Therefore, drug repurposing is gaining attention owing to their known biological activities and excellent safety profiles. Ormeloxifene (ORM), non-steroidal, selective estrogen receptor modulator (SERM), and exhibit diverse pharmacological activities. The aim of this study is to assess the therapeutic activity of ORM and to investigate the underlying molecular mechanism against hepatocellular carcinoma. Objective: To investigate the therapeutic activity of ormeloxifene in human hepatocellular carcinoma cells. Methodology: MTT and colony formation assays were performed in SK-Hep-1, Hep3B and C3A cells. In vitro functional assays were carried out for investigating effect of ORM on migration and invasion abilities of HCC cells using Boyden chamber and Matrigel assays respectively. Results: Functional analysis revealed that ORM treatment led to suppression of proliferation and colony formation in human hepatocellular carcinoma cells in dose and time-dependent manner compared to vehicle treated group. ORM treatment, as shown by wound healing and Matrigel invasion assay, respectively, suppresses the migration and invasion of human hepatocellular carcinoma cells. Further, experiments are underway to determine the effect of ORM on EMT markers using western blotting and qPCR techniques. Conclusion: Taken together, ORM exhibited potent anticancer effects against HCC and could be further explored as a novel therapeutic modality for the treatment of HCC

Decline of Monarch Butterflies Overwintering in Mexico- Is the Migratory Phenomenon at Risk?

1.During the 2009-2010 overwintering season and following a 15-year downward trend, the total area in Mexico occupied by the eastern North American population of overwintering monarch butterflies reached an all-time low. Despite an increase, it remained low in 2010-2011. 2. Although the data set is small, the decline in abundance is statistically significant using both linear and exponential regression models. 3. Three factors appear to have contributed to reduce monarch abundance: degradation of the forest in the overwintering areas; the loss of breeding habitat in the United States due to the expansion ofGM herbicide-resistant crops, with consequent loss of milkweed host plants, as well as continued land development; and severe weather. 4. This decline calls into question the long-term survival of the monarchs' migratory phenomeno