PALAEOCLIMATIC EVOLUTION IN LOUTRA ARIDEAS CAVE (ALMOPIA SPELEOPARK, MACEDONIA, N. GREECE) BY STABLE ISOTOPIC ANALYSIS OF FOSSIL BEAR BONES AND TEETH

Carbon and oxygen stable isotope values (δ13C, δ18O) were obtained from structural carbonate in the bioapatite of bear bones (Ursus ingressus) from Loutra Arideas cave, Almopia Speleopark, Macedonia, N. Greece. Samples of Late Pleistocene bear bones were studied for palaeoclimatic reconstruction of the area. The age range of the fossil layers is from 32ka BP to a maximum of 38ka BP. Generally, the palaeoclimatic proxy is correlated with literature data for climatic variations in the area during Late Pleistocene, whereas dietary behavior was investigated taking into account possible diagenetic processes that may have affected the carbonate matrix of the bones

GEOCHEMICAL INVESTIGATION OF AQUIFER POLLUTION FROM WASTE MANAGEMENT. THE CASE OF KOMOTINI LANDFILL (GREECE)

According to European legislation, environmental control and monitoring of landfills has become of crucial importance. This study includes a thorough geochemical approach aiming to evaluate the environmental impact of the landfill of Komotini, N. Greece. Samples of waters were taken from inside the working landfill as well as from the area of the neighbouring old landfill. The waters were analyzed chemically (major elements and heavy metals) and isotopically (D and 18O). Also, biogas flow was measured and the ratio CH4/CO2. Based on the geomorphological, hydrogeological and land use data of the area, we proceeded to analyses of waters both from the area of the landfill and from the wider region (drainage basin). The obtained results were used to construct digital maps (GIS) in order to determine the special dispersion of the polluted aquifers. The biogas flow in the old and new garbage burial sites was measured by accumulation chamber device for methane and carbon dioxide ratio determination. The obtained results show an important agent of pollution in the water samples downstream from the landfill and in a distance more than 2km, along the dispersion of the leachate. The land use of the area was taken into account to evaluate the importance and the criticality of the situation

Sleep Quality and Physical Activity as Predictors of Mental Wellbeing Variance in Older Adults during COVID-19 Lockdown:ECLB COVID-19 International Online Survey

Background. The COVID-19 lockdown could engender disruption to lifestyle behaviors, thus impairing mental wellbeing in the general population. This study investigated whether sociodemographic variables, changes in physical activity, and sleep quality from pre- to during lockdown were predictors of change in mental wellbeing in quarantined older adults. Methods. A 12-week international online survey was launched in 14 languages on 6 April 2020. Forty-one research institutions from Europe, Western-Asia, North-Africa, and the Americas, promoted the survey. The survey was presented in a differential format with questions related to responses "pre" and "during" the lockdown period. Participants responded to the Short Warwick-Edinburgh Mental Wellbeing Scale, the Pittsburgh Sleep Quality Index (PSQI) questionnaire, and the short form of the International Physical Activity Questionnaire. Results. Replies from older adults (aged &gt;55 years, n = 517), mainly from Europe (50.1%), Western-Asia (6.8%), America (30%), and North-Africa (9.3%) were analyzed. The COVID-19 lockdown led to significantly decreased mental wellbeing, sleep quality, and total physical activity energy expenditure levels (all p &lt; 0.001). Regression analysis showed that the change in total PSQI score and total physical activity energy expenditure (F-(2,F- 514) = 66.41 p &lt; 0.001) were significant predictors of the decrease in mental wellbeing from pre- to during lockdown (p &lt; 0.001, R-2: 0.20). Conclusion. COVID-19 lockdown deleteriously affected physical activity and sleep patterns. Furthermore, change in the total PSQI score and total physical activity energy expenditure were significant predictors for the decrease in mental wellbeing.</p

The impact of the 2020 global sulfur cap on maritime CO2 emissions

Purpose: As of January 1, 2020, the upper limit of sulfur emissions outside emission control areas decreased from 3.5% to 0.5%. This paper aims to present some of the challenges associated with the implementation of the sulfur cap and investigates its possible side effects as regard the drive of the International Maritime Organization (IMO) to reduce carbon dioxide (CO2) emissions. Even though it would appear that the two issues (desulfurization and decarbonization) are unrelated, it turns out that there are important cross-linkages between them, which have not been examined, at least by the regulators. Design/methodology/approach: A literature review and a qualitative risk assessment of possible CO2 contributors are presented first. A cost-benefit analysis is then conducted on a specific case study, so as to assess the financial, as well as the environmental impact of two main compliance choices, in terms of CO2 and sulfur oxide. Findings: From a financial perspective, the choice of a scrubber ranks better comparing to a marine gas oil (MGO) choice because of the price difference between MGO and heavy fuel oil. However, and under different price scenarios, the scrubber choice remains sustainable only for big vessels. It is noticed that small containerships cannot outweigh the capital cost of a scrubber investment and are more sensitive in different fuel price scenarios. From an environmental perspective, scrubber ranks better than MGO in the assessment of overall emissions. Research limitations/implications: Fuel price data in this paper was based on 2019 data. As this paper was being written, the COVID-19 pandemic created a significant upheaval in global trade flows, cargo demand and fuel prices. This made any attempt to perform even a rudimentary ex-post evaluation of the 2020 sulfur cap virtually impossible. Due to limited data, such an evaluation would be extremely difficult even under normal circumstances. This paper nevertheless made a brief analysis to investigate possible COVID-19 impacts. Practical implications: The main implication is that the global sulfur cap will increase CO2 emissions. In that sense, this should be factored in the IMO greenhouse gas discussion. Originality/value: According to the knowledge of the authors, no analysis examining the impact of the 2020 sulfur cap on CO2 emissions has yet been conducted in the scientific literature

The impact of the 2020 global sulfur cap on maritime CO2 emissions

Purpose: As of January 1, 2020, the upper limit of sulfur emissions outside emission control areas decreased from 3.5% to 0.5%. This paper aims to present some of the challenges associated with the implementation of the sulfur cap and investigates its possible side effects as regard the drive of the International Maritime Organization (IMO) to reduce carbon dioxide (CO2) emissions. Even though it would appear that the two issues (desulfurization and decarbonization) are unrelated, it turns out that there are important cross-linkages between them, which have not been examined, at least by the regulators. Design/methodology/approach: A literature review and a qualitative risk assessment of possible CO2 contributors are presented first. A cost-benefit analysis is then conducted on a specific case study, so as to assess the financial, as well as the environmental impact of two main compliance choices, in terms of CO2 and sulfur oxide. Findings: From a financial perspective, the choice of a scrubber ranks better comparing to a marine gas oil (MGO) choice because of the price difference between MGO and heavy fuel oil. However, and under different price scenarios, the scrubber choice remains sustainable only for big vessels. It is noticed that small containerships cannot outweigh the capital cost of a scrubber investment and are more sensitive in different fuel price scenarios. From an environmental perspective, scrubber ranks better than MGO in the assessment of overall emissions. Research limitations/implications: Fuel price data in this paper was based on 2019 data. As this paper was being written, the COVID-19 pandemic created a significant upheaval in global trade flows, cargo demand and fuel prices. This made any attempt to perform even a rudimentary ex-post evaluation of the 2020 sulfur cap virtually impossible. Due to limited data, such an evaluation would be extremely difficult even under normal circumstances. This paper nevertheless made a brief analysis to investigate possible COVID-19 impacts. Practical implications: The main implication is that the global sulfur cap will increase CO2 emissions. In that sense, this should be factored in the IMO greenhouse gas discussion. Originality/value: According to the knowledge of the authors, no analysis examining the impact of the 2020 sulfur cap on CO2 emissions has yet been conducted in the scientific literature

Clastic sedimentary features of beachrocks and their palaeo-environmental significance: comparison of past and modern coastal regimes

International audienceClastic sedimentary features of beachrocks and unconsolidated deposits of parent beaches were investigated along the northern Aegean coastline (Greece) to assess their suitability in palaeo-environmental reconstruction. Twelve paired datasets were collected in the Thermaikos, Toroneos, Siggitikos and Ierissos gulfs of the Chalkidiki Peninsula, the adjoining Kavala Gulf and Thassos Island, comprising beachrock cores and companion beach subsurface sediments. Particle size analyses based on univariate and bivariate statistics suggest that, during the time period of beachrock formation, depositional conditions differed distinctly from those of the modern parent beaches. The results imply difference of maturity level of beach evolution from the time of cementation (coarser materials-early stage of beach formation) to modern situation (finer materials-reworked and 'mature' beach sediments). Furthermore, the findings indicate increasing coastal protection due to beachrock exposure in the modern swash zone. In conclusion, it is suggested that textural analysis of beachrocks in comparison with unconsolidated sediments of the parent beach might provide information regarding differences of coastal depositional regimes and future research could focus on specific-layer analysis and comparison

Chondrosarcoma of the proximal phalanx of the fourth digit: A rare location

Introduction: Cartilaginous tumors involving the small bones of the hands and feet are usually benign such as enchondroma, chondromyxoid fibroma and chondroblastoma. The small bones of the hands and feet are rarely involved by primary chondrosarcoma. Proximal phalanges are the most common sites in the hands, but the fourth digit is the least common site. Case Presentation: We report a case of a 76-year-old Greek female who presented to our hospital with a painful swollen mass measuring 4.5 × 2.6 cm on the fourth digit of the left hand. The radiograph showed a destructive, permeative lytic tumor of the proximal phalanx with extension into soft tissue. The patient underwent curettage, and the microscopic examination of the specimen revealed grade 2 chondrosarcoma. Conclusion: Cartilaginous tumors involving the small bones of the hands and feet are usually benign such as enchondroma, chondromyxoid fibroma and chondroblastoma. Primary chondrosarcoma is the third most common malignancy of bone after myeloma and osteosarcoma, but the small bones of the hands and feet are very rarely involved by chondrosarcoma (1% of all chondrosarcoma). However, in these cases differentiation between a benign lesion and chondrosarcoma may be difficult. Occasionally chondrosarcoma of the hands and feet is associated with multiple recurrences or distal metastasis. © 2013 S. Karger AG, Basel

CCL21 and beta-cell antigen releasing hydrogels as tolerance-inducing therapy in Type I diabetes

Type-I Diabetes (T1D) is caused by defective immunotolerance mechanisms enabling autoreactive T cells to escape regulation in lymphoid organs and destroy insulin-producing β-cells in the pancreas, leading to insulin dependence. Strategies to promote β-cell tolerance could arrest T1D. We previously showed that secretion of secondary lymphoid chemokine CCL21 by CCL21 transgenic β-cells induced tolerance and protected non-obese diabetic (NOD) mice from T1D. T1D protection was associated with formation of lymph node-like stromal networks containing tolerogenic fibroblastic reticular cells (FRCs). Here, we developed a polyethylene glycol (PEG) hydrogel platform with hydrolytically degradable PEG-diester dithiol crosslinkers to provide controlled and sustained delivery of CCL21 and β-cell antigens for at least 28 days in vitro and recapitulate properties associated with the tolerogenic environment of CCL21 transgenic β-cells in our previous studies. CCL21 and MHC-II restricted antigens were tethered to gels via simple click-chemistry while MHC-I restricted antigens were loaded in PEG-based polymeric nanovesicles and incorporated in the gel networks. CCL21 and antigen release kinetics depended on the PEG gel tethering strategy and the linkers. Importantly, in vitro functionality, chemotaxis, and activation of antigen-specific T cells were preserved. Implantation of CCL21 and β-cell antigen gels under the kidney capsule of pre-diabetic NOD mice led to enrichment of adoptively transferred antigen-specific T cells, formation of gp38 + FRC-like stromal cell networks, and increased regulation of specific T cells with reduced accumulation within pancreatic islets. Thus, our platform for sustained release of β-cell antigens and CCL21 immunomodulatory molecule could enable the development of antigen-specific tolerance therapies for T1D. [Display omitted] •Different PEG-DD linkers can form hydrogels with fast (PEG-DD1) or slow (PEG-DD2) degradation and molecule release profiles.•Tethering CCL21 on PEG-DD linkers controls and prolongs its release while maintaining its functionality as a chemoattractant.•Beta cell peptides tethered on PEG-DD or loaded in nanovesicles have controlled release and maintain their functionality.•CCL21+BDC2.5 gels in NOD mice promote FRC-like networks and antigen-specific T cell enrichment in the implant site.•CCL21+BDC2.5 gels lead to a decrease of antigen-specific T cells and reduced infiltration in pancreatic islets

Relationship Between General and Specific Coordination in 8- to 17-Year-Old Male Basketball Players.

The purpose of the present study was to investigate the relationships between general coordination, sport-specifi c coordination, and sport-specifi c fi tness of 8- to 17-year-old male basketball players. 312 males with training experience ranging from one year in the 8-year-old cohort up to 10 years for the 17-yearolds performed basketball-specifi c fi tness (20 m sprint, Illinois, countermovement jump), general coordination (20 m run with three obstacles), semi-basketball-specifi c coordination (20 m sprint dribbling two balls, countermovement jump with arm swing) and basketball-specifi c coordination (Illinois ball dribbling) tests. There were moderate to large correlations between the results of both general and basketball- specifi c coordination with the results of most basketball-specifi c coordination tests in all age groups. Correlations between general and basketball-specifi c coordination were large in four age groups (11–14 yr., r = .52 to r = .76), moderate in fi ve groups (8–10, 15 & 16 yr., r = .37 to r = .46), while not signifi cant in the 17-year-olds. These results suggest that the importance of general coordination for sport-specifi c skills improvements during a sports-specifi c skill acquisition phase, remains high at the skill refi nement phase, and decreases when sport-specifi c skills have been mastered to near-perfection